Ethical, legal, and social aspects of health technologies for home-based paediatric palliative care – a systematic review by Erik Bjørnerud, Simen A. Steindal, Bjørn M. Hofmann, Anette Winger, Kirsti Riiser, Weiqin Chen, Heidi Holmen

“…The eligible studies employed a range of different methods from randomised controlled trials to usability studies. …”
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Evaluation of Drug Resistance Pattern and Molecular Detection of ISAba1 and ISAba2 in Acinetobacter baumannii Strains Isolated from Hospitalized Patients by Seyed Mohammad Mahdi Mousavi, Hamid Reza Goli, Elham Amiri, Mehrdad Gholami

“…The antibiotic susceptibility pattern of the isolates was evaluated using the disk diffusion method according to the CLSI 2021 guidelines. The minimum inhibitory concentration (MIC) of colistin was determined using the micro broth method. …”
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The Clinical Study of Intratumoral and Peritumoral Radiomics Based on DCE-MRI for HER-2 Positive and Low Expression Prediction in Breast Cancer by Shang Y, Wang Y, Guo Y, Li S, Liao J, Hai M, Wang M, Tan H

“…Radiomics provides a non-invasive method to assess tumor characteristics, including both the core and surrounding tissue, with the potential to improve the accuracy of HER-2 status prediction.Objective: To explore the clinical value of intratumoral and peritumoral radiomics features from dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) for preoperative prediction of human epidermal growth factor receptor-2 (HER-2) expression status in breast cancer.Methods: Two tasks were designed, including Task1-distinguished HER-2 positive and HER-2 negative from 382 breast cancer patients and Task2-distinguished HER-2 low and HER-2 zero expression from 249 patients with HER-2 negative. …”
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Communicating treatment options to older patients with advanced kidney disease: a conversation analysis study by Lucy E. Selman, Chloe B. Shaw, Ryann Sowden, Fliss E. M. Murtagh, James A. Tulsky, Ruth Parry, Fergus J. Caskey, Rebecca K. Barnes

“…The OSCAR study (Optimising Staff-Patient Communication in Advanced Renal disease) aimed to identify how clinicians present kidney failure treatment options in consultations with older patients and the implications of this for patient engagement. Methods An observational, multi-method study design was adopted. …”
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Development and Validation of a Predictive Model Using Inflammatory Biomarkers for Active Tuberculosis Risk in Diabetic Patients by Zhang X, Fu H, Li J, Yan J, Huang J, Xu Z, Li M, Qian M, Wang L, Li H, Du Y

“…Xuan Zhang,1,2,* Haiyan Fu,2,3,* Jie Li,1,2 Junfang Yan,1 Jingjing Huang,4 Zhaoyuan Xu,1,2 Mingwu Li,2,5 Mengni Qian,3 Lifeng Wang,3 Hongjuan Li,2,3 Yingrong Du1,2 1Cardiology Department, The 3rd People’s Hospital of Kunming, Kunming, Yunnan, People’s Republic of China; 2Yunnan Infectious Disease Clinical Medical Center, Kunming, Yunnan, People’s Republic of China; 3Hospice Care Center, The 3rd People’s Hospital of Kunming, Kunming, Yunnan, People’s Republic of China; 4Medical Record Department, The 3rd People’s Hospital of Kunming, Kunming, Yunnan, People’s Republic of China; 5Tuberculosis Department, The 3rd People’s Hospital of Kunming, Kunming, Yunnan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hongjuan Li, The 3rd People’s Hospital of Kunming, No. 319 WuJing Road GuanDu area, Kunming, People’s Republic of China, Tel +86 871-63510928, Email 56624140@qq.com; Yingrong Du, The 3rd People’s Hospital of Kunming, No. 319 WuJing Road GuanDu area, Kunming, People’s Republic of China, Tel +86 871-63543252, Email dyr_km@163.comAim: Exploring the value of inflammatory markers in diagnosing active pulmonary tuberculosis in diabetics.Patients and Methods: Routine clinical indicators and a range of inflammatory markers were assessed in 276 diabetic patients (DM) and 276 patients with diabetes mellitus combined with active tuberculosis (DM-PTB) from Kunming, Yunnan Province, China. …”
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Mechanisms of Acetate in Alleviating SETDB1-Linked Neuroinflammation and Cognitive Impairment in a Mouse Model of OSA by Zhao Z, Xiang L, Hong JS, Wang Y, Feng J

“…We aimed to investigate roles of acetate (ACE) and SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) in neuroinflammation of OSA.Methods: After C57BL/6J mice were exposed to OSA-associated intermittent hypoxia (IH) or normoxia for four weeks, the composition of the gut microbiota (GM) and the levels of serum short-chain fatty acids (SCFAs) were measured by 16S rRNA and GC-MS methods, respectively. …”
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Unveiling Potential Blood Markers for Endometriosis Through the Integration and Experimental Validation of Immune Cell Traits Genome and Genome-Wide Associated Data by Mei J, Jiang XY, Zhang B, Wang L, Zhang AX, Li JJ, Chen SX, Xu X, Hu JJ, Zhou SG

