Global, regional, and national liver cancer attributable to smoking and alcohol use burden, 1990–2021: analysis for the global burden of disease 2021 study by Chenyi Liu, Taiting Shi, Shu Li, Shiwen Wu, Jiawen Chen, Chao Cai, Mingqin Lu

“…Smoking and alcohol consumption are major risk factors for liver cancer. Methods We analyzed data from the Global Burden of Disease (GBD) Study 2021. …”
Get full text

Artificial intelligence in Anatomy: Potential uses and challenges by Lubna Faisal

“…For this new innovative technologies and teaching methods should be incorporated for both learning and assessment of anatomy [2]. …”
Get full text

Clinical efficacy and quality of life in elderly patients with lumbar degenerative disease treated with TLIF combined with unilateral pedicle screw fixation: a randomized controlle... by Cheng-Peng Li, Kai-Kai Feng, Xiao-Bing Xiang, Kai-Yin Gao, Wei-Wei Zhang, Zhen-Yu Nie, Dong Zhao, Wen-Xin Liao, Guang-Ru Cao

“…Pain and functional status were preoperatively evaluated, in addition to being postoperatively evaluated at 1, 6, and 12 months, using the visual analogue scale (VAS), Oswestry Disability Index (ODI), Japanese Orthopaedic Association (JOA) score, and Short Form-36 (SF-36) health survey questionnaire. …”
Get full text

Multi-Focus Image Fusion Based on Dual-Channel Rybak Neural Network and Consistency Verification in NSCT Domain by Ming Lv, Sensen Song, Zhenhong Jia, Liangliang Li, Hongbing Ma

“…In multi-focus image fusion, accurately detecting and extracting focused regions remains a key challenge. Some existing methods suffer from misjudgment of focus areas, resulting in incorrect focus information or the unintended retention of blurred regions in the fused image. …”
Get full text

Synthesis and investigation of the physicochemical properties of 2-(5-((theophylline-7'-yl)methyl)-4-phenyl-4H-1,2,4-triazole-3-ylthio)-acetic acid salts by A. S. Gotsulya, O. O. Mikolasyuk, O. I. Panasenko, Ye. G. Knysh

“…After cooling to the reaction mixture with stirring, adds an equal volume of water. The precipitate dissolves, then falles again. …”
Get full text

Randomised trial comparing weight loss through lifestyle and GLP-1 receptor agonist therapy in people with MASLD by Ahmad Moolla, Toryn Poolman, Nantia Othonos, Jiawen Dong, Kieran Smith, Thomas Cornfield, Sarah White, David W. Ray, Sofia Mouchti, Ferenc E. Mózes, Helena Thomaides-Brears, Stefan Neubauer, Jeremy F. Cobbold, Leanne Hodson, Jeremy W. Tomlinson

“…Impact and implications: Weight loss, through either lifestyle intervention or pharmacotherapy with GLP-1RA has an equally beneficial impact on the liver, and both strategies should be considered in the management of people with MASLD. …”
Get full text

Squalomix: shark and ray genome analysis consortium and its data sharing platform [version 2; peer review: 2 approved] by John Rozewicki, Kazuaki Yamaguchi, Osamu Nishimura, Ryo Misawa, Takashi Asahida, Mitsumasa Koyanagi, Akihisa Terakita, Filipe Castro, André Machado, Milton Tan, Salvatore D'Aniello, Shotaro Hirase, Akane Kawaguchi, Chiharu Tanegashima, Akinori Teramura, Masaru Yagura, Taiki Niwa, Kaori Tatsumi, Yuta Ohishi, Susumu Hyodo, Mitsutaka Kadota, Itsuki Kiyatake, Keiichi Sato, Kazuyuki Yamada, Kiyonori Nishida, Yasuko Semba, Shinya Yamauchi, Sho Tanaka, Tatsuya Sakamoto, Norio Miyamoto, Atsushi Toyoda, Rui Matsumoto, Iker Irisarri, Atsuko Yamaguchi, Tazro Ohta, Kiyomi Murakumo, Junna Kawasaki, Masayuki Horie, Yoshinobu Uno, Shigehiro Kuraku

“…Their peculiar body fluid composition has also hindered the establishment of methods to perform routine cell culturing required for their karyotyping. …”
Get full text

Exploring the co‐morbid relationship between Alzheimer's disease and lung cancer in the 5xFAD transgenic mouse model by Mingfeng Li, Xinghan Wu, Lin Jiang, Min Liu, Gong Yanju, Xiaomeng Li, Fan Tian, Fan Ye, Jinlong Wang, Siyuan Wang, Chuan Qin, Ling Zhang

“…However, the precise mechanism by which AD antagonizes lung cancer progression warrants further elucidation. Methods To this end, we established a co‐morbidity model using 5xFAD transgenic mice induced with the carcinogen urethane. …”
Get full text

Comparative evaluation of three polymerase chain reaction primer sets for accurate molecular detection of Trypanosoma lewisi in wild rodents in Indonesia by Aditya Yudhana, Gusti Ayu Illiyin Putri Santosa, April Hari Wardhana, Frenky Laksana Putra, Ryanka Edila, Dyah Haryuningtyas Sawitri, Ratih Novita Praja, Muhammad Aqil Kurnianto, Aldi Gusnizar Rizaldy Tanjung, Marc Desquesnes, Makoto Matsubayashi

“…DNA amplification products were visualized using agarose gel electrophoresis. Diagnostic performance was evaluated based on sensitivity and specificity calculations using microscopy as the reference standard. …”
Get full text

“Koshimagari Exercise” for Adult Spinal Deformity in Older Adults: Assessment of Home-Based Exercise Outcomes in a Prospective Multicenter Study by Hidetomi Terai, Shinji Takahashi, Masatoshi Hoshino, Hiroshi Taniwaki, Koji Tamai, Toshimitsu Ohmine, Tamotsu Nakatsuchi, Goya Shinbashi, Masatoshi Teraguchi, Masakazu Minetama, Kei Watanabe, Naritoshi Sato, Takuya Kitamura, Masaru Kanda, Tadao Tsujio, Yuichi Takeuchi, Tatsuki Mizouchi, Katsuhito Ishizu, Toshihito Ebina, Yasunari Muraoka, Tomonori Sodeyama, Hiroshi Mikami, Yuji Kasukawa, Takahiko Hyakumachi, Kazuhiro Ishida, Kazufumi Miyagishima, Yosuke Oishi, Kiyonori Yo, Ryota Kimura, Hiromichi Sato, Keiji Nagata, Yu Yamato, Ko Matsudaira, Naohisa Miyakoshi, Yukihiro Matsuyama, Hirotaka Haro, Hiroshi Hashizume, Hiroshi Yamada, Takashi Kaito, Project Committee of the Japanese Society for Spine Surgery and Related Research (JSSR)

“…Clinical evaluations were conducted using the Oswestry Disability Index (ODI), five-level classification system of EuroQol-5 Dimensions (EQ-5D), Japanese edition of Scoliosis Research Society-22r (SRS-22r), and visual analog scale (VAS) for LBP at baseline and 3, 6, and 12 months. …”
Get full text

Platelet-rich plasma therapy for knee osteoarthritis: Insights from real-world clinical data in Japan by Yoshitomo Saita, Yohei Kobayashi, Sayuri Uchino, Hirofumi Nishio, Takanori Wakayama, Shin Fukusato, Yasumasa Momoi, Ryosuke Nakajima, Nanako Yamamoto, Shinnosuke Hada, Haruka Kaneko, Muneaki Ishijima

“…The eligibility criteria included chronic knee pain unresponsive to conservative treatment for KOA. Visual Analog Scale (VAS) for knee pain were collected at baseline and 3 and 6 months post-treatment. …”
Get full text

White matter hyperintensity tissue property spatial variations as a function of cognitive status in Parkinson’s disease by Mariyemuguli Reheman, Sagar Buch, Naying He, Pei Huang, Qiurong Yu, Xinhui Wang, Yu Liu, Youmin Zhang, Zhijia Jin, Yan Li, Peng Liu, Shengdi Chen, E. Mark Haacke, Fuhua Yan

“…Water content, T1, and T2* measures were derived from qMRI data and tissue property heatmaps and periventricular distance profiles were constructed for all groups to visualize location-dependent tissue alterations of WMH relative to the lateral ventricles. …”
Get full text

Presaccadic attentional shifts are not modulated by saccade amplitude by Luan Zimmermann Bortoluzzi, Estêvão Carlos-Lima, Gabriela Mueller de Melo, Melissa Hongjin Song Zhu, Gustavo Rohenkohl

“…Interestingly, recent studies have shown that PSA effects on visual perception are not equally distributed around the visual field. …”
Get full text

Supporting the editing of dot maps using the spectral clustering algorithm by Dziuba Natalia, Szombara Stanisław

“…In the study, equal-size spectral clustering algorithm was used, which was modified with a function equalizing the number of points in clusters. …”
Get full text

