Febuxostat Improves Postprandial Glucose Regulation and Insulin Sensitivity in Hyperuricemic Individuals with Prediabetes or Newly Diagnosed Type 2 Diabetes: A Prospective Cohort S... by Liu S, Liu Q, Gu R, Wu M, Meng S, Yan L, Chen Q, Zhu C, Chen S, Xu B, Liu F, Chen H

“…This study aimed to investigated the impact of the urate-lowering drug febuxostat on blood glucose levels, insulin sensitivity, and β-cell function in subjects with HUA who present with normoglycemia, prediabetes, or newly diagnosed type 2 diabetes (T2DM).Methods: We assessed the glucose metabolism of participants with HUA using a 3-h oral glucose tolerance test (OGTT). …”
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Diaphragm Fatigue Does Not Impact Breathing Mechanics or Function in People with Chronic Low Back Pain by Mitchell UH, Robinson LT, Brinkman J, Bruening DA, Bowden AE, Allen SP

“…The purpose of this comparative cross-sectional study is to investigate whether diaphragm fatigue affects breathing mechanics and function in individuals with CLBP.&#x00A0Methods: Volunteers were recruited between the ages of 35– 65 years old with and without CLBP. …”
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Comparison of eight weeks of resistance training and high-intensity intermittent aerobic training on the expression of microRNAs associated with adipose tissue angiogenesis and ant... by Hamid Sadeghian, Marefat Siahkohian, Mohsen Akbarpour Beni, Lotfali Bolboli

“…The animals were randomly divided into six equal groups after transfer to the laboratory environment and one week of exposure to the new environment: 1. …”
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The Impact of Triglyceride-Glucose Index on Carotid Atherosclerosis: A Prospective Cohort Study in Middle Aged and Elderly Low-Income in Rural Chinese by Meng J, Lu Y, Gao X, Hao J, Li X, Ning X, Zhang W, Wang J

“…This study aimed to assess the relationship between the TyG index and carotid plaque incidence and IMT changes over a six-year period in a cohort of middle-aged and elderly individuals with low income and low education in rural China.Methods: The study was conducted from 2014 to 2020 in 18 rural villages in Tianjin, China. …”
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Antimicrobial Effects of Thonningianin a (TA)-Loaded Chitosan Nanoparticles Encapsulated by a PF-127 hydrogel in Diabetic Wound Healing by Lin Q, Zhu F, Shiye A, Liu R, Wang X, Ye Z, Ding Y, Sun X, Ma Y

“…To promote diabetic wound healing, a composite of thonningianin A (TA)-loaded chitosan nanoparticles (CNPS) encapsulated by a Pluronic F-127 (PF-127) hydrogel (TA-CNPS-PF) was developed in this study.Methods: TA-CNPS was prepared by ionic gelation method and TA-CNPS was thoroughly dispersed into PF-127 hydrogel to prepare TA-CNPS-PF. …”
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Transarterial Chemoembolization, Molecular Targeted Treatments, and Programmed Death-(Ligand)1 Inhibitors, for Hepatocellular Carcinoma with Lung Metastasis: A Retrospective Cohort... by Lu J, Chen X, Liu Y, Ding Y, Li B, Yang J, Peng W, Yang X

“…However, the efficacy of combining TACE with these treatments remains uncertain.Purpose: To compare the efficacy and adverse reactions of TACE combined with MTT and PD-(L)1 versus MTT and (PD-[L]1) in patients with HCC and lung metastasis.Materials and Methods: We retrospectively analyzed data from patients treated between January 2019 and May 2024 at the Affiliated Hospital of Southwest Medical University and West China Hospital of Sichuan University. …”
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Exploring Salvia miltiorrhiza’s Therapeutic Effects on Adenomyosis by Inhibiting TNF-α/HIF-1α/IL-17-Driven Inflammatory Cascade: Mechanistic Insights... by Yang Q, Hong J, Zheng X, Liu X, Lin H, Chen L, Zhong F, Zhang Q, Jiang J, Sun P

“…However, its mechanisms in addressing adenomyosis remain unclear.Methods: Ultra-performance liquid chromatography coupled with Q Exactive™ HF-X mass spectrometry (UPLC-QE-MS) was employed to identify the constituents of DS. …”
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True- and pseudo-mitral annular disjunction in patients undergoing cardiovascular magnetic resonance by Kamil Stankowski, Federica Catapano, Dario Donia, Renato Maria Bragato, Pedro Lopes, João Abecasis, António Ferreira, Leandro Slipczuk, Pier-Giorgio Masci, Gianluigi Condorelli, Marco Francone, Stefano Figliozzi

“…In all measurements, systolic MAD extent (2.3 [1.7–3.0] mm) resulted equal to or greater than diastolic MAD extent (2.0 [1.5–2.9] mm). …”
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IVIG Resistance in Kawasaki Disease: Clinical and Laboratory Risk Factors and the Potential Role of Administration Timing by Peng Y, Jing F, Liu D, Li B, Xu Y, Tan Z, Chen O, Yang Y, Si F, Jiang W, Li C, Cheng Z, Zhou X, Feng S, Su Y, Yi Q

