Acute Lateral Ankle Sprain Impairs Function and Strength Without Altering Muscle or Tendon Stiffness: A Controlled Observational Study by Pedro Bainy Franz, José Roberto deSouza Júnior, Hortência Cordeiro deLima, Estevão deSouza Diniz, Rogério deBrito Aguiar, Jeam Marcel Geremia, Henrique Mansur, Rita deCássia Marqueti, João Luiz Quagliotti Durigan

“…Ankle function, pain, and edema were evaluated using the Foot and Ankle Outcome Score, Visual Analog Scale, and figure‐of‐eight method. Plantar flexion strength was measured via isometric dynamometry. …”
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Rapid and sensitive detection of Mycobacterium tuberculosis using the RPA/Cas12f1_ge4.1 system with fluorescence and lateral flow readouts by Zhongliang Deng, Xingyong Weng, Honghua Tang, Tintao Zou, Xuan Zhou, Hangxi Liu, Piaoting Wen, Gemiao Luo, Tian Gan, Jun He

“…ABSTRACT Tuberculosis remains a major global health threat, with existing detection methods often limited by efficiency and resource demands. …”
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Integrating clinical trial landscapes and bibliometric analysis: unveiling the impact of PD-1/PD-L1 inhibitors on renal cell carcinoma research and therapeutic trajectories summary by Yuanbin Huang, Yuanbin Huang, Xinmiao Ma, Hengxing Zhu, Chen Shen, Ke Hu, Yang Yu, Aoyu Yang, Zhuo Liu, Chuanyang Liu, Wenrui Shi, Wei Wang, Xueyan Xia, Jiawen Wang, Xiancheng Li

“…Thus, we aim to assess the global scientific outcomes of studies focusing on PD-1/PD-L1 in RCC from 2005 to 2024 and to identify emerging research trends.MethodsData were collected from the Web of Science Core Collection using a predefined search strategy. …”
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Insights into De Quervain’s Tenosynovitis as an Unintended Consequence of Problematic Smartphone Usage: A Cross-sectional Observational Study by Aswin Sugumaran, Dilip Kumar Naidu, Madhan Raju, Sabari Vaasan Lakshmikanthan, S Karthikeyan, Kevin Dhas, Vamsi Krishna, Praveen Raja

“…Aim: To investigate the association between problematic smartphone usage and the development of DQT and to assess its physical impact using the Visual Analogue Scale (VAS), Patient-rated Wrist/Hand Evaluation (PRWE) and quick Disabilities of the Arm, Shoulder and Hand (DASH) scores. …”
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The Incorporation of CBD into Biodegradable DL-Lactide/Glycolide Copolymers Creates a Persistent Antibacterial Environment: An In Vitro Study on <i>Streptococcus mutans</i> and <i>... by Ronit Vogt Sionov, Ahmad Siag, Emma Theresa Mersini, Natalya M. Kogan, Tatiana Alkhazov, Igor Koman, Praveen Rowlo, Vitaly Gutkin, Menachem Gross, Doron Steinberg

“…Biofilm formation on the polymer scaffolds was visualized by HR-SEM. Its anti-inflammatory effect was determined by measuring the IL-6 release from LPS-stimulated RAW 264.7 macrophages by ELISA. …”
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Pseudomonas oryzihabitans D1-104/3 and P. gessardii C31-106/3 differentially modulate the antioxidative response of duckweed (Lemna minor L.) to salt stress by Tatjana Popržen, Dragana Antonić Reljin, Branka Uzelac, Marija Milovančević, Danijela Paunović, Milana Trifunović-Momčilov, Marija Marković, Martin Raspor, Ivan Nikolić, Slaviša Stanković, Olga Radulović

“…Fluorescence microscopy was used to visualize bacterial presence on duckweeds.ResultsFluorescence microscope revealed that Pseudomonas bacteria colonized all duckweed surfaces. …”
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The value of home-centered dressing change model in wound healing after low simple anal fistulectomy—a cross-sectional study by Zhang Linhan, Jia Shize, Wei Kaikai, Wan Xingyang, Ren Donglin, Lin Hongcheng, Liu Zhimin

