Effectiveness and Safety of Shenxiong Huanglian Detoxification Granule Combined with Donepezil for the Treatment of Alzheimer’s Disease: Study Protocol for a Multicenter, Pra... by Lin J, Liu X, Lin X, Liu N, Pei H, Zhao Y, Yu G, Wang W, Chen C, Hou T, Li X, Lin X, Li H

“…A total of 386 eligible individuals with mild to moderate Alzheimer’s disease will receive random assignment and equal access to the test or control group. The effectiveness and safety of Shenxiong Huanglian Detoxification Granule in combination with donepezil will be observed. …”
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Anti-leukemia effect of B7 gene-modified leukemia cell-derived exosomes by ZHANG Difan, WANG Minghui, ZHAO Jie, WAN Jiangbo, HUANG Fang, HAO Siguo

“…Objective·To investigate the immunotherapeutic effects of exosomes derived from leukemia cells with high expression of B7 molecules (co-stimulatory molecules CD80 and CD86) in tumor-bearing mice.Methods·L1210 leukemia cells were transfected with lentiviral vectors containing the CD80 and CD86 genes, and thereby the leukemia cells with high expression of CD80 and CD86 molecules were obtained. …”
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A Peptide Encoded by lncRNA HOXB-AS3 Promotes Cigarette Smoke-Induced Inflammation in Bronchial Epithelial Cells via EZH2-Mediated H3K27me3 Modification by Lin M, Zhou X, Yang Y, Xie P, Li Q, He C, Lin Q, Wei X, Ding Y

“…This study aimed to investigate the role of a peptide encoded by lncRNA HOXB-AS3 in cigarette smoke extract (CSE)-induced inflammation and in 16HBE cells.Methods: Open reading frames (ORF) Find software was utilized to predict the encoding potential of HOXB-AS3. …”
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Effect of Hardiness Training on Self-Esteem and Adjustment of Addicted Male by Mohammad Javad Aghajani

“…Method: This research is a pre-post test and control group. …”
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Diagnostic Performance of Clinical Metagenomic Next-Generation Sequencing for Suspected Central Nervous System Infections in a Municipal Hospital: A Retrospective Study in China by Wang H, Zhao J, Wang X, Li M, Hu T, Xu H, Dong M, He W, Che Z

“…However, there are few related studies investigating in a municipal hospital.Patients and Methods: A total of 52 suspected CNSi patients were retrospectively recruited in Xinxiang central hospital between July 2019 and April 2023. …”
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Modified Huanjingjian Prevents Chemotherapy-Induced Alopecia by Inhibiting Genomic DNA Methylation of the Wnt Signaling Pathway in Mice by Liu X, Du T, Xi R, Cheng L, Wang Y, Lu H, Guo D, Zhu J, Liu T, Li F

“…And our main aim was to explore the efficacy and the mechanism of MHJJ in mice.Methods: UPLC-QE-Orbitrap-MS characterized MHJJ’s chemical composition. …”
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Knowledge, Attitude, and Practice Toward Antitubercular Agents Among Pulmonary Tuberculosis Patients in Southwestern China: A Cross-Sectional Study by Pi Y, Tan J, Yang P, Pan J, Yang X, Xiang M, Li T

“…Yinhuan Pi,1,2,* Junyi Tan,3,* Pei Yang,1 Jing Pan,2 Xianghui Yang,2 Mingque Xiang,2 Tianju Li2 1Business Affairs Section, Chongqing Blood Center, Chongqing, People’s Republic of China; 2Department of Infectious Diseases, The Ninth People’s Hospital of Chongqing, Chongqing, People’s Republic of China; 3Department of Gastroenterology, Chongqing University Three Gorges Hospital, Chongqing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Tianju Li, Department of Infectious Diseases, The Ninth People’s Hospital of Chongqing, Chongqing, People’s Republic of China, 400700, Email tianjulee@126.comObjective: To investigate the knowledge, attitudes, and practice (KAP) toward first-line antitubercular agents among patients with pulmonary tuberculosis (TB) in southwestern China, and to examine sociodemographic disparities in KAP.Methods: A simple sampling survey was conducted among TB patients clinically diagnosed with active pulmonary TB at the Ninth People’s Hospital of Chongqing. …”
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Digital Therapeutics–Based Cardio-Oncology Rehabilitation for Lung Cancer Survivors: Randomized Controlled Trial by Guangqi Li, Xueyan Zhou, Junyue Deng, Jiao Wang, Ping Ai, Jingyuan Zeng, Xuelei Ma, Hu Liao

“…Home-based cardiac telerehabilitation through wearable devices and mobile apps is a substitution for traditional, center-based rehabilitation with equal efficacy and a higher completion rate. However, it has not been widely used in clinical practice. …”
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Effect of Shenmai injection on the preservation quality of suspended red blood cells prepared from high hemoglobin population in Xizang plateau by ZHONG Rui, HE Zeng, WANG Hong, LI Wanjing, LIU Jiaxin, CAO Ye

