IMMUNE DISTURBANCES IN PATIENTS WITH EPILEPSY AND OPPORTUNITY OF IMMUNOMODULATION BY RECOMBINANT HUMAN IL-2 by L. V. Lipatova, N. B. Serebryanya, N. A. Sivakova, A. V. Vasilenko, T. V. Kapustina

“…The aim of our study is to evaluate the dynamics of immunological parameters in patients with epilepsy (PE) during the treatment with rIL-2-medicament (Roncoleukinum®), cytokine drug of Interleukins series containing recombinant human Interleukin-2 (rIL-2), which is a structural and functional analog of the endogenous IL-2. The results of the research of specialties of system inflammation response in epileptic patients reveal the increased level of the inflammation markers in plasma and CNS (increased concentration and violation of balance of cytokines of IL-1 p family defined by decrease of RAIL-1 concentration and RAIL-1/IL-1 coefficient). …”
Get full text

The prognostic value of amplitude-integrated electroencephalography in neonates with hypoxic-ischemic encephalopathy by Vasiljević Brankica, Maglajlić-Đukić Svjetlana, Gojnić Miroslava

“…All neonates with HIE were categorized into three grades according to the Sarnat and Sarnat clinical scoring system (mild HIE, moderate HIE and severe HIE). aEEG traces were recorded with a cerebral function monitor (CFM) during the first 72 h of life. …”
Get full text

The Causal Relationship Between Asthma and Hippocampal Volume: A Study Based on Bidirectional Mendelian Randomization Analysis by Dandan Han, Shaohua Zhao

“…While observational studies suggest that asthma may affect hippocampal structure and function through mechanisms such as chronic inflammation and hypoxia, its causal relationship remains unclear. …”
Get full text

Ballroom Dancing Promotes Neural Activity in the Sensorimotor System: A Resting-State fMRI Study by Yingzhi Lu, Qi Zhao, Yingying Wang, Chenglin Zhou

“…This study aims at investigating differences in the spontaneous brain activity and functional connectivity in the sensorimotor system between ballroom dancers and nondancers, to further support the functional alteration in people with expertise. …”
Get full text

Research and application of Gaussian coupled control bistable stochastic resonance system with independent parameter regulation by Tiantian Hou, Shangbin Jiao, Yi Wang, Nianlong Song, Jianghua Li, Wenchuan Cui

“…The structural parameters of the GBCSR system are co-optimized using the Brain Storm Optimization (BSO) algorithm. …”
Get full text

The ArcAB two-component system is associated with the susceptibility of Aggregatibacter actinomycetemcomitans to superoxide and hydrogen peroxide by Mohammad Farid Ratman, Yuichi Oogai, Airi Matsumoto, Masanobu Nakata

“…This bacterium is associated not only with oral infections but also with systemic infections, such as infective endocarditis and brain abscesses. …”
Get full text

Mipep deficiency in adipocytes impairs mitochondrial protein maturation and leads to systemic inflammation and metabolic dysfunctions by Yuka Nozaki, Masaki Kobayashi, Tomoyoshi Fukuoh, Mamiko Ishimatsu, Takumi Narita, Kanari Taki, Yuto Hirao, Shota Ayabe, Miku Yokoyama, Yuina Otani, Yuhei Mizunoe, Mami Matsumoto, Nobuhiko Ohno, Tomonori Kaifu, Shogo Okazaki, Ryo Goitsuka, Yoshimi Nakagawa, Hitoshi Shimano, Yoichiro Iwakura, Yoshikazu Higami

Get full text

Genomic insights into genes expressed specifically during infancy highlight their dominant influence on the neuronal system by Weidi Wang, Zhe Liu, Daihui Peng, Guan Ning Lin, Zhen Wang

“…Results Leveraging comprehensive human GWAS associations with temporal and spatial brain expression data, we discovered a distinctive co-expression cluster comprising 897 genes highly expressed specifically during infancy, enriched in functions related to the neuronal system. …”
Get full text

Advancing the modified face name associative memory exam in cognitive aging research: insights into connectomic correlates and task reliability by Yilin Liu, Yilin Liu, Mark H. Sundman, Mark H. Sundman, Dalen Hinderaker, Allison Yu-Chin Chen, Allison Yu-Chin Chen, Jacob M. Green, Jacob M. Green, Lisbeth G. Haaheim, Lisbeth G. Haaheim, Hannah M. Siu, Hannah M. Siu, Catherine Jezerc, Kaitlyn Lai, Carol Chen, Parker Guss, Ying-hui Chou, Ying-hui Chou, Ying-hui Chou

Get full text

Infections with Chlamydia pneumoniae and SARS-CoV-2 and Alzheimer’s disease pathogenesis by Alexa Romanella, Maegan McCall, Rachel Corwin, Alaha Abdul Faruq, Emily Lingo, Sanya Bhambhani, Christine J. Hammond, Brian J. Balin

“…Our focus included: genetic risk with expression of APOEε4 and other biomarkers common to AD including interleukin-6 (IL-6), chemokine ligand 2 (CCL2), neuropilin-1 (NRP1), and structural/functional aspects of the infectious processes and resultant neuroinflammation.ResultsBoth Cpn and SARS-CoV-2 may infect the neuroepithelium of the olfactory system to enter the brain. …”
Get full text