“…The purpose of this study was to determine independent risk factors for IVIG resistance, investigate the response to IVIG treatment at different time points and determine whether the time option of IVIG treatment altered IVIG resistance.Methods: The clinical data of 6264 KD patients in southwest China were analyzed retrospectively. …”
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Development of an Early-Warning Model for Predicting the Capecitabine-Induced Diarrhea by Liu Z, Qiu S, Xu Y, Wang X, Sun J, Cui L, Ye L, Liang Z, Gao S, Chen W, Wang Z

“…The aim of this study was to construct an early-warning model for predicting the Cap-induced diarrhea.Methods: A Cap-induced diarrhea model in mice was constructed in 36 mice, and the exposure levels of Cap and its five metabolites were quantified in plasma and colon and correlated their exposure levels to the diarrhea. …”
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Analyzing Shigella in Wuhan: Serotypes, Antimicrobial Resistance, and Public Health Implications by Deng S, Li C, Zhang H, Xie Y, Wang X, Luo W, Chen Z, Tang F

“…Shiyong Deng,1,* Changzhen Li,1,* Hui Zhang,2,* Yuduan Xie,3,* Xiaomei Wang,1,* Wanjun Luo,4 Zhi Chen,5 Feng Tang1 1Department of Laboratory Medicine, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430016, People’s Republic of China; 2Laboratory Department, Qiaokou Center for Disease Control and Prevention, Wuhan, 430030, People’s Republic of China; 3Department of Clinical Laboratory, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of China; 4Hospital-Acquired Infection Control Department, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430016, People’s Republic of China; 5Microbiological Laboratory, Wuhan Center for Disease Control and Prevention, Wuhan, 430024, People’s Republic of China*These authors contributed equally to this workCorrespondence: Feng Tang, Email tang33feng66@163.com Zhi Chen, Email 694867557@qq.comObjective: This study aims to delineate the epidemiological characteristics and antibiotic resistance of Shigella flexneri isolates from Wuhan, focusing on serotype distribution, resistance patterns, and genetic diversity.Methods: Our study analyzed 40Shigella flexneri isolates collected from 2011 to 2022 in Wuhan, assessing their serotype distribution and resistance to multiple antibiotics. …”
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Barriers and Facilitators to Adherence to Exercise-Based Cardiac Rehabilitation Among Coronary Artery Disease Patients: A Scoping Review by Zhao X, Zhang S, Zhang F, Wu X, Zhang Z, Liu Y, Jiang J, Li Z, Li S, Zheng S, Yang X, Ju X, Li H, Gong L, Kong D

“…This limitation hinders the full potential of rehabilitation, necessitating a deeper exploration of the factors influencing exercise adherence and the development of targeted intervention strategies.Objective: This study aims to identify the barriers and facilitators affecting ERCR adherence among CAD patients and provide intervention recommendations for clinical practice.Methods: A systematic search was conducted across nine databases, including PubMed, Cochrane Library, Embase, Web of Science, EBSCO, CNKI, Wanfang, VIP, and CBM. …”
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Understanding and Overcoming Negative Attitudes That Hinder Adoption of Reablement in Dementia Care: An Explorative Qualitative Study by Tuntland H, Ashfaq K, Zingmark M, Metzelthin SF

“…This study aimed to explore the negative attitudes that hinder the adoption of reablement and to identify strategies to mitigate these factors.Methods: An exploratory qualitative approach involving semi-structured interviews was adopted. …”
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Cutaneous Nontuberculous Mycobacteria Infections Following Cosmetic Procedures: A Retrospective Study by Zeng R, Xiong J, Gao W, Peng J, Shi Y, Zhang W, Jiang H, Cheng C, Ge G, Wang Z, Mei Y, Chen Z, Wang H

“…The diagnosis and treatment of these infections remain a significant challenge for clinicians.Objective: We examined the clinical characteristics, microbiology, histopathology, and treatment strategies of NTM infections following cosmetic procedures, including botulinum toxin injection, lipolysis injection, hyaluronic acid injection, mesotherapy, autologous fat grafting, and other related procedures.Methods: This retrospective study of cosmetology-related cutaneous NTM infections diagnosed based on culture or molecular identification was conducted at a tertiary dermatology hospital in China. …”
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Astragaloside IV Attenuates Chronic Prostatitis by Activating Keap1/Nrf2/HO-1 Pathway: Suppressing Ferroptosis and Enhancing Antioxidant Defense by Shi J, Xuan Y, Zhang Q, Chen J, Zhu W, Zhang H, Duan Y

“…However, regulatory mechanisms linking AS-IV to ferroptosis inhibition in CP/CPPS remain unknown.Patients and Methods: This study aimed to investigate the therapeutic potential of astragaloside IV (the primary bioactive component of Astragalus membranaceus) for the treatment of CP/CPPS by suppressing ferroptosis via the Keap1/Nrf2/HO-1 pathway. …”
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Incidence and Predictors of Acute Kidney Injury Among Critically Ill Adult Patients Admitted at Mbarara Regional Referral Hospital by Muhindo R, Kiptoo J, Tumuhimbise C, Nakyanzi C, Ssentongo FG, Kavubu M, Ssewanyana E, Isiiko J, Kyomya J, Mutekanga A, Aguma AR, Owokuhaisa J, Yadesa TM

