Predictive Scores for Identifying Chronic Opioid Dependence After General Anesthesia Surgery by Sun M, Chen WM, Lu Z, Lv S, Fu N, Yang Y, Wang Y, Miao M, Wu SY, Zhang J

“…Mingyang Sun,1,2,* Wan-Ming Chen,3,4,* Zhongyuan Lu,1,2 Shuang Lv,1,2 Ningning Fu,1,2 Yitian Yang,1,2 Yangyang Wang,1,2 Mengrong Miao,1,2 Szu-Yuan Wu,5– 11 Jiaqiang Zhang1,2 1Department of Anesthesiology and Perioperative Medicine, People’s Hospital of Zhengzhou University, Henan Provincial People’s Hospital, Zhengzhou, Henan, People’s Republic of China; 2Academy of Medical Sciences of Zhengzhou University, Zhengzhou, Henan, People’s Republic of China; 3Graduate Institute of Business Administration, College of Management, Fu Jen Catholic University, Taipei, Taiwan; 4Artificial Intelligence Development Center, Fu Jen Catholic University, Taipei, Taiwan; 5Department of Food Nutrition and Health Biotechnology, College of Medical and Health Science, Asia University, Taichung, Taiwan; 6Big Data Center, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, Yilan, Taiwan; 7Division of Radiation Oncology, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, Yilan, Taiwan; 8Department of Healthcare Administration, College of Medical and Health Science, Asia University, Taichung, Taiwan; 9Cancer Center, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, Yilan, Taiwan; 10Centers for Regional Anesthesia and Pain Medicine, Taipei Municipal Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; 11Department of Management, College of Management, Fo Guang University, Yilan, Taiwan*These authors contributed equally to this workCorrespondence: Szu-Yuan Wu, College of Medical and Health Science, Asia University, Taichung, Taiwan; Director, Big Data Center, Lo-Hsu Medical Foundation, LotungPoh-Ai Hospital, No. 83, Nanchang St., Luodong Township, Yilan County, 265, Taiwan, Email szuyuanwu5399@gmail.com Jiaqiang Zhang, Department of Anesthesiology and Perioperative Medicine, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, No. 7 Weiwu Road, Jinshui District, Zhengzhou, Henan, 450003, People’s Republic of China, Email jiaqiang197628@163.comPurpose: To address the prevalence and risk factors of postoperative chronic opioid dependence, focusing on the development of a predictive scoring system to identify high-risk populations.Methods: We analyzed data from the Taiwan Health Insurance Research Database spanning January 2016 to December 2018, encompassing adults undergoing major elective surgeries with general anesthesia. …”
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Activation of TLR4/CCL2 in Intact Neurons Drives Radicular Injury-Induced Global Nerve Trunk Hypersensitivity in Radiculopathy Preclinical Models by Tong SH, Zhou J, Ye F, Ding P, Mei JL, Liao P, Lu YF, Zong Y, Gao CA, Zhang SY, Gao JJ, Liu DL, Huang YG

“…However, the underlying mechanisms remain unclear.Methods: An L5 spinal nerve compression rat model was established. …”
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The effects of normal and interrupted sleep combined with acute caffeine supplementation on some immune system indices and anaerobic power in male athletes by Mohammad hossein Hashemzadeh, Farhad Rahmaninia, Payam Saidie

“…Participants were randomly and equally assigned to 2 groups and 2 sessions: 1) normal sleep, caffeine/placebo (NSP/NSC) and 2) Interrupted sleep, caffeine/placebo (ISP/ISC). …”
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Exploring Autophagy-Related Gene Expression in Hepatocellular Carcinoma via TCGA, GEPIA2, and HPA Databases: Implications for Prognosis by Gu X, Chen Y, Hu X, Li Y, Zhu R, Li H, Yuan Z, Wang Y

