Evaluation of multidrug-resistant bacteria and their molecular mechanisms found in small animal veterinary practices in Portugal by Joana Moreira da Silva, Joana Moreira da Silva, Juliana Menezes, Juliana Menezes, Juliana Menezes, Laura Fernandes, Laura Fernandes, Cátia Marques, Cátia Marques, Cátia Marques, Sofia Santos Costa, Dorina Timofte, Andreia J. Amaral, Andreia J. Amaral, Andreia J. Amaral, Constança Pomba, Constança Pomba, Constança Pomba

“…The goal of our work was to evaluate the environmental contamination and staff carriage by MDROs in veterinary practices across Portugal.MethodsFourteen SAVPs were enrolled. Environmental samples were collected from critical areas such as operating room, wards and pre-operative area. …”
Get full text

Prospective study of continuous rhythm monitoring in patients with early post-infarction systolic dysfunction: clinical impact of arrhythmias detected by an implantable cardiac mon... by Jesus Hernandez-Hernandez, Ana Martin-Garcia, Javier Jimenez-Candil, Pedro L Sanchez, Carlos González-Juanatey, Javier García-Fernández, Alba Cruz-Galban, Olga Duran-Bobin, Javier Garcia-Seara, Teba Gonzalez-Ferrero, Jose Morinigo, Manuel Sanchez-Garcia, Gonzalo Fernandez-Palacios, Jose Seijas-Amigo, Juliana Elices, Javier Portales-Fernandez, Francisco Martin-Herrero, Ana García-Campos, Jose A Perez-Rivera, Marta Alonso-Fernandez-Gatta, Alfonso Macías, Paloma Perez-Espejo

“…Among patients with post-infarction left ventricular dysfunction, modern implantable cardiac monitoring devices (ICM) allow a unique opportunity to determine in real-time the burden of non-sustained ventricular tachycardias and their relationship to the subsequent occurrence of sustained or symptomatic events.Methods and analysis Approximately 200 patients with left ventricular ejection fraction (LVEF) equal to or less than 40% after acute myocardial infarction will be included in the study. …”
Get full text

Maltreatment and parenting in youth with primary and secondary callous‐unemotional traits: Anxiety matters by Jessica J. Todorov, Gregor Kohls, Ruth Pauli, Jack Rogers, Anka Bernhard, Katharina Ackermann, Nora M. Raschle, Jules R. Dugre, Aranzazu Fernandez‐Rivas, Miguel Angel Gonzalez‐Torres, Amaia Hervas, Areti Smaragdi, Karen Gonzalez, Ágnes Vetró, Dimitris Dikeos, Arne Popma, Christina Stadler, Kerstin Konrad, Christine M. Freitag, Graeme Fairchild, Rory T. Devine, Stephane A. De Brito

“…Youth with primary and secondary CU traits were equally high on levels of abuse, neglect, and maladaptive parenting (all p values >0.05). …”
Get full text

Impact of multidimensional assessment on anti-fracture treatment decisions in patients with fragility hip fractures within a Fracture Liaison Service by Chiara Ceolin, Stefania Sella, Cristina Simonato, Ester Bukli, Giulia Bano, Valentina Camozzi, Anna Bertocco, Marco Onofrio Torres, Alberta Cecchinato, Martin Diogo, Mor Peleg Falb, Francesca Guidolin, Maria Grazia Rodà, Michele Cannito, Antonio Berizzi, Andrea Venturin, Vito Cianci, Elisa Pala, Mariachiara Cerchiaro, Deris Gianni Boemo, Maria Vittoria Nesoti, Gaetano Paride Arcidiacono, Paolo Simioni, Pietro Ruggieri, Giuseppe Sergi, Sandro Giannini, Marina De Rui, on behalf of the Hip-POS working group

“…While FLS models effectively reduce refracture risk and maintain cost-effectiveness, it is unclear if these benefits apply equally to all patients, especially those with higher comorbidities and reduced functional capacity, who may face worse prognoses. …”
Get full text

A Multicenter Randomized Double-Blind Vehicle-Controlled Parallel Group Phase 2 Study Evaluating the Efficacy and Safety of GN-037 Cream in Patients with Mild-to-Moderate Plaque Ps... by Burhan Engin, Müge Güler Özden, Özge Sevil Karstarlı Bakay, Selda Pelin Kartal, İlkin Zindancı, Salih Levent Çınar, Recep Dursun, Gizem Pehlivan Ulutaş, Tuğba Özkök Özkök Akbulut, Fatma Aslı Hapa, Emel Bülbül Başkan, Mehmet Melikoğlu, Algün Polat Ekinci, Neslihan Demirel Öğüt, Pelin Hızlı, Zafer Türkoğlu, Özlem Su Küçük, Zeynep Topkarcı, Ümit Türsen, Filiz Canpolat, Hanife Uçgun, Şirin Yaşar, Selami Aykut Temiz, Asena Çiğdem Doğramacı, Sedat Altuğ, Serhat Kozlu, Nadir Ulu, Server Serdaroğlu

