Geometrical Features of Subbasal Corneal Whorl-like Nerve Patterns in Dry Eye Disease by Ziqing Feng, MD, Kang Yu, MD, Yupei Chen, MS, Gengyuan Wang, MS, Yuqing Deng, MD, Wei Wang, MD, Ruiwen Xu, MD, Yimin Zhang, MD, Peng Xiao, PhD, Jin Yuan, MD, PhD

“…Participants: The study included 29 healthy subjects (51 eyes) and 62 DED patients (95 eyes). Methods: All subjects underwent comprehensive ophthalmic examinations, dry eye tests, and in vivo confocal microscopy to visualize the whorl-like corneal nerve at the inferior whorl (IW) region and the straight nerve at the central cornea. …”
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Exploring family physicians’ mental health referrals via centralized referral systems in Quebec, Canada: a qualitative descriptive study by Jessica Spagnolo, Marie Beauséjour, Marie-Josée Fleury, Jean-François Clément, Claire Gamache, Lyne Couture, Carine Sauvé, Shane Knight, Christine Gilbert, Richard Fleet, Helen-Maria Vasiliadis

“…Methods: A qualitative descriptive study with 20 participants working in the healthcare sector was conducted. …”
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The efficacy and safety of glycosaminoglycan-peptide complex in patients with knee osteoarthritis and comorbidity: a multicenter prospective study by L. I. Alekseeva, E. A. Taskina, N. G. Kashevarova, E. P. Sharapova, E. A. Strebkova, S. G. Anikin, N. V. Chichasova, T. A. Raskina, E. V. Zonova, E. N. Otteva, E. I. Shmidt, S. P. Yakupova, I. B. Vinogradova, O. N. Ivanova, V. A. Lila, B. V. Zavadovsky, P. A. Shesternya, A. M. Lila

“…Objective: to evaluate the efficacy and safety of glycosaminoglycan-peptide complex (GPC, Rumalon) used in patients with knee osteoarthritis (OA) and comorbidities (hypertension and/or type 2 diabetes mellitus (T2DM).Patients and methods: A 10-month multicenter (13 centers from 10 subjects of the Russian Federation) prospective study included 179 patients with Stages II–III primary tibiofemoral knee OA and comorbidity, a walking pain intensity of ≥40 mm on a visual analogue scale (VAS), and a need for nonsteroidal anti-inflammatory drugs (for at least 30 days in the previous 3 months). …”
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Machine Learning Model Based on Prognostic Nutritional Index for Predicting Long‐Term Outcomes in Patients With HCC Undergoing Ablation by Nan Zhang, Ke Lin, Bin Qiao, Liwei Yan, Dongdong Jin, Daopeng Yang, Yue Yang, Xiaohua Xie, Xiaoyan Xie, Bowen Zhuang

“…The PDP and SHAP algorithms were employed for visual interpretation. Furthermore, time‐AUC and decision curve analysis demonstrated that the Aorsf model provided superior clinical benefits compared to other models. …”
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Does the number of drain tubes influence the formation of postoperative spinal epidural hematoma following biportal endoscopic unilateral laminotomy for bilateral decompression (BE... by Zhuolin Zhong, Jingjing Ying, Shaohua Zhang, Kaili Cai, Xiaowei Jing, Zhengyu Xu, Lejian Jiang, Tianxin Wu, Guojun Wei, Qingfeng Hu

“…Demographic data were collected, including preoperative visual analog scale (VAS) scores for leg pain and preoperative blood pressure (BP). …”
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Opioid versus opioid-free analgesia after surgical discharge: protocol for a systematic review and meta-analysis by Charbel El-Kefraoui, Ghadeer Olleik, Marc-Aurele Chay, Araz Kouyoumdjian, Philip Nguyen-Powanda, Fateme Rajabiyazdi, Uyen Do, Alexa Derksen, Tara Landry, Alexandre Amar-Zifkin, Agnihotram V. Ramanakumar, Marc-Olivier Martel, Gabriele Baldini, Liane Feldman, Julio F Fiore Jr

