Combined TACE with Targeted and Immunotherapy versus TACE Alone Improves DFS in HCC with MVI: A Multicenter Propensity Score Matching Study by Chen X, Wu X, Peng W, Liu L, Liu X, Wan X, Xu H, Zheng Y, Zhao H, Mao Y, Lu X, Sang X, Chang X, Zhou K, Pan J, Guan M, Hu D, Tan H, Zhang Y, Du S

“…This study evaluates the efficacy of different adjuvant treatments on disease-free survival (DFS) and overall survival (OS) in HCC patients with MVI following curative resection.Methods: A retrospective cohort of 409 HCC patients with MVI who underwent curative resection from three clinical centers between 2017 and 2024 was analyzed. …”
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Efficacy and safety of intensive triglyceride-lowering therapy on reducing recurrence of hypertriglyceridemia-associated pancreatitis (REDUCE): protocol for a multicentre, randomis... by Tao Chen, Weiqin Li, Chunping Zhu, Na Liu, Xin Xu, Lihui Deng, Dong Wu, Yao Wu, Jianhua Wan, Xin Huang, Lu Ke, Wenhua He, Hongwei Zhang, Duan Wang, Nong-Hua Lu, Yin Zhu, Ling Ding, Jianing Li, Jianwen Sheng, Nonghua Lu, Huifang Xiong, Liang Xia, Gaifang Liu, Jinyi Sheng, Lingyu Luo, Yupeng Lei, Huajing Ke, Lanting Wang, Shihang Zhang, Zhihua Tang, Youshun Liu, Guan Gui, Yingjie Chen, Yinyu Pan

“…The efficacy and safety of intensive TG-lowering therapy on reducing recurrence of HTG-AP trial aims to determine whether intensive TG-lowering therapy (with a TG goal of <150 mg/dL (equal to 1.7 mmol/L)), compared with usual care (with a TG goal of <500 mg/dL (equal to 5.65 mmol/L)), can reduce recurrence in patients after a first episode of HTG-AP.Methods and analysis This is an investigator-initiated, multicentre, open-label, parallel, superiority, randomised, controlled trial. …”
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Expansion-assisted selective plane illumination microscopy for nanoscale imaging of centimeter-scale tissues by Adam Glaser, Jayaram Chandrashekar, Sonya Vasquez, Cameron Arshadi, Rajvi Javeri, Naveen Ouellette, Xiaoyun Jiang, Judith Baka, Gabor Kovacs, Micah Woodard, Shamishtaa Seshamani, Kevin Cao, Nathan Clack, Andrew Recknagel, Anna Grim, Pooja Balaram, Emily Turschak, Marcus Hooper, Alan Liddell, John Rohde, Ayana Hellevik, Kevin Takasaki, Lindsey Erion Barner, Molly Logsdon, Chris Chronopoulos, Saskia EJ de Vries, Jonathan T Ting, Steven Perlmutter, Brian E Kalmbach, Nikolai Dembrow, Bosiljka Tasic, R Clay Reid, David Feng, Karel Svoboda

“…We illustrate ExA-SPIM by reconstructing individual neurons across the mouse brain, imaging cortico-spinal neurons in the macaque motor cortex, and visualizing axons in human white matter.…”
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A Novel Retinal Nerve Fiber Layer Biomarker of Amyotrophic Lateral Sclerosis (ALS) Identified Using Longitudinal in vivo Ocular Imaging by Khorrami F, Gupta N, Zhou X, Liang Y, Yucel YH

“…We aim to assess the presence of inner retinal pathology in a mouse model of ALS and its possible progression with age.Methods: Transgenic SOD1G93A mice (n=8, 4M/4F) and age-matched controls (n=8, 4M/4F) underwent in vivo retinal imaging with confocal scanning laser ophthalmoscopy (cSLO) coupled with optical coherence tomography (OCT) at 20 weeks of age. …”
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Photorefractive keratectomy for correction of myopia: Our one-year experience by Resan Mirko, Vukosavljević Miroslav, Milivojević Milorad

“…Methods. A prospective study with a follow-up period of 6 months included 55 patients of which 100 myopic eyes were treated by PRK method (one eye was included in 10 patients). …”
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Intravitreal panitumumab and retinal pigment epithelium proliferation in laser-induced retinal degeneration in rabbits by Mukharram M. Bikbov, Gyulli M. Kazakbaeva, Songhomitra Panda-Jonas, Songhomitra Panda-Jonas, Songhomitra Panda-Jonas, Iskander D. Valishin, Aigul M. Nizamutdinova, Jost B. Jonas, Jost B. Jonas, Jost B. Jonas, Jost B. Jonas, Jost B. Jonas, Jost B. Jonas, Jost B. Jonas

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SCENIC SOURCES OF SEMANTICS OF LITERARY TELEVISION THEATER OF THE 1960-1980TH / Сценические истоки семантики литературного телетеатра 1960–1980-х годов... by ROSTOVA N.V. / РОСТОВА Н.В.

