Deep brain stimulation of Hippocampus in Treatment-resistant Schizophrenia (DBS-HITS): protocol for a crossover randomized controlled trial by Chang Lu, Zhaolin Zhai, Kaiming Zhuo, Qiong Xiang, Jingxin Xue, Yuqing Zhao, Liqin Lang, Chunhong Shao, Liang Chen, Dengtang Liu

“…Abstract Background Ventral hippocampus (vHipp) in schizophrenia is in a state of hyperactivity and hypermetabolism, where the glutamate/gamma-aminobutyric acid (GABA) imbalance leads to downstream dopamine hyperactivity in the midbrain-limbic system. High-frequency deep brain stimulation (DBS) can disrupt the abnormal synchronization of functional circuits and modulate local brain networks. …”
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Chronic haloperidol exposure impairs neurodevelopment via Notch1 signaling in human stem cell-derived brain organoids by Hyunsu Kang, Jae-Hyeok Lee, Hana Cho, Ki-Suk Kim

“…Notch1 signaling regulates the development and function of the nervous system by balancing stem cell proliferation and differentiation. …”
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Six weeks that changed the preterm infant brain: lessons learned from the Family Nurture Intervention randomized controlled trials by Robert J. Ludwig, Robert J. Ludwig, Michael M. Myers, Michael M. Myers, Martha G. Welch, Martha G. Welch

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T-2 toxin-induced spatial learning and memory impairment in mice via the gut-brain axis and the intervening effects of resveratrol by Sheng-Quan Su, Gui-Yuan Xiong, Chun-Yan Yao, Xiao-Ling Liu, Yin-Yin Xia, Jin-Yun Long, Xiu-Kuan Li, Liang-Mei Wang, Long Yi, Wu-Wei Xu, Wu-Qiang Lu, Qian-Qian Li, Ting Hu, Hao Liu, Ke-Xue Wang, Peng Luo, Tong-Jian Cai

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Sphingosine 1-Phosphate Activation of EGFR As a Novel Target for Meningitic Escherichia coli Penetration of the Blood-Brain Barrier. by Xiangru Wang, Ravi Maruvada, Andrew J Morris, Jun O Liu, Michael J Wolfgang, Dong Jae Baek, Robert Bittman, Kwang Sik Kim

“…Central nervous system (CNS) infection continues to be an important cause of mortality and morbidity, necessitating new approaches for investigating its pathogenesis, prevention and therapy. …”
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Brain-Specific Increase in Leukotriene Signaling Accompanies Chronic Neuroinflammation and Cognitive Impairment in a Model of Gulf War Illness by Sahithi Attaluri, Raghavendra Upadhya, Maheedhar Kodali, Leelavathi N. Madhu, Dinesh Upadhya, Bing Shuai, Ashok K. Shetty

“…Therefore, drugs capable of modulating LT signaling may reduce neuroinflammation and improve cognitive function in GWI. Additional findings demonstrate that altered LT levels in the brain could be tracked efficiently by analyzing brain-derived EVs in the circulating blood.…”
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A Comprehensive Review of the Role of the Microbiota–Gut–Brain Axis via Neuroinflammation: Advances and Therapeutic Implications for Ischemic Stroke by Hui Guo, Xiang Tang, Xinyi He, Yizhen Weng, Quanquan Zhang, Qi Fang, Lulu Zhang

“…Emerging evidence has revealed bidirectional communication between the gut microbiome and the central nervous system, termed the “microbiota–gut–brain axis”. This axis serves as a critical regulator of glial cell function, positioning it as an essential target for ameliorating the onset and progression of ischemic stroke. …”
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Massage positively influences daytime brain activity and reduces arousal state in poor sleepers: a randomized controlled trial by Ilias Ntoumas, Christina Karatzaferi, Fotini Boubougiatzi, Nefeli Manakou, Artemis Aslanidi, Christoforos D. Giannaki, Fotini Papanikolaou, Efthimios Dardiotis, Eleftherios Lavdas, Giorgos K. Sakkas

“…Fifteen participants (aged 21.6 ± 1.3 years) participated in three different conditions over one week apart: 1) 30-min Sports massage condition (ACT), 2) 30-min Relaxation massage condition (REL) and 3) control condition with no massage. Brain activity was monitored using a polysomnography EEG system, while vitals and relaxation/stress state were assessed by validated questionnaires and functional tests. …”
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Kinin B₁ Receptor Agonist Enhances Blood-Brain Barrier Permeability in Healthy and Glioblastoma Environments by Carolina Batista, João Victor Roza Cruz, Michele Siqueira, João Bosco Pesquero, Joice Stipursky, Fabio de Almeida Mendes

“…<b>Background/Objectives</b>: The low permeability of the blood-brain barrier (BBB) represents a significant challenge to effective systemic chemotherapy for primary and metastatic brain cancers. …”
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Response of astrocytes and their interaction with surrounding brain cells after acute ischemia-reperfusion analyzed by single-cell transcriptome sequencing by YongHong Wu, Lei Xie, Jing Sun, Qing Wang, WangXiao Xia, Qiang Cai, XiaoYun Lu, XingChun Gou