“…Jie Mei,1– 3,* Xi-Ya Jiang,1,2,* Bin Zhang,4,* Li Wang,5 Ai-Xi Zhang,6 Jie-Jie Li,1– 3 Shun-Xia Chen,1,2 Xiao Xu,1,2 Jing‑Jing Hu,7 Shu-Guang Zhou1– 3 1Department of Gynecology, The Fifth Affiliated Clinical College of Anhui Medical University, Maternal and Child Health Center of Anhui Medical University, Hefei, Anhui, 230001, People’s Republic of China; 2Department of Gynecology, Anhui Women and Children’s Medical Center, Hefei, Anhui, 230001, People’s Republic of China; 3Department of Gynecology, Linquan Maternity and Child Healthcare Hospital, Fuyang, Anhui, 236400, People’s Republic of China; 4Department of Scientific Research, Hefei Maternity and Child Healthcare Hospital, Hefei, Anhui, 230001, People’s Republic of China; 5Department of Clinical Laboratory, Linquan Maternity and Child Healthcare Hospital, Fuyang, Anhui, 236400, People’s Republic of China; 6Department of Public Health, Linquan Maternity and Child Healthcare Hospital, Fuyang, Anhui, 236400, People’s Republic of China; 7Department of reproduction, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230032, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shu-Guang Zhou; Jing‑Jing Hu, Email zhoushuguang@ahmu.edu.cn; janejj55@126.comBackground: While endometriosis (EM) has been previously associated with multiple immune factors, the causal relationship underlying these associations remains unclear.Objective: In this study, Two-sample Mendelian randomization (MR) method was employed to investigate the causal relationship between 731 immune cell traits and EM based on tabulated data from genome-wide association studies (GWAS).Methods: MR method includes inverse variance weighting (IVW), the weighted median (WM), MR-Egger, the weighted model, and the simple model. …”
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Updated Surveillance Metrics and History of the COVID-19 Pandemic (2020-2023) in Canada: Longitudinal Trend Analysis by Scott A Wu, Alan G Soetikno, Egon A Ozer, Sarah B Welch, Yingxuan Liu, Robert J Havey, Robert L Murphy, Claudia Hawkins, Maryann Mason, Lori A Post, Chad J Achenbach, Alexander L Lundberg

“…The rolling 1-sided t test of speed equal to 10 became entirely insignificant from mid-October 2022 onward. …”
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Integrating Bulk and Single-Cell Transcriptomic Data to Identify Ferroptosis-Associated Inflammatory Gene in Alzheimer’s Disease by Zhou H, Peng Y, Huo X, Li B, Liu H, Wang J, Zhang G

“…Finally, candidate genes were validated in ferroptosis models using reverse transcription quantitative PCR (RT-qPCR) and immunofluorescence methods.Results: Bulk RNA-seq analysis identified SLC11A1, an inflammatory gene associated with AD. …”
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Health Economics Evaluation of Bictegravir/Emtricitabine/Tenofovir for a First-Line Treatment of HIV-1 Infection in China by Wang W, Zhou D, Zhou K, Zhang D, Li H, Zhang H, Jiang X, Wang R, Wang X, Tang W

“…Wenjuan Wang,1,* Dachuang Zhou,1,* Kejia Zhou,1 Di Zhang,1 Hao Li,1 Hongliu Zhang,1 Xin Jiang,1 Ruihua Wang,1 Xi Wang,2 Wenxi Tang1 1Center for Pharmacoeconomics and Outcomes Research, China Pharmaceutical University, Nanjing, Jiangsu Province, 211198, People’s Republic of China; 2Infection Center, Beijing You’an Hospital, Capital Medical University, Beijing, 100069, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wenxi Tang, Email tokammy@cpu.edu.cn Xi Wang, Email wangxi35@ccmu.edu.cnPurpose: This study aims to evaluate the economic value of Bictegravir/emtricitabine/tenofovir (B/F/TAF) as a first-line treatment for HIV-1 infection in China, where such evaluations are currently lacking.Patients and Methods: We developed a monthly-cycle Markov model to evaluate the economics of B/F/TAF versus dolutegravir/lamivudine (DTG/3TC) as a first-line ART for adult HIV-1 patients over a lifelong time. …”
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Causal Effects of Inflammatory Cytokines and Immune Cell Phenotypes on Spontaneous Abortion: Evidence From Mendelian Randomization by Lin S, Tian X, Kong S, Zhang B, Wang S, Zhu K, Liu X, Yeung WSB, Cao D, Yao Y

“…Five different MR analysis methods and Bayesian-weighted Mendelian randomization (BWMR) analysis were employed to assess the genetic causal connection. …”
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The Value of Using Bedside Point of Care Testing for International Normalized Ratio in Patients on Warfarin Undergoing Dental Procedures and Bleeding Assessment; A Single Center Pr... by Albarkheel A, Alshareef H, Albar A, Altbaili SY, Alminaqash MA, Alotibie A, Sheikh A, Alahmadi A, Alaifan B, Tamim H, Owaidah T