“…When trials report outcomes for a common domain (eg, pain intensity) using different scales, we will convert effect sizes to a common standard metric (eg, Visual Analogue Scale). Minimally important clinical differences reported in previous literature will be considered when interpreting results. …”
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Effectiveness of bright light therapy and combination with myopic defocus for controlling myopic eye growth in schoolchildren: study protocol for a randomised controlled trial (pha... by Dennis Yan-yin Tse, Rachel Ka Man Chun, Chi Ho To, Ian G Morgan, Jinxiao Lian, Carly SY Lam, Wai-Ching Lam, Christopher Kai Shun Leung, Lai Ming Ho, Ying Hon, Billy Kin Kwok Cheung, Desmond Man Kit Lam, Andy Chi Wai Kong, Thomas C Lam

“…Introduction Myopia and its complications can lead to irreversible visual impairment and even blindness, making this a worldwide public health concern for the 21st century. …”
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Hyperuricemia predicts adverse clinical outcomes after arthroscopic microfracture of osteochondral lesions of the talus by Yuanqiang Li, Zhenyu Wang, Guo Zheng, Lin Ma, Xin Xin Li, Yan Liang, Xinyu Xie, Xiaolin Zhang, Chengsong Yuan, Wan Chen

“…Clinical characteristics recorded and analyzed included Visual Analog Scale (VAS score), American Orthopaedic Foot & Ankle Society score (AOFAS), and 36-Item Short Form Health Survey score (SF-36). …”
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Low density of intratumoral M1-macrophage infiltration may correlate with worse prognosis in low-grade early-stage uterine endometrioid carcinoma by Michiko Nagamine, Hiroshi Ogi, Maki Hirai, Ikoi Omatsu, Sanzo Moriwaki, Saya Shibata, Satoru Yasukawa, Kaori Yoriki, Motohiro Kojima, Taisuke Mori, Kyoko Itoh, Eiichi Konishi

“…In addition, clusters of foam cells in the stroma were visually examined. Results: Compared with the cured group, the primary tumor of recurrent group demonstrated significantly lower densities of CD68-positive macrophages and M1 macrophage. …”
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Contemporary carotid artery stenting practices and peri-procedural outcomes in different European countries: ROADSAVER study multicentric insights by Stefan Müller-Hülsbeck, Zsolt Vajda, Piotr Odrowąż-Pieniążek, Zoltán Ruzsa, Roel Beelen, Aleksandar Gjoreski, Koen Deloose, Sérgio Castro, Benjamin Faurie, Alejandro Tomasello Weitz, Arne Schwindt, Paweł Latacz, Antonio Orgaz Pérez-Grueso, Vladimir Cvetić, Ralf Langhoff, Sasko Kedev, all ROADSAVER study investigators

“…Trial registration Clinicaltrials.gov identifier: NCT03504228. Visual Abstract…”
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Characterisation of combined abiotic and biotic stresses effects on lettuce plants via a multi-analysis approach by Roberta Bulgari, Roberta Bulgari, Jouhaina Riahi, Riccardo Cecire, Riccardo Cecire, Luisella Celi, Mery Malandrino, Gica Stefanescu Miralles, Gica Stefanescu Miralles, Lorenzo Comba, Luca Alfarano, Luca Alfarano, Massimo Pugliese, Massimo Pugliese

“…These findings pave the way to the development of proactive, reliable, and effective methods for stress detection in lettuce cultivation, also including non-destructive optical approaches.…”
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Real-time detection of Chinese cabbage seedlings in the field based on YOLO11-CGB by Hang Shi, Hang Shi, Changxi Liu, Changxi Liu, Miao Wu, Miao Wu, Hui Zhang, Hui Zhang, Hang Song, Hang Song, Hao Sun, Hao Sun, Yufei Li, Yufei Li, Jun Hu, Jun Hu