“…We evaluated the incidence, predictors, treatment, and outcomes of AKI among very ill adult patients at a public tertiary hospital in southwestern Uganda.Methods: This prospective cohort study categorized patients who had a NEWS-2 above 5 as critically ill. …”
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How Does Disease Severity Affect Clinical Outcomes and Economic Burden of Patients with COPD —— A Retrospective Population-Based Cohort Study in Tianjin, China by Wang L, Huang K, He X, Zhang J, Yang T, Wu J

“…This study aimed to clarify the effect of severity on disease burden by comparing clinical and economic outcomes stratified by disease severity based on the Global Initiative for Chronic Obstructive Lung Disease (GOLD) in a Chinese setting.Methods: A retrospective population-based cohort study was conducted using electronic health records of 80 hospitals (2016– 2019). …”
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Construction of Cationic Carbon Dots Carrying Survivin siRNA Delivery System and Its Active Targeting Therapy for Liver Cancer by Xue W, Du J, Wei Y, Zhou S, Wang S, Yang Y, Chen L, Yu S

“…Wenqiang Xue,1,* Jinglei Du,2,* Yingying Wei,2 Shizhao Zhou,2 Shicai Wang,4 Yongzhen Yang,3 Lin Chen,3 Shiping Yu2 1Department of Interventional Therapy, Shanxi Provincial People’s Hospital, Taiyuan, 030001, People’s Republic of China; 2Department of Interventional Therapy, Shanxi Province Cancer Hospital/ Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/ Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, 030001, People’s Republic of China; 3Key Laboratory of Interface Science and Engineering in Advanced Materials, Ministry of Education, Taiyuan University of Technology, Taiyuan, 030024, People’s Republic of China; 4Department of Interventional Therapy, Taiyuan Central Hospital, Taiyuan, 030001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yongzhen Yang, Key Laboratory of Interface Science and Engineering in Advanced Materials, Ministry of Education, Taiyuan University of Technology, Taiyuan, 030024, People’s Republic of China, Email yangyongzhen@tyut.edu.cn Shiping Yu, Department of Interventional Therapy, Shanxi Province Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, 030001, People’s Republic of China, Email yushiping@sxmu.edu.cnBackground: Small interfering RNA (siRNA) provides a new method for anti-tumor therapy by targeting Survivin gene in liver cancer. …”
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Characteristics of the Epidemiological Situation in Patients with Tuberculosis of Various Age Groups Based on the Numerical Criteria of Selective Rating with the Help of the Comput... by Ilnуtskуy G.

“…In adults, it was lower and equaled 96.8 ± 2.2. The average rate of tuberculosis in Lviv region among the adolescents (26.7 ± 9.8) was higher than in children (6.7 ± 0.5) and lower than in adults (72.9 ± 2.3) per 100 thousand population. …”
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Enhancing Diabetes Treatment: Comparing Pioglitazone/Metformin with Dapagliflozin Versus Basal Insulin/Metformin in Type 2 Diabetes by Lin Y, Shi J, Yu X, Sun J, Lixia S, Dou J, Zhang M, Li X, Tian Z, Deng H, Feng B, Su Q, Peng Y

“…Yi Lin,1,* Jianxia Shi,1,* Xuemei Yu,2 Jiao Sun,3 Suo Lixia,4 Jiaqing Dou,5 Min Zhang,6 Xiaohua Li,7 Zhufang Tian,8 Hongyan Deng,9 Bo Feng,10 Qing Su,11 Yongde Peng1 1Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 2Central Hospital of Fengxian District, Shanghai, People’s Republic of China; 3Huadong Hospital Affiliated to Fudan University, Shanghai, People’s Republic of China; 4Shanghai Jiading Central Hospital, Shanghai Jiading Central Hospital, Shanghai, People’s Republic of China; 5Chaohu Hospital of Anhui Medical University, Chaohu, People’s Republic of China; 6Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, People’s Republic of China; 7Seventh People’s Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 8Xi‘an Central Hospital, Xi’an, Shanxi, People’s Republic of China; 9Wuhan Fourth Hospital, Wuhan, People’s Republic of China; 10Dongfang Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China; 11Xinhua Hospital Affiliated to Shanghai Jiaotong University, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yongde Peng, Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University, 100 haining Road, Shanghai, 200080, People’s Republic of China, Tel +86-13386259649, Email pengyongde0908@126.comAim: The aim of this study was to compare the efficacy and safety of fixed-dose combination (FDC) of pioglitazone and metformin supplemented with dapagliflozin (test group) with those of basal insulin supplemented with metformin (control group) in patients with inadequately controlled type 2 diabetes mellitus (T2DM).Methods: This 16-week, prospective, randomized, open-label study enrolled patients aged 18– 75 years with glycated hemoglobin (HbA1c) levels between ≥ 8% and ≤ 11%. …”
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