Ultradeep N-glycoproteome atlas of mouse reveals spatiotemporal signatures of brain aging and neurodegenerative diseases by Pan Fang, Xiangming Yu, MengYang Ding, Cong Qifei, Hongyu Jiang, Qi Shi, Weiwei Zhao, Weimin Zheng, Yingning Li, Zixiang Ling, Wei-Jun Kong, Pengyuan Yang, Huali Shen

“…Furthermore, the region-resolved brain N-glycoproteomes for Alzheimer’s Diseases, Parkinson Disease and aging mice reveal the spatiotemporal signatures and distinct pathological functions of the N-glycoproteins. …”
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Diagnostic, Therapeutic, and Prognostic Applications of Artificial Intelligence (AI) in the Clinical Management of Brain Metastases (BMs) by Kyriacos Evangelou, Panagiotis Zemperligkos, Anastasios Politis, Evgenia Lani, Enrique Gutierrez-Valencia, Ioannis Kotsantis, Georgios Velonakis, Efstathios Boviatsis, Lampis C. Stavrinou, Aristotelis Kalyvas

“…Intraoperatively, AI-driven systems can enable optimal tumor resection by integrating functional brain maps into preoperative imaging, thus facilitating the identification and safeguarding of eloquent brain regions through augmented reality (AR)-assisted neuronavigation. …”
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Pediatric brain tumor patients display altered immune activation and reduced lymphopoiesis at the onset of disease by Marco Rosichini, Giada Del Baldo, Carmen Dolores De Luca, Francesca Benini, Shirley Genah, Maria Vinci, Alfredo Cerimele, Marianna Coccetti, Sara Flamini, Rita Carsetti, Antonella Cacchione, Andrea Carai, Angela Mastronuzzi, Franco Locatelli, Enrico Velardi

“…Abstract Optimal immune function is crucial in preventing cancer development and growth and for the success of anti-cancer therapies. …”
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Exploring the Dynamic Changes of Brain Lipids, Lipid Rafts, and Lipid Droplets in Aging and Alzheimer’s Disease by Michele Cerasuolo, Irene Di Meo, Maria Chiara Auriemma, Giuseppe Paolisso, Michele Papa, Maria Rosaria Rizzo

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Reduced inflammatory phenotype in microglia derived from neonatal rat spinal cord versus brain. by Sam Joshva Baskar Jesudasan, Kathryn G Todd, Ian R Winship

“…Recent studies suggest that microglial functional response properties vary across different regions of the CNS. …”
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Physiological and pathophysiological effects of L-tryptophan’s metabolites on the brain and immunity – a challenge for drug development by Petar Iliev, Simeon Ivanov, Simeon Lazarov, Georgeta Bocheva

“…Also, TRP is a vital biochemical precursor for several functional neuroactive molecules, including serotonin and melatonin, which are of great importance for memory and learning, emotional regulation, circadian cycle, hunger, pain, etc. …”
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Neuroinflammation and hypoxia promote astrocyte phenotypic transformation and propel neurovascular dysfunction in brain arteriovenous malformation by Tianqi Tu, Zhenghong Peng, Lihan Zhang, Jieru Yang, Kecheng Guo, Xiaogang Tang, Jiasen Ye, Fan Zhang, An Huang, Jiaxing Yu, Changren Huang, Hongqi Zhang, Donghai Wang, Jianhua Peng, Yong Jiang

“…Astrocytes, as a key component of the central nervous system, play a crucial role in regulating neurovascular function, maintaining the integrity of the blood–brain barrier, and ensuring neural homeostasis. …”
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LAG3 limits regulatory T cell proliferation in α-synuclein gut-to-brain transmission model by Wei-Xin Kong, Zhi-Ling Zhang, Jin Li, Si Zhu, Chong Li, Xiao-Li Dong, Ting-Ting Gan, Di Hu, Feng-Chu Liang, Ping-Yi Xu, Wen-Yuan Guo

“…Conclusions Our findings demonstrated that LAG3 intrinsically limits Treg cell proliferation and function in the environment with pathological α-syn and promotes the gut-to-brain transmission of α-syn. …”
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Porphyromonas gingivalis-induced periodontitis promotes neuroinflammation and neuronal loss associated with dysfunction of the brain barrier by Yiting Jiang, Yiting Jiang, Yiting Jiang, Yiting Jiang, Yiting Jiang, Yiting Jiang, Lina Xu, Lina Xu, Lina Xu, Lina Xu, Lina Xu, Xuri Zhao, Hui Shen, Hui Shen, Hui Shen, Hui Shen, Hui Shen, Che Qiu, Che Qiu, Che Qiu, Che Qiu, Che Qiu, Zhiyan He, Zhiyan He, Zhiyan He, Zhiyan He, Zhiyan He, Zhongchen Song, Zhongchen Song, Zhongchen Song, Zhongchen Song, Zhongchen Song, Wei Zhou, Wei Zhou, Wei Zhou, Wei Zhou, Wei Zhou

“…WB, Evans blue staining and flow cytometry were used to evaluate the blood-brain barrier (BBB) function including the infiltration of P. gingivalis and immune cells, and BBB permeability. …”
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The Conservative Treatment of a Rare Postoperative Complication of DBS—Brain Abscess: Case Series by Lu G, Liu J, Wei X, Yan J, Sun J, Dong W, Zhao L, Qiu C, Luo B, Zhang W

