Systemic Administration of Glibenclamide Fails to Achieve Therapeutic Levels in the Brain and Cerebrospinal Fluid of Rodents. by Carolina Lahmann, Holger B Kramer, Frances M Ashcroft

“…Our results therefore suggest that little glibenclamide reaches the central nervous system when given systemically, that glibenclamide is rapidly removed across the BBB when given intracranioventricularly, and that any glibenclamide that does enter (and is below our detection limit) is insufficient to influence neuronal function as assessed by anaesthesia sensitivity.…”
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Radiation-induced white matter dysfunction in patients with nasopharyngeal carcinoma by Xingyou Zheng, Li Li, Jian-ming Gao, Yang Hu, Limeng Deng, Ya-fei Kang, Youming Zhang, Youming Zhang

“…Our findings of decreased WW-FCS and GW-FCS in such brain regions (such as visual cortex, posterior thalamic radiation, and anterior limb of internal capsule, as well as superior cerebellar peduncle) suggest potential functional impairments in visual and motor systems.…”
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Subcutaneous adipose tissue-secreted proteins as endocrine regulators of physical and cognitive function in older adults by Cheehoon Ahn, Ian Tamburini, James A. Sanford, Mingqi Zhou, Farah Gamie, Reichelle X. Yeo, Carlos H. Viesi, Maria Pino, Katie L. Whytock, Lauren E. Oberlin, Theresa Mau, Joshua N. Adkins, Jamie N. Justice, Ashlee N. Wood, Zana M. Ross, Paul.D. Piehowski, Chelsea M. Hutchinson Bunch, Kirk I. Erickson, Frederico G.S. Toledo, Nancy E. Lane, Peggy M. Cawthon, Anne B. Newman, Stephen B. Kritchevsky, Steven R. Cummings, Bret H. Goodpaster, Erin E. Kershaw, Marcus M. Seldin, Lauren M. Sparks

“…Declines in skeletal muscle and cognitive function in older adults have been linked to abnormalities in abdominal subcutaneous adipose tissue (ASAT), yet the underlying molecular mediators remain poorly understood. …”
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Applying Dynamical Systems Theory to Improve Personalized Medicine Following Mild Traumatic Brain Injury by Shawn R. Eagle, Rebecca J. Henry

“…We need to utilize an equally complex treatment approach to match the extraordinary complexity of the human brain. Dynamical systems theory has been used to describe systems composed of multiple subsystems who function somewhat independently but are ultimately interconnected. …”
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Modern Views on the Neuropeptide Oxytocin. Part II. Oxytocin in the Process of Evolution. The Role of Oxytocin in the Behavioural, Somatic and Autonomic Functions of Humans and Ani... by Elena A. Leonova, Albina A. Bakhova, Irina L. Cherednik, Yulia V. Kashina, Aleksandr N. Ardelyan

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Augmenting flexibility: mutual inhibition between inhibitory neurons expands functional diversity by Belle Liu, Alexander James White, Chung-Chuan Lo

“…Summary: Recent advances in microcircuit analysis of nervous systems have revealed a plethora of mutual connections between inhibitory interneurons across many different species and brain regions. …”
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Neuroanatomical and functional correlates in tic disorders and Tourette's syndrome: A narrative review by Anna Sara Liberati, Giulio Perrotta

“…From a neurophysiological perspective, the disorder has classically been associated with neurochemical imbalances (particularly dopamine and serotonin) and structural and functional alterations affecting, in particular, brain areas and circuits involved in the processing and coordination of movements: the basal ganglia, thalamus, motor cortical area, and cingulate cortex; however, more recent research is demonstrating the involvement of many more brain regions and neurotransmission systems than previously observed, such as the prefrontal cortex and cerebellum. …”
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Visual Dysfunctions in Mild Traumatic Brain Injury: A Focus on Accommodative System Impairments by Nawaf M. Almutairi

“…<b>Objective</b>: This paper analyzes the pathophysiology of mild traumatic brain injury (mTBI) and its effects on visual and oculomotor functions, focusing on the deficits of the accommodative system and their underlying mechanism. …”
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The NIH BRAIN Initiative’s impacts in systems and computational neuroscience and team-scale research 2014–2023 by Farah Bader, Clayton Bingham, Karen K David, Hermon Gebrehiwet, Crystal L Lantz, Grace CY Peng, Mauricio Rangel-Gomez, James Gnadt, On behalf of the NIH BRAIN Initiative Integrative and Quantitative Neuroscience Team

