Microbiota-derived metabolites as drivers of gut–brain communication by Hany Ahmed, Quentin Leyrolle, Ville Koistinen, Olli Kärkkäinen, Sophie Layé, Nathalie Delzenne, Kati Hanhineva

“…However, more research is needed to understand the molecular mechanisms underlying how gut microbiota associated metabolites alter brain functions, and to examine if different interventional approaches targeting the gut microbiota could be used in prevention and treatment of neurological disorders, as reviewed herein.Abbreviations:4-EPS 4-ethylphenylsulfate; 5-AVA(B) 5-aminovaleric acid (betaine); Aβ Amyloid beta protein; AhR Aryl hydrocarbon receptor; ASD Autism spectrum disorder; BBB Blood–brain barrier; BDNF Brain-derived neurotrophic factor; CNS Central nervous system; GABA ɣ-aminobutyric acid; GF Germ-free; MIA Maternal immune activation; SCFA Short-chain fatty acid; 3M-4-TMAB 3-methyl-4-(trimethylammonio)butanoate; 4-TMAP 4-(trimethylammonio)pentanoate; TMA(O) Trimethylamine(-N-oxide); TUDCA Tauroursodeoxycholic acid; ZO Zonula occludens proteins…”
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THE EFFECT OF HYPOXIC BRAIN DAMAGE ON THE SURVIVAL OF PREMATURE INFANTS by N. V. Likholetova, A. M. Anuryev, S. M. Gorbacheva, T. I. Pavlova, A. B. Pavlov

“…The central nervous system injuries are a common neonatal pathology, hypoxia being one of the main causes of cerebral dysfunction. …”
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Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured c... by Yan Li, Peng Hao, Hongmei Duan, Fei Hao, Wen Zhao, Yudan Gao, Zhaoyang Yang, Kwok-Fai So, Xiaoguang Li

“…The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after injury. …”
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Design of EEG based thought identification system using EMD & deep neural network by Rahul Agrawal, Chetan Dhule, Garima Shukla, Sofia Singh, Urvashi Agrawal, Najah Alsubaie, Mohammed S. Alqahtani, Mohamed Abbas, Ben Othman Soufiene

“…Abstract Biological communication system for neurological disorder patients is similar to the Brain Computer Interface in a way that it facilitates the connection to the outside world in real time. …”
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Impact of online support of physical activity management using a wearable device on renal function in patients with acute coronary syndrome: a randomized controlled trial protocol by Toshimi Sato, Daisuke Suzuki, Yuichiro Sasamoto, Masahiro Ono, Namiko Shishito, Kohko Kanazawa, Akihito Watanabe, Koichi Naito, Shinichiro Morishita, Masahiro Kohzuki

“…Background Acute coronary syndromes (ACS) often cause rapid decline in renal and cardiac function. In patients with ACS, combined renal dysfunction is associated with increased overall mortality and cardiovascular events. …”
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CuO-NPs Induce Apoptosis and Functional Impairment in BV2 Cells Through the CSF-1R/PLCγ2/ERK/Nrf2 Pathway by Linhui Yang, Lina Zhu, Bencheng Lin, Yue Shi, Wenqing Lai, Kang Li, Lei Tian, Zhuge Xi, Huanliang Liu

“…The downregulation of CX3CR1, CSF-1R, brain-derived neurotrophic factor (BDNF), and IGF-1 protein expression indicates impairment of the repair and protection functions of microglia in the nervous system. …”
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Normal hearing function genetics: have you heard all about it? An integrated approach of genome-wide association studies and transcriptome-wide association studies in three Italian... by Aurora Santin, Aurora Santin, Giulia Pianigiani, Alessandro Gialluisi, Alessandro Gialluisi, Alessandro Pecori, Beatrice Spedicati, Beatrice Spedicati, Simona Costanzo, Mariarosaria Persichillo, Francesca Bracone, Giuseppe Giovanni Nardone, Paola Tesolin, Stefania Lenarduzzi, Anna Morgan, Amalia De Curtis, Wouter van der Valk, Wouter van der Valk, Francis Rousset, Marta Roccio, Marta Roccio, Heiko Locher, Heiko Locher, Licia Iacoviello, Licia Iacoviello, Maria Pina Concas, Giorgia Girotto, Giorgia Girotto

