A predictive model for Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis by Rui Huang, Rui Huang, Dan Wu, Dan Wu, Ling Wang, Ling Wang, Ping Liu, Ping Liu, Xiaoru Zhu, Xiaoru Zhu, Leqiu Huang, Leqiu Huang, Mengmeng Chen, Mengmeng Chen, Xin Lv, Xin Lv

“…The outcome of this study carries important clinical value for early diagnosis and treatment of EBV-HLH.MethodsA retrospective analysis was conducted on 60 patients diagnosed with EBV-HLH and 221 patients diagnosed with EBV-IM at our hospital between November 2018 and January 2024. …”
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A Study of Multimodality Imaging Features of Brown Tumor or Osteitis Fibrosa Cystica by Dhruv Patel, Abhijeet Ashok Salunke, Nandlal Bharwani, Ritesh Suthar, Umank Tripathi, M. Varun, Dipesh Dave, Keval Patel, Vikas Warikoo, Jebin Aron, Rahul Shah, Shashank J. Pandya

“…We performed paired t-tests on the blood investigation values and Visual Analog Scale (VAS) scores for all patients. …”
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The potential for dementia prevention in Brazil: a population attributable fraction calculation for 14 modifiable risk factorsResearch in context by Claudia K. Suemoto, Wyllians V. Borelli, Ismael L. Calandri, Laiss Bertola, Raphael M. Castilhos, Paulo Caramelli, Ricardo Nitrini, Sonia M.D. Brucki, Jerson Laks, Naaheed Mukadam, Gill Livingston, Cleusa P. Ferri

“…The three risk factors with the highest PAFs were less education (9.5%, 95% CI = 8.9–10.1), untreated visual loss (9.2%, 95% CI = 8.6–9.8), and midlife depression (6.3%, 95% CI = 5.8–6.8). …”
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Unravelling Metazoan and Fish Community Patterns in Yujiang River, China: Insights from Beta Diversity Partitioning and Co-Occurrence Network by Yusen Li, Dapeng Wang, Yuying Huang, Jun Shi, Weijun Wu, Chang Yuan, Shiqiong Nong, Chuanbo Guo, Wenjian Chen, Lei Zhou

“…However, traditional survey methods often fail to comprehensively capture species diversity, particularly for low-abundance taxa. …”
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Venous Sinus Stenting Using a Ledge‐Reducing Catheter, 0.088‐in. Catheter‐Extender With an External Single Point of Control: Technique and Multicenter Clinical Experience by Oded Goren, Fabio Settecase, George Luh, Tareq Kass‐Hout, Rami Morsi, Coleman O. Martin, Ahmad K. Almekkawi, Nicholas A. Telischak, Matthew D. Alexander, Michael G. Abraham, Sivani Lingam, Ramesh Grandhi, M. Shazam Hussain, Tudor G. Jovin, Priyank Khandelwal, Thanh T. Nguyen, Piers Klein, Joey D. English, Mohamad K. Abdalkader

“…The primary indication for venous stenting was intracranial hypertension (79%, 56/71) and/or debilitating pulsatile tinnitus (87%, 62/71). Visual changes were present in 74%, with papilledema in 63%. …”
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Epidemiological trends of hepatitis C incidence and death in Mainland China between 2004 and 2018 and its predictions to 2030 by Guo Tian, Yang Zheng, Yinghua He, Can Chen, Xiaobao Zhang, Yuxia Du, Shigui Yang, Tianan Jiang, Lanjuan Li

“…Temporal-spatial scanning analysis was conducted to visualize the grading of hepatitis C incidence in mainland China. …”
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Varied cellular abnormalities in thin vs. normal endometrium in recurrent implantation failure by single-cell transcriptomics by Xiaoying Fu, Xiaoyan Guo, Han Xu, Yini Li, Bihui Jin, Xirong Zhang, Chongyi Shu, Yuhang Fan, Yiqi Yu, Yuqing Tian, Jiao Tian, Jing Shu

“…Scanning and transmission electron microscopy were employed to visualize ultrastructural details of the endometrial tissue, while hematoxylin and eosin staining facilitated the examination of tissue morphology and cellular composition. …”
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Effect of fusion and arthroplasty for cervical degenerative disc disease in patients with physically demanding occupations by Harjot Uppal, MBA, George Abdelmalek, MD, Neil Patel, MD, Daniel Coban, MD, Stuart Changoor, MD, Nikhil Sahai, MD, Kumar Sinha, MD, Ki Hwang, MD, Arash Emami, MD