“…The primary endpoint was treatment success defined as percentage of patients with at least two-grade improvement in Investigator’s Global Assessment Score (IGA) and IGA score equal to 0 or 1 evaluated at weeks 2, 4, 6, and 8 in each arm compared with baseline. …”
Get full text

Optimizing treatment for depression in primary care using psychotherapy versus antidepressant medication in a low-resource setting: protocol for the OptimizeD randomized controlled... by Julia R. Pozuelo, Anuja Lahiri, Rahul S. P. Singh, Arvind Kushwah, Mimansa Khanduri, Akanksha Shukla, Azaz Khan, Sruthi G., Varun Shende, Yashika Parashar, Yashwant K. Mehra, Anant Bhan, Ronald C. Kessler, Daisy R. Singla, John A. Naslund, Karmel W. Choi, Pim Cuijpers, Robert DeRubeis, Mohammad M. Herzallah, Chunling Lu, Jordan W. Smoller, Tyler J. VanderWeele, Abhijit R. Rozatkar, Tamonud Modak, Michelle Melwyn Joel, Debasis Biswas, Shubham Atal, Umay Kulsum, Steven D. Hollon, Vikram Patel

“…The Optimizing Depression (OptimizeD) trial aims to explore whether different patients respond differently to behavioral activation therapy versus antidepressant medication and if providing each patient with their optimal treatment improves outcomes in primary care. Methods We plan to randomize 1,500 patients with moderate to severe depression (defined as a Patient Health Questionnaire [PHQ-9] score ≥ 10) from primary healthcare settings in Bhopal, India, with equal allocation either to a culturally adapted behavioral activation therapy delivered by trained counselors (Healthy Activity Program) or to antidepressant medication (fluoxetine). …”
Get full text

Improving Muscle Function Through a Multimodal Behavioural Intervention for Knee Osteoarthritis and Obesity: The POMELO Trial by Kristine Godziuk, Mary Forhan, Flavio T. Vieira, Joao F. Mota, Jason Werle, John A. Batsis, Lorenzo M. Donini, Mario Siervo, Carla M. Prado

“…We investigated the feasibility and efficacy of a multimodal behavioural intervention compared to usual care to enhance physical function and muscle mass in this population. Methods The POMELO (Prevention Of MusclE Loss in Osteoarthritis) study is a two‐arm pilot randomized controlled trial; NCT05026385. …”
Get full text

Comparison of the efficacy and safety of various anti-inflammatory drugs in urate-lowering therapy initiation in patients with gout (preliminary data) by M. N. Chikina, M. S. Eliseev, O. V. Zhelyabina

“…Non-steroidal anti-inflammatory drugs (NSAIDs), colchicine and glucocorticoids (GC) are used to prevent arthritis attacks in gout, but data on their comparative effectiveness is lacking.Objective: to compare the efficacy and safety of various anti-inflammatory drugs at the start of treatment in patients with gout.Patients and methods. Of the 108 patients with gout, observed in the V.A. …”
Get full text

User-Driven Development of a Digital Behavioral Intervention for Chronic Pain: Multimethod Multiphase Study by Afra Selma Taygar, Sara Laureen Bartels, Rocío de la Vega, Ida Flink, Linnéa Engman, Suzanne Petersson, Sophie I Johnsson, Katja Boersma, Lance M McCracken, Rikard K Wicksell

“…ObjectiveThis study aimed to clarify how a digital behavioral intervention for people with chronic pain can be developed through a user-centered approach to address the needs and preferences of the target population. MethodsThis study used a multimethod approach involving end users, namely, patients with chronic pain and therapists, to develop prototypes for a digital behavioral intervention across 3 phases. …”
Get full text

Soluble IL-2 Receptor in Dermatomyositis: Its Associations with Skin Ulcers and Disease Activity by Linrong He, Xiaoming Shu, Xia Liu, Yongpeng Ge, Sizhao Li, Xin Lu, Guochun Wang

“…Disease activity was evaluated by using physician global disease activity and myositis disease activity assessment visual analog scale (MYOACT) on admission. 20 DM patients were followed. …”
Get full text

The first experience of using upadacitinib in the treatment of rheumatoid arthritis in real clinical practice (results of the multicenter project “RACURS”) by V. N. Amirjanova, A. E. Karateev, E. Y. Pogozheva, A. A. Baranov, V. I. Mazurov, R. R. Samigullina, O. N. Anoshenkova, N. A. Lapkina, T. Yu. Grineva, E. L. Nasonov, A. M. Lila

