The Effect of Polymorphisms in the CYP2D6 and CYP2C9 Genes on the Clinical Efficacy of Tramadol and Ketorolac When Using the Accelerated Recovery Protocol in Patients With Uncompli... by A. A. Muradyan, D. A. Blagovestnov, D. A. Sychev, P. A. Yartsev, M. L. Rogal, L. N. Kerimova, V. T. Koroshvili, I. A. Yepifanova

“…Analgesic efficacy was assessed using a visual analog scale (VAS) and McGill Pain Questionnaire.Results. …”
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Episode-specific cortical functional connectome reorganization and neurobiological correlates in bipolar disorder: a cross-sectional study by Xiaobo Liu, Bin Wan, Xi-Han Zhang, Ruifang Cui, Siyu Long, Ruiyang Ge, Lang Liu, Jinming Xiao, Zhen-Qi Liu, Jiadong Yan, Ke Xie, Meng Yao, Xin Wen, Sanwang Wang, Yujun Gao

“…The mBD showed expanded visual and prefrontal regions but compressed motor and precuneus regions. …”
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Melanin-concentrating hormone attenuates the hedonic feeding induced by orexin-A in the ventral tegmental area of high-fat diet male mice by Xiaoning Liu, Xiaoning Liu, Helin Yang, Wenguang Xu, Xuezhe Wang, Wenhui Tang, Xiaoxuan Wang, Yang Jiao, Xinchi Luan, Pengmeng Li, Feifei Guo

“…To visualize the projections from the LHA to VTA, we employed fluorescent gold retrograde tracing combined with immunofluorescence staining. …”
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Comparison of clinical effectiveness between stapled transanal rectal resection and procedure for prolapse and hemorrhoids for young male patients with prolapsed hemorrhoids by Pei Yan, Gao Jihua, Qi Wenyue, Tian Maosheng, Wu Qiong, Duan Bingqian, Wang Ran, Liu Ziyi

“…[Objectives] To compare the clinical effectiveness between stapled transanal rectal resection (STARR) and procedure for prolapse and hemorrhoids (PPH) for young male patients with prolapsed hemorrhoids. [Methods] This was a retrospective analysis of 84 young male patients with prolapsed hemorrhoids who were treated at the Department of Colorectal Surgery, The First Affiliated Hospital of Hebei College of Chinese Medicine, between January 2019 and December 2019. …”
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Psychiatric drugs dispensing trends in the affected population following Brumadinho dam failure by Marcelo Farah Dell'Aringa, Gabriel Elias Correa-Oliveira, Francesco Della Corte, Luca Ragazzoni, Ives Hubloue, Virginia Murray, Thais Piazza, Claudia Garcia Serpa Osorio-de-Castro, Elaine Miranda, Francesco Barone-Adesi

“…This study aims to investigate the impact of this disaster in the dispensing of psychiatric drugs.MethodsWe evaluated monthly aggregated data from 12 months before to 12 months after the event from two data sources, one accounting for psychiatric drugs dispensed by private pharmacies and the other by public health services. …”
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Global trends and interdisciplinary insights in Tai Chi research: a bibliometric analysis (2004–2024) by Bei Li, Xiwei Zhu, Xiwei Zhu, Xiwei Zhu, Haoli Zhang, Su Zhang, Yanwei Li, Shuxi Wu, Shuxi Wu, Shuxi Wu, Jie Han, Jie Han, Jie Han

“…Therefore, a bibliometric analysis of Tai Chi literature can help us better understand the research status and development trends in this field.MethodsThe article and commentary on Tai Chi from 2004 to 2024 were retrieved from the Web of Science Core Collection. …”
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Performance and Safety of a Sodium Hyaluronate, Xanthan Gum, and Osmoprotectants Ophthalmic Solution in the Treatment of Dry Eye Disease: An Observational Clinical Investigation by Mercedes Molero Senosiaín, Barbara Burgos-Blasco, Pilar Perez-García, Álvaro Sánchez-Ventosa, Marta Villalba-González, María Dolores López Pérez, José Carlos Díaz, Vanesa Díaz-Mesa, Alberto Villarrubia Cuadrado, Enrique Artiaga Elordi, Jose Manuel Larrosa Poves, Alejandro Blasco, Antonio Mateo, Claudine Civiale, Laura Bonino, Antonio Cano-Ortiz