“…At the 10-year anniversary of the NIH BRAIN Initiative, this report analyzes the impact of the initiative’s functional neuroscience ecosystem as funding experiments in the domains of systems and integrative neuroscience, and computational neuroscience, with an eye on comparison with other funding models and best practices.…”
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Altered functional network topology and connectivity in female nurses with shift work sleep disorder by Hu-Cheng Yang, Hu-Cheng Yang, Si-Yu Gu, Shu-Fang Wang, Jian-Ping Liu, Shu Wang, Hai-Juan Chen, Li Chen, Chun-Mei Song, Qing-He Li, Zhen-Yu Dai, Ping-Lei Pan

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Cholesterol‐loaded nanoparticles ameliorate synaptic and cognitive function in Huntington's disease mice by Marta Valenza, Jane Y Chen, Eleonora Di Paolo, Barbara Ruozi, Daniela Belletti, Costanza Ferrari Bardile, Valerio Leoni, Claudio Caccia, Elisa Brilli, Stefano Di Donato, Marina M Boido, Alessandro Vercelli, Maria A Vandelli, Flavio Forni, Carlos Cepeda, Michael S Levine, Giovanni Tosi, Elena Cattaneo

“…These results demonstrate that cholesterol supplementation to the HD brain reverses functional alterations associated with HD and highlight the potential of this new drug‐administration route to the diseased brain.…”
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Hierarchical regulation of functionally antagonistic neuropeptides expressed in a single neuron pair by Ichiro Aoki, Luca Golinelli, Eva Dunkel, Shripriya Bhat, Erschad Bassam, Isabel Beets, Alexander Gottschalk

“…Our findings suggest that peptidergic autocrine motifs, exemplified by the interaction between NLP-10 and FLP-1, might represent a widespread mechanism in nervous systems across species. These mutual functional interactions among peptidergic co-transmitters could fine-tune brain activity.…”
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fMRI Study on the Functional Connectivity of Nucleus Accumbens in Patients with Knee Osteoarthritis by Yang XIAO, Jiao LIU, kun HU, Meiqin LIN, Youxue TU, Jing TAO, Lidian CHEN, Jia HUANG

“…About the correlation between brain regions with differences in functional connectivity of bilateral NAc and the pain subtest of KOOS in the two groups, the rsFCs of bilateral NAc-right DLPFC/bilateral NAc-left S2 were positively correlated with pain subtest of the KOOS in the KOA group.Conclusion:It suggests that the abnormal functional connectivity between default mode network, where the brain regions related to cognitive control, emotional regulation, sensory processing and NAc, which is related to the central dopamine system, may be one of the underlying mechanisms of pain syndrome of KOA.…”
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Disrupted functional connectome in a rodent model of autism during social isolation by Robert Gergely Kemecsei, Robert Gergely Kemecsei, Szizel Dániel-Papp, David Barnabas Balazs, Estifanos Ghebrihiwet Tewelde, Andras Csillag, Gergely Zachar

“…Based on correlational activations we reconstructed and analyzed the functional connectome of the observed brain regions. …”
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Assessing Functional Connectivity Dynamics During Cognitive Tasks Involving the Dorsal Stream by Huifang E. Wang, Jorge Gonzalez-Martinez, Viktor Jirsa, Patrick Chauvel, F.-Xavier Alario, Catherine Liegeois-Chauvel

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Functional changes in the hypothalamic-pituitary-adrenal axis after successful cardiopulmonary resuscitation by Le An, Zhijiang Qi, Huan Shao, Chunsheng Li

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Functional Diversity of Serotonin Neurons in the Dorsal and Median Raphe Nuclei in Emotional Responses by Yu Ohmura, Kazuki Nagayasu

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THE PROBLEMS OF COOPERATION BETWEEN ANAESTHESIOLOGY , NEUROSURGERY AND FUNCTIONAL DIAGNOSTICS IN CASE OF EPILEPSY SURGERY by A. S. Shershever, G. V. Cherkasov, S. A. Lavrova

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Potential role of ghrelin in neuroprotection and cognitive function: implications for diabetic cognitive impairment by Yuhan Zhang, Ruihua Zhang, Xin Wang, Leilei Shi, Hongzhe Zhu, Jiping Liu

“…Despite ghrelin’s multiple functions in the central nervous system, its use as a therapeutic agent for neurologic dysfunction remains unclear. …”
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Rapid and quantitative functional interrogation of human enhancer variant activity in live mice by Ethan W. Hollingsworth, Taryn A. Liu, Joshua A. Alcantara, Cindy X. Chen, Sandra H. Jacinto, Evgeny Z. Kvon

“…Abstract Functional analysis of non-coding variants associated with congenital disorders remains challenging due to the lack of efficient in vivo models. …”
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