Elevated thiamine level is associated with activating interaction between HIF-1α and SLC19A3 in experimental myopic guinea pigs by Zhongyu Ma, Jiawen Hao, Zhaohui Yang, Miao Zhang, Ruixue Zhang, Jizhao Xin, Bo Bao, Xuewei Yin, Xuewei Yin, Hongsheng Bi, Hongsheng Bi, Hongsheng Bi, Dadong Guo, Dadong Guo, Dadong Guo, Dadong Guo

“…This study aimed to investigate the process of thiamine changes in choroidal tissue of guinea pigs with negative lens-induced myopia (LIM).MethodsThe right eyes of guinea pigs in the LIM group wore −6.0D lenses to model experimental myopia. …”
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Investigating the molecular mechanisms and clinical potential of APO+ endothelial cells associated with PANoptosis in the tumor microenvironment of hepatocellular carcinoma using s... by Zhaorui Cheng, Xiangyu Yang, Yi Ren, Huimin Wang, Qi Zhang, Sailing Lin, Wenhao Wu, Xiaolu Yang, Jiahan Zheng, Xinzhu Liu, Xin Tao, Xiaoyong Chen, Yuxin Qian, Xiushen Li

“…This study aims to investigate these mechanisms using single-cell RNA sequencing data. Methods: Single-cell RNA sequencing data from HCC patients were obtained from the GEO database. …”
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Maintenance of patient-reported health-related quality of life post neoadjuvant relugolix prior to the initiation of prostate radiation therapy by Min Jung Koh, Min Ji Koh, Jessica Y. Hsueh, Lindsey Gallagher, Malika Danner, Alan Zwart, Marilyn Ayoob, Deepak Kumar, Michael Carrasquilla, Paul Leger, Nancy A. Dawson, Simeng Suy, Sean P. Collins

“…The five-item EQ-5D-3L, a well-established tool for quantifying patient-reported health status, was administered to each patient at baseline (prior to relugolix treatment) and again 1 h before the start of SBRT. Higher EQ Visual Analog Scale (VAS) overall scores reflected better quality of life (range 0 to 100). …”
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Post-registration experience of nivolumab in advanced hepatocellular carcinoma: an international study by Dominik Bettinger, Bo Yu, David Szafron, Yinghong Wang, Mahvish Muzaffar, Thomas Marron, Uqba Khan, Yi-Hsiang Huang, David J Pinato, Ahmed Kaseb, Anwaar Saeed, Tomi Jun, Sirish Dharmapuri, Musharraf Navaid, ChiehJu Lee, Anushi Bulumulle, Sonal Paul, Petros Fessas, Neil Nimkar, Hannah Hildebrand, Tiziana Pressiani, Yehia I Abugabal, Nicola Personeni, Lorenza Rimassa, Celina Ang, Abdul Rafeh Naqash, Francesca Benevento

“…Achievement of an objective response predicted for improved OS (25.4 months vs 13.2 months, p<0.001).Conclusions This study confirms safety and efficacy of nivolumab in advanced HCC across various lines of therapy and degrees of liver dysfunction. Despite equal ORR and toxicity to nivolumab, patients with CP-B functional class have shorter survival than the patients with CP-A.…”
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Intravascular lithotripsy vs. rotational atherectomy on coronary microcirculation: a retrospective multicenter propensity-matched multicenter study by Xi Zhang, Xi Zhang, Xi Zhang, Peijian Wang, Chenguang Li, Tao Zhao, Tao Zhao, Tao Zhao, Jiaji He, Jiaji He, Jiaji He, Bin Liu, Qing Jin, Qing Jin, Qing Jin, Pin Gan, Pin Gan, Pin Gan, Jilei Zhang, Jilei Zhang, Jilei Zhang, Qiang Xue, Qiang Xue, Qiang Xue

“…These findings suggest that IVL may offer advantages in preserving coronary microvascular function across various clinical scenarios when both techniques are equally available and applicable, but further large-scale prospective studies are needed to verify these results.…”
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Association between atherogenic index of plasma and physical dysfunction: a cross-sectional study of middle-aged and older adults in China by Jianghui Zhou, Jianghui Zhou, Jianghui Zhou, Jianghui Zhou, Jianghui Zhou, Yun Chang, Yun Chang, Yun Chang, Yun Chang, Hechen Shen, Hechen Shen, Hechen Shen, Hechen Shen, Hechen Shen, Meng Zhang, Meng Zhang, Meng Zhang, Meng Zhang, Meng Zhang, Yuchao Wang, Yuchao Wang, Yuchao Wang, Yuchao Wang, Yuchao Wang, Xiaoyu Liang, Xiaoyu Liang, Xiaoyu Liang, Xiaoyu Liang, Wenqing Gao, Wenqing Gao, Wenqing Gao, Wenqing Gao, Wenqing Gao