“…The investigation assessed corneal and conjunctival fluorescein staining (NEI score), hyperemia index (Keratograph®), fluorescein tear film break-up time (TFBUT), best-corrected visual acuity, dry eye symptoms (SANDE), and quality of life (DEQS). …”
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Performance Comparison of 10 State-of-the-Art Machine Learning Algorithms for Outcome Prediction Modeling of Radiation-Induced Toxicity by Ramon M. Salazar, PhD, Saurabh S. Nair, MS, Alexandra O. Leone, MBS, Ting Xu, PhD, Raymond P. Mumme, BS, Jack D. Duryea, BA, Brian De, MD, Kelsey L. Corrigan, MD, Michael K. Rooney, MD, Matthew S. Ning, MD, Prajnan Das, MD, Emma B. Holliday, MD, Zhongxing Liao, MD, Laurence E. Court, PhD, Joshua S. Niedzielski, PhD

“…Figures were generated to visually compare the performance of the algorithms. …”
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Prediction of EGFR mutations in non-small cell lung cancer: a nomogram based on 18F-FDG PET and thin-section CT radiomics with machine learning by Jianbo Li, Qin Shi, Yi Yang, Jikui Xie, Qiang Xie, Ming Ni, Xuemei Wang, Xuemei Wang

“…Radiomics-based nomograms provide a non-invasive and visually intuitive prediction tool for screening NSCLC patients with EGFR mutations in a clinical setting.…”
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The interdependence of mid-trimester blood pressure and glucose levels in shaping fetal growth and neonatal outcomes: implications for risk–benefit assessment and co-management by Lijuan Lv, Jingbo Yang, Linjie Li, Chuanyi Huang, Huihua Shi, Yiwen Fang, Lushu Zuo, Ting Liu, Hongli Duan, Jiying Wen, Qing Yang, Amanda Henry, Cha Han, Aihua Yin, Xin Zhou

“…Heatmaps were created to visualize the contributions of BP and FPG by categorizing them into ordered groups. …”
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Effect of simultaneous intravitreal ranibizumab and extended-release dexamethasone injection on patients with naïve versus refractory retinal vein occlusion macular edema: a prospe... by Yao-Yao Sun, Jie Meng, Shan-Shan Li, Qin Xiao, Tian-Zi Zhang, Heng Miao, Ming-Wei Zhao, Hui-Jun Qi

“…The mean changes in best-corrected visual acuity (BCVA) and central macular thickness (CMT) were measured as main outcomes. …”
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Modified double-row suture bridge technique for anterior colliculus fractures combined with deltoid ligament injury: a retrospective study by Jianlong Ni, Zhihao Chen, Wang Wei, Ruiying Li, Dazhi Wang, Dongjian Wang, Zenan Tian, Zhikun Jia, Qichun Song, Meng Feng, Zhibin Shi

“…The purpose of the present study was to describe the application of a modified double-row suture bridge technique and evaluate its early clinical outcomes in the management of anterior colliculus fracture combined with deltoid ligament injury. Methods From 2020 to 2022, 12 patients with anterior colliculus fracture combined with deltoid ligament injury were treated using a modified double-row suture bridge technique. …”
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Rapid detection of SARS-CoV-2 RNA using a one-step fast multiplex RT-PCR coupled to lateral flow immunoassay by Insaf Bel Hadj Ali, Hejer Souguir, Mouna Melliti, Mohamed Vall Taleb Mohamed, Monia Ardhaoui, Kaouther Ayouni, Sondes Haddad-Boubaker, Yusr Saadi Ben Aoun, Henda Triki, Ikram Guizani

“…Methods We developed various simplex fast-PCRs for screening sets of primer pairs newly designed or selected from literature or from validated WHO diagnostics, targeting S, N, E, RdRp or ORF1ab genes. …”
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Pointwise Structure–Function Analysis of the Ellipsoid Zone in Retinitis Pigmentosa Using an Artificial Intelligence-Assisted OCT and Microperimetry Overlay by Jesse A. Most, BA, An D. Le, MS, PhD, Melanie D. Tran, BS, Evan H. Walker, MS, Aneesh Swamy, Dirk-Uwe G. Bartsch, PhD, William R. Freeman, MD, Truong Nguyen, PhD, Cheolhong An, PhD, Shyamanga Borooah, MBBS, PhD

“…Subjects: Patients with clinically confirmed RP. Methods: Same-day spectral-domain OCT (SD-OCT) and microperimetry near-infrared images were overlaid in patients with confirmed RP. …”
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Prevention of extubation failure in neurocritical care patients with residual disorder of consciousness: the Brain-Injured Patients Extubation Readiness (BIPER) study protocol for... by Emmanuel Futier, Bruno Pereira, Russell Chabanne, Elodie Caumon, Dominique Morand, Audrey De Jong, Jean-Michel Constantin, Matthieu Jabaudon, Thomas Godet, Benjamin Andanson, Pierre Borrel, Leo Astier, Nathalie Bourguignon, Lise Laclautre

