Genomic and Transcriptomic Profiles in Smokers and Never-Smokers Lung Squamous Cell Carcinoma Patients by Canale M, Virga A, Angeli D, Fonzi E, Gnetti L, Dubini A, Tedaldi G, Urbini M, Bocchialini G, Petracci E, Verlicchi A, Cravero P, Citarella F, Bennati C, Andrikou K, Delmonte A, Crinò L, Carbognani P, Ulivi P, Ampollini L

“…Molecular profiling of SCC in never-smokers could unveil tumor vulnerabilities and new treatment strategies.Patients and Methods: We considered a patient cohort of 17 former or current smokers (51.5%) and 16 never-smoker SCC patients (48.5%). …”
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Measuring what matters: Building impact pathways to actionable information for the weADAPT platform by S. Bharwani, K. Williamson, R. Butterfield

“…This study addresses this gap by assessing the usability and impact of the weADAPT online platform through a mixed-methods approach, combining a user survey and semi-structured interviews. …”
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Single-cell analysis reveals the loss of FABP4-positive proliferating valvular endothelial cells relates to functional mitral regurgitation by Xiaohu Wang, Mengxia Fu, Weiteng Wang, Songren Shu, Ningning Zhang, Ruojin Zhao, Xiao Chen, Xiumeng Hua, Xin Wang, Wei Feng, Xianqiang Wang, Jiangping Song

“…Key findings from the scRNA-seq analysis were validated using pathological staining to visualize key markers in the mitral valve leaflets. …”
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Clinical efficacy of Ni-Ti memory alloy four-corner arthrodesis concentrator in the treatment of scaphoid nonunion advanced collapse: a follow-up of over 10 years by Baochuang Qi, Minzheng Guo, Chen Meng, Teng Wang, Chuan Li, Yongqing Xu

“…Pain levels at the wrist joint were evaluated using the visual analog scale (VAS). Postoperative wrist bone fusion status was assessed through anteroposterior and lateral radiographs of the wrist joint. …”
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Natural orifice transluminal endoscopic surgery in urology: The Chinese experience by Xiaofeng Zou, Guoxi Zhang, Tianpeng Xie, Yuanhu Yuan, Rihai Xiao, Gengqing Wu, Xiaoning Wang, Hui Xu, Folin Liu, Yuting Wu, Yunfeng Liao, Quanliang Liu, Yinghao Sun, Bo Yang, Linhui Wang, Chuanliang Xu, Xiaofeng Gao

“…Objective: To describe the Chinese experience of natural orifice transluminal endoscopic surgery (NOTES) in urology. Methods: From December 2008 to May 2017, 35 animal experiments and 305 clinical surgeries of NOTES or natural orifices specimen extractions (NOSE) were performed in China. …”
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The Potential Benefits of a Novel Food Supplement Based on Cannabis Sativa, Boswellia, and Fish Oil for Pain and Inflammation in Physical Activity: Unraveling the Role of Orexin-A... by Antonietta Messina, Antonietta Monda, Valentina Vassallo, Girolamo Di Maio, Rita Polito, Marco La Marra, Salvatore Allocca, Maria Casillo, Fiorenzo Moscatelli, Cristina Scavone, Francesco Taturi, Vincenzo Monda, Giovanni Messina, Chiara Schiraldi, Marcellino Monda

“…Pain was assessed using the Visual Analog Scale (VAS). Metabolic parameters, inflammatory cytokines (IL-6, IL-8, TNF-α, IFN-γ, and IL-10), and serum orexin-A levels were measured before and after the intervention. …”
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Impact of postoperative depression and immune-inflammatory biomarkers on the prognosis of patients with esophageal cancer receiving minimally invasive esophagectomy: a retrospectiv... by Pei-xin Tan, Lin-xin Wu, Shuang Ma, Shi-jing Wei, Tai-hang Wang, Bing-chen Wang, Bing-bing Fu, Jia-shuo Yang, Qing Zhao, Qing Zhao, Li Sun, Yi Liu, Tao Yan

“…This study aimed to investigate the interrelationship between depression and prognosis in patients with EC, with a focus on immune-inflammatory biomarkers.MethodsThis single-center retrospective trial was conducted at the National Cancer Center/Cancer Hospital of the Chinese Academy of Medical Sciences. …”
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16 weeks of moderate intensity resistance exercise improves strength but is insufficient to alter brain structure in Gulf War Veterans with chronic musculoskeletal pain: a randomiz... by Stephanie M. Van Riper, Jacob V. Ninneman, Jacob V. Ninneman, Aaron J. Stegner, Aaron J. Stegner, Brady A. Riedner, Brady A. Riedner, Laura D. Ellingson, Ryan J. Dougherty, Patrick J. O’Connor, Gunnar A. Roberge, Gunnar A. Roberge, Andrew L. Alexander, Andrew L. Alexander, Andrew L. Alexander, Doug C. Dean, Doug C. Dean, Doug C. Dean, Jill N. Barnes, Dane B. Cook, Dane B. Cook