“…Functional outcomes were measured using the Visual Analog Scale for neck and arm pain (VAS-neck, VAS-arm) and the Neck Disability Index (NDI), with attention to timelines for returning to full-time work. …”
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Predicting the risk of postoperative avascular necrosis in patients with talar fractures based on an interpretable machine learning model by Jian Zhang, Jian Zhang, Jian Zhang, Jihai Xu, Jihai Xu, Jiapei Yu, Jiapei Yu, Jiapei Yu, Hong Chen, Hong Chen, Xin Hong, Songou Zhang, Xin Wang, Xin Wang, Chengchun Shen, Chengchun Shen, Chengchun Shen

“…PurposeThis study aims to develop and validate an interpretable machine learning model for predicting avascular necrosis (AVN) following talar fracture, thereby aiding in personalized prevention and treatment.MethodsA retrospective cohort study included patients undergoing surgical intervention for talar fractures at Ningbo No.6 Hospital between January 2018 and December 2023. …”
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Study of Concentration of Angiotensin-Converting Enzyme 2 Receptor Proteins in Different Age-groups and Genders with Reference to Susceptibility toward Severe Acute Respiratory Syn... by Shareef M Buvvaji, Vinod Joshi, Bennet Angel, Annette Angel, Poorna Khaneja, Monika Dheer, Bhawna Sharma, Neha Singh, Shilpa Barthwal, Ramesh Joshi, Ambreen S Khan, Nuzhat M Peer, Khushbu Kumari, Reshu Chauhan, Aarya Chitransh

“…Conclusion: The study highlighted that there was equal expression of ACE2 in all age-groups and genders, and that ACE2 did not emerge as the determinant of susceptibility of a person toward SARS-CoV-2 infection.…”
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Greater pain and functional impairment in chronic erosive hand osteoarthritis compared to treated rheumatoid arthritis: A comparative study by S. Berkani, S. Tuffet, A. Rousseau, N. Rincheval, E. Maheu, B. Combes, A. Saraux, B. Fautrel, L. Gossec, F. Berenbaum, J. Sellam, A. Courties

“…Objectives: To compare the burden of established chronic rheumatoid arthritis (RA) and erosive hand osteoarthritis (EHOA), in terms of pain, functional impairment, comorbidities, and cardiometabolic diseases (CMD). Methods: This study included EHOA patients from the inclusion visit of the DIGICOD cohort and RA patients from the 10th year visit of the ESPOIR cohort. …”
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A pilot study to explore utility of electronic informed consent in a low- income setting; the case of a Controlled human infection study in Blantyre, Malawi [version 2; peer review... by Clara Ngoliwa, Joel Gondwe, Chikondi Chakwiya, Anthony E. Chirwa, Pemphero Liwonde, Evaristar Kudowa, Vitumbiko Nkhoma, Linda Chantunga, Modesta Reuben, Edward Mangani, Tiferanji Sochera, Neema Toto, Lumbani Makhaza, Dingase Dula, Stephen B. Gordon, Ben Morton, Tarsizio Chikaonda, Marc Y.R. Henrion, Edna Nsomba

“…Objectives We aimed to explore the utility of electronic consent (e-consent) in an ongoing human infection study in Blantyre, Malawi. Methods The approved paper consent forms were digitized using Open Data Kit (ODK). …”
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Scleral Buckling for Primary Retinal Detachment: Outcomes of Scleral Tunnels versus Scleral Sutures by Matthew R. Starr, Edwin H. Ryan, Anthony Obeid, Claire Ryan, Xinxiao Gao, Malika L. Madhava, Sean M. Maloney, Adam Z. Adika, Krishi V. Peddada, Kareem Sioufi, Luv G. Patel, Michael J. Ammar, Nora J. Forbes, Antonio Capone Jr., Geoffrey G. Emerson, Daniel P. Joseph, Dean Eliott, Carl D. Regillo, Jason Hsu, Omesh P. Gupta, Yoshihiro Yonekawa, for the Primary Retinal Detachment Outcomes (PRO) Study Group

“…Pre- and postoperative variables were evaluated including visual acuity, anatomic success, and postoperative strabismus. …”
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Herbal extract (Cervus elaphus Linnaeus, Angelica gigas Nakai, and Astragalus membranaceus Bunge) ameliorates chronic fatigue: A randomized, placebo-controlled, double-blind trial by SoYoung Ahn, Parivash Jamrasi, Byunggul Lim, Ji-won Seo, Xinxing Li, Shu Jiang, Yunho Sung, Seo Hyun Ahn, Chaeyoung Shin, Dongjin Noh, Bora Jin, Seonjoo Lee, Ki Won Lee, Jin Soo Kim, Young Tae Koo, Wook Song