“…An absolutely new scenic form of a narration was offered in it, where the usual theatrical conventions were violated, the purposes, obligatory for comprehension of theatricality and literary frame were overcome, and the prerequisites created for future television theater with the similar division of the script into unequal episodes became a specific feature of telework were created. The esthetic methods of transposing of a literary work on stage opened by Nemirovich-Danchenko: lack of external action, movement in its pre-Chekhov understanding; unlimited time of performing of classical prose; non-obligation of splitting the action on acts, identical on time; acceptability of long monologues; inclusion the reader into the action; combination of action fragments with verbal descriptions; visual manifestation of a narration structure in a hint, a detail, plasticity, i.e. really conditional receptions, appeared to be absolutely natural to the television theater and became the basis for detection of its specifics. …”
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A comparative analysis of unilateral biportal endoscopic and open laminectomy in multilevel lumbar stenosis by Jian-yuan Ouyang, Qi-Yuan Yang, Lan-lan Chen, Qin Li, Yu-hao Zheng, Xiao Luo, Bing Tan

“…At the 1-year follow-up, the imaging findings, visual analogue scale (VAS), Oswestry disability index (ODI), and Zurich Claudication Questionnaire (ZCQ) were assessed. …”
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Bioinformatics-based screening and validation of PANoptosis-related biomarkers in periodontitis by Qing Sun, Qing Sun, JinYue Hu, JinYue Hu, RuYue Wang, RuYue Wang, ShuiXiang Guo, ShuiXiang Guo, GeGe Zhang, GeGe Zhang, Ao Lu, Ao Lu, Xue Yang, Xue Yang, LiNa Wang, LiNa Wang

“…Protein-protein interaction (PPI) networks of these PRGs were constructed using the STRING database and visualized with Cytoscape. Subnetworks were identified using the MCODE plugin. …”
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Association of blood cadmium levels with all-cause and cause-specific mortality among adults with non-alcoholic fatty liver disease: a prospective cohort study by Congxi Xu, Congxi Xu, Zhi Li, Shirui Hao, Jian Zhang, Jinlong Li, Kuopeng Liang, Xiaojuan Wang, Yi Zhang, Yi Zhang, Guangyuan Zhao, Mengyun Bai, Dengxiang Liu, Jitao Wang

“…This study aimed to evaluate the predictive value of blood cadmium levels for mortality risk in patients with NAFLD.MethodsThis study analyzed data from 13,450 patients with NAFLD in the National Health and Nutrition Examination Survey (NHANES) database, covering the years 1999 to 2018. …”
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A rapid and portable dual-mode RAA-CRISPR/Cas12a system for one-pot detection of spring viraemia of carp virus (SVCV) by Tian Hu, Zewei Hou, Yichen Zhao, Ye Zhang, Yufeng Si, Liqun Lu, Hao Wang

“…The fluorescence-based method exploits trans-cleavage activity of Cas12a to generate detectable fluorescent signals, while the LFD assay employs a FAM-biotin dual-labeled ssDNA probe for visual detection via colloidal gold accumulation on lateral flow strips. …”
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A pilot study of intraoperative melphalan to prevent recurrent PVR: the IOMPVR study by Carlos A. Moreira-Neto, Jose S Pulido, Luca Bongiovanni de Miranda Gonçalves, Gabriel Nunes Cavalcanti, Acacio Souza Lima, José de Paula Barbosa Neto, Daniel Lavinsky, Talita Virginia Fernandes de Oliveira, Fernando Ejii Ogata, Lucas Zago Ribeiro, Luiz Fernando Teixeira, Flavia Borelli Gomes do Nascimento, Luiz H. Lima, Octaviano Jr. Magalhães, Michel Eid Farah, Maurício Maia

“…The logarithm of the minimum angle of resolution best-corrected visual acuity improved from the mean ± standard deviation preoperatively of 2.11 ± 0.22 to 0.89 ± 0.37 at 30 and to 0.84 ± 0.42 at 90 days postoperative (P < 0.001). …”
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Quantitative insights into stroke recovery utilizing delayed vessel ratio from color-coded multiphase computed tomography angiography by Yu Lin, Yu Lin, Yu Lin, Xiaoxiao Zhang, Zhen Xing, Xiefeng Yang, Qingwen Tong, Shaomao Lv, Jinan Wang, Jinan Wang, Dairong Cao, Dairong Cao, Dairong Cao, Dairong Cao

“…Background and objectiveThe color-coded multiphase computed tomography angiography (cmCTA) is an accredited technique that employs color-coding to visually depict the temporal dynamics of collateral blood flow in patients with acute ischemic stroke (AIS). …”
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Interactive effects of atmospheric oxidative pollutants and heat on circulatory disease mortality by Wenli Wang, Wenli Wang, Yang Chen, Ruoyu Li, Ruoyu Li, Linsheng Yang, Yu Jiang, Yu Jiang, Jianjun Xiang, Jianjun Xiang, Jing Wu, Jing Wu, Jing Li, Jing Li, Baoying Liu, Baoying Liu, Huaying Lin, Chuancheng Wu, Chuancheng Wu