“…Xiangran Gu,1,* Yuan Chen,2,* Xinyue Hu,1,* Yunhui Li,3 Renlong Zhu,2 Hongxu Li,1 Zhengrong Yuan,1 Yajie Wang2,3 1College of Biological Sciences and Technology, Beijing Forestry University, Beijing, People’s Republic of China; 2Department of Clinical Laboratory, Peking University Ditan Teaching Hospital, Beijing, People’s Republic of China; 3Department of Clinical Laboratory, Beijing Ditan Hospital, Capital Medical University, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhengrong Yuan, College of Biological Sciences and Technology, Beijing Forestry University, No. 35 Tsinghua East Road, Haidian District, Beijing, 100083, People’s Republic of China, Email zryuan@bjfu.edu.cn Yajie Wang, Department of Clinical Laboratory, Beijing Ditan Hospital, Capital Medical University, Beijing, People’s Republic of China, Email wangyajie@ccmu.edu.cnObjective: This study aimed to identify autophagy-related genes (ARGs) with prognostic significance in hepatocellular carcinoma (HCC) using bioinformatics and survival analysis.Materials and Methods: ARGs were sourced from multiple references, including the Human Autophagy Database (HADb), relevant literatures, the Gene Set Enrichment Analysis (GSEA), and a final list was confirmed after eliminating duplicate entries. …”
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Safety, tolerability and immunogenicity of a condensed, multi-dose prime regimen of PfSPZ Vaccine for the prevention of Plasmodium falciparum malaria infection by Andrea A. Berry, Thomas L. Richie, L. W. Preston Church, Matthew B. Laurens, Colleen Boyce, Natasha KC, Sudhaunshu Joshi, Abra Rachida Koudjra, Lauryn Butler, Mei-Chun Chen, Yonas Abebe, Tooba Murshedkar, Eric R. James, Peter F. Billingsley, B. Kim Lee Sim, Stephen L. Hoffman, Kirsten E. Lyke

“…Solicited local and systemic adverse events recorded for 2 and 7 days after immunizations, respectively, occurred with equal frequency and severity in the 23 vaccinees and 7 controls receiving two immunizations, as did unsolicited adverse events recorded for 28 days and laboratory abnormalities 1 and 5 weeks after V2. …”
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Correlation of Novel Inflammation Index with Postoperative Acute Kidney Injury in Patients with Joint Arthroplasty: A Retrospective Cohort Study by Yan YT, Liu R, Liu J, Zhang WJ, Wang S, Tang TY, Lei YQ, Zhu XY, Liu KX, Zheng QJ, Liu HM

“…This study investigated the association between novel inflammation indices and postoperative AKI.Methods: This retrospective cohort study included 1434 patients who underwent hip or knee arthroplasty, with 1225 patients comprising the complete case analysis dataset. …”
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Real-World Assessment of the Association Between PCSK9i Adherence and LDL Reduction and Variability in a Chinese Clinical Practice by Ye X, Zhang S, Zhong X, Li M, Liu M, Zhuang X, Liao X

“…Xiaomin Ye,1,2,* Shaozhao Zhang,1,2,* Xiangbin Zhong,1,2 Miaohong Li,1,2 Menghui Liu,1,2 Xiaodong Zhuang,1,2 Xinxue Liao1,2 1Cardiology Department, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of China; 2NHC Key Laboratory of Assisted Circulation, Sun Yat-Sen University, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xinxue Liao, Cardiology Department, First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan 2nd Road, Guangzhou, 510080, People’s Republic of China, Tel +86-13903063724, Fax +86-020-28823388, Email liaoxinx@mail.sysu.edu.cn Xiaodong Zhuang, Cardiology Department, First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan 2nd Road, Guangzhou, 510080, People’s Republic of China, Tel +86-13760755035, Email zhuangxd3@mail.sysu.edu.cnBackground: Real-world evidence about adherence to proprotein convertase subtilisin/kexin type-9 inhibition (PCSK9i) is needed in Chinese population.Objective: We aimed to evaluate the adherence patterns using anti-PCSK9 monoclonal antibody in Chinese clinical practice and explored the association between adherence to PCSK9i and low-density lipoprotein cholesterol (LDL-C) reduction ratio and variability.Methods: A total of 5373 patients initiating PCSK9i in the First Affiliated Hospital of Sun Yat-sen University were included as sub-analysis of the RED-CARPET registry. …”
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Socio-economic inequalities in minimum dietary diversity among Ethiopian children aged 6–23 months: a decomposition analysis by Nigusu Worku, Amare Mesfin Workie, Lamrot Yohannes, Mihret Getnet, Mihret Getnet, Wubshet Debebe Negash, Wubshet Debebe Negash, Adina Yeshambel Belay, Lakew Asmare, Hiwot Tadesse Alemu, Demiss Mulatu Geberu, Melak Jejaw, Kaleb Assegid Demissie, Misganaw Guadie Tiruneh, Asebe Hagos

“…Wealth and educational status show positive CIX values for inequality, as exhibited by the concentration curve under the equality line. The CIX with household and maternal education status were (CIX: 0.1034, p < 0.0029) and (CIX: 0.1057, p < 0.0002), respectively. …”
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Effectiveness of ICS/LABA and LAMA/LABA in COPD due to biomass by Alejandra Ramírez-Venegas, Francisco Montiel-Lopez, Robinson E. Robles-Hernández, Bartolome R. Celli, Raúl H. Sansores, Maricruz Cassou-Martínez, José L. Pérez Lara-Albisua, Claudia González-González, María E. Mayar-Maya, Aloisa P. Hernández-Morales, Rafael J. Hernández-Zenteno, Ramcés Falfán-Valencia, Ireri Thirión-Romero, Oliver Pérez-Bautista, Rogelio Pérez-Padilla