“…[Objective] To investigate the effect of Shenmai injection on the preservation quality of suspended red blood cells of high hemoglobin population in Xizang plateau. [Methods] Whole blood (400 mL, n=8) collected by the Xizang Autonomous Region Blood Center was centrifuged at 3 000 g for 10 minutes to remove most of the plasma, followed by the addition of 100 mL of MAP preservation solution to obtain plateau suspended red blood cells, which were then divided into three equal portions. …”
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Quantitative Proteomic Study Reveals Amygdalin Alleviates Liver Fibrosis Through Inhibiting mTOR/PDCD4/JNK Pathway in Hepatic Stellate Cells by Huang H, Ru SJ, Chen JM, Liu W, Fang SH, Liu Q, Meng Q, Liu P, Zhou H

“…This study aimed to elucidate the potential mechanism of action of amygdalin against liver fibrosis.Methods: Quantitative proteomic profiling of the mouse liver tissues from control, carbon tetrachloride (CCl4)-induced fibrosis, and amygdalin-treated groups was performed to explore the key effector proteins of amygdalin. …”
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DHLCA Alleviates Diabetic Kidney Disease via TGR5/FXR Activation and Gut Microbiota Remodeling by Zhou H, Mu X, Hu H, Zhao S, Hu N, Yang M, Jiang J

“…This study aimed to investigate the role of BA metabolism in the progression of DKD.Methods: Plasma BA profiles were measured in healthy controls (HC), patients with type 2 diabetes mellitus (T2DM), and patients with DKD using ultra-high-performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS). …”
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Hub Genes PRPF19 and PPIB: Molecular Pathways and Potential Biomarkers in COPD by Zhao J, Ge X, Li H, Jing G, Ma W, Fan Y, Chen J, Zhao Z, Hou J

“…Robust genetic analysis is essential to establish a causal link.Methods: Genome-wide DNA methylation analysis was performed using the Illumina Infinium HumanMethylation850 BeadChip in peripheral blood from 8 COPD patients and 8 healthy smoking controls. …”
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Emerging Research Trends on Medication Adherence in Tuberculosis Treatment: A Bibliometric Study of Research Between 2015 and 2024 to Inform Future Research Trajectory by Maulana S, Lutfian L, Wardika IJ, Fadhli R, Anggreani D, Haposan JH, Wildana F, Efendi MA, Platini H, Haroen H

“…This study aims to conduct a comprehensive bibliometric analysis of research on medication adherence in TB treatment within this region.Methods: A bibliometric analysis was conducted using the Scopus database to identify research articles related to medication adherence in TB treatment in Southeast Asia, published in English between 2015 and 2024. …”
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Navigating Care Challenges in Elderly Patients Following Hypoglossal Nerve Stimulator Implantation by Michael Joo, Erin Gurski, Efstathia Polychronopoulou, Mukaila Raji, Rizwana Sultana

“…Other difficulties that are less commonly reported but equally important to consistent and proper use of HNS included headaches, concerns of device malfunction, change in comfort levels after cardiac procedures, and general intolerance of the device. …”
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Knowledge, Attitudes, and Practices of Chinese Breast Cancer Patients Towards Comprehensive Postoperative Self-Management: a Cross-Sectional Study by Wei X, Ye P, Chen L, Tang H, Yin W, Shao M, Bai R, Li Y, Yu J, Wang W, Zhang J

“…Xiaoyu Wei,1,* Ping Ye,2,* Lingling Chen,3 Huiqin Tang,1 Weiwei Yin,4 Min Shao,5 Ru Bai,6 Yun Li,5 Jiya Yu,7 Wei Wang,5 Jing Zhang8 1Department of Operating Room, The Second Affiliated Hospital of Bengbu Medical University, Bengbu, 233000, People’s Republic of China; 2Department of Gynecologic Oncology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, 233004, People’s Republic of China; 3Department of Nursing, The Second Affiliated Hospital of Bengbu Medical University, Bengbu, 233000, People’s Republic of China; 4Department of Thoracic Surgery, The Second Affiliated Hospital of Bengbu Medical University, Bengbu, 233000, People’s Republic of China; 5Department of Oncological surgery, The Second Affiliated Hospital of Bengbu Medical University, Bengbu, 233000, People’s Republic of China; 6Department of Oncological surgery, The First Affiliated Hospital of Bengbu Medical University, Bengbu, 233004, People’s Republic of China; 7Department of Nursing, Bengbu Medical University, Bengbu, 233030, People’s Republic of China; 8Department of Mental Health, Bengbu Medical University, Bengbu, 233030, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lingling Chen, Department of Nursing, The Second Affiliated Hospital of Bengbu Medical University, Bengbu, 233000, People’s Republic of China, Tel +86-13909629122, Email 1314chenlingling@163.com Jing Zhang, Department of Mental Health, Bengbu Medical University, Bengbu, 233030, People’s Republic of China, Tel +86-13505522198, Email 0700007@bbmc.edu.cnPurpose: To comprehensively assess the knowledge, attitudes, and practices (KAP) of Chinese breast cancer (BC) patients regarding postoperative self-management (POSM) and identify factors influencing self-management behaviors.Methods: Questionnaire surveys were administered to BC patients who underwent surgery. …”
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Association Between Premorbid Frailty Status and Functional Independence in Acute Ischemic Stroke Patients Following Endovascular Treatment in the Late Window by Huang L, Gong C, Qiu Z, Jiang S, Song M, Wang Z, Chen Y, Xu T, Hu P, Chen S, Chen Y, Nguyen TN, Liu C

