Improving the Minimum Free Energy Principle to the Maximum Information Efficiency Principle by Chenguang Lu

“…However, it has a theoretical flaw, a possibility of being misunderstood, and a limitation (only likelihood functions are used as constraints). This paper first introduces the semantic information G theory and the <i>R</i>(<i>G</i>) function (where <i>R</i> is the minimum mutual information for the given semantic mutual information <i>G</i>). …”
Get full text

A soft neural interface with a tapered peristaltic micropump for wireless drug delivery by Hyeokjun Lee, Soojeong Song, Jeongdae Ha, Yoon Kyeung Lee, Kyung-In Jang

“…Abstract Achieving precise, localized drug delivery within the brain remains a major challenge due to the restrictive nature of the blood–brain barrier and the risk of systemic toxicity. …”
Get full text

INSULIN RESISTANCE AS A RISK FACTOR FOR COGNITIVE DYSFUNCTION by Antoniya Hachmeriyan, Nadezhda Stefanova, Gabriela Panayotova

“…Conclusion: Although secreted peripherally, insulin plays a profound role in cognitive function, and IR facilitates the brain's susceptibility to neurodegeneration. …”
Get full text

Abnormal α-synuclein binds to synaptotagmin 13, impairing extracellular vesicle release in synucleinopathies by Yasuo Miki, Shuji Shimoyama, Makoto T. Tanaka, Hanae Kushibiki, Asa Nakahara, Xiaopeng Wen, Masanori Hijioka, Tomoya Kon, Megha Murthy, Tomonori Furukawa, Conceição Bettencourt, Fumiaki Mori, Hiroki Mizukami, Shirushi Takahashi, Mari Tada, Yoshihisa Kitamura, Akiyoshi Kakita, Thomas T. Warner, Koichi Wakabayashi

“…Abstract Background Despite increasing in vitro research, direct evidence of how abnormal α-synuclein (α-Syn) dysregulates vesicular transport and synaptic function in the human brain is lacking. Methods We performed a transcriptome analysis using brain tissues from a multiple system atrophy (MSA) mouse model, which develops human α-Syn-positive glial cytoplasmic inclusion-like structures and neuronal cytoplasmic inclusion-like structures after tamoxifen injection. …”
Get full text

Changes in the cytokine response in the hypothlamus of animals under the influence of chronic social stress: RNAseq data by A. G. Galyamina, I. L. Kovalenko, D. A. Smagin, N. A. Popova

“…It has been shown that the effect of stress is also manifested in changes in the level of expression of genes involved in the functioning of various physiological systems in the brain of mice, in particular, in the hypothalamus. …”
Get full text

Energy state guides reward seeking via an extended amygdala to lateral hypothalamus pathway by Kuldeep Shrivastava, Vikshar Athreya, Yi Lu, Jorge Luis-Islas, Ashley Han, Tess F. Kowalski, Mark A. Rossi

“…Abstract Impaired regulation of food intake underlies numerous health problems, including obesity and type 2 diabetes, yet how brain systems controlling reward seeking become dysregulated to promote overeating is unknown. …”
Get full text

Altered Effective Connectivity of Hippocampus-Dependent Episodic Memory Network in mTBI Survivors by Hao Yan, Yanqin Feng, Qian Wang

“…However, less is known regarding how external force altered the way functionally connected brain structures of the episodic memory system interact. …”
Get full text

Maternal immune activation followed by peripubertal stress combinedly produce reactive microglia and confine cerebellar cognition by Momoka Hikosaka, Md Sorwer Alam Parvez, Yuki Yamawaki, Souichi Oe, Yuan Liang, Yayoi Wada, Yukie Hirahara, Taro Koike, Hirohiko Imai, Naoya Oishi, Sina M. Schalbetter, Asuka Kumagai, Mari Yoshida, Takeshi Sakurai, Masaaki Kitada, Urs Meyer, Shuh Narumiya, Gen Ohtsuki

“…Reduced excitability of remaining Purkinje cells, cerebellum-involved brain-wide functional dysconnectivity, and behavioral abnormalities indicate cerebellar cognitive dysfunctions in 2HIT animals, which are ameliorated by both systemic and cerebellum-specific microglia replacement.…”
Get full text

A Proposed Neurological Interpretation of Language Evolution by Alfredo Ardila

“…It is proposed that grammar probably originated from the internal representation of actions, resulting in the creation of verbs; this is an ability that depends on the so-called Broca’s area and related brain networks. It is suggested that grammar is the basic ability for the development of so-called metacognitive executive functions. …”
Get full text

Central Role of the EGF Receptor in Neurometabolic Aging by Sana Siddiqui, Meng Fang, Bin Ni, Daoyuan Lu, Bronwen Martin, Stuart Maudsley

“…It appears that both normal and pathophysiological aging, as well as neurodegenerative disorders, are all profoundly influenced by this “neurometabolic” interface, that is, communication between the brain and metabolic organs. An important aspect of this “neurometabolic” axis that needs to be investigated involves an elucidation of molecular factors that knit these two functional signaling domains, neuronal and metabolic, together. …”
Get full text