“…Conclusions Among patients with COPD-B and COPD-C with a history of exacerbation, FF/VI was equally effective as UMEC/VI in preventing exacerbations and improving dyspnoea and HRQL.…”
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Pragmatic, multicentre, factorial, randomised controlled trial of sepsis electronic prompting for timely intervention and care (SEPTIC trial): a protocol by Daniel Brodie, Manish Sharma, Matthew J Cummings, Hassan Mohamed, William N Southern, Edward J Schenck, Benjamin L Ranard, David Y Zhang, Jeremy R Beitler, Min Qian, Jo R Applebaum, Jason S Adelman, Shing M Lee, Richard Trepp, Hanson Hsu, Jean Scofi, Sarah C Rossetti, Natalie H Yip, Baruch S Fertel

“…The SEPTIC trials are pragmatic, multicentre, blinded, randomised controlled trials, with equal allocation to compare four SIRS-based sepsis screening alert groups: no alerts (control), nurse alerts only, prescribing clinician alerts only, or nurse and prescribing clinician alerts. …”
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Exploring the Impact of the Multimodal CAPABLE eHealth Intervention on Health-Related Quality of Life in Patients With Melanoma Undergoing Immune-Checkpoint Inhibition: Prospective... by Itske Fraterman, Lucia Sacchi, Henk Mallo, Valentina Tibollo, Savannah Lucia Catherina Glaser, Stephanie Medlock, Ronald Cornet, Matteo Gabetta, Vitali Hisko, Vadzim Khadakou, Ella Barkan, Laura Del Campo, David Glasspool, Alexandra Kogan, Giordano Lanzola, Roy Leizer, Manuel Ottaviano, Mor Peleg, Konrad Śniatała, Aneta Lisowska, Szymon Wilk, Enea Parimbelli, Silvana Quaglini, Mimma Rizzo, Laura Deborah Locati, Annelies Boekhout, Lonneke V van de Poll-Franse, Sofie Wilgenhof

“…Baseline HRQoL was on average 10 points higher in the intervention group compared with controls, although equally matched on baseline and clinical characteristics. …”
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Imaging and Clinical Outcomes Six Months After Middle Meningeal Artery Embolization with Squid for Chronic Subdural Hematoma: A Prospective Study by Ángela H. Schmolling, Carlos Pérez-García, Isabel Bérmudez, Alfonso López-Frías, Eduardo Fandiño, Carmen Trejo, Santiago Rosati, Daniel Padrón, Lara Guardado, José Carlos Méndez, Juan Arrazola, Manuel Moreu

“…Procedures were performed under general anesthesia in 72.3% of patients, with radial and femoral access used equally frequently, and 32.7% underwent bilateral embolization. …”
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Neutrophil elastase inhibitor (Sivelestat) in the treatment of acute respiratory distress syndrome induced by COVID-19: a multicenter retrospective cohort study by Yuting Li, Jianjun Zhao, Jiahui Wei, Yanhong Zhang, Haitao Zhang, Ying Li, Ting Liao, Yang Hu, Bo Yuan, Xinmei Zhang, Wanyan Liu, Changgang Liu, Qingsong Cui, Shunzi Wu, Hongmei Jiang, Wenge Liu, Weiheng Liu, Hongguang Xu, Gang Li, Yuyan Cai, Liting Chen, Bingwei Chen, Dong Zhang

“…The differences in continuous outcomes were assessed with the Wilcoxon signed-rank test. Kaplan–Meier method was used to show the 28-day survival curves in the matched cohorts. …”
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Efficacy of Rikkunshito on Chemotherapy-Induced Nausea and Vomiting in Patients With Uterine Corpus or Cervical Cancer Treated With Cisplatin-Based Regimen-Placebo-controlled, Doub... by Yosuke Konno MD, Shunsuke Ohnishi MD, Shinichiro Minobe PhD, Eiji Nomura PhD, Takayuki Nagasawa PhD, Etsuko Fujimoto MD, Tatsuru Ohara PhD, Shin Nishio MD, Hisamori Kato PhD, Yoshihito Yokoyama PhD, Etsuko Miyagi PhD, Hideki Tokunaga PhD, Koji Nishino MD, Akira Kikuchi PhD, Yoshio Yoshida PhD, Takashi Iwata PhD, Daito Noguchi MD, Wataru Kudaka PhD, Shunsuke Oyamada PhD, Keisuke Ariