The circadian clock gene BMAL1 modulates autoimmunity features in lupus by Shuichiro Nakabo, Donavon Sandoval-Heglund, Norio Hanata, Stephen Brooks, Victoria Hoffmann, Mingzeng Zhang, William Ambler, Zerai Manna, Elaine Poncio, Sarfaraz Hasni, Shamima Islam, Stefania Dell’Orso, Mariana J. Kaplan, Mariana J. Kaplan

“…BMAL1 expression was quantified in SLE neutrophils and compared with clinical disease.ResultsIMQ-treated Bmal1Mye−/− and WT displayed comparable systemic inflammation. While renal function did not differ, serum anti-dsDNA levels and renal immune complex deposition were significantly increased in Bmal1Mye−/−. …”
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Early life stress induces decreased expression of CB1R and FAAH and epigenetic changes in the medial prefrontal cortex of male rats by Arijana Demaili, Anna Portugalov, Anna Portugalov, Mouna Maroun, Mouna Maroun, Irit Akirav, Irit Akirav, Katharina Braun, Katharina Braun, Jörg Bock, Jörg Bock, Jörg Bock

“…Several studies in both animal models and in humans have provided substantial evidence that early life stress (ELS) induces long-term changes in behavior and brain function, making it a significant risk factor in the aetiology of various mental disorders, including anxiety and depression. …”
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Dynamic Electroneurostimulation in Rehabilitation: a Prospective Randomized Study of 60 Patients after Surgical Treatment of Colorectal Malignancies by Victor A. Drobyshev, Lubov A. Shpagina, Andrey A. Vlasov, Marina V. Umnikova, Tatyana M. Smarzh

“…Upon completion of the rehabilitation the autonomic nervous system balance index (LF/HF) was adjustedby 4.8 and the centralization index by 6.0 times against the baseline, the anxiety and depression index on the HADS scale was reducedby 1.5 times, the quality of life on the SF-36 scale improved: physical functioning by 1.5 times, pain by 1.2 times, general health by 1.5times, which differed from the similar indicators in the 2nd group.Dynamic electroneurostimulation using NEURODENS-PCM device can have pain-relieving and vegetative-regulating effects due toactivation of antinociceptive brain structures and influence on suprasegmental parts of the autonomic nervous system. …”
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Prognostic Value of the Goutallier Scale for Paravertebral Muscle Atrophy in Predicting Disability and Pain Outcomes in Degenerative Lumbar Spinal Stenosis: A Longitudinal Cohort S... by Giuseppe Corazzelli, Sergio Corvino, Chiara Di Domenico, Federico Russo, Vincenzo Meglio, Settimio Leonetti, Valentina Pizzuti, Marco Santilli, Alessandro D’Elia, Francesco Ricciardi, Sergio Paolini, Raffaele de Falco, Oreste de Divitiis, Vincenzo Esposito, Gualtiero Innocenzi

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Sex differences in the sensitization of prenatally programmed hypertension by Baojian Xue, Alan Kim Johnson, Alexander G. Bassuk, Alexander G. Bassuk, Alexander G. Bassuk

“…These mechanisms operate at various levels from the periphery to the central nervous system (e.g., blood vessel, heart, kidney, and brain). …”
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Assessing the metabolism of the olfactory circuit by use of 18F-FDG PET-CT imaging in patients suspected of suffering from Alzheimer’s disease or frontotemporal dementia by Daniël S. L. Loewenstein, Max van Grinsven, Cécile de Pont, Paul L. J. Dautzenberg, Astrid M. van Strien, Dylan Henssen

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Photostimulation as a therapy method for spinal cord contusion while asleep and awake by Semyachkina-Glushkovskaya, Oksana V., Sarantseva, Elena I., Iskra, Tatiana D.

“…Traumatic spinal cord injury is one of the most complex problems in modern medicine, characterized by a signifi cant number of severe consequences and complications, development of traumatic spinal cord disease with a complex of structural and functional disorders leading to limited self-care and mobility, persistent endocrine shifts and changes in internal organs and systems, loss of control of pelvic functions, high mortality rates, and an extremely high level of social and psychological maladaptation of patients. …”
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Information and methodological aspects of developing platforms of spatial management of natural assets in resource limitations by V.V. Mykytenko, I.V. Dragan

“…The structure, content and functions of information and methodological support of the system of spatial management of natural resource assets of the platform type are improved. …”
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Multilayered neuroprotection by cannabinoids in neurodegenerative diseases by Ahmed Hasbi, Susan R. George

