Clinical Characteristics of Auditory Mismatch Negativity in Patients with Chronic Disorders of Consciousness Following Intracerebral Haemorrhage: A Prognostic Prediction Study by Lv X, Yang N, Lv J, Li L, Gao Y, Xiang Z, Li Z, Lang X, Tao D, Zhao Y, Duan H, Li H

“…Xuehai Lv,1,* Nuan Yang,2,* Jingwei Lv,3 Linxi Li,4 Yuemin Gao,5 Zhengmao Xiang,6 Zhengfan Li,4 Xiaoguang Lang,5 Dan Tao,7 Yuqin Zhao,5 Haili Duan,5 Hongling Li1 1Second Department of Rehabilitation Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, 050000, People’s Republic of China; 2Graduate School, Hebei Medical University, Shijiazhuang, Hebei Province, 050017, People’s Republic of China; 3School of Basic Medicine, Hebei Medical University, Shijiazhuang, Hebei Province, 050017, People’s Republic of China; 4Graduate school, Hebei North University, Zhangjiakou, Hebei Province, 075000, People’s Republic of China; 5Department of Clinical Rehabilitation Medicine, Handan Central Hospital, Handan, Hebei Province, 056001, People’s Republic of China; 6Graduate school, Chengde Medical University, Chengde, Hebei Province, 067000, People’s Republic of China; 7Academy of Geography, Sociology, and International Studies, Hong Kong Baptist University, Hong Kong, 519000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hongling Li, Second Department of Rehabilitation Medicine, The Second Hospital of Hebei Medical University, No. 215 of Hepingxi Road, Xinhua District, Shijiazhuang, Hebei Province, 050000, People’s Republic of China, Tel +86 15803210622, Email lihongling_lhl@163.comObjective: To examine the clinical features of auditory mismatch negativity (MMN) and its potential utility in prognostic prediction in patients with chronic disorders of consciousness (DOC) following intracerebral haemorrhage (ICH).Methods: Between September 2023 and July 2024, 24 patients with chronic DOC following ICH were recruited. …”
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Evaluation of Environmental Effects of Applied Pesticides on Canola (Brassica napus L.), Sugar Beet (Beta vulgaris L.), and Potato (Solanum tuberosum L.) Fields in Ali Abad Katool... by Zahra Deilam, Hossein Kazemi, Maral Niazmoradi, Javid Gherekhloo

“…The highest environmental effect of pesticides per hectare belongs to Mancozeb fungicide with EIQ-FUR equal to 61.72. This fungicide has an average EIQ (25.72) compared to pesticides such as Cyproconazole+Carbendazim, Chlorpyrifos and Diazinon, etc., but due to the high percentage of the effective substance and the amount used in the potato fields of the region (3 liters per hectare), causes the most damage and toxicity to the environment. …”
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Mechanism of magnesium sulfate suppressing vascular calcification in rats with chronic renal failure through TLR4/NF-κB pathway by Dong Li-ming, Li Yin-hui, Li Li

“…ObjectiveTo explore the effect of magnesium sulfate on vascular calcification （VC） in rats with chronic renal failure （CRF） through the pathway of Toll-like receptor 4 （TLR4）/nuclear transcription factor-κB （NF-κB）.MethodsA total of 50 Sprague-Dawley （SD） rats were randomized into five groups of control， model， magnesium sulfate-L （25% magnesium sulfate， 2 mL）， magnesium sulfate-H （25% magnesium sulfate， 4 mL） and magnesium sulfate-H+PDTC （25% magnesium sulfate， 4 mL+NF-κB inhibitor PDTC， 100 mg/kg） （<italic>n</italic>=10 each）. …”
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The Role of L-Sorbose Metabolism in Enhancing Fitness and Virulence in Escherichia coli Under Acidic Conditions by Qiu T, Chen X, Deng X, Zhang G, Wen S, Wu J, Sun D, Li T, Yan B, Dai M, Zhong LL, Tian GB