“…Guanghan Lu,* Jingxuan Liu,* Xiang Wei, Jiuqi Yan, Jian Sun, Wenwen Dong, Liang Zhao, Chang Qiu, Bei Luo, Wenbin Zhang Department of Functional Neurosurgery, Nanjing Brain Hospital, Nanjing, Jiang Su, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wenbin Zhang, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, People’s Republic of China, Email wenbinzhang@njmu.edu.cnBackground: Deep Brain Stimulation (DBS) is an established treatment option for movement disorders such as Parkinson’s disease and dystonia, so more and more patients (over 160,000 patients till 2019) worldwide have undergone DBS for a variety of neurological and non-neurological conditions, with numbers increasing each year. …”
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Novel transferrin receptor-mediated enzyme replacement therapy efficiently treats myogenic and neurogenic aspects of Pompe disease in mice by Kelly George, Raquel Riley, Shan Zhou, Elizabeth Allen, Laurie Smith, Elena Kistanova, Sofia Kinton, Lilu Guo, Dinesh Bangari, Ayman Ismail, Jayaprakash Thummapudi, Fawzi Boumezbeur, Erwan Selingue, Dorothée Tamarelle, Cecile Capdevila, Tuan-Minh Do, Dominique Lesuisse, Nina Leksa, Pablo Sardi, Arjan van der Flier

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Relationship between the LHPP Gene Polymorphism and Resting-State Brain Activity in Major Depressive Disorder by Lingling Cui, Xiaohong Gong, Yanqing Tang, Lingtao Kong, Miao Chang, Haiyang Geng, Ke Xu, Fei Wang

“…Results demonstrated that MDD patients with LHPP rs35936514 CT/TT genotype may influence the regional brain activity. These findings implicate the effects of the rs35936514 variation on the neural system in MDD.…”
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Hesperidin facilitating gastrointestinal motility by “Gut-brain axis” and “SCF/C-Kit signaling pathways” by Yunfei Li, Xinying Zhou, Yusong Du, Mingyuan An, Shasha Wan, Zewei Sun, Qingzhen Zhong

“…In conclusion, hesperidin exhibits promising potential as a feed additive for broilers, as its dietary supplementation of hesperidin improves gastrointestinal motility through modulation of both “gut-brain axis” signaling pathways and “SCF/C-Kit signaling pathways” within broiler chicken's digestive system. …”
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Effects of subliminal emotional facial expressions on language comprehension as revealed by event-related brain potentials by Miguel Rubianes, Laura Jiménez-Ortega, Francisco Muñoz, Linda Drijvers, Tatiana Almeida-Rivera, José Sánchez-García, Sabela Fondevila, Pilar Casado, Manuel Martín-Loeches

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APOE genotype and brain amyloid are associated with changes in the plasma proteome in elderly subjects without dementia by Sarah M. Philippi, Kailash BP, Towfique Raj, Joseph M. Castellano

“…Abstract Objective Recent work has bolstered the possibility that peripheral changes may be relevant to Alzheimer's disease pathogenesis in the brain. While age‐associated blood‐borne proteins have been targeted to restore function to the aged brain, it remains unclear whether other dysfunctional systemic states can be exploited for similar benefits. …”
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Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain by Pierre Lemaitre, Samar HK Tareen, Emanuela Pasciuto, Loriana Mascali, Araks Martirosyan, Zsuzsanna Callaerts‐Vegh, Suresh Poovathingal, James Dooley, Matthew G Holt, Lidia Yshii, Adrian Liston

“…Here, we test a brain‐specific IL2 delivery system for the prevention of neurological decline in aging mice. …”
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An integrated micro- and macroarchitectural analysis of the Drosophila brain by computer-assisted serial section electron microscopy. by Albert Cardona, Stephan Saalfeld, Stephan Preibisch, Benjamin Schmid, Anchi Cheng, Jim Pulokas, Pavel Tomancak, Volker Hartenstein

“…The analysis of microcircuitry (the connectivity at the level of individual neuronal processes and synapses), which is indispensable for our understanding of brain function, is based on serial transmission electron microscopy (TEM) or one of its modern variants. …”
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Gut-brain axis and vascular dementia: a review on mechanisms and Chinese herbal medicine therapeutics by Dexiu Wang, Huiying Yao, Luoqi Wang, Bowen Lu, Wenkai Liu, Jinghan Li, Yujin Gong, Yuhao Cai, Yuehan Li, Xin Cai, Rui Zhang, Rui Zhang

“…Emerging evidence has revealed that intestinal flora dysbiosis may be implicated not only in gastrointestinal (GI) pathologies but also in central nervous system (CNS) disorders, including VD. The gut-brain axis (GBA) serves as a critical bidirectional pathway through which intestinal flora influences brain physiology and function. …”
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Periodontitis-related salivary microbiota aggravates Alzheimer’s disease via gut-brain axis crosstalk by Jiangyue Lu, Shuang Zhang, Yuezhen Huang, Jun Qian, Baochun Tan, Xueshen Qian, Jia Zhuang, Xihong Zou, Yanfen Li, Fuhua Yan

“…The intestine and central nervous system jointly engage in crosstalk; microbiota-mediated immunity significantly impacts AD via the gut-brain axis. …”
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FREQ‐NESS Reveals the Dynamic Reconfiguration of Frequency‐Resolved Brain Networks During Auditory Stimulation by Mattia Rosso, Gemma Fernández‐Rubio, Peter Erik Keller, Elvira Brattico, Peter Vuust, Morten L Kringelbach, Leonardo Bonetti

“…In conclusion, FREQ‐NESS effectively maps the brain's spatiotemporal dynamics, providing a comprehensive view of brain function by revealing a landscape of simultaneous, frequency‐resolved networks and their interaction.…”
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