Can serum metabolic signatures inform on the relationship between healthy lifestyle and colon cancer risk? by Komodo Matta, Vivian Viallon, Anastasia Chrysovalantou Chatziioannou, Nivonirina Robinot, Roland Wedekind, Christina C. Dahm, Agnetha Linn Rostgaard-Hansen, Anne Tjønneland, Therese Truong, Chloé Marques, Pauline Frenoy, Rudolf Kaaks, Renée Turzanski Fortner, Matthias B. Schulze, Sabrina Sieri, Mario Fordellone, Rosario Tumino, Fulvio Ricceri, Tonje Braaten, Therese Haugdahl Nøst, Maria-Jose Sánchez, Olatz Mokoroa-Carollo, Sandra Colorado-Yohar, Camino Trobajo-Sanmartín, Keren Papier, Rhea Harewood, Kostas Tsilidis, Salvatore Vaccarella, Mattias Johansson, Elisabete Weiderpass, Cyrille Delpierre, Sebastien Lamy, Kristin Benjaminsen Borch, Pekka Keski-Rahkonen, Elio Riboli, Heinz Freisling, Marc Gunter, Pietro Ferrari

“…Metabolomics offers potential to uncover biological mechanisms linking lifestyle and colon cancer. Methods Lifestyle and untargeted metabolomic data were available from a nested case–control study within the European Prospective Investigation into Cancer and Nutrition (EPIC), including 1,067 colon cancer cases and 1,067 controls matched on age, sex, study centre, and blood collection time. …”
Get full text

A systematic review of the cost-effectiveness of anti-VEGF drugs for the treatment of diabetic retinopathy by Robert Hodgson, Matthew Walton, Helen Fulbright, Laura Bojke, Ruth Walker, Alexis Llewellyn, Sofia Dias, Lesley Stewart, David Steel, John Lawrenson, Tunde Peto, Mark Simmonds

“…Results of these studies suggest that anti-vascular endothelial growth factor treatments offer some additional benefits in terms of preserved visual acuity but also incur substantial additional costs relative to pan-retinal photocoagulation. …”
Get full text

Effectiveness of Chemical Management for Broadleaf Weeds in Autumn-Sown Chickpea (Cicer arietinum L.) by Mozhgan Veisi, Mehdi Minbashi Moeini, Sepideh Hatami, Mohammad Saleh Mansouri

“…Sophia, Alyssum spp. and total weeds. In the visual evaluation, the highest efficiency belonged to aclonifen at 4 l.ha-1, followed by PRE aclonifen at 2 and 3 l. ha-1, flumioxazin and oxyfluorfen + aclonifen. …”
Get full text

Anti-VEGF drugs compared with laser photocoagulation for the treatment of diabetic retinopathy: a systematic review and meta-analysis by Mark Simmonds, Alexis Llewellyn, Ruth Walker, Helen Fulbright, Matthew Walton, Rob Hodgson, Laura Bojke, Lesley Stewart, Sofia Dias, Thomas Rush, John G Lawrenson, Tunde Peto, David Steel

“…Overall, anti-vascular endothelial growth factor was slightly better than panretinal photocoagulation at preventing vision loss, measured as best corrected visual acuity, at up to 2 years follow-up [mean difference in the logarithm of the minimum angle of resolution −0.089 (or 3.6 Early Treatment Diabetic Retinopathy Study letters), 95% confidence interval −0.180 to −0.019]. …”
Get full text

Assessment of the thoracic aorta after aortic root replacement and/or ascending aortic surgery using 3D relaxation-enhanced angiography without contrast and triggering by Carsten Gietzen, Jan Paul Janssen, Juliana Tristram, Burak Cagman, Kenan Kaya, Robert Terzis, Roman Gertz, Thorsten Gietzen, Henry Pennig, Alexander C. Bunck, David Maintz, Thorsten Persigehl, Navid Mader, Kilian Weiss, Lenhard Pennig

“…The purpose of this study was to evaluate the performance of REACT after surgery of the aortic root and/or ascending aorta by performing an intraindividual comparison to CE-MRA.Material and methodsThis retrospective single center study included 58 MRI studies of 34 patients [mean age at first examination 45.64 ± 11.13 years, 31 (53.44%) female] after ascending aortic surgery. …”
Get full text

Transcorneal electrical stimulation restores DNA methylation changes in retinal degeneration by Ben Yi Tew, Gerald C. Gooden, Pei-An Lo, Pei-An Lo, Dimitrios Pollalis, Dimitrios Pollalis, Brandon Ebright, Brandon Ebright, Alex J. Kalfa, Alejandra Gonzalez-Calle, Alejandra Gonzalez-Calle, Biju Thomas, Biju Thomas, David N. Buckley, Thomas Simon, Zeyi Yang, Ege Iseri, Ege Iseri, Cody L. Dunton, Vadim Backman, Stan Louie, Stan Louie, Gianluca Lazzi, Gianluca Lazzi, Gianluca Lazzi, Mark S. Humayun, Mark S. Humayun, Bodour Salhia

“…With promising results, there is a need for detailed molecular characterization of the therapeutic effects of TES.MethodsControlled, non-invasive TES was delivered using a custom contact lens electrode to the retinas of Royal College of Surgeons (RCS) rats, a model of retinal degeneration. …”
Get full text