“…While metabolic flexibility is critical for E. coli fitness to host environments, the role of secondary carbon sources like L-Sorbose remains poorly characterized.Methods: The functional importance of L-Sorbose metabolism in E. coli CFT073 was investigated under acidic conditions simulating gastrointestinal and urinary tract environments. …”
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Transcriptomic Changes and Pathological Mechanisms in Familial and Sporadic Idiopathic Restless Legs Syndrome: Implications for Inflammation and Cell Adhesion Molecules by He XR, Song JM, Zhao JP, Zhang J, Feng JT, Chen SQ, Zhou ZY, Wang HM, Zhang Y, Feng Y, Wu YC, Zhu XY

“…The study aims to investigate transcriptomic changes and underlying pathological mechanisms in familial and sporadic idiopathic RLS to uncover potential contributors to its pathogenesis.Patients and Methods: This study included 37 RLS patients, 39 unrelated healthy controls and 19 healthy relatives of RLS patients with a positive family history. …”
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A Nomogram for Diagnosing Ventilator-Associated Pneumonia Using Circulating Inflammation Indicators in ICU Patients by Yang J, Bao W, Wang H, Zhou J, Hu Q, Wang Y, Li Y

“…Jiajia Yang,1,&ast; Weiyuan Bao,2,&ast; Hongmei Wang,1 Jie Zhou,3 Qiang Hu,4 Ying Wang,1 Yuancheng Li5 1Department of Infection Management, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, 215008, People’s Republic of China; 2Department of Logistics Support, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, 215008, People’s Republic of China; 3Intensive care unit, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, 215008, People’s Republic of China; 4Department of Respiratory and Critical Care Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, 215008, People’s Republic of China; 5Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, 210042, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Ying Wang, Department of Infection Management, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, No. 242, Guangji Road, Suzhou, 215008, People’s Republic of China, Email wangy830224@sina.com Yuancheng Li, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, Jiangsu, 210042, People’s Republic of China, Email ycli@pumcderm.cams.cnPurpose: To construct a risk nomogram model of ventilator-associated pneumonia (VAP) patients with mechanical ventilation in the intensive care unit (ICU) based on peripheral blood inflammatory indicators and to evaluate its diagnostic value.Patients and Methods: A matched 1:2 case: control study was conducted. …”
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Intravoxel Incoherent Motion Improves the Accuracy of Preoperative Prediction of Vessels Encapsulating Tumor Clusters in Hepatocellular Carcinoma by Li M, Zhang G, Li J, Ren Y, Jin X, Ke Q, Guo C, Lv J, Lu H, Xu Y, Liang W, Quan X, Li X

“…Therefore, this study used preoperative IVIM to predict VETC pattern in HCC and performed preoperative noninvasive recurrence risk stratification.Patients and Methods: Patients with suspicious HCC were included prospectively. …”
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Fu-Fang-Qi-Di-Hua-Yu-Tang Improves Diabetic Macrovascular Disease via PI3K/AKT Pathway Regulation by Zhang S, Yan M, Liang P, Zhang Y, Liu J, Huang H, Li G, Wu H

“…Shizhao Zhang,1,&amp;ast; Mei Yan,2,&amp;ast; Pengpeng Liang,1 Ye Zhang,3 Jiamin Liu,1 Hai Huang,1 Guiyun Li,1 Hongyan Wu1,2 1Shenzhen Hospital, Shanghai University of Traditional Chinese Medicine, Shenzhen, 518000, People’s Republic of China; 2School of Clinical Medicine, Jiangxi University of Chinese Medicine, Nanchang, 330000, People’s Republic of China; 3Pediatrics (TCM), Shenzhen Maternity and Child Healthcare Hospital Co-Construction Hospital, Shenzhen, 518000, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Hongyan Wu, Email wu.hy@163.comObjective: This study aimed to investigate the active ingredients and mechanisms of Fu-Fang-Qi-Di-Hua-Yu-Tang (FFQD) in alleviating atherosclerosis and insulin resistance in diabetic macrovascular disease (DMD) mice.Methods: Chemical profiling of FFQD was performed using UPLC-Q-TOF-MS. …”
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Comparative Cost-Effectiveness of Two Artificial Liver Therapies in Early-Stage Hepatitis B Virus-Related Acute-on-Chronic Liver Failure: A Retrospective Cohort Study by Chen J, Luo Q, Wang L, Zheng L, Zhang Y, Liu Y, Peng L, Xu W