“…The restricted cubic splines were used to examine possible non-linear associations and visualize the dose–response relationship between AIP and physical dysfunction. …”
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Predicting diabetic retinopathy stages using a simple nerve conduction measuring device, DPNCheck®: a retrospective observational study by Mayu Sakai, Mayu Sakai, Mayu Sakai, Takehiro Kato, Takehiro Kato, Takuma Ishihara, Ken Takao, Ken Takao, Tokuyuki Hirose, Tokuyuki Hirose, Sodai Kubota, Sodai Kubota, Saki Kubota-Okamoto, Saki Kubota-Okamoto, Toshinori Imaizumi, Toshinori Imaizumi, Yoshihiro Takahashi, Yoshihiro Takahashi, Masami Mizuno, Masami Mizuno, Takuo Hirota, Takuo Hirota, Yukio Horikawa, Yukio Horikawa, Hirokazu Sakaguchi, Hirokazu Sakaguchi, Shin Tsunekawa, Daisuke Yabe, Daisuke Yabe, Daisuke Yabe

“…Aims/introductionDiabetic retinopathy (DR) often remains asymptomatic until it reaches advanced stages, when delayed treatment can lead to irreversible visual impairment. To promote timely ophthalmology visits, this study investigated the utility of a simple nerve conduction device, DPNCheck®, as a predictor of DR severity. …”
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Greater neural pattern similarity to the native language is associated with better novel word learning by Yuan Feng, Yuan Feng, Yuan Feng, Yuan Feng, Aqian Li, Aqian Li, Aqian Li, Aqian Li, Jing Qu, Jing Qu, Jing Qu, Jing Qu, Huiling Li, Huiling Li, Huiling Li, Huiling Li, Xiaoyu Liu, Xiaoyu Liu, Xiaoyu Liu, Xiaoyu Liu, Jingxian Zhang, Jingxian Zhang, Jingxian Zhang, Jingxian Zhang, Jiayi Yang, Jiayi Yang, Jiayi Yang, Jiayi Yang, Leilei Mei, Leilei Mei, Leilei Mei, Leilei Mei

“…Nevertheless, it is still unclear how the utilization of the L1 neural strategies affects visual word learning in a new language.MethodsTo address this question, the present study scanned native Chinese speakers while performing implicit reading tasks before 9-day form-meaning learning in Experiment 1 and before 12-day comprehensive word learning in Experiment 2. …”
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Analysis and simulation of the workspace of a tomato harvesting manipulator by LIANG Xi-feng, WANG Yong-wci, MIAO Xiang-wen, CUI Shao-rong

“…In addition, Monte Carlo method can straightforwardly and visually describe manipulator workspace with high speed.…”
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CREATING THE KULTUK POLYGON FOR EARTHQUAKE PREDICTION: VARIATIONS OF (234U/238U) AND 87SR/86SR IN GROUNDWATER FROM ACTIVE FAULTS AT THE WESTERN SHORE OF LAKE BAIKAL by S. V. Rasskazov, E. P. Chebykin, A. M. Ilyasova, E. N. Vodneva, I. S. Chuvashova, S. A. Bornyakov, A. K. Seminsky, S. V. Snopkov, V. V. Chechel'nitsky, N. A. Gileva

“…In 1970s and 1980s, only quite laborious methods were available for measuring uranium isotopic ratios. …”
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Anti-VEGF drugs compared with laser photocoagulation for the treatment of diabetic retinopathy: a systematic review and economic analysis by Mark Simmonds, Matthew Walton, Rob Hodgson, Alexis Llewellyn, Ruth Walker, Helen Fulbright, Laura Bojke, Lesley Stewart, Sofia Dias, Thomas Rush, John Lawrenson, Tunde Peto, David Steel

“…Anti-vascular endothelial growth factor therapy may be more effective in people with poorer initial visual acuity. Anti-vascular endothelial growth factor had no impact on vision in people with non-proliferative retinopathy. …”
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A CECT-Based Radiomics Nomogram Predicts the Overall Survival of Patients with Hepatocellular Carcinoma After Surgical Resection by Peng Zhang, Yue Shi, Maoting Zhou, Qi Mao, Yunyun Tao, Lin Yang, Xiaoming Zhang

“…The optimal performance model was further visualized as a nomogram, and its predictive accuracy was evaluated via calibration curves and decision curve analysis (DCA). …”
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Risk factors for methotrexate treatment failure in tubal ectopic pregnancy: a retrospective cohort study by Linru Fu, Xinyan Liu, Zhao Tian, Zhe Du, Xinyi Wang, Xiuqi Wang, Xiaodong Li, Tao Xu, Zhijing Sun