“…Neurodegenerative diseases are a complex ensemble of ailments characterized by progressive neuronal deterioration and ultimate loss, resulting in drastic impairments of memory, cognition and other brain functions. These incapacitating conditions are challenging for the public health system worldwide, with unfortunately no real cure and lack of efficient drugs capable of delaying or reversing these diseases. …”
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Rapid synergistic thrombolysis of ischemic stroke guided by high-resolution and high-speed photoacoustic cerebrovascular imaging by Mengtao Han, Zhiwei Xue, Mengchen Yu, Nanlin You, Yaguang Ren, Zhiqiang Xu, Zhifeng Wu, Yiming He, Zonghai Sheng, Chengbo Liu, Donghai Wang, Jingqin Chen

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Increasing reproductive capacity in female blue swimmer crabs using vitellogenesis-inhibiting hormone dsRNA by Supawadee Duangprom, Siriporn Nonkhwao, Jirawat Saetan, Sineenart Songkoomkrong, Prateep Amonruttanapun, Chompunut Samhuay, Benyamat Boonobrom, Montakan Tamtin, Prasert Sobhon, Napamanee Kornthong

“…We investigated the impact of dsRNA-VIH on the reproductive function of female blue swimmer crabs, Portunus pelagicus, by evaluating its capacity to inhibit VIH in the eyestalks. …”
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Expression patterns of kiss2 and gpr54‐2 in Monopterus albus suggest these genes may play a role in sex reversal in fish by Ti‐Lin Yi, Meng‐Ting Pei, Dai‐Qin Yang

“…We identified only two genes: kiss2 and gpr54‐2. kiss2 expression was extremely high in the gonads of males, intermediate in females, and low in intersex; and reduced in all tissues of intersex. gpr54 expression was also extremely high in the gonads of males, high in intersex, but low in females. gpr54 expression in brain was high in all three sexes. In conclusion, (a) kiss1 has been functionally replaced in M. albus; (b) the functions of gpr54‐2 in brain are not sex‐specific; (c) kiss2 appears to undergo a ‘reset’ in the expression during the sex change; and (d) sex‐specific expression patterns in the gonads indicate that these two genes may play a role in sex reversal in fish.…”
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How mindfulness-based training improves stress-related health: a selective review of randomized clinical trials comparing psychological mechanisms of action by Lara M. C. Puhlmann, Lara M. C. Puhlmann, Lara M. C. Puhlmann, Veronika Engert, Veronika Engert, Veronika Engert

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Pigment-dispersing factor neuropeptides act as multifunctional hormones and modulators in tardigrades by Soumi Dutta, Lars Hering, Milena M. Grollmann, Niklas Metzendorf, Vladimir Gross, Kazuharu Arakawa, Susanne Neupert, Monika Stengl, Friedrich W. Herberg, Georg Mayer

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Nature-aligned Education Technologies as the Basis of Forming an Individual Noospheric Consciousness by Natalya V. Maslova, Natalia V. Antonenko, Oksana A. Alekseeva

“…It is shown that the introduction of noospheric consciousness into the realization of individual basic functions displays his/her ability to self-awareness of an integrated system of structural-functional dynamics of the psyche. …”
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Acupuncture treatment of vascular cognitive impairment through peripheral nerve stimulation pathway: a scoping review by Xinming Yang, Xinming Yang, Bo Li, Bo Li, Bo Li, Linna Wu, Ying Cui, Ying Cui

“…The nerve stimulation effects of acupuncture can enhance the regulation of cerebral blood flow, modulate neuroimmune responses, improve brain function, and promote neuroplasticity through multiple central nervous system pathways, ultimately improving cognitive function and treating VCI.ConclusionAcupuncture is a treatment modality that influences the central nervous system through peripheral nerve stimulation to treat VCI. …”
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Clinical value of determination HIV viral load in the cerebrospinal fluid of HIV-infected patients by V. B. Musatov, A. A. Yakovlev, S. G. Andreeva, M. V. Ivanova

“…Observed in some patients HIV replication in the cerebrospinal fluid in the absence of morphological and laboratory changes in the composition of cerebrospinal fluid may reflect indirect effects of HIV the brain, manifested in the form of functional disorders of the central nervous system.…”
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The unevenness of respiratory rhythm as an indicator of emotional stress by Yu. E. Vagin

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Case Report: Pediatric CNS-isolated hemophagocytic lymphohistiocytosis secondary to uniparental disomy of PRF1 mutation by Jiao Xue, Zhenfeng Song, Hongshan Zhao, Chengqing Yang, Fei Li, Zhi Yi, Kaixuan Liu, Ying Zhang

“…Genetic analyses were performed using whole-exome sequencing (WES). NK cell function testing, Granzyme B staining, perforin staining, CD107a mobilization, and soluble CD25 levels were determined.ResultsWe report the case of a 5-year-old girl who presented with involuntary movements, an unsteady gait, and a progressively irritable temper. …”
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Learning Dendritic-Neuron-Based Motion Detection for RGB Images: A Biomimetic Approach by Tianqi Chen, Yuki Todo, Zhiyu Qiu, Yuxiao Hua, Delai Qiu, Xugang Wang, Zheng Tang

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