“…Jia Chen,1,&amp;ast; Qiumin Luo,1,&amp;ast; Lu Wang,2,&amp;ast; Lihua Zheng,1 Yeqiong Zhang,1 Ying Liu,1 Liang Peng,1,3 Wenxiong Xu1 1Department of Infectious Diseases and Guangdong Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People’s Republic of China; 2Department of Diagnostics, second School of Clinical Medicine, Binzhou Medical University, Yantai, Shandong, People’s Republic of China; 3Key Laboratory of Tropical Disease Control, Ministry of Education, Sun Yat-sen University, Guangzhou, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Wenxiong Xu, Department of Infectious Disease, Third Affiliated Hospital of Sun Yat-sen University, 600&amp;num; Tianhe Road, Tianhe District, Guangzhou, Guangdong province, 510630, People’s Republic of China, Tel +8613760783281, Email xuwenx@mail.sysu.edu.cn Liang Peng, Department of Infectious Disease, Third Affiliated Hospital of Sun Yat-sen University, 600&amp;num; Tianhe Road, Tianhe District, Guangzhou, Guangdong province, 510630, People’s Republic of China, Tel +8613533978874, Email pliang@mail.sysu.edu.cnPurpose: This study aimed to compare the cost-effectiveness of the double plasma molecular adsorption system sequential low-volume plasma exchange (DPMAS+LPE) versus conventional plasma exchange (PE) in treating early-stage hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF).Patients and Methods: A total of 215 early-stage HBV-ACLF patients were assigned to either DPMAS+LPE or conventional PE groups. …”
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Long Non-Coding RNA lncTAF15:1-1 Promotes CCL5 Secretion and Cell Migration of Monocyte-Derived Dendritic Cells via PI3K/AKT/mTOR Pathway in Systemic Lupus Erythematosus by Xiang M, Sun Z, Ge Y, Zhang Z, Zheng C, Gao Z, Wang J, Xu J, Liang J, Wang Y

“…Hence, this study tried to reveal the underlying roles of one lncRNA, lncTAF15:1– 1, in modulating DC functions and its involvement with CCL5 secretion in SLE pathogenesis.Methods: The expression levels of lncTAF15:1– 1 were measured using qPCR in cultivated monocyte-derived dendritic cells (moDCs). …”
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CD8+ T Cell-Derived Perforin Exacerbates Dysbiosis and Inflammatory Bowel Disease via &amp;beta;-Hydroxybutyrate Suppression in Mouse Colonic Epithelium by Huang S, Pan L, Li M, Pang S, Tian Y, Shi W, Zong Y, Zhang D, Tian D

“…However, the exact mechanisms remain unclear.Methods: We applied a DSS-induced colitis model in wild-type and perforin-deficient (Prf1−/−) mice. …”
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Association Between Neutrophil Percentage to-Albumin Ratio, Neutrophil to-Lymphocyte Ratio, Platelet-to Lymphocyte Ratio and in-Hospital Mortality in Elder Patients with Bloodstrea... by Yu Z, Liu C, Gong M, Zhang P, Pei C, Liu X, Han X, Zhu P, Xu G, Du Y

“…This study aimed to investigate the association and the predictive value of NPAR, NLR and PLR with in-hospital mortality.Methods: This study included older patients with BSI who were hospitalized in a large healthcare center in Beijing from December 2011 to January 2024. …”
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Advancing Heart Valve Replacement: Risk Mitigation of Decellularized Pulmonary Valve Preparation for Its Implementation in Public Tissue Banks by Rodríguez Martínez JI, Castells-Sala C, Piteira AR, Montagner G, Trojan D, Martinez-Legazpi P, Acosta Ocampo A, Fernández-Santos ME, Bermejo J, Jashari R, Pérez ML, Agustí E, Tabera J, Vilarrodona A