“…This study tested the effects of 16 weeks of resistance exercise training (RET) on gray matter (GM) volume and white matter (WM) microstructure in Gulf War Veterans (GWVs) with CMP compared to GWV waitlist controls (WLC).MethodsFifty-four GWVs were randomly assigned to 16 weeks of RET (n = 28) or WLC (n = 26). …”
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Qingda granules mitigate cardiac inflammation in spontaneously hypertensive rats via the MCP-1/CCR2 signaling pathway by Jianfeng CHU, Huai WANG, Tianyi WANG, Meizhong PENG, Xueling ZHOU, Yan LU, Shan LIN, Aling SHEN, Changgeng FU, Jun PENG

“…Objective: This study investigated effects and underlying mechanisms of Qingda granules (QDG) on cardiac inflammation in spontaneously hypertensive rats (SHRs). Methods: Twelve SHRs (17 weeks old) were randomly divided into SHR and SHR + QDG groups, with six rats in each group. …”
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Colorectal cancer risk factors: A multi-center, case-control study in Egypt by Essam A. El-Moselhy, Mohamed M. Abdel-Halim, Alshaimaa M.M. Eid Eid, Ahmed M. Ghazy, Neamat A. Abdelmageed, Amir A. Eldamaty, Sherif A. Sherif, Asmaa A. Attia, Fatma M. Kotb, Abdelhamid A. Abdelhafez, Mohamad M. Abdelnaser, Mohamed H. El Sisi, Ahmed M. Abdelnaby, Moshira A. Ibrahim, Osama O. Khalil, Mohmed Tag El-Din, Esam M. Osman, Abd-Elnaser S. Mohammed, Alyaa H. Abo-Rahma, Ahmed E. Abdrabo, Ayman M. El Guindy, Karima M-S Kholief

“…This study aimed to define characteristics and risk factors (RFs) of CRC in Egypt. Methods: A multi-center, hospital-based, case-control study was conducted. …”
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Approaches used to prevent and reduce the use of restrictive practices on adults with learning disabilities: a realist review by Joy Duxbury, Alina Haines-Delmont, John Baker, Peter Baker, Gary Bourlet, Elaine Craig, James Ridley, Rachel Whyte, Beth Morrison, Michaela Thomson, Anthony Tsang, Tella Lantta

“…In line with realist methods, eight context–mechanism–outcome configurations and an overarching programme theory were used to explain the why and how of preventing and reducing the use of restrictive practices for people with a learning disability. …”
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Distinct immunity dynamics of natural killer cells in mild and moderate COVID-19 cases during the Omicron variant phase by Yukari Nishikawa, Kosuke Yamaguchi, Ma’arif Athok Shofiudin, Momone Mimura, Miyako Takata, Shu Mihara, Takeru Kawakami, Ayumu Doi, Risa Matsuda, Hiroyuki Kato, Ryo Okamoto, Kengo Mukuda, Naoki Kinoshita, Kensaku Okada, Tsuyoshi Kitaura, Masaki Nakamoto, Hisashi Noma, Yusuke Endo, Akira Yamasaki, Hiroki Chikumi

“…This study analyzed alterations in natural killer (NK) cell-associated immunity dynamics in mild and moderate COVID-19 cases during the Omicron phase of the COVID-19 pandemic.MethodsWe conducted a retrospective observational cohort study of patients aged ≥16 with confirmed SARS-CoV-2 infection who were hospitalized at Tottori University Hospital between January 2022 and May 2022. …”
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Patient-reported outcome tools of acupuncture clinical trials in mainland China: a cross-sectional study by Feng Cao, Feng Cao, Yue Dong, Zhi-Qiang Li, Zhi-Qiang Li, Xue-Feng Wang, Xue-Feng Wang, Cheng-Yuan Su, Cheng-Yuan Su, Jia-Xuan Lv, Zhong-Yu Shi, Ming-Hong Du, Xin-Yue Zhang, Hong-Guo Rong, Hong-Guo Rong, Hong-Guo Rong, Yu-Tong Fei, Yu-Tong Fei, Yu-Tong Fei

“…Musculoskeletal symptoms (13.5%), neurological disorders (11.7%), and mental health conditions (9.6%) were the most common conditions assessed by PRO tools. The Visual Analogue Scale (VAS) was the most frequently used measurement (30%), followed by concepts related to health-related quality of life (HRQOL). …”
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Elevated septal native T1 time in cardiac magnetic resonance imaging suggesting myocardial fibrosis in young kidney transplant recipients by Tim Alexander Ubenauf, Jeannine von der Born, Rizky I. Sugianto, Carl Grabitz, Elena Lehmann, Nima Memaran, Nele Kanzelmeyer, Jan Falk, Nigar Babazade, Samir Sarikouch, Diane Miriam Renz, Bernhard Magnus Wilhelm Schmidt, Anette Melk