“…The home dressing change group had lower costs related to dressing changes and follow-up and lower visual analogue scale pain scores, with statistically significant differences (P<0.05). …”
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HORNBILL: A First-in-Human Phase I/IIa Study of the Safety, Tolerability, and Early Pharmacodynamics of BI 764524 for Diabetic Macular Ischemia by Quan Dong Nguyen, MD, MSc, Chirag Jhaveri, MD, Maged Habib, MD, Yasir J. Sepah, MBBS, Khaled Nassar, MD, PhD, Bartlomiej Krawczyk, PhD, Gudrun Simons, PhD, Andrea Giani, MD, Elizabeth Pearce, PhD, Martin Gliem, MD, Mohamed Ahmed, MBBCh, MD, Sobha Sivaprasad, DM

“…The primary MD end point was the number of participants with drug-related AEs; secondary end points included changes from baseline in foveal avascular zone (FAZ) area, best-corrected visual acuity (BCVA), and central subfield thickness (CST). …”
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Gegen Qinlian Decoction Attenuates Colitis-Associated Colorectal Cancer via Suppressing TLR4 Signaling Pathway Based on Network Pharmacology and In Vivo/In Vitro Experimental Valid... by Yaoyao Xu, Qiaoyan Cai, Chunyu Zhao, Weixiang Zhang, Xinting Xu, Haowei Lin, Yuxing Lin, Daxin Chen, Shan Lin, Peizhi Jia, Meiling Wang, Ling Zhang, Wei Lin

“…But the precise mechanisms underlying its anti-inflammatory and anti-tumor effects are not fully elucidated. <b>Methods</b>: Use network pharmacology to identify targets and pathways of GQD. …”
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Good Arts, Good Mental Health®: the effectiveness of an Australian health promotion media campaign in promoting community mental wellbeing via the arts by Christina R. Davies, Melanie T. Pescud, Rhonda Clifford, Richard McGrath, Annie Thomson, Mia Jeffrey, Melissa Stoneham, Terri Pikora, Peter Wright, Sonya Girdler, Sonya Girdler, Loretta Baldassar, Stephen Clift

“…The campaign was distributed through a variety of platforms, channels, visual, audio, and static assets. To gauge the success of the campaign, a process evaluation and (short-term) outcome evaluation were conducted by sourcing online analytics and conducting an online survey of the campaign target group (n = 661).ResultsOverall, campaign reach and frequency were optimal and met set targets. …”
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A novel nomogram for predicting osteoporosis with low back pain among the patients in Wenshan Zhuang and Miao Autonomous Prefecture of China by Man Jia, Man Jia, Qinzuo Dong, Zeqin Ren, Liwei Xing, Jinjie Li, Xiaomei Wang, Shun Yu, Xiaoyan Wang, Rong Zhao, Rong Zhao

“…However, there are currently no convenient tools available to identify patients with low back pain caused by osteoporosis.MethodsWe consecutively enrolled 769 patients diagnosed with low back pain in our hospital from January 2019 to March 2024. …”
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The clinical course and outcomes following arthroscopic frozen shoulder 360° release by Brandon Ziegenfuss, BSc(Hons), MPH, Kristine Italia, MD, FPOA, Kathir Azhagan Stalin, MBBS, Sarah Whitehouse, PhD, Ashish Gupta, MBBS, MSc, FRACS, FAOrthA, Kenneth Cutbush, MBBS, FRACS, FAOrthA

“…The aim of this study is to evaluate the clinical outcomes following the FS 360° arthroscopic release. Methods: An observational prospective cohort study was conducted assessing patient-reported outcome measures (PROMs) in patients who underwent the 360° arthroscopic release between July 2013 and January 2019. …”
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L-shaped association between oxidative balance score and vision-related functional burden in adults in the United States, NHANES 2005–2008 by Juntong Li, Juntong Li, Sheng Ye, Xiang Li, Xiang Li, Hui Liu, Yue Yang, Xuelei Lu, Heyue Jin, Li Liu, Li Liu

“…ObjectiveThis study aims to investigate the relationship between oxidative balance score (OBS) and vision-related functional burden (VRFB) in US adults.MethodsThe study utilized data from two consecutive cycles of the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2008. …”
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PSMA response evaluation in follow-up PSMA-PET/CT after stereotactic ablative body radiotherapy (SABR) for oligometastases in prostate cancer by Anna-Lena Zang, Timo Maier, Sandra Freitag-Wolf, Alexander Fabian, Severin Rodler, Jürgen Dunst, David Krug, Ulf Lützen, Olaf Wittenstein