“…The present study aims to document the work performed for the safe implementation in public tissue banks of a new decellularization method for human pulmonary heart valves, based on previous risk evaluation.Methods: After assessing new preparation method associated risks, using EuroGTP-II methodologies, an extensive array of in vitro studies were defined to validate the new technique, mitigate the risks and provide quality and safety data.Results: Initial evaluation of risks using EuroGTP II tool, showed Final Risk Score of 23 (high risk), and four studies were devised to mitigate identified risks: (i) tissue structure integrity; (ii) cell content; (iii) microbiological safety; and (iv) cytotoxicity evaluation in final tissue preparation. …”
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Reduced Thioredoxin Regulates IL-1&amp;beta; Secretion via NLRP3 of IL-1&amp;beta;+ Alveolar Macrophages in COPD by Wang L, Shi R, Li Z, Ma R, Wang C, Xu C, Guo R, Xiao C, Du X, Yang W

“…The aim of this paper is to investigate the changes in the redox protein thioredoxin (TRX) in COPD and the role TRX plays in IL-1β release.Methods: We analyzed data from single-cell RNA sequencing (scRNA-seq) of COPD lung tissue in the GEO database. …”
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Triphasic CT Radiomics Model for Preoperative Prediction of Hepatocellular Carcinoma Pathological Grading by Huang H, Pan X, Zhang Y, Yang J, Chen L, Zhao Q, Huang L, Lu W, Deng Y, Huang Y, Ding K

“…., Shanghai, 200232, People’s Republic of China; 3Department of Pathology, The Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530031, People’s Republic of China; 4Department of Radiology, The First People’s Hospital of Qinzhou, Qinzhou, Guangxi, 530550, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Ke Ding, Department of Radiology, The Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530031, People’s Republic of China, Email 272480365@qq.com Yingying Huang, Department of Radiology, The First People’s Hospital of Qinzhou, Qinzhou, Guangxi, 530031, People’s Republic of China, Email 273749105@qq.comObjective: This study aimed to develop and validate a triphasic CT-based radiomics model for the synchronous prediction of multiple critical pathological markers in hepatocellular carcinoma (HCC).Materials and Methods: This retrospective study analyzed 174 patients with 187 hepatocellular carcinoma (HCC) lesions. …”
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Preoperative radiological parameters correlated to hallux valgus recurrence after distal chevron metatarsal osteotomy by Y. Hernanz-González, J.C. Martínez-Ávila, E. Sánchez-Morata, A. Gómez-Sánchez, J.D. Serrano-Alonso, J. Vilá-Rico

“…Radiologic HV recurrence was defined by a final hallux valgus angle (HVA) equal or greater than 20 degrees. Conclusions: Greater age at time of surgical treatment and preoperative noncongruent I metatarsophalangeal joint were identified as predictors for HV recurrence. …”
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Mechanistic Insights into Shenzhuo Formula for Diabetic Retinopathy: Integrating UPLC-Q-TOF-MS/MS, Network Pharmacology, Single-Cell RNA Sequencing Data, and Experimental Validatio... by Zang X, Zhang L, Ma J, Wang A, Ding L, Wang Y, Sun J, Li J, Hang X, Li X, Zhao L

“…This study aims to investigate the underlying mechanisms of SZF to expand treatment strategies for DR.Methods: SZF components were analyzed using Ultra Performance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry/Mass Spectrometry (UPLC-Q-TOF-MS/MS). …”
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A Multi-Algorithm Machine Learning Model for Predicting the Risk of Preterm Birth in Patients with Early-Onset Preeclampsia by Xu Y, Zu Y, Zhang Y, Liang Z, Xu X, Yan J