“…Non-contrast CMR imaging has the potential to visualize early structural cardiac changes and could become an important diagnostic adjunct in the follow-up of KTx recipients. …”
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Engineering and Evaluation of a Live-Attenuated Vaccine Candidate with Enhanced Type 1 Fimbriae Expression to Optimize Protection Against <i>Salmonella</i> Typhimurium by Patricia García, Arianna Rodríguez-Coello, Andrea García-Pose, María Del Carmen Fernández-López, Andrea Muras, Miriam Moscoso, Alejandro Beceiro, Germán Bou

“…<i>fimA</i> expression was quantified by qRT-PCR, and fimbriation visualized by transmission electron microscopy. Adhesive properties were evaluated through FimH sequence analysis, yeast agglutination, mannose-binding/inhibition assays, and HT-29 cell adherence. …”
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Fatal risk factors and the efficacy of glucocorticoid therapy in severe fever with thrombocytopenia syndrome: a multicenter retrospective cohort study by Fang Zhong, Shiyu Zhang, Chengxi Zheng, Dilihumaer Zhayier, Shuting Liu, Qinyu You, Hongming Huang, Bin Zhu, Jin Tian, Zhiliang Hu, Zhiliang Hu, Zhiliang Hu, Xin Zheng, Baoju Wang, Zhihang Peng, Zhihang Peng, Zhihang Peng

“…A nomogram was used to visualize the predictive model. ROC curves, calibration curves, and DCA curves were conducted to assess model accuracy and clinical applicability. …”
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Meta-analysis of the synergistic effect of traditional Chinese medicine compounds combined with conventional Western medicine in the treatment of osteoporosis by Huan Jin, Huan Jin, Cai Huang, Yan Zhang, Ying Dong, Qi Xiong, Di Wang, Di Wang, Ziyi He, Ziyi He, Lin Shen, Chen Ma, Zixian Wang, Lingfeng Zeng, Bo Shuai

“…This study systematically evaluated the synergistic effect of traditional Chinese medicine (TCM) compounds combined with conventional Western medicine (such as bisphosphonates and calcium) compared to Western medicine alone in the treatment of OP through a meta-analysis.MethodsBased on Preferred Reporting Items for Systematic Reviews and Meta-Analyses and the Measurement Tool for Systematic Review Assessment guidelines, databases such as PubMed and Embase were systematically searched (as of March 2025), and 13 randomized controlled trials (RCTs), involving a total of 2,403 patients, were included.ResultsThe integrated Chinese and Western medicine group showed significantly higher lumbar and femoral neck Bone mineral density (BMD) growth rates than the control group, alongside reduced pain visual analogue scale (VAS) scores. …”
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Association of white matter hyperintensity burden and infarct volume in the anterior choroidal artery territory with early neurological progression: a dual-center retrospective stu... by Weiwei Gao, Weiwei Gao, Lixue Wang, Junyi Huang, Yitao Yu, Jingjing She, Jingjing She, Jingjing She, Mingyang Wang, Lijuan Cai, Lijuan Cai, Taishan Kang, Xingyu Chen, Xingyu Chen, Jianzhong Lin, Renjing Zhu, Renjing Zhu, Renjing Zhu

“…WMH burden and infarct volume were assessed using the Fazekas visual rating scale and an automated volumetric quantification method based on lesion prediction algorithm, respectively. …”
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Impact of Teleworking on Work‐Related and Home‐Related Stress at During the First Global Lockdown–The International COVISTRESS Study by Sébastien Couarraze, Guillaume Decormeille, Louis Delamarre, Fouad Marhar, Karen Gbaglo, Raimundo Avilès Dorlhiac, Mickael Berthon, Andy Su‐I Liu, Samuel Antunes, Bruno Pereira, Julien S Baker, Morteza Charkhabi, Ukadike C Ugbolue, Reza Bagheri, José J. Gil‐Cosano, Marek Zak, The COVISTRESS Network, Maëlys Clinchamps, Frédéric Dutheil

“…Work‐related and home‐related stress levels were evaluated using an uncalibrated visual analog scale, with a range from 0 (none) to 100 (maximum). …”
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How could 20-minute neighbourhoods impact health and health inequalities? A policy scoping review by Roxana Pollack, Jonathan R Olsen, Alison Heppenstall, Andreas Hoehn, Jennifer Boyd, Vicki Ponce Hardy, Jennifer Littlejohn, Amy Stevenson, Richard Mitchell, Petra Meier, Jonathan Stokes

“…We used Sankey diagrams to visually aggregate the thematic codes for each place relating to pathways to health outcomes and social determinants (mechanisms). …”
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