Congestion Enriches Intra-hepatic Macrophages Through Reverse Zonation of CXCL9 in Liver Sinusoidal Endothelial CellsSUMMARY by Siyuan Ma, Nawras W. Habash, Mrunal K. Dehankar, Nidhi Jalan-Sakrikar, Shawna A. Cooper, Abid A. Anwar, Sofia Jerez, Papawee Sutthirat, Jinhang Gao, Tamir Diamond, Jing Jiao, Caixin Qiu, Jingchun Yang, Sumera I. Ilyas, Markcus Lee, Usman Yaqoob, Sheng Cao, Rebecca G. Wells, Vijay H. Shah, Moira B. Hilscher

“…We studied spatial changes in immune cells in the sinusoid that contribute to congestive fibrosis and portal hypertension (PHTN). Methods: To visualize the distribution of immune cells in congestive hepatopathy (CH), we performed imaging mass cytometry (IMC) on liver tissue from patients with CH, Fontan-associated liver disease (FALD), and controls. …”
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Model of superior semicircular canal dehiscence: asymmetrical vestibular dysfunction induces reversible balance impairment by Sean S. Hong, P. Ashley Wackym, P. Ashley Wackym, Damian J. Murphy, Eran Peci, Matthew Y. Kiel, Aaron Tucker, Nicolas L. Carayannopoulos, Shrivaishnavi C. Chandrasekar, Nikhil Suresh, Umut A. Utku, Justin D. Yao, Justin D. Yao, Todd M. Mowery, Todd M. Mowery

“…In this study, we completed our assessment of this model to include reversible asymmetrical vestibular impairments that interfere with balance.MethodsAdult Mongolian gerbils (N = 6) were trained to complete a balance beam task. …”
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Catheter-associated urinary tract infections in urethral stricture patients indwelling suprapubic catheter: Insights from a retrospective investigation into specific antibiogram an... by Jiahao Lin, Changhao Hou, Yubo Gu, Wei Yuan, Xianjie Xiu, Zhenwei Yu, Ruihang Zhang, Guangyu Mao, Qiang Fu, Lujie Song

“…Clinical data, bacterial pathogens, and resistance patterns were collected. Heatmaps visualized resistance profiles. Descriptive statistics summarized demographics and perioperative variables; while binary logistic regression models were applied to identify independent risk factors for SPCAB and MDRB. …”
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The Connection between Galaxy Mergers, Star Formation, and Active Galactic Nuclei Activity in the HSC-SSP by Kiyoaki Christopher Omori, Connor Bottrell, Sabine Bellstedt, Aaron S. G. Robotham, Hassen M. Yesuf, Andy D. Goulding, Marcin Sawicki, Tohru Nagao, Tsutomu T. Takeuchi

“…We quantitatively examine the merger–SFR–AGN connection using Hyper Suprime-Cam Subaru Strategic Program (HSC-SSP) galaxies using novel methods for both galaxy classification and property measurements. …”
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Atelectasis predicts poor prognosis in pediatric macrolides-unresponsive Mycoplasma pneumoniae pneumonia with A2063/2064G mutations treated with azithromycin by Jie Cheng, Ya Liu, Guangli Zhang, Yuanyuan Li, Xiaoyin Tian, Liping Tan, Zhengxiu Luo

“…ObjectiveWe aimed to investigate prognostic indicators for pediatric macrolides-unresponsive Mycoplasma pneumoniae pneumonia (MUMPP) cases with A2063/2064G mutations with azithromycin therapy.MethodsThis was a retrospective observational cohort study conducted at the Children’s Hospital of Chongqing Medical University. …”
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Topical Application of VitB6 Ameliorates PM2.5-Induced Dry Eye via NFκB Pathway in a Murine Model by Jinyu Hu, Yanmei Zeng, Liying Tang, Lei Ye, Cheng Chen, Qian Ling, Xiaoyu Wang, Liangqi He, Xu Chen, Yixin Wang, Qianmin Ge, Yi Shao

