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761
INHIBITORS OF ANGIOGENESIS IN BRAIN TUMORS – REVIEW
Published 2019-02-01“…Malignant glial and metastatic tumors are highly vascularized tumors and like all solid tumors, they require angiogenesis for their growth. [1] For glioblastoma (GBM) this microvascularization is very likely and those vessels have abnormal structure, shape and organization.[2] The permeability of those blood vessels is high and very variable in space and time.[3, 4] This abnormal permeability and aberrant morphologic vascularnetworkare associated with abnormal - blood flow, oxygen and nutrients delivery, and also decreased delivery of applied systemic medications.[5] The microenviorment of the tumor has zones of hypoxia, interstitial hypertension and necrosis.[6, 7, 8, 9, 10] According to Hobbs et al., when the tumor’diameter reaches 1-2mm,the integrity of blood brain barrier (BBB) is structurally and functionally impaired. …”
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Mineralogy of the human brain: a review
Published 2025-04-01“…Some of the biogenic phases may represent evolutionary remains, whereas others are crucial for many physiological functions of the neurological system. Yet an excess concentration of these minerals in the brain may be a precursor and/or a consequence of several neurodegenerative conditions, such as Alzheimer's and Parkinson's diseases. …”
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763
Can ephapticity contribute to brain complexity?
Published 2024-01-01“…These results offer fresh insights into the dynamics of communication within the nervous system and underscore the fundamental role of ephapticity in regulating complex brain functions.…”
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764
Enhancing Hand Sensorimotor Function in Individuals with Cervical Spinal Cord Injury: A Novel Tactile Discrimination Feedback Approach Using a Multiple-Baseline Design
Published 2025-03-01“…<b>Conclusions</b>: These findings indicate that the ability of the brain to compare and align predictive control with sensory feedback might be compromised in patients with damage to the afferent pathways of the central nervous system. …”
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765
Parkinsonian central pain is linked to the connectivity of the nucleus accumbens and the anterior insula
Published 2024-03-01“…Levodopa and oxycodone had no specific effects on functional connectivity. Responders had a decrease in connectivity between the anterior insula and the posterior cingulate cortex, while non-responders showed an increase in connectivity.The correlation between pain intensity and specific brain connectivity may represent a “hyper-awareness” of pain and a distortion of learning and memory systems in PD patients with central pain, leading to a state of chronic pain. …”
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766
Dual effects of GABAAR agonist anesthetics in neurodevelopment and vulnerable brains: From neurotoxic to therapeutic effects
Published 2026-01-01“…Debates regarding the specific effects of general anesthesia on developing brains have persisted for over 30 years. A consensus has been reached that prolonged, repeated, high-dose exposure to anesthetics is associated with a higher incidence of deficits in behavior and executive function, while single exposure has a relatively minor effect on long-term neurological function. …”
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767
Constructed transferrin receptor-targeted liposome for the delivery of fluvoxamine to improve prognosis in a traumatic brain injury mouse model
Published 2025-12-01“…The dysregulation of blood–brain barrier (BBB) activates pathological mechanisms such as neuroinflammation after traumatic brain injury (TBI), and glymphatic system dysfunction accelerates toxic waste accumulation after TBI. …”
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768
Automated fluorine-18 radiolabeling via an alkyne–azide cycloaddition reaction on a dual peptide-functionalized liposome surface for in vivo PET imaging
Published 2025-04-01“…The in vivo uptake of these liposomes is evaluated in an orthotopic glioma mouse model (Gli36ΔEGFR cell line) using PET/computed tomography (CT).Results and discussionThe results demonstrate a higher tumor/background ratio, a faster clearance rate, and a lower uptake in healthy brain tissue and peripheral regions for mApoE- and MSLP-functionalized liposomes than for non-functionalized liposomes, prompting further characterization. …”
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769
Improvement of classification accuracy of functional near-infrared spectroscopy signals for hand motion and motor imagery using a common spatial pattern algorithm
Published 2025-05-01“…Objective: Classifying motor imagery tasks via functional near-infrared spectroscopy (fNIRS) poses a significant challenge in brain-computer interface (BCI) research due to the high-dimensional nature of the signals. …”
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770
Functional activity and connectivity signatures of ketamine and lamotrigine during negative emotional processing: a double-blind randomized controlled fMRI study
Published 2024-10-01“…Abstract Ketamine is a highly effective antidepressant (AD) that targets the glutamatergic system and exerts profound effects on brain circuits during negative emotional processing. …”
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Molecular mechanisms and therapeutic strategies of Naegleria fowleri Carter (1970): a review of the fatal brain-eating amoeba
Published 2024-05-01“…Naegleria fowleri is a thermophilic free-living amoeba that can cause a rare and fatal infection of the brain called primary amoebic meningoencephalitis (PAM). …”
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773
Functional Annotation of Small Noncoding RNAs Target Genes Provides Evidence for a Deregulated Ubiquitin-Proteasome Pathway in Spinocerebellar Ataxia Type 1
Published 2012-01-01“…In this study, we functionally annotated the target genes of the small noncoding RNAs (ncRNAs) that were selectively activated in the affected brain compartments. …”
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Edaravone Dexborneol Treatment Attenuates Neuronal Apoptosis and Improves Neurological Function by Suppressing 4-HNE-Associated Oxidative Stress After Subarachnoid Hemorrhage
Published 2022-04-01“…Phase II and III studies have demonstrated that Chinese patients treated with edaravone dexborneol within 48 h of AIS onset have better functional outcomes than those treated with edaravone alone. …”
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776
Injured Cardiac Tissue-Targeted Delivery of TGFβ1 siRNA by FAP Aptamer-Functionalized Extracellular Vesicles Promotes Cardiac Repair
Published 2025-03-01“…Consequently, hEV@FAP-siTGFβ 1 significantly improved cardiac function, reduced myocardial fibrosis, and decreased cardiomyocyte cross‐sectional area (P < 0.05) without inducing systemic toxicity.Conclusion: hEV@FAP represents a novel approach for targeted delivery of therapeutic siRNA to injured cardiac tissues, providing a promising nanomedicine for cardiac repair. …”
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