“…Yanhong Xu,1,&amp;ast; Yizheng Zu,2,&amp;ast; Ying Zhang,1,&amp;ast; Zewei Liang,1 Xia Xu,1,3– 5 Jianying Yan1,3– 5 1College of Clinical Medicine for Obstetrics &amp; Gynecology and Pediatrics, Fujian Medical University Fujian Maternity and Child Health Hospital, Fuzhou, Fujian, People’s Republic of China; 2The Affiliated Changzhou Second People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, People’s Republic of China; 3Fujian Clinical Research Center for Maternal-Fetal Medicine, Fuzhou, Fujian, People’s Republic of China; 4Laboratory of Maternal-Fetal Medicine, Fujian Maternity and Child Health Hospital, Fuzhou, Fujian, People’s Republic of China; 5National Key Obstetric Clinical Specialty Construction Institution of China, Fuzhou, Fujian, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Xia Xu, College of Clinical Medicine for Obstetrics &amp; Gynecology and Pediatrics, Fujian Medical University Fujian Maternity and Child Health Hospital, No. 18 Daoshan Road, Gulou District, Fuzhou, Fujian, People’s Republic of China, Email xuxia0623@fjmu.edu.cn Jianying Yan, College of Clinical Medicine for Obstetrics &amp; Gynecology and Pediatrics, Fujian Medical University Fujian Maternity and Child Health Hospital, No. 18 Daoshan Road, Gulou District, Fuzhou, Fujian, People’s Republic of China, Email yanjy2019@fjmu.edu.cnPurpose: To analyze the risk factors for preterm birth in patients with early-onset preeclampsia (EOPE) based on multi-algorithm machine learning and to construct a predictive model to explore the predictive value of the model.Methods: A retrospective analysis was conducted on 442 EOPE patients from a single tertiary center, divided into preterm birth (&lt; 37 weeks, n=358) and term-born (≥ 37 weeks, n=84) groups. …”
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Insufficient Evidence to Recommend Shu Mian Capsule in Managing Depression With or Without Comorbid Insomnia: A Systematic Review With Meta-Analysis and Trial Sequential Analysis by Zhao FY, Xu P, Kennedy GA, Jin X, Wang YM, Zhang WJ, Yue LP, Ho YS, Fu QQ, Conduit R

“…Fei-Yi Zhao,1– 3,&ast; Peijie Xu,4,&ast; Gerard A Kennedy,2,&ast; Xiaochao Jin,5,6 Yan-Mei Wang,3 Wen-Jing Zhang,3 Li-Ping Yue,1 Yuen-Shan Ho,7 Qiang-Qiang Fu,8 Russell Conduit2 1Department of Nursing, School of International Medical Technology, Shanghai Sanda University, Shanghai, 201209, People’s Republic of China; 2School of Health and Biomedical Sciences, RMIT University, Bundoora, Melbourne, VIC, 3083, Australia; 3Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200071, People’s Republic of China; 4School of Computing Technologies, RMIT University, Melbourne, VIC, 3000, Australia; 5Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China; 6Shanghai Jiaotong University School of Nursing, Shanghai, People’s Republic of China; 7School of Nursing, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, People’s Republic of China; 8Yangpu Hospital, School of Medicine, Tongji University, Shanghai, 200090, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yuen-Shan Ho, School of Nursing, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, People’s Republic of China, Tel +852 2766-6410, Fax +852 2364-9663, Email janice.ys.ho@polyu.edu.hk Qiang-Qiang Fu, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, 200090, People’s Republic of China, Tel + 86 021-6569 0520, Fax + 86 021-6569 6249, Email qiangqiang.fu@tongji.edu.cnAim: This systematic review with trial sequential analysis (TSA) aims to evaluate the efficacy and safety of Shu Mian Capsule (SMC), a commercial Chinese polyherbal preparation, for managing depression with or without comorbid insomnia.Methods: Controlled clinical trials assessing SMC against waitlist control, placebo or active controls, or as an adjunct treatment were searched across seven databases. …”
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The Intelligence Structures of School-Age Children with Attention Deficit Hyperactivity Disorder: A Multicenter Cross-Sectional Study in China by Zhu L, Jia F, Cao A, Hao Y, Li F, Liu R, Li H, Yu X, Zhao J, Li F, Zhang Y, Yu Y, Wei H, Dai Y, Zhang X, Liu X, Peng B, Li T, Chen L

“…The present study was aimed at investigating the intelligence structures of school-age children with ADHD who speak Chinese, using a multicenter and large sample size approach, offering some references for clinicians.Patients and Methods: 772 children aged 6 to 12 years with ADHD took part in the cross-sectional study. …”
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