“…Bioinformatics and biostatistics analyses allowed the identification of three novel candidate genes, namely, SLC1A6, ASTN2, and ARF4-AS1. Functional studies and replication in larger and independent cohorts will be essential to confirm the biological role of these genes in regulating hearing function; however, these results confirm GWAS and TWAS as powerful methods for novel gene discovery, thus paving the way for a deeper understanding of the entangled genetic landscape underlying the auditory system.…”
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Younger adult brain utilizes interhemispheric strategy via ipsilateral dorsal premotor cortex for fine control of dexterous finger movements, unlike the aging brain by Gen Miura, Gen Miura, Tomoyo Morita, Tomoyo Morita, Jihoon Park, Jihoon Park, Eiichi Naito, Eiichi Naito

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The Functional Characterization of Venous Thromboembolic Disease (FUVID) study: rationale, design, and methods of a prospective, observational, multicenter study to evaluate mechan... by Ayesha Zia, Michael D. Nelson, Jimin Ren, Song Zhang, Robert F. Mattrey, Brian L. Han, Tarique Hussain, Joshua S. Greer, Manal Al-Qahtani, Kendra Malone, Sonja E. Stutzman, Deseray V. Sida, Sharon Primeaux, Marcela D. Torres, Clay T. Cohen, Shelley Crary, Jonathan Bernstein, Hilary B. Whitworth, Riten Kumar, Kisha A. Beg, Osman Khan, Madhvi Rajpurkar, Kerry Hege, Beverly A. Schaefer, Gary M. Woods, Lauren E. Amos, Marisol Betensky, Rukhmi V. Bhat, Sarah O’ Brien, Julie Jaffray, Rohit Jesudas, Martha M. Pacheco, Cristina Tarango, Angela C. Weyand, Hope P. Wilson, Jessica Garcia, Mary P. Dang, Ruchika Sharma, Neil A. Goldenberg, Frederikus A. Klok, Christoph Male, Benjamin Levine, Bryce N. Balmain, Tony G. Babb, Leah M. Adix, BS, Steven Ambrusko, MD, Shames Alaesa, BSc, Kristen Bradley, BSN, RN, Brain R. Branchford, MD, Katie Carlberg, MD, James D. Cooper, MD, Susan A. Corley, MPH, Marissa Di Miero, MBA, Anna Eidenberger, Edith Freyer, DNP, Kevin Guerrero, Arun Gurunathan, MD, Brandon Hathorn, BSc, Muhammad Khan, Shawn D. Lade, BS, Deanna M. Maida, MD, Marie Martinelli, MD, Corey Mozingo, BS, Raksa Moran, RN, Sharon A. Primeaux, MS, Leslie Raffini, MD, MSCE, Rhea Robinson, BSN, Cynthia Sabo, MSN, Negin Saleh, Anjali A. Sharathkumar, MBBS, MD, MS, Rachel Simon, DNP, APRN, CPNP-PC, Lakshmi Srivaths, MD, MacKenzie Tasset, BS, Katrina Williams, BS, Rebekah Summerall Woodward, MPH, Benjamin Levine, Neil A. Goldenberg, MD, PhD, Frederikus A. Klok, MD, PhD, Christoph Male, MS, MSc, Tony G. Babb, PhD, Madhvi Rajpurkar, MD, Song Zhang, PhD

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Generation, interrogation, and future applications of microglia-containing brain organoids by Julia Di Stefano, Federica Di Marco, Ilaria Cicalini, Una FitzGerald, Damiana Pieragostino, Marleen Verhoye, Peter Ponsaerts, Elise Van Breedam

“…Brain organoids encompass a large collection of in vitro stem cell–derived 3D culture systems that aim to recapitulate multiple aspects of in vivo brain development and function. …”
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Innovative approaches to blood-brain barrier modelling: The chip revolution by Avijit Bej, Nandita Mandal, Anwesha Das, Arijit Nandi

“…The blood-brain barrier (BBB) is essentially involved in regulating the communication between the neurons in the central nervous system (CNS) and the rest of the body after excluding undesirable elements that may harm the neural tissues. …”
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Corticotropin-Releasing Factor and the Brain-Gut Motor Response to Stress by Yvette Taché, Vicente Martinez, Mulugeta Million, Jean Rivier

“…It is known that brain CRF is involved in the cross-talk between the immune and gastrointestinal systems because systemic or central administration of interleukin-1-beta delays gastric emptying while stimulating colonic motor activity through activation of CRF release in the brain. …”
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Role and mechanisms of exercise therapy in enhancing drug treatment for glioma: a review by Guanghui Wu, Guanghui Wu, Yisheng Chen, Yisheng Chen, Yisheng Chen, Yisheng Chen, Yisheng Chen, Yisheng Chen, Chong Chen, Jianling Liu, Qiaowu Wu, Yazhen Zhang, Runqiong Chen, Jianzhong Xiao, Yusheng Su, Haojun Shi, Chunsheng Yu, Miao Wang, Yifan Ouyang, Airong Jiang, Zhengzhou Chen, Xiao Ye, Chengwan Shen, Aikebaier Reheman, Xianjun Li, Ming Liu, Ming Liu, Jiancheng Shen, Jiancheng Shen

“…Exercise not only improves patients’ physical function and cognitive abilities but may also enhance the efficacy of conventional drug treatments by modulating the immune system, suppressing inflammatory responses, and improving blood-brain barrier permeability. …”
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A Bayesian model of category-specific emotional brain responses. by Tor D Wager, Jian Kang, Timothy D Johnson, Thomas E Nichols, Ajay B Satpute, Lisa Feldman Barrett

“…Understanding emotion is critical for a science of healthy and disordered brain function, but the neurophysiological basis of emotional experience is still poorly understood. …”
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Bridging the brain and gut: neuroimmune mechanisms of neuroinflammation and therapeutic insights by Ludmila Müller, Svetlana Di Benedetto

“…The gut-brain axis plays a pivotal role in modulating CNS function, as alterations in gut microbiota composition can trigger neuroinflammatory pathways, affect systemic immunity, and influence disease susceptibility. …”
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Mechanobiology of the blood-brain barrier during development, disease and ageing by Simon Konig, Vignesh Jayarajan, Selina Wray, Roger Kamm, Emad Moeendarbary

“…Here we highlight the central role of mechanics in BBB development, pathology, and ageing, identify key knowledge gaps, and argue that combining innovative BBB model systems with mechanical probing techniques could transform therapeutic strategies targeting brain vascular dysfunction.…”
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Brain Morphometry and Cognitive Features in the Prediction of Irritable Bowel Syndrome by Arvid Lundervold, Ben René Bjørsvik , Julie Billing , Birgitte Berentsen , Gülen Arslan Lied , Elisabeth K. Steinsvik , Trygve Hausken , Daniela M. Pfabigan , Astri J. Lundervold 

“…While brain–gut interactions are recognized in IBS pathophysiology, the relationship between brain morphometry, cognitive function, and clinical features remains poorly understood. …”
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Emerging role of microglia in the developing dopaminergic system: Perturbation by early life stress by Kaijie She, Naijun Yuan, Minyi Huang, Wenjun Zhu, Manshi Tang, Qingyu Ma, Jiaxu Chen

“…Indirectly, early life stress may influence microglial function through various pathways, such as astrocytic activation, the hypothalamic–pituitary–adrenal axis, the gut–brain axis, and maternal immune signaling. …”
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Self-esteem modulates the similarity of the representation of the self in the brains of others by Moriah S. Stendel, Taylor D. Guthrie, Victoria Guazzelli Williamson, Robert S. Chavez

“…In the current study, we used functional magnetic resonance imaging in a round-robin design within 19 independent groups of participants (total N = 107) to test how self-esteem modulates the representation of self-other similarity in multivariate brain response patterns during interpersonal perception. …”
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The progress of the microbe-gut-brain axis in sepsis-associated encephalopathy by Chen He, Chen He, Hui Shi, Zhijie Yu, Chunhan Ma, Zhiqiang Jiao, Jin Li, Fei Yang, Fei Yang

“…Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction that is caused by sepsis without direct brain injury or central nervous system infection and is manifested as anxiety-like behavior and cognitive dysfunction. …”
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