“…Results: A significant improvement in overall fatigue scores was observed on the fatigue severity scale (p = 0.038), multidimensional fatigue inventory (p = 0.037), and 24-hour visual analog scale (p = 0.002) in the CAA group compared to those in the placebo group. …”
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Clinical manifestation and management of severe blepharokeratoconjunctivitis combined with corneal perforation by Xu Li, Ping Hou, Xiao-Lin Qi, Su-Xia Li, Wei-Yun Shi, Hua Gao, Ting Zhang

“…A paired t-test was used to compare the uncorrected visual acuity (UCVA) before and after surgery for the perforated eye. …”
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Nitrogen dioxide exposure attenuates or even reverses the association between physical activity and fasting plasma glucose levels in non-diabetic elderly Chinese adults by Chen Zhang, Qingsi Wu, Xuqiu Cheng, Ziwei Tian, Junzhe Li, Qiang Liu, Yan Zhang, Xianwei Guo, Guimei Chen, Huaibiao Li, Changliu Liang, Bing Hu, Dongmei Zhang, Chunmei Liang, Jie Sheng, Fangbiao Tao, Jun Wang, Yuyou Yao, Linsheng Yang

“…This study aimed to examine whether long-term exposure to NO2 attenuates the association between PA and FPG levels in non-diabetic older adults. Methods A total of 2600 non-diabetic elderly Chinese adults were included in this cross-sectional study. …”
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Safety and efficacy of MCO-010 optogenetic therapy in patients with Stargardt disease in USA (STARLIGHT): an open-label multi-center Ph2 trialResearch in context by Byron L. Lam, Vitaliy Zak, Victor H. Gonzalez, Ninel Z. Gregori, Sai H. Chavala, Subrata Batabyal, Michael Carlson, Sanghoon Kim, Ananta Ayyagari, Jean Chang, Hayley Lane, Nozhat Choudry, John Koester, Mark Von Tress, Jody Piltz-Seymour, Najam A. Sharif, Stephen H. Tsang, Vinit B. Mahajan, David S. Boyer, Allen C. Ho, Samuel B. Barone, Samarendra K. Mohanty

“…Visual field perimetry and Michigan Retinal Degeneration Questionnaire (MRDQ) were exploratory endpoints. …”
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Gene-environment interactions and colorectal cancer risk: A case-control study on xenobiotic metabolizing enzyme polymorphisms in the Jammu& Kashmir, India population by Gowhar Rashid, Gulzar A. Bhat, Tahseen Bilal Rather, Kulsum Akhter, Ishrat Parveiz, Irfan Maqbool, Syed Nisar Ahmad, Malik Tariq Rasool, Farooq Ahmad Jan, Syed Mudassar

“…The study included 246 histopathologically confirmed colorectal cancer (CRC) cases, and an equal number of matched controls based on age (±5 years), gender, and place of residence. …”
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Disease phenotypic and outcome of very-early onset inflammatory bowel disease in Asian children: an understudied population by Way-Seah Lee, Way-Seah Lee, Kee-Seang Chew, James-Guoxian Huang, James-Guoxian Huang, Pornthep Tanpowpong, Karen S. C. Mercado, Almida Reodica, Veena Logarajah, K. L. W. Hathagoda, Shaman Rajindrajith, Yoko Kin-Yoke Wong, Suporn Treepongkaruna, Marion Margaret Aw, Marion Margaret Aw

“…We studied disease phenotype, clinical characteristics, management and outcome of VEO-IBD in South and Southeast Asian children.Materials and methodsWe extracted data from a multicentre Asian pediatric (onset <18 years) IBD registry. …”
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Effect of <i>CTLA4</i> gene polymorphism on relapse probability among patients with acute leukemias after allogenic hematopoietic stem cells transplantation by D. S. Romaniuk, A. A. Khmelevskaya, M. Yu. Drokov, N. N. Popova, V. A. Vasilieva, L. A. Kuzmina, G. A. Efimov, E. N. Parovichnikova, V. G. Savchenko

“…The overall survival, the event-free survival and relapse probability were calculated using the Kaplan–Mayer method. A log-rank test was used to assess the statistical significance of group disparities. …”
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