“…The intervention condition consists of extubation triggered by a clinical score evaluating deglutition, gag reflex, cough and visual tracking (Coma Recovery Scale-Revised Visual Scale).Objective: To determine whether adoption of an extubation protocol based on a clinical score can lessen extubation failure compared with usual care in brain-injured patients with residual disorder of consciousness.Outcome: The primary outcome measure is extubation failure, defined within 5 days following extubation. …”
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Surviving Persecution: Ismailism and Taqiyyah in the Centuries after the Mongol Invasion by Shafique N. Virani, Seddigheh Kardan, Zeinab Farokhi

“…One of their methods of survival was pious circumspection (taqiyyah), in its multiple meanings. …”
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A RT-ERA-CRISPR/Cas12a assay for rapid point-of-care duck hepatitis A virus detection by Di Sun, Yukun Zhu, Mingshu Wang, Jingming Wang, Wenze Cheng, Zheng Li, Yuan Deng, Xumin Ou, Renyong Jia, Shun Chen, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Yu He, Zhen Wu, Anchun Cheng

“…Isothermal amplification technologies are often combined with lateral flow assays or visual readout methods for detecting pathogen nucleic acids in non-laboratory settings. …”
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Vaccination coverage, hesitancy and associated factors: a household survey of a cohort of children born in 2017 and 2018 in urban areas of state capital cities in the Brazilian Nor... by Ramon da Costa Saavedra, Martha Suely Itaparica de Carvalho Santiago, Maria da Glória Lima Cruz Teixeira, Maria Bernadete de Cerqueira Antunes, Rejane Christine de Sousa Queiroz, Luisa Helena de Oliveira Lima, Alberto Novaes Ramos Jr, Anderson Fuentes Ferreira, Adjoane Mauricio Silva Maciel, Jaqueline Caracas Barbosa, Ana Paula França, Carla Magda Allan Santos Domingues, José Cássio de Moraes, Adriana Ilha da Silva, Alberto Novaes Ramos Jr., Ana Paula França, Andrea de Nazaré Marvão Oliveira, Antonio Fernando Boing, Carla Magda Allan Santos Domingues, Consuelo Silva de Oliveira, Ethel Leonor Noia Maciel, Ione Aquemi Guibu, Isabelle Ribeiro Barbosa Mirabal, Jaqueline Caracas Barbosa, Jaqueline Costa Lima, José Cássio de Moraes, Karin Regina Luhm, Karlla Antonieta Amorim Caetano, Luisa Helena de Oliveira Lima, Maria Bernadete de Cerqueira Antunes, Maria da Glória Lima Cruz Teixeira, Maria Denise de Castro Teixeira, Maria Fernanda de Sousa Oliveira Borges, Rejane Christine de Sousa Queiroz, Ricardo Queiroz Gurgel, Rita Barradas Barata, Roberta Nogueira Calandrini de Azevedo, Sandra Maria do Valle Leone de Oliveira, Sheila Araújo Teles, Silvana Granado Nogueira da Gama, Sotero Serrate Mengue, Taynãna César Simões, Valdir Nascimento, Wildo Navegantes de Araújo

“…Results Natal was the capital with the lowest vaccination coverage, below 75.0% for most immunizers. Teresina had rates equal to or greater than 90.0% for all vaccines. …”
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Global burden of breast cancer and application of patient-reported outcomes in clinical trials: a systematic analysis based on the global burden of disease study 2021 and WHO inter... by Jiaxin Hao, Jiaxin Hao, Yijia Gong, Yijia Gong, Xiaowen Zhang, Xiaowen Zhang, Xiaowen Zhang, Minghong Du, Minghong Du, Minghong Du, Huan Wang, Huan Wang, Huan Wang, Guolin Guo, Mengqing Zhou, Tian Tian, Hongguo Rong, Hongguo Rong, Hongguo Rong

“…This study aims to evaluate the global burden and the application of patient-reported outcomes (PROs) in clinical trials of breast cancer.MethodsData of breast cancer burden is extracted from the Global Burden of Disease Study (GBD) 2021 database. …”
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Acute Pharmacological Effects of Two Synthetic Cathinones in Humans: An Observational Study of <i>N</i>-Ethylhexedrone and <i>N</i>-Ethyl-nor-pentedrone by Melani Núñez-Montero, Clara Pérez-Mañá, Olga Hladun, Lourdes Poyatos, Dolly Andrea Caicedo, Georgina De la Rosa, Martha Catalina Argote, Soraya Martín, Mireia Ventura, Nunzia La Maida, Annagiulia Di Trana, Silvia Graziano, Simona Pichini, Magì Farré, Esther Papaseit

“…However, still, little is known with regard to their pharmacological effects in humans. <b>Methods</b>: For the first time, we conducted a naturalistic, prospective observational study in 16 participants (7 women and 9 men) with a previous history of psychostimulant recreational use. …”
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