“…However, the similarity between the characteristics of Chinese cabbage seedlings and some weeds is a great challenge for accurate detection.MethodsThis study introduces an enhanced detection method for Chinese cabbage seedlings, employing a modified version of YOLO11n, termed YOLO11-CGB. …”
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[68Ga]Ga-FAPI-46 PET/CT for Staging Suspected/Confirmed Lung Cancer: Results on the Surgical Cohort Within a Monocentric Prospective Trial by Lucia Zanoni, Emilia Fortunati, Giulia Cuzzani, Claudio Malizia, Filippo Lodi, Veronica Serena Cabitza, Irene Brusa, Stefano Emiliani, Marta Assenza, Filippo Antonacci, Francesca Giunchi, Alessio Degiovanni, Marco Ferrari, Filippo Natali, Thomas Galasso, Gian Piero Bandelli, Simona Civollani, Piero Candoli, Antonietta D’Errico, Piergiorgio Solli, Stefano Fanti, Cristina Nanni

“…To evaluate T&N-staging diagnostic performance of [68Ga]Ga-FAPI-46 PET/CT (FAPI) in a suspected/confirmed lung cancer surgical cohort. Methods: Patients were enrolled in a prospective monocentric trial (EudraCT: 2021-006570-23) to perform FAPI, in addition to conventional-staging-flow-chart (including [18F]F-FDG PET/CT-FDG). …”
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Mapping the key players in Kawasaki disease; role of inflammatory genes and protein-protein interactions by Wael Hafez, Feras Al-Obeidat, Asrar Rashid, Afsheen Raza, Nouran Hamza, Nesma Ahmed, Marwa M. Abdeljawad, Raziya Kadwa, Abdelhameed Elmesery, Muneir Gador, Dina Khair, Gihan Zina, fatema Abdulaal, Mina Wassef Girgiss, Maha Abdelhadi, Ahmed Abdelrahman, Mahmad Anwar Ibrahim, Mohamed El Sherbiny

“…Heatmaps were generated to visualize gene expression patterns. Results: Eighteen hub genes were identified in the KD versus control comparison, whereas 20 hub genes were identified in the acute versus convalescent analysis. …”
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Long-Term Effectiveness of Polymerized-Type I Collagen Intra-Articular Injections in Patients with Symptomatic Knee Osteoarthritis: Clinical and Radiographic Evaluation in a Cohort... by Adrián Borja-Flores, Salvador I. Macías-Hernández, Gabriela Hernández-Molina, Andric Perez-Ortiz, Eloy Reyes-Martínez, José Belzazar-Castillo de la Torre, Laura Ávila-Jiménez, María Cristina Vázquez-Bello, Marco Antonio León-Mazón, Janette Furuzawa-Carballeda, Gonzalo Torres-Villalobos, Fernanda Romero-Hernández, Cidronio Albavera-Hernández, Jesús Pérez-Correa, Hilda A. Castro-Rocha

“…The aim was to evaluate the effect of intra-articular injections (IAIs) of polymerized-collagen among patients with symptomatic knee osteoarthritis (OA) in delaying or preventing joint replacement surgery. Patients and Methods. This was a cohort study of 309 patients with knee OA. …”
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Postoperative pain and influencing factors after prophylactic extraction of impacted mandibular third molars: a multicenter prospective cohort study by Zhiwei Cao, Chengzhi Zhao, Renyi Wang, Qianxing Du, Kun Zhang, Jihong Zhao, Yang Xue, Bing Han, Jiuyan Jiang, Liwei Hu, Xuejuan Liao, Jian Pan