“…<b>Background/Objectives:</b> Dry eye (DE) is mainly characterized by dryness, foreign body sensation, eye pain and visual impairment. Their possible causes are mainly inflammation, tissue damage and neurosensory abnormalities, and vitamin B6 (VitB6) attenuates the inflammatory response by modulating the NF-κB pathway to quench reactive oxygen species (ROS). …”
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Randomized controlled trial of nalfurafine for refractory pruritus in hemodialysis patients by Ping Zhang, Shilong Xiang, Bicheng Liu, Xiaohui Wang, Xiaoping Yang, Chaoyang Ye, Zunsong Wang, Yanlin Li, Li Zhou, Caili Wang, Hongbo Li, Jian Huang, Ai Peng, Xiaoping Wang, Deguang Wang, Jie Xiao, Wenli Chen, Hong Cheng, Nan Mao, Jianqin Wang, Lin Yang, Jianghua Chen

“…The primary end point was the mean decrease in the mean visual analogue scale (VAS) from baseline.Results A total of 141 patients were included. …”
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Safety Profile of Antipsychotics as Predictors of the Quality of Life in Patients with Schizophrenia—An Inpatient Welfare Institution-Based Cross-Sectional Study by Aleksandra D. Petrovic, Ana M. Barjaktarevic, Olivera Z. Kostic, Sara S. Mijailovic, Slobodan M. Jankovic, Marija V. Andjelkovic, Marijana S. Stanojevic Pirkovic, Katarina D. Parezanovic Ilic, Vladimir S. Janjic, Jana Mojsilovic, Jana Arsenijevic, Danijela B. Jovanovic, Sanja Knezevic, Nevena Folic, Milovan Stevic, Dejana Ruzic Zecevic, Nemanja Z. Petrovic, Marina J. Kostic

“…UKU scores were negatively correlated with the EuroQoL 5-Dimension 5-Level (EQ-5D-5L) index, Visual Analog Scale (VAS) score, the Quality-of-Life Enjoyment and Satisfaction Questionnaire—Short Form (Q-LES-Q-SF) score, and the scores of physical and psychological domains of the World Health Organization Quality-of-Life Scale (WHOQOL-BREF). …”
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Safety and cost analysis of selective histopathological examination following appendicectomy and cholecystectomy (FANCY study): protocol and statistical analysis plan of a prospect... by Willem A Bemelman, Pieter J Tanis, Lianne Koens, Vivian P Bastiaenen, Bartholomeus JGA Corten, Elise AJ de Savornin Lohman, Joske de Jonge, Anne C Kraima, Hilko A Swank, Jaap LP van Vliet, Gijs JD van Acker, Anna AW van Geloven, Klaas H in 't Hof, Philip R de Reuver, Charles C van Rossem, Gerrit D Slooter, Valeska Terpstra, Marcel GW Dijkgraaf

“…After visual inspection and digital palpation of the removed specimen, the operating surgeon will report whether macroscopic abnormalities suspicious for a malignant neoplasm are present, and if he or she believes additional microscopic examination by the pathologist is indicated. …”
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Comparison of seropositive and seronegative rheumatoid arthritis patients using or about to be initiated with biological DMARDS by Zehra Özsoy, Şerife Asya Germe, Gizem Ayan, Güllü Sandal Uzun, Mustafa Ekici, Erdinç Ünaldı, Levent Kılıç, Ali Akdoğan, Şule Apras Bilgen, Sedat Kiraz, Ali İhsan Ertenli

“…Demographic characteristics, disease duration, bDMARD use follow-up period, comorbidities, RA extra-articular findings, visual analog scale (VAS) global, VAS pain, VAS fatigue, Health Assessment Questionnaire-Disability index were recorded for RA patients included in the study. …”
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N-Butyl-2-Cyanoacrylate Adhesive Versus Absorbable Tacks in Laparoscopic Groin Hernia Repair: A Multicenter Randomized Clinical Trial by Clayton C. Petro, MD, Benjamin K. Poulose, MD, Michael J. Rosen, MD, Alfredo M. Carbonell, II, DO, Adel G. El-Ghazzawy, MD, Jeremy A. Warren, MD, Emanuele Lo Menzo, MD, Ajita S. Prabhu, MD, David M. Krpata, MD, Samuel Szomstein, MD, Vimal Narula, MD, Crystal F. Totten, MD, Kelly R. Haisley, MD, Andrew C. Bernard, MD, Henrik O. Berdel, MD, Jessica K. Reynolds, MD, Zachary D. Warriner, MD, John S. Roth, MD

“…The primary outcome was improvement in pain (visual analog scale [VAS]) at 6 months. The noninferiority margin was 0.9 (α = 0.025; β = 80%). …”
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Investigating the effects of mobile bottom fishing on benthic carbon processing and storage: a systematic review protocol by Stacey L. Felgate, John Aldridge, Stefan G. Bolam, Sarah Breimann, Emil de Borger, Jolien Claes, Jochen Depestele, Graham Epstein, Clement Garcia, Natalie Hicks, Michel Kaiser, Jack H. Laverick, Gennadi Lessin, Finbarr G. O’Neill, Sarah Paradis, Ruth Parker, Ryan Pereira, Alex J. Poulton, Claire Powell, Craig Smeaton, Paul Snelgrove, Justin Tiano, Johan van der Molen, Sebastiaan van de Velde, Marija Sciberras

“…Results will be reported in narrative and quantitative syntheses using a variety of visual tools including forest plots. Meta-analysis will be conducted where sufficient data exists.…”
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Effectiveness of Local Wound Infiltration with Morphine, Ketorolac, and Bupivacaine Compared to Bupivacaine Alone Following Tibial Osteotomy in Pediatric Patients: A Randomized Con... by Piyanuch Musikachart, Thanase Ariyawatkul, Jidapa Wongcharoenwatana, Nath Adulkasem, Perajit Eamsobhana

“…Primary outcomes were Visual Analog Scale (VAS) pain scores measured every 4 hours during the first 48 hours after surgery. …”
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Turtle Study: A Phase 2 Study of Durvalumab Plus Carboplatin and Etoposide in Elderly Patients With Extensive-Stage SCLC (LOGiK 2003) by Hidenobu Ishii, MD, PhD, Koichi Azuma, MD, PhD, Yuta Yamanaka, MD, Hiroshige Yoshioka, MD, PhD, Yukihiro Toi, MD, Naoki Shingu, MD, Katsuhiko Naoki, MD, PhD, Masaki Okamoto, MD, PhD, Yuko Tsuchiya-Kawano, MD, PhD, Taishi Harada, MD, Hiroyuki Inoue, MD, PhD, Hiroshi Ishii, MD, PhD, Kazunori Tobino, MD, PhD, Chiho Nakashima, MD, PhD, Yoshifusa Koreeda, MD, Yasushi Hisamatsu, MD, Shinsuke Tsumura, MD, Takashi Inagaki, MD, Keiko Mizuno, MD, PhD, Takayuki Shimose, MMath, Isamu Okamoto, MD, PhD

“…We evaluated the safety and efficacy of durvalumab plus carboplatin and etoposide in elderly patients with ES-SCLC. Methods: In this prospective, single-arm, multicenter, phase 2 clinical trial, patients with ES-SCLC aged above or equal to 75 years received chemotherapy with up to four cycles of durvalumab 1500 mg on day 1, carboplatin at a dose equivalent to an area under the curve of 5 on day 1, and etoposide 80 mg/m2 on days 1 to 3 every 3 weeks as induction therapy. …”
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Clinical characteristics and risk factors of bacillary layer detachment in central serous chorioretinopathy: a comparative multicenter study by Antonio M. Casella, Raphaela M. Fuganti, Ahmad M. Mansour, José Ignácio Fernández-Vigo, Suthasinee Sinawat, Ali Osman Saatci, Jay Chhablani, Arman Zarnegar, Juliana Prazeres, Igor Kozak, Lorenzo López Guajardo, Michel E. Farah, Claudio Zett, Francisco Rodriguez, William E. Smiddy, Janet L. Davis, Philip J. Rosenfeld, Stephen G. Schwartz, Luiz H. Lima, Maurício Maia