“…We acquired astrocyte subclusters’ transcriptional characteristics involved in diversified functions. To explore what stimulus signals cause astrocyte heterogeneity, we present a blueprint for cellular communication between astrocyte subclusters and other surrounding brain cells 12 h after ischemia-reperfusion, and identified 9 genes which are potential and promising for being therapeutic targets and 6 genes were specific to astrocyte subcluster 2 that tend to resist ischemia-reperfusion injury. …”
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A Narrative Review of the Efficacy of Long COVID Interventions on Brain Fog, Processing Speed, and Other Related Cognitive Outcomes by Bryana Whitaker-Hardin, Keith M. McGregor, Gitendra Uswatte, Kristine Lokken

“…Long COVID is associated with pervasive symptoms affecting multiple organ systems. Neurocognitive symptoms are reported by up to 40% of long COVID patients, with resultant effects of loss of daily functioning, employment issues, and enormous economic impact and high healthcare utilization. …”
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Cognitive impairment and vulnerability of cholinergic brain network in the Alzheimer’s continuum: free-water imaging based on diffusion tensor imaging by Simin Zhao, Yuting Nie, Lulu Wen, Xinzuo Qin, Liyuan Huang, Changbiao Chu, Miao Qu, Miao Qu

“…BackgroundIncreased extracellular free water (FW) is considered to provide better pathophysiological information than conventional diffusion tensor imaging (DTI) metrics. The cholinergic brain network is a key hub for cognitive function, and microstructural changes detected by free water imaging in this system may be associated with cognitive impairment in Alzheimer’s disease (AD). …”
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Temporal changes of neurobehavior in rats following varied blast magnitudes and screening of serum biomarkers in early stage of brain injury by Ning Ma, Hong Wang, Qing Lu, Jinren Liu, Xiaolin Fan, Liang Li, Qi Wang, Xiao Li, Boya Yu, Yuhao Zhang, Junhong Gao

“…Abstract Blast neurotrauma has been linked to impairments in higher-order cognitive functions, including memory, attention, and mood. Current literature is limited to a single overpressure exposure or repeated exposures at the same level of overpressure. …”
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Effects of Thermal Manipulation and Serotonin Modulation on Brain HSP70 and HSP90 Gene Expression in Late Embryogenesis of Broilers by Hamed KHasti, Ladan Emadi, Shahrzad Azizi, Elham Mohammadi, Hadi Tavakkoli

“…ABSTRACT Introduction Broiler chickens are particularly vulnerable to elevated temperatures compared to mammals because they have feathers instead of sweat glands, undergo rapid growth and are intensively bred in commercial systems. Serotonin, as neurotransmitter, is essential for the development of the embryonic brain and neural functions, helping the body adapt to difficult environments such as heat stress (HS) that broiler chickens are susceptible to by regulating physiological and metabolic processes. …”
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FOXO3a-BAP1 axis regulates neuronal ferroptosis in early brain injury after subarachnoid hemorrhage by Chengli Liu, Qi Tian, Zhijie Li, Guijun Wang, Wenrui Han, Shengming Jiang, Zhou Sun, Qingqing Xu, Long Wang, Jianming Liao, Mingchang Li

“…Forkhead box protein O3a (FOXO3a) is a transcription factor involved in the regulation of cellular function and survival in the nervous system, including the oxidative stress response and neuronal death. …”
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Curcumin-Loaded Gelatin Nanoparticles Cross the Blood-Brain Barrier to Treat Ischemic Stroke by Attenuating Oxidative Stress and Neuroinflammation by Yang Q, Li R, Hong Y, Liu H, Jian C, Zhao S

“…In recent years, nano-delivery systems have attracted great interest in the field of stroke therapy as an effective method to improve drug solubility and cross the blood-brain barrier (BBB).Methods: In this study, a novel nanomedicine (Cur@GAR NPs) for ischemic stroke treatment was developed based on Cur-loaded gelatin nanoparticles (Cur@Gel NPs) that were then functionalized and modified with rabies virus glycoprotein (RVG29) to target brain tissue. …”
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High-Calorie Diet Consumption Induces Lac-Phe Changes in the Brain in a Time-of-Day Manner Independent of Exercise by Jarne Jermei, Han Jiao, Ayano Shiba, Julia C. Goedhart, Roberta Tandari, Andries Kalsbeek, Eduard A. Struys, Chun-Xia Yi

“…Second, despite the central role of the central nervous system in the homeostatic control of energy metabolism, little is known about the presence and function of Lac-Phe in the brain. …”
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Inhibition of S100A8/A9 ameliorates neuroinflammation by blocking NET formation following traumatic brain injury by Guihong Shi, Yiyao Cao, Jianye Xu, Bo Chen, Xu Zhang, Yanlin Zhu, Liang Liu, Xilei Liu, Luyuan Zhang, Yuan Zhou, Shenghui Li, Guili Yang, Xiao Liu, Fanglian Chen, Xin Chen, Jianning Zhang, Shu Zhang

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Dopaminergic system and its relationship with the hypothalamic-pituitary-gonadal and hypothalamic-pituitary-thyroid systems (review) by I. N. Molodovskaya

“…Most studies focus on the functions of dopamine in the central nervous system. …”
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Development of Nanocomposite Microspheres for Nasal Administration of Deferiprone in Neurodegenerative Disorders by Radka Boyuklieva, Plamen Katsarov, Plamen Zagorchev, Silviya Abarova, Asya Hristozova, Bissera Pilicheva

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