A Violet‐Light‐Responsive ReRAM Based on Zn2SnO4/Ga2O3 Heterojunction as an Artificial Synapse for Visual Sensory and In‐Memory Computing by Saransh Shrivastava, Wei‐Sin Dai, Stephen Ekaputra Limantoro, Hans Juliano, Tseung‐Yuen Tseng

“…Abstract Due to the imitation of the neural functionalities of the human brain via optical modulation of resistance states, photoelectric resistive random access memory (ReRAM) devices attract extensive attraction for synaptic electronics and in‐memory computing applications. …”
Get full text

Cognitive impairments in cerebrovascular disease by A. Yu. Emelin

Get full text

Significance of Neuromorphological Studies in the Investigation of Postresuscitative Pathology: Development of Academician V. A. Negovsky's Views by M. Sh. Avrushchenko, V. V. Moroz, I. V. Ostrova

“…Under discussion are the problems associated with the time course of changes in the postresuscitative process, the impact of the duration of a terminal condition on brain damage, the significance of structure-function relationships, the selective vulnerability of different regions of the central nervous system, the role of the body’s individual and typological characteristics, as well as the methodological approaches to preventing and treating brain dysfunction. …”
Get full text

A microRNA signature that correlates with cognition and is a target against cognitive decline by Md Rezaul Islam, Lalit Kaurani, Tea Berulava, Urs Heilbronner, Monika Budde, Tonatiuh Pena Centeno, Vakthang Elerdashvili, Maria‐Patapia Zafieriou, Eva Benito, Sinem M Sertel, Maria Goldberg, Fanny Senner, Janos L Kalman, Susanne Burkhardt, Anne Sophie Oepen, Mohammad Sadman Sakib, Cemil Kerimoglu, Oliver Wirths, Heike Bickeböller, Claudia Bartels, Frederic Brosseron, Katharina Buerger, Nicoleta‐Carmen Cosma, Klaus Fliessbach, Michael T. Heneka, Daniel Janowitz, Ingo Kilimann, Luca Kleinedam, Christoph Laske, Coraline D Metzger, Matthias H Munk, Robert Perneczky, Oliver Peters, Josef Priller, Boris S. Rauchmann, Nina Roy, Anja Schneider, Annika Spottke, Eike J Spruth, Stefan Teipel, Maike Tscheuschler, Michael Wagner, Jens Wiltfang, Emrah Düzel, Frank Jessen, Delcode Study Group, Silvio O Rizzoli, Wolfram‐Hubertus Zimmermann, Thomas G Schulze, Peter Falkai, Farahnaz Sananbenesi, Andre Fischer

“…Since changes in cognitive function develop slowly over time in these patients, they are often diagnosed at an advanced stage of molecular pathology, a time point when causative treatments fail. …”
Get full text

Intracellular spatial transcriptomic analysis toolkit (InSTAnT) by Anurendra Kumar, Alex W. Schrader, Bhavay Aggarwal, Ali Ebrahimpour Boroojeny, Marisa Asadian, JuYeon Lee, You Jin Song, Sihai Dave Zhao, Hee-Sun Han, Saurabh Sinha

Get full text

Impact of Lipid Nutrition on Neural Stem/Progenitor Cells by Nobuyuki Sakayori, Ryuichi Kimura, Noriko Osumi

“…These adult-born neurons are involved in various brain functions, including olfaction-related functions, learning and memory, pattern separation, and mood control. …”
Get full text

Sciatic nerve analysis in thyroid hormone transporters Mct8 and Oatp1c1 knockout mice by Steffen Mayerl, Andrea Alcaide Martin, Reinhard Bauer, Heike Heuer

“…These abnormalities have been attributed to impaired TH transport across brain barriers and into neural cells, thereby affecting brain development and function. …”
Get full text

Delayed remote ischemic postconditioning improves long term sensory motor deficits in a neonatal hypoxic ischemic rat model. by Pradilka N Drunalini Perera, Qin Hu, Junjia Tang, Li Li, Margaret Barnhart, Desislava M Doycheva, John H Zhang, Jiping Tang

“…<h4>Results</h4>HI induced rats performed significantly worse than sham but both groups of delayed RIPC treatment showed improvement of sensory motor functions. Furthermore, compared to the HI induced group, the delayed RIPC treatment groups showed no further detrimental changes on brain tissue, both grossly and morphologically, and no changes on the systemic organ weights.…”
Get full text

Inflammation in Schizophrenia: The Role of Disordered Oscillatory Mechanisms by Lucinda J. Speers, David K. Bilkey

“…In this review, we outline the potential role of inflammation in the disorder, with a particular focus on how cytokine release might affect the development and function of GABAergic interneurons. One consequence of this change in inhibitory control is a disruption in oscillatory processes in the brain. …”
Get full text

Neural and behavioral reinstatement jointly reflect retrieval of narrative events by Matthias Nau, Austin Greene, Hannah Tarder-Stoll, Juan Antonio Lossio-Ventura, Francisco Pereira, Janice Chen, Christopher Baldassano, Chris I. Baker

“…Collectively, these results suggest that retrieval engages mechanisms similar to those that direct our eyes during natural vision, reflecting common constraints within the functional organization of the nervous system. Moreover, they highlight the importance of considering behavioral and neural reinstatement together in our understanding of remembering.…”
Get full text