“…Inclusion criteria included a CSC diagnosis with RPE leakage, BALAD confirmed by three authors, age over 18, and a detailed medical history from the 30 days before symptom onset. The study assessed visual acuity, choroidal thickness, psychiatric disorders, corticosteroid use, prior CSC treatments, and hyperreflective material on OCT. …”
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Comparative Efficacy of Bone Graft Materials in Transforaminal Lumbar Interbody Fusion: A Systematic Review and Meta-Analysis by Sami Al Eissa, Fahad Al Helal, Majed Abaalkhail, Abdullah Al Shehri, Raed Al Mousa, Abdullah Bin Shabib, Hussam Al Angari, Abdulrahman M. AlJahani, Dana W. AlDughiman

“…Titanium cages had a fusion rate of 87% (95% CI: 75%-99%), with moderate heterogeneity (I² = 79.9%). Visual Analogue Scale (VAS) scores for back pain in Heinz et al. (2017) decreased from 7.47 to 3.08 in Group A and from 6.78 to 3.17 in Group B at 12 months post-op. …”
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Association between out-of-pocket expenditure and health-related quality of life among patients receiving cancer treatment: a cross-sectional study from Nepal by Pratik Khanal, Suman Sapkota, Nirmal Poudel, Achyut Raj Pandey, Bidwata Bhattarai, Etna Khatiwada, Ravi Kant Mishra, Biraj Man Karmacharya, Shiva Raj Adhikari, Kjell Arne Johansson, Krishna Kumar Aryal

“…We used the European Quality of Life 5 dimensions (EQ-5D-5L) and the European Quality of Life Visual Analogue Scale (EQ-VAS) to obtain their HRQoL. …”
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Effects of exercise and exercise timing on energy intake and appetite control in Danish individuals with overweight or obesity with and without type 2 diabetes: a protocol for a ra... by Louise Groth Grunnet, Martin Bæk Blond, Jonas Salling Quist, Kristine Beaulieu, Graham Finlayson, Kristine Færch, Lea Jalking, Natja Poder Launbo, Marie Møller Jensen, Hanne Enghoff Pedersen, Marina Kjærgaard Gerstenberg

“…Blood samples will be collected and subjective appetite will be assessed using Visual Analogue Scales in the fasted state before exercise/rest, immediately post-exercise/rest and at 15, 30, 45 and 60 min post-exercise/rest. …”
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Efficiency and safety of leflunomide in rheumatoid arthritis: Results of a Russian observational multicenter of trial by R. M. Balabanova, T. V. Dubinina, D. V. Goryachev, O. N. Anoshenkova, E. A. Antonova, I. Yu. Ilyevsky, O. V. Semagina, N. V. Yasyukevih

“…In 2011, the Russian Federation registered and since it has been successfully using leflunomide**.Objective: to evaluate the efficacy and tolerability of leflunomide** used to treat RA in routine clinical practice.Subjects and methods.The investigation enrolled patients with varying duration of RA that met the 1987 classification criteria. …”
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Dynamical network-based evaluation for neuromuscular dysfunction in stroke-induced hemiplegia during standing by Jinping Li, Na Zhang, Ying Xu, Juan Wang, Xianglian Kang, Runing Ji, Ke Li, Ying Hou

“…The DC values and rankings of back, hip and calf muscles on the affected side were significantly decreased, whereas those on the unaffected side were significantly increased in hemiplegia group compared with the healthy group (p < 0.05). Without visual feedback, subjects exhibited enhanced muscle coordination and increased muscle involvement (p < 0.05). …”
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