Gut microbiota-driven neuroinflammation in Alzheimer’s disease: from mechanisms to therapeutic opportunities by Wenhui Lei, Wenhui Lei, Yiwen Cheng, Xia Liu, Jie Gao, Zhangcheng Zhu, Wenwen Ding, Wenwen Ding, Xiaocui Xu, Xiaocui Xu, Yating Li, Zongxin Ling, Ruilai Jiang, Xiaoying Chen

“…Notably, the gut microbiota, through the microbiota-gut-brain axis (MGBA), is crucial in modulating neuroinflammation. …”
Get full text

Characteristic alterations of gut microbiota and serum metabolites in patients with chronic tinnitus: a multi-omics analysis by Jiang Wang, Jia-Hui Xiang, Xu-Yuan Peng, Min Liu, Le-Jia Sun, Min Zhang, Li-Yuan Zhang, Zhi-Bin Chen, Zheng-Quan Tang, Lei Cheng

“…ABSTRACT Chronic tinnitus is a central nervous system disorder. Currently, the effects of gut microbiota on tinnitus remain unexplored. …”
Get full text

The changes in neural complexity and connectivity in thalamocortical and cortico-cortical systems after propofol-induced unconsciousness in different temporal scales by Zhenhu Liang, Luxin Fan, Bin Zhang, Wei Shu, Duan Li, Xiaoli Li, Tao Yu

“…However, the alterations in complexity, functional connectivity, and directional connectivity within the thalamocortical and corticocortical systems across various scales during propofol-induced unconsciousness remain uncertain. …”
Get full text

Blood-cerebrospinal fluid (CSF) barrier dysfunction means reduced CSF flow not barrier leakage - conclusions from CSF protein data by Hansotto REIBER

“…Serum protein concentrations in lumbar CSF increase with hyperbolic functions, but the levels of proteins that do not pass the barrier remain constant (brain proteins) or increase linearly (leptomeningal proteins). …”
Get full text

Spinal afferent neurons: emerging regulators of energy balance and metabolism by Mohammad Jarrah, Dana Tasabehji, Aviva Fraer, Mohamad Mokadem, Mohamad Mokadem, Mohamad Mokadem, Mohamad Mokadem, Mohamad Mokadem

Get full text

Therapeutic potential of plant-derived exosome-like nanoparticles for CNS diseases: advancements in preparation and characterization by Mengmeng Liu, Hongli Wang, Yizhuang Yang, Jianhua Wang, Zhen Sun, Shiyuan Zhao, Weihua Kong, Wenxue Sun, Cuiyun Wang, Lei Feng

“…Background: Central nervous system (CNS) diseases pose significant therapeutic challenges owing to their complex pathophysiology and the restrictive nature of the blood-brain barrier (BBB).Introduction: Plant-derived exosome-like nanoparticles (PDELNs) exhibit intrinsic bioactivity, low immunogenicity, and ability to cross the BBB, making them a promising therapeutic strategy for CNS disorders.Discussion: This review explores the preparation, isolation, and characterization of PDELNs, with a focus on their therapeutic applications in CNS diseases. …”
Get full text

Impact of Observation Duration in Action Observation Therapy: Manual Dexterity, Mirror Neuron System Activity, and Subjective Psychomotor Effort in Healthy Adults by Anri Sasaki, Eizaburo Suzuki, Kotaro Homma, Nariyuki Mura, Katsuhiko Suzuki

Get full text

FBXW7 regulates MYRF levels to control myelin capacity and homeostasis in the adult central nervous system by Hannah Y. Collins, Ryan A. Doan, Jiaxing Li, Jason E. Early, Megan E. Madden, Tyrell Simkins, David A. Lyons, Kelly R. Monk, Ben Emery

Get full text

Soluble CD4 antigens in the cerebrospinal fluid as a marker of lymphocytic infiltration of the central nervous system by Vrbić Miodrag, Vrbić Svetislav, Škorić Snežana, Mihailović Vesna, Ranković Žarko, Konstantinović Ljiljana, Kostić Velimir, Krstić Milijanka, Jovanović Maja

“…They were significantly higher (p<0.05) compared to acute serous meningitis (13.5 ± 8 U/ml), while in purulent meningitis they were measurable only after the disease progression - in correlation with the disturbed brain system function. The obtained results suggested the significance of CD4 antigen levels in CSF as a sensitive and specific marker of lymphocytic infiltration of the brain parenchyma, the measurement of which could contribute to early identification of the CNS infections better understanding of their pathogenesis, and the assessment of the actual level of the destruction of neurons.…”
Get full text

Single-cell chromatin accessibility landscape profiling reveals the diversity of epigenetic regulation in the rat nervous system by Peiyao Ma, Shanshan Duan, Wen Ma, Qiuting Deng, Yeya Yu, Peng Gao, Yue Yuan, Chuanyu Liu

“…Abstract The mammalian nervous system controls complex functions through highly specialized and interacting structures. …”
Get full text