“…During the first week of taking the drug, there was a marked decrease in pain from 60 to 30 mm on a visual analogue scale, which lasted until the third month of therapy. …”
Get full text

Differential correlations of refractive error, axial length, and axial length-to-corneal curvature ratio with anterior segment biometrics in myopic refractive surgery candidates by Jian Zhang, Youlin Zhu, Ping Yuan, Xiaojuan Dong, Manyun Xie, Zongrui Ma, Rong Tian

Get full text

Age-related features of calcium pyrophosphate deposition disease by M. S. Eliseev, O. V. Zhelyabina, M. N. Chikina

“…The age-related features of the disease have not been studied.Objective: to study age-related features of CPPD.Subjects and methods. A total of 113 patients (54 men and 59 women) who had received inpatient or outpatient treatment at the V.A. …”
Get full text

Comparison of the effects of IMRT and IMPT on MRI features of normal brain tissue: a retrospective study by Jian Xu, Lili Zhang, Tingting Liu, Qingzeng Liu, Jian Zhu

“…Finally, box plots and the Mapping of Dose Distribution and Differences in Radiomics Feature Variation were utilized to visually illustrate the extent of brain tissue changes in each dose region following radiotherapy. …”
Get full text

The i‐gel® supraglottic airway device compared to endotracheal intubation as the initial prehospital advanced airway device: A natural experiment during the COVID‐19 pandemic by Daniel B. Levi, Joris Hoogendoorn, Shenae Samuels, Lindsay Maguire, Ruben Troncoso, Scott Gunn, Matthew Katz, Christine VanDillen, Susan A. Miller, Jay L. Falk, Steven H. Katz, Linda Papa

“…The objective was to compare first‐pass success and timing to successful airway placement between ETI and the i‐gel® SGA under extenuating circumstances. Methods This pre/post study compared airway placement metrics in prehospital patients requiring advance airway management for non‐trauma‐related conditions. …”
Get full text

Triple positivity for autoantibodies in patients with rheumatoid arthritis is associated with a severe course of the disease but not with bone turnover markers by Tomasz Budlewski, Joanna Sarnik, Olga Brzezinska, Anna Lewandowska-Polak, Tomasz Poplawski, Joanna Samanta Makowska

“…This study aimed to evaluate the correlation between autoantibody profiles, disease activity, bone turnover markers, and selected SNPs in a cohort of Polish RA patients. Material and methods A total of 138 RA patients from the Department of Rheumatology, Medical University of Lodz, were enrolled. …”
Get full text

Evaluating the Efficacy and Safety of 48-Week Low-Dose Dienogest Administration in Patients With Dysmenorrhea Caused by Endometriosis: Protocol for a Randomized, Open-Label, Parall... by Kyoko Kikuno, Ryuta Asada, Takuma Ishihara, Yoshimasa Bomoto, Saki Murase, Yoko Ueda, Tomomi Shiga, Yoh Hayasaki, Tatsuro Furui, Satoko Matsuzaki, Masahiko Takemura, Kazutoshi Matsunami, Makoto Kubo, Naoki Ito, Masanori Isobe, Ken-ichirou Morishige

“…The primary endpoint is the change in the pain visual analog scale (VAS) score from baseline to 48 weeks. …”
Get full text

Patient-specific computational flow simulation reveals significant differences in paravisceral aortic hemodynamics between fenestrated and branched endovascular aneurysm repair by Kenneth Tran, MD, Celine Deslarzes-Dubuis, MD, Sebastien DeGlise, MD, Adrien Kaladji, MD, Weiguang Yang, PhD, Alison L. Marsden, PhD, Jason T. Lee, MD

“…CFS is a novel tool for quantifying and visualizing the unique patient-specific hemodynamic effect of different complex EVAR strategies. …”
Get full text

In vitro Study of Fungus-Like Organisms Peronospora ficariae and Wilsoniana bliti as Potential Inhalant Allergens by Sztandera-Tymoczek M, Wdowiak-Wróbel S, Świderska U, Palusińska-Szysz M, Szuster-Ciesielska A

“…They negatively impact crop production, reduce the quality of agricultural goods, and lessen the visual appeal of decorative plants. Additionally, these fungi can pose a health hazard to humans, as they are significant sources of allergens. …”
Get full text

Expression characteristics of miR-502-5p/p53/NF-κB signaling pathway in patients with different degrees of knee osteoarthritis: a cross-sectional observational study with methodolo... by Xiaozhe Zhang, Kesong Shi, Anmin Ruan, Pu Chen, Tao Zhang, Qingpu Wang

“…Clinical assessments included Visual Analog Scale (VAS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores. …”
Get full text