“…Postoperative pain was assessed using the Visual Analog Scale (VAS) at 1, 3, 7, and 30 days, while postoperative infection was documented at the same intervals. …”
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Non-tuberculous mycobacteria and other acid fast bacilli pathogens identification by qPCR and MALDI-ToF MS in tuberculosis-like lesions of slaughtered cattle from Ecuador by Solon Alberto Orlando, Solon Alberto Orlando, Leila Estefania Vera Loor, Joselyn Calderón, Melissa Joseth Carvajal-Capa, Fabrizio Arcos Alcívar, Pablo Torres-Lasso, W. Favián Maza Valle, Oliverio N. Vargas González, Naomi Mora-Jaramillo, Ariana León-Sosa, Ariana Rivera, Angel Sebastián Rodríguez-Pazmiño, Bernardo Castro-Rodriguez, Greta Franco Sotomayor, Greta Franco Sotomayor, Sandra Uruchima-Campoverde, Manuel Gonzalez, Jose Manuel Benitez-Medina, Natalia Jimenez-Pizarro, Javier Hermoso de Mendoza, Henry Parra-Vera, Miguel Angel Garcia-Bereguiain

“…While the importance of NTM in opportunistic infections in humans has been gaining attention, surveillance and control programs for cattle health and production remain predominantly focused on bovine tuberculosis (BTB) that it is caused exclusively by MTBC.MethodsIn this study, we conducted a comprehensive inspection of 5,803 cattle carcasses destined for human consumption across 22 abattoirs in five provinces of Ecuador’s coastal region, searching for lesions visually compatible with BTB (BTB-like lesions).ResultsA high prevalence of 13.4% (CI 95%: 12.8–14.6) for BTB-like lesions and 3.1% (CI 95%: 2.6–3.5) for acid-fast bacilli (AFB) presence in lesions was observed. …”
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Comparison of intraoperative and postoperative outcomes between open, wiltse, and percutaneous approach to traumatic thoracolumbar spine fractures without neurological injury: A sy... by Abdulrahman O. Al-Naseem, MB ChB (Hons), MSc, Yusuf Mehkri, MD, Sachiv Chakravarti, MD, Eli Johnson, MD, Margot Kelly-Hedrick, MD, Cathleen Kuo, MD, Melissa Erickson, MD, MBA, Khoi D. Than, MD, Brett Rocos, MD, BSc (Hons), MB, ChB, Deb Bhowmick, MD, Christopher I. Shaffrey, MD, Norah Foster, MD, Ali Baaj, MD, Nader Dahdaleh, MD, C. Rory Goodwin, MD, PhD, Theresa L. Williamson, MD, Yi Lu, MD, PhD, Muhammad M. Abd-El-Barr, MD, PhD

“…This systematic review and meta-analysis aims to compare perioperative outcomes between these approaches. Methods: PubMed, Web of Science, Scopus, Embase, and the Cochrane Library were searched for all relevant observational comparative studies. …”
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Association of autoantibodies with the IFN signature and NETosis in patients with systemic lupus erythematosus by Ellen D. Kaan, Tammo E. Brunekreef, Julia Drylewicz, Lucas L. van den Hoogen, Maarten van der Linden, Helen L. Leavis, Jacob M. van Laar, Michiel van der Vlist, Henny G. Otten, Maarten Limper

“…Patients with high and low NET inducing capacity were equally distributed between the clusters. Variance between the clusters is mainly driven by antibodies against histones, RibP2, RibP0, EphB2, RibP1, PCNA, dsDNA, and nucleosome. …”
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Time to endovascular thrombectomy for acute ischaemic stroke in language other than English (LOTE) communities in South-Western Sydney by Dennis Cordato, Peter Thomas, Alan McDougall, Cecilia Cappelen-Smith, Christopher Blair, Nathan Manning, Jing ji, Longting Lin, Mark Parsons, Andrew K Cheung, Daniel Wardman, Chushuang Chen, Suzanne J Hodgkinson, Helen Badge, Vivek Pidugun, Timmy Pham

“…Patients requiring interpreters equally exhibited shorter ATP times (152 vs 170 min; p=0.01) and higher stroke severity. …”
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