Mechanism of Electroacupuncture Quchi (LI 11) -Yanglingquan (GB 34) in Rats with Spasticity of Cerebral Apoplexy by Bin GUO, Penghan WANG, Linxing HUANG, Zhiqiang XIE, Lina XIE, Weiai LIU, Lizhen YI, Xin LIU, Zenghui YUE

“…The expression of BDNF-TrkB protein and gene in the model group decreased significantly compared with that in the blank group and the sham operation group respectively (<italic>P</italic>&lt;0.01).Conclusion:Electroacupuncture Quchi (LI 11) -Yanglingquan (GB 34) regulate the expression of BDNF-TrkB gene and protein in hippocampus of the brain. High expression of the neurotrophic factor in hippocampus may promote the remodeling of synapses and improve the motor function of the central nervous system, thus achieving the relief of spasticity.…”
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HY-Deepnet : A new Optimal Deep transfer learning empowered framework for an autonomous Alzheimer’s disease detection and diagnosis system by S. Veluchamy, R. Bhuvaneswari, K. Ashwini, Samah Alshathri, Walid El-Shafai

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KaiXinSan-JiaWei ameliorates cognitive dysfunction in APP/PS1 mice by intervening in gut microbiota and its metabolites by Lulu Mana, Fang Chen, Xiaoxia Yuan

“…BackgroundAlzheimer’s disease (AD) is a degenerative disease of the central nervous system characterized by progressive cognitive impairment and memory loss. …”
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Gut and oral microbial compositional differences in women with breast cancer, women with ductal carcinoma in situ, and healthy women by Emma McCune, Anukriti Sharma, Breanna Johnson, Tess O'Meara, Sarah Theiner, Maribel Campos, Diane Heditsian, Susie Brain, Jack A. Gilbert, Laura Esserman, Michael J. Campbell

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Quantum magnetization exchange through transient hydrogen bond matrix defines magnetic resonance signal relaxation and anisotropy in central nervous system by Dmitriy A. Yablonskiy, Alexander L. Sukstanskii

“…Abstract The integrity of cellular membranes (lipid bilayers) and myelin sheaths covering axons is a crucial feature controlling normal brain structural and functional networks. Yet, in vivo evaluation of this integrity at the nanoscale level of the cellular membranes organization is challenging. …”
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Label-free masterful spectrofluorimetric systems for minuscule tracking of natural antioxidant vincamine in the pharmaceutical, environmental, and biological samples: Comparative g... by Eman Yosrey, Heba Elmansi, Shereen Shalan, Jenny Jeehan Nasr

“…The evaluation showed that the proposed works effectively strike a compromise between sustainability and functionality postulates. This highlighted that designed approaches are perfectly suited as ecological frameworks for minuscule assaying of VN in crucial pharmaceutical, biological, and environmental samples.…”
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Transcranial electrical stimulation in the treatment of peptic ulcer by Dariya N. Tarasova, Vsevolod V. Skvortsov, Boleslav N. Levitan

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A high-fidelity CRISPR-Cas13 system improves abnormalities associated with C9ORF72-linked ALS/FTD by Tristan X. McCallister, Colin K. W. Lim, Mayuri Singh, Sijia Zhang, Najah S. Ahsan, William M. Terpstra, Alisha Y. Xiong, M. Alejandra Zeballos C, Jackson E. Powell, Jenny Drnevich, Yifei Kang, Thomas Gaj

“…By utilizing a Cas13 variant with reduced collateral effects, we develop here a high-fidelity RNA-targeting CRISPR-based system for C9ORF72-linked ALS/FTD. When delivered to the brain of a transgenic rodent model, this Cas13-based platform curbed the expression of the G4C2 repeat-containing RNA without affecting normal C9ORF72 levels, which in turn decreased the formation of RNA foci, reduced the production of a dipeptide repeat protein, and reversed transcriptional deficits. …”
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Neuropathic Cystinosis: A Rare Case Report by Ahmed Muthana, Rabab Farhan Thejeal, Ikhlas Ali Ahmed

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Adaptive trial for the treatment of depressive symptoms associated with concussion using accelerated intermittent theta burst stimulation (ADEPT): rationale, design and methods by Lindsay M. Oberman, Adriana I. Penafiel, Rachel Dieterich, Cuong T. Phan, Yi-Yu Chou, Dzung L. Pham, Maheen M. Adamson, Maheen M. Adamson, Christopher E. Hines, Zeynab Rezaee, Zhi-De Deng, Hemant Pal, Sarah H. Lisanby, Sarah H. Lisanby, David L. Brody, David L. Brody

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mRNA Trafficking in the Nervous System: A Key Mechanism of the Involvement of Activity-Regulated Cytoskeleton-Associated Protein (Arc) in Synaptic Plasticity by Michal Fila, Laura Diaz, Joanna Szczepanska, Elzbieta Pawlowska, Janusz Blasiak

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The antioxidant system was unexpectedly strongly suppressed in apis mellifera worker bees emerged from larvae reared on combs adulterated with paraffin or stearin by Aneta Strachecka, Patrycja Staniszewska, Krzysztof Olszewski, Magdalena Chęć, Mariusz Gagoś, Piotr Dziechciarz, Maciej S. Bryś, Jerzy Paleolog

“…Additionally, the level of global DNA methylation in the brain of these bees was identified. We showed for the first time that paraffin or stearin strongly suppressed the activity of the antioxidant system, including Vg, in honeybee workers emerged from larvae reared on combs adulterated with these compounds. …”
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Translational interdisciplinary research on human chorionic gonadotropin’s enhancement of neuroendocrine crosstalk: a novel medical hypothesis for systemic adjunctive treatment of... by João Francisco Pollo Gaspary, João Francisco Pollo Gaspary, Luis Felipe Dias Lopes, Antonio Geraldo Camara

“…IntroductionIt is increasingly recognized that the brain continuously interacts with other body systems such as the immune system, the gut-brain axis, and the endocrine system. …”
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GeneSurfer enables transcriptome-wide exploration and annotation of gene co-expression modules in 3D spatial transcriptomics data by Chang Li, Julian Thijssen, Thomas Kroes, Ximaine van der Burg, Louise van der Weerd, Thomas Höllt, Boudewijn Lelieveldt

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Safety and Efficacy in Mitral Regurgitation Management with the MitraClip^® G4 System: Insights from a Single-Center Study by Georgios E. Papadopoulos, Ilias Ninios, Sotirios Evangelou, Andreas Ioannidis, Vlasis Ninios

“…Conclusions: The MitraClip^® G4 system provides significant improvements in MR severity, functional class, and QoL. …”
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Changes in the miRNA-mRNA Regulatory Network Precede Motor Symptoms in a Mouse Model of Multiple System Atrophy: Clinical Implications. by Simon Schafferer, Rimpi Khurana, Violetta Refolo, Serena Venezia, Edith Sturm, Paolo Piatti, Clara Hechenberger, Hubert Hackl, Roman Kessler, Michaela Willi, Ronald Gstir, Anne Krogsdam, Alexandra Lusser, Werner Poewe, Gregor K Wenning, Alexander Hüttenhofer, Nadia Stefanova

“…Multiple system atrophy (MSA) is a fatal rapidly progressive α-synucleinopathy, characterized by α-synuclein accumulation in oligodendrocytes. …”
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A novel human pluripotent stem cell gene activation system identifies IGFBP2 as a mediator in the production of haematopoietic progenitors in vitro by Paolo Petazzi, Telma Ventura, Francesca Paola Luongo, Heather McClafferty, Alisha May, Helen Alice Taylor, Michael J Shipston, Nicola Romanò, Lesley M Forrester, Pablo Menendez, Antonella Fidanza

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GPU Accelerated Trilateral Filter for MR Image Restoration by Suthir Sriram, Nivethitha Vijayaraj, T. Srilekha, M. Praveena, Thangavel Murugan

“…The bilateral filter served as foundation to develop this filter while adding another intensity comparison function to deal with brain MR image noise. A weighting control function based on intensity entropy is established for intensity-based weight calculations. …”
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The Role of Akt Signalling Pathway in Neurological and Cardiovascular Pathologies by Akshat D. Modi, Aahmad Ali Mahoon, Dharmeshkumar M. Modi

“…This narrative review discusses the role of PI3K/Akt/mTOR signalling pathway in traumatic central nervous system injuries (brain and spinal cord), cardiac injury (myocardial infarction), inflammatory disease (myocarditis), and rare neurological cancer (chordoma) along with therapeutic targets that are known to prevent worsened outcomes and promote recovery following those conditions.…”
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Adaptive GCN and Bi-GRU-Based Dual Branch for Motor Imagery EEG Decoding by Yelan Wu, Pugang Cao, Meng Xu, Yue Zhang, Xiaoqin Lian, Chongchong Yu

“…This approach lays the foundation for future exploration of personalized and adaptive brain–computer interface (BCI) systems.…”
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