“…Therefore, we aimed to explore whether frailty, a reflection of the patient’s physical status based on peripheral organ health at admission, could be associated with outcomes among AIS patients treated by EVT in the late window of 6– 24 hours from stroke onset.Patients and Methods: This was a post-hoc analysis of our RESCUE-BT trial, with findings validated in an external cohort. …”
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Mediation Effect of Relaxin in Cerebrospinal Fluid on the Association Between Smoking and Sleep by Xu Z, Ma M, Liu Y, Tang J, Luo X, Chen YH, Wang K, Chen X, Kang Y, Zheng K, Hu W, Chen L, Wang F, Wu Y

“…Zeping Xu,1,* Mingwei Ma,2,* Yanlong Liu,2,* Jiayi Tang,3 Xingguang Luo,4 Yu-Hsin Chen,2 Kexin Wang,2 Xiyi Chen,2 Yimin Kang,5 Ke Zheng,6 Weiming Hu,7 Li Chen,2 Fan Wang,8 Yuyu Wu9,10 1Department of Pharmacy, Ningbo Medical Center Li Huili Hospital, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, Zhejiang, 315040, People’s Republic of China; 2School of Mental Health, Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 3Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, People’s Republic of China; 4Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA; 5Psychosomatic Medicine Research Division, Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, People’s Republic of China; 6Department of Geriatrics, Wenzhou Seventh People’s Hospital, Wenzhou, Zhejiang Province, People’s Republic of China; 7Department of Psychiatry, The Third Hospital of Quzhou, Quzhou, People’s Republic of China; 8Beijing Huilongguan Hospital, Peking University, Beijing, Beijing Municipality, People’s Republic of China; 9Zhejiang Provincial Clinical Research Center for Mental Disorders, The Affiliated Wenzhou Kangning Hospital, Wenzhou Medical University, Wenzhou, People’s Republic of China; 10School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fan Wang; Yuyu Wu, Email fanwang@bjmu.edu.cn; douzipo@163.comObjective: This study investigates the influence of CSF relaxin (RLN) on the association between smoking and sleep quality, considering previous findings linking smoking and RLN with psychiatric conditions.Methods: In a case-control study of 168 Chinese adult males (70 smokers, 98 non-smokers), levels of relaxin in cerebrospinal fluid (CSF) were measured. …”
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Molecular Subtyping of Hepatocellular Carcinoma via Lysosome-Related Genes for Prognosis and Therapy Prediction by Yao Y, Zhu T, Shen X, Ma J, Zhu X, Jiang J

“…Therefore, we aim to explore the novel molecular subtypes of HCC via lysosome-related genes (LRGs) for prognosis and therapy prediction in this study.Methods: Using the data of TCGA, differential expression and survival analyses were performed. …”
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Association of MiRNA Polymorphisms Involved in the PI3K/ATK/GSK3β Pathway with T2DM in a Chinese Population by Zhou X, Yang M, Yang Y, Xu F, Wang F, Jiao M, Tao W, Li Y

“…The purpose of this study was to investigate the association of SNPs in miRNA genes targeting the PI3K/AKT/GSK3β pathway with T2DM.Methods: This case-control study included 1,416 subjects with T2DM and 1,694 non-diabetics. …”
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Macrophage Membrane-Coated Liposomes Delivering Vonoprazan Disrupt Mitochondrial Oxidative Phosphorylation in Diffuse Large B-Cell Lymphoma by Wang W, Wang L, Fan Q, Xu J, Li Y, Xu J, Zhao B, Ge D, Xiong L, Wu Y, Zhu Y, Chen M

“…This study constructed a macrophage membrane-coated liposomal formulation (MM-Lipid@Vpz) for the targeted delivery of vonoprazan to combat DLBCL, which enables the evasion of the reticuloendothelial system, ensuring enhanced specificity in tumor targeting.Methods: The vonoprazan was delivered by encapsulating liposomes with pre-isolated macrophage membranes, targeted to DLBCL cells and evaluated for changes in cell function. …”
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