“…A nomogram was developed to visualize the predictive factors. Results A total of 359 patients were included, with 268 (74.7%) succeeding with MTX and 91 (25.3%) required surgery. …”
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A first-in-human, prospective pilot trial of umbilical cord-derived mesenchymal stem cell eye drops therapy for patients with refractory non-Sjögren's and Sjögren's syndrome dry ey... by Di Zhang, Taige Chen, Qi Liang, Xuebing Feng, Jiaxuan Jiang, Zeying Chen, Yun Tang, Yiran Chu, Bin Wang, Kai Hu

“…Abstract Background Patients with refractory dry eye disease (DED) often face the threat of diminished visual quality and have limited responses to existing treatments. …”
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Comparison of therapeutic effects of 0.05% Cyclosporine A versus 0.1% Fluorometholone in Chinese patients with mild dry eye unresponsive to artificial tears: a randomized control s... by Huijuan Gao, Lu Zhao, Aoxue Du, Xia Zhang, Mengdi Chai, Lin Liu, Emmanuel Eric Pazo, Ruihua Wei

“…Abstract Background To assess and compare the therapeutic outcomes of 0.05% Cyclosporine A (CsA) ophthalmic solution versus 0.1% Fluorometholone (FML) eyedrops in Chinese patients with mild dry eye disease (DED) unresponsive to conventional artificial tears (AT). Methods A total of 43 patients with mild DED, who have failed to respond to conventional AT therapy for over 3 months, were randomly assigned to receive either 0.05% CsA or 0.1% FML twice daily for 6-months. …”
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Late gadolinium enhancement cardiovascular magnetic resonance with generative artificial intelligence by Omer Burak Demirel, Fahime Ghanbari, Christopher W. Hoeger, Connie W. Tsao, Adele Carty, Long H. Ngo, Patrick Pierce, Scott Johnson, Kathryn Arcand, Jordan Street, Jennifer Rodriguez, Tess E. Wallace, Kelvin Chow, Warren J. Manning, Reza Nezafat

“…The generative AI-based model improved visual image sharpness, resulting in lower blur metric compared to low-resolution counterparts (AI-enhanced from 1.5 × 3 mm2 resolution: 0.3 ± 0.03 vs 0.35 ± 0.03, P < 0.01). …”
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Predicting Imminent Conversion to Exudative Age-Related Macular Degeneration Using Multimodal Data and Ensemble Machine Learning by T.Y.Alvin Liu, MD, Yuxuan Liu, MS, Madeleine S. Gastonguay, BS, Dan Midgett, PhD, Nathanael Kuo, PhD, Yujie Zhao, Kareef Ullah, Gwyneth Alexander, Todd Hartman, Neslihan D. Koseoglu, MD, Craig Jones, PhD

“…Participants: Patients seen at the Wilmer Eye Institute between 2013 and 2021 with eAMD in ≥1 eye. Methods: Spectral domain OCT volumes prior to conversion and the corresponding clinical data (age, best-corrected visual acuity, sex, and fellow-eye status) were collected and used for model training or testing. …”
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Comparison of the effects of acupoint application combined with moxibustion in different sequences on alleviating symptoms in patients with knee osteoarthritis based on inheritance... by LI Suqian (李苏茜), TANG Ling (唐玲), E Haiyan (鄂海燕), CHEN Hong (陈宏), DENG Jianhua (邓建华), ZHOU Jie (周洁), LI Ye (李野)

“…The course of treatment was 2 weeks. The visual analogue scale (VAS) was used for knee pain measurement, and a self-made scale were used to evaluate patient satisfaction. …”
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Posterior iliac crest vs. proximal tibia: distinct sources of anti-inflammatory and regenerative cells with comparable 6-month clinical outcomes in treatment of osteoarthritis by E. Mormone, L. Savastano, G. Rossi, F. Maruccia, G. Di Maggio, N. P. Sinisi, M. Sandri, M. Copetti, E. De Santis, V. Guerra, G. Biancofiore, C. Cisternino, E. Caradonna, P. Graziano, F. L. Gorgoglione

“…Thirty patients with knee OA grade I-IV, according to Kellgren-Lawrence (KL), were distributed into each group. Visual Analog Scale (VAS) and Western Ontario & McMaster Universities Arthritis Index (WOMAC) score were used for clinical outcome evaluation. …”
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The role of adipose-derived stem cells in knee osteoarthritis treatment: insights from a triple-blind clinical study by Simin Sajadi, Mohammad Amin Khadembashiri, Gholamreza Raissi, Mohamad Mehdi Khadembashiri, Korosh Mansouri, Homayoun Hadizadeh-Kharazi, Mohammad Taghi Joghataei, Seyed Pezhman Madani, Bijan Forogh, Sina Parsipour

“…This study aims to evaluate the safety and efficacy of allogeneic ADMSC in treating knee OA. Methods This triple-blind, interventional clinical trial included 20 patients with idiopathic knee OA, meeting the American College of Rheumatology (ACR) criteria. …”
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