“…Levene’s test assessed variance equality.Results: The study included 88 patients (61.4% female, mean age 49.7 ± 14.1 years). …”
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Clinical features of the pulmonary tuberculosis course combined with different diabetes mellitus types in the Zaporizhzhia region by O. M. Raznatovska, Yu. M. Bobrovnycha-Dvizova

“…The outcomes of the study were processed by modern analysis methods on a personal computer using the statistical package of the Statistica® for Windows 6.0 (StatSoft Inc., No. …”
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AQP1 Affects Necroptosis by Targeting RIPK1 in Endothelial Cells of Atherosclerosis by Wang P, Zheng L, Yang Y, Yue X, Liu J, Fan K, Zhou H, Dong H

“…Then we collected femoral atherosclerosis and normal aortic samples, further conducted single-cell sequencing and spatial transcriptomic methods to confirm the potential function and pathway of AQP1 in endothelial cells. …”
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DENTAL STATUS IN CHILDREN WITH MALIGNANT SOLID NEOPLASMS by Yu.V. Popelo

“…The urgency of this issue is due to a pronounced tendency to a rapid increase in the prevalence of disease with malignant formation, which requires a detailed study of the efficiency of already implemented methods and improving or developing new schemes for the sustainable maintenance of dental health in patients of this profile. …”
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COMPARATIVE EXPERIMENTAL AND CLINICAL EVALUATION OF OSTEOGENIC PROPERTIES OF BONE MARROW AND FATTY AUTOLOGICAL STOMATIC CELLS by V. F. Kutsevlyak, V. I. Kutsevlyak, I.V. Tsyganova

“…In the initial survey, the average indexes of periodontal disease in patients of both groups were equal. Radiologically, in patients of the experimental group, an increase in the height of interalveolar septal walls was determined at 1-1.5 mm, in comparison with preoperative orthopantomograms. …”
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Genome Variability for the Development of Coronary Heart Disease in Type 2 Diabetes Mellitus: A Bibliometric Analysis by Bekenova NB, Vochshenkova TA, Zhylkybekova A, Ablakimova N, Mussin NM, Albayev RK, Kaliyev AA, Tamadon A

“…The aims of this study are to employ bibliometric analysis methods for mapping the array of research on genome variability concerning the development of coronary heart disease in individuals with type 2 diabetes mellitus.Methods: We derived the data from the Web of Science (WoS) Core Collection database and Scopus on January 6, 2023. …”
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Genomic Characterization and Antimicrobial Resistance of ESBL-Producing, Escherichia coli Isolates in Suzhou, China by Wang C, Zhang H, Zhao R, Tsui CKM, Deng S

“…Cailin Wang,1,* Hong Zhang,2,* Rongfen Zhao,2 Clement Kin-Ming Tsui,3– 5 Shuwen Deng1 1Medical Research Center, People’s Hospital of Suzhou New District, Suzhou, Jiangsu, People’s Republic of China; 2Department of Medical Microbiology, People’s Hospital of Suzhou New District, Suzhou, Jiangsu, People’s Republic of China; 3Infectious Disease Research Laboratory, National Centre for Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore; 4Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore; 5Faculty of Medicine, University of British Columbia, Vancouver, BC, V6T1Z3, Canada*These authors contributed equally to this workCorrespondence: Shuwen Deng, Email danyanghhh@qq.com Clement Kin-Ming Tsui, Email clementsui@gmail.comBackground: The prevalence of third-generation cephalosporin-resistant and extended-spectrum beta-lactamases (ESBL) producing Escherichia coli poses a significant global public health concern due to their resistance to multiple antibiotics; however, their prevalence and epidemiological patterns in China are not very well investigated.Objective: This study aimed to investigate the molecular epidemiology, and antimicrobial susceptibility of ESBL-producing E. coli among clinical isolates in China.Methods: Phenotypic ESBL-producing E. coli isolates were collected from in-patients at a non-tertiary hospital in Suzhou from 2018.06.01 − 2019.11.30. …”
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STYLISTIC MEANS OF IMPLEMENTING THE IDEA OF THE WORLD’S IRIDESCENCE IN PH.K. DICK’S “UBIK” IN THE CONTEXT OF TRANSLATION TRANSFORMATIONS by Svitlana F. Aleksenko, Larysa I. Taranenko

“…Among the typical translation methods, instrumental in the rel- evant textual sequences in “Ubik”, a share of lexical and semantic transformations equals 60.2% of the re- searched sets of translation counterparts, with modulation and specification being the dominant ones and logical synonymy, calquing and lexical compensation trailing behind. …”
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Macrophage Membrane Coated Manganese Dioxide Nanoparticles Loaded with Rapamycin Alleviate Intestinal Ischemia-Reperfusion Injury by Reducing Oxidative Stress and Enhancing Autopha... by Sheng R, Wang W, Zeng W, Li B, Yu H, Li X, Liang Y, Wang Y, Liao Y, Liu D

“…The aim of this study is to fabricate macrophage membrane-coated manganese dioxide nanospheres loaded with rapamycin [Ma@(MnO₂+RAPA)] for alleviating intestinal I/R injury.Methods: We engineered honeycomb MnO2 nanospheres coated with a macrophage membrane to act as a drug delivery system, encapsulating RAPA. …”
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