“…A bivariate three-dimensional model was used to visualize their synergistic effects, and stratified analyses were conducted to compare differences between heat wave and non-heat wave periods.ResultsO3, Ox, and NO2 exhibit synergistic effects with ambient temperature, and their combined exposure significantly increases the mortality risk of circulatory system diseases, myocardial infarction, and stroke, with some health effects showing a “nonlinear exposure-response relationship with an inverted U-shaped pattern.” …”
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Brain functional alternation in patients with systemic sclerosis: a resting-state functional magnetic resonance imaging study by Xinyu Tong, Huilin He, Shihan Xu, Rui Shen, Zihan Ning, Xiaofeng Zeng, Qian Wang, Dong Xu, Zuo-Xiang He, Xihai Zhao

“…SSc patients predominantly showed decreased intra-network and inter-network FC in the auditory network, visual network, default mode network, frontoparietal network and attention network (intra-network FC: P < 0.01, uncorrected, cluster size > 30; inter-network FC: P < 0.05, FDR correction). …”
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Long-term safety and effectiveness of canakinumab in patients with monogenic autoinflammatory diseases: results from the interim analysis of the RELIANCE registry by Tilmann Kallinich, Juergen Rech, Ivan Foeldvari, Norbert Blank, Frank Weller-Heinemann, Gerd Horneff, Ioana Andreica, Joerg Henes, Jasmin B Kuemmerle-Deschner, Florian Meier, Frank Dressler, Michael Borte, Markus Hufnagel, Birgit Kortus-Götze, Prasad T Oommen, Tobias Krickau, Aleš Janda, Catharina Schuetz, Michael Fiene, Julia Weber-Arden

“…Patient-reported disease activity (Visual Analogue Scale (VAS), Autoinflammatory Disease Activity Index), fatigue (VAS); markers of inflammation (C-reactive protein, serum amyloid A and erythrocyte sedimentation rate) remained well-controlled throughout.Conclusion Data from this analysis confirm the long-term safety and effectiveness of canakinumab for the treatment of CAPS, FMF, TRAPS and MKD/HIDS.…”
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Repeat expansions in RFC1 gene in refractory chronic cough by Barnaby Hirons, Peter S.P. Cho, Katie Rhatigan, Joe Shaw, Riccardo Curro, Bianca Rugginini, Natalia Dominik, Richard D. Turner, Ewan Mackay, James H. Hull, Hisham Abubakar-Waziri, Harini Kesavan, Caroline J. Jolley, Robert D. Hadden, Andrea Cortese, Surinder S. Birring

“…The prevalence and identifying clinical characteristics of RFC1 repeat-expansion disorders in patients with RCC are unknown. Methods Consecutive patients with RCC underwent RFC1 genotyping, cough severity visual analogue scale (VAS) and cough-specific health status assessment (Leicester Cough Questionnaire (LCQ)). …”
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Relationship between high-resolution computed tomography quantitative imaging analysis and physiological and clinical features in antisynthetase syndrome-related interstitial lung... by Donald P Tashkin, Rohit Aggarwal, Chester V Oddis, Grace Kim, Fereidoun Abtin, Daniela Markovic, Christina Charles-Schoeman, Galina Marder, Jonathan Goldin, Paul F Dellaripa, Swamy Venuturupalli, Gary Matt Hunninghake, Tracy J Doyle, Siamak Moghadam-Kia, Sangmee Sharon Bae, Cato Chan, Daniel Sullivan, Jeremy Falk

“…Higher QILD scores over time were also associated with worse dyspnoea scores, pulmonary visual analogue scale, physician and patient global disease activity, health status in 6/8 domains of the Short Form-36 and higher oxygen requirements. …”
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Effects of 2 different flap techniques on clinical outcomes after epulis excision by SUN Wentao, DONG Jiachen, SUN Mengjun, LIAO Yue, SONG Zhongchen

“…Objective·To evaluate the effects of normally positioned flap (NPF) and coronally advanced flap (CAF) techniques on clinical results after epulis excision.Methods·A total of 55 patients with epulis who visited the Department of Periodontology, Shanghai Ninth People′s Hospital, Shanghai Jiao Tong University School of Medicine from August 2022 to December 2023 were included. …”
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Identification and verification of the optimal feature genes of ferroptosis in thyroid-associated orbitopathy by Xuemei Li, Xuemei Li, Xuemei Li, Xuemei Li, Xuemei Li, Chao Xiong, Chao Xiong, Chao Xiong, Chao Xiong, Chao Xiong, Siyi Wang, Siyi Wang, Siyi Wang, Zhangjun Ren, Zhangjun Ren, Zhangjun Ren, Qi Jin, Qi Jin, Qi Jin, Jinhai Yu, Jinhai Yu, Jinhai Yu, Jinhai Yu, Jinhai Yu, Yunxiu Chen, Yunxiu Chen, Yunxiu Chen, Puying Gan, Puying Gan, Puying Gan, Puying Gan, Qihua Xu, Qihua Xu, Qihua Xu, Qihua Xu, Qihua Xu, Yaohua Wang, Yaohua Wang, Yaohua Wang, Yaohua Wang, Yaohua Wang, Hongfei Liao, Hongfei Liao, Hongfei Liao, Hongfei Liao, Hongfei Liao

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