“…PSMA response was evaluated by visual and quantitative assessment of local PSMA uptake pre- and post-SABR. …”
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Unveiling biomarkers via plasma metabolome profiling for diabetic macrovascular and microvascular complications by Zhixi Li, Yuhan Ren, Feng Jiang, Kai Zhang, Xuan Meng, Yingfeng Zheng, Mingguang He

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Effectiveness of mucoactives (carbocisteine and hypertonic saline) in addition to usual airway clearance management with usual airway clearance management alone in acute respirator... by Mike Clarke, Marc Chikhani, Cliona McDowell, Ranjit Lall, Michael McKelvey, Margaret McFarland, Brenda O'Neill, Cecilia O'Kane, Murali Shyamsundar, Gavin Perkins, Clifford C Taggart, Gordon Sturmey, Barry Williams, John Warburton, Paul Dark, Bronwen Connolly, Ashley Agus, Naomi Dickson, Mark Borthwick, Bronagh Blackwood, Daniel F McAuley, Christina Campbell, Judy Bradley

“…Participants will be equally allocated across four trial arms. All participants will receive usual airway clearance management. …”
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HPV genotyping agreement between paired cervical cytological sample and biopsy across lesion severity and vaccination by Shimin Chen, Qiaoyun Du, Jian Yin, Xiaoqian Xu, Wen Chen, Qinjing Pan, Xun Zhang, Ying Hong, Wenhua Zhang, Bin Liu, Jianfeng Cui, Shangying Hu, Fanghui Zhao

“…Conclusions In conclusion, HPV genotyping by cytological samples and FFPE biopsies performed equally well regardless of lesion severity and vaccination status, directly supporting reliable utility of cytological HPV genotyping for clinical decisions. …”
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From rural practice to scientific evidence: synergistic antiplasmodial and antioxidant properties of combined Ageratum conyzoides and Bidens pilosa extracts by Patrick Valere Tsouh Fokou, Courthney Akwi Mboh, Kenneth Lifoter Navti, Marius Jaurès Tsakem Nangap, Raoul Kemzeu, Canis Parfait Donbou Djiotie, Aubin Youbi Kamche, Hubert Nana Djigang, Arnold Tegen Tah, Mariscal Brice Tchatat Tali, Lauve Rachel Tchokouaha Yamthe, Vincent Ngouana, Fabrice Fekam Boyom

“…Aim: This study evaluates the in vitro and in vivo antiplasmodial, hemolytic, and antioxidant activities of a combined extract of Ageratum conyzoides (A. conyzoides) and Bidens pilosa (B. pilosa), a traditionally used but scientifically unvalidated combination. Methods: Plant leaves were extracted via aqueous decoction and cold maceration, combining equal parts to mimic traditional preparation. …”
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Searching for Axion Dark Matter Gegenschein of the Vela Supernova Remnant with FAST by Wenxiu Yang, Yitian Sun, Yougang Wang, Katelin Schutz, Yichao Li, Calvin Leung, Wenkai Hu, Shuanghao Shu, Kiyoshi Masui, Xuelei Chen

“…If we are embedded in a Milky Way dark matter halo comprised of axions, their stimulated decay would enable us to observe a counterimage (“axion gegenschein”) with a frequency equal to half the axion mass in the opposite direction of a bright radio source. …”
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Efficacy of Kegan Liyan oral liquid vs. Lianhuaqingwen capsules for patients with mild COVID-19: a double-blinded, randomized, controlled, non-inferiority trial by Yuewei Li, Yihe Chi, Mengting Zhu, Feiting Fan, Zhongyang Deng, Jingmin Xiao, Shaohan Jin, Luoqi Lin, Xiaochun Chen, Ruhong Xu, Long Fan, Xuhua Yu, Ziyao Liang, Jingyu Quan, Shangzhao Li, Xinying Peng, Yuanbin Chen, Yuanbin Chen, Yuanbin Chen, Lin Lin, Lin Lin, Lin Lin, Lei Wu, Lei Wu, Lei Wu

“…This trial aims to assess whether KGLY is non-inferior to LHQW in treating mild COVID-19.MethodsA total of 127 participants (63 in KGLY group and 64 in LHQW group) were randomly allocated to receive either KGLY therapy or LHQW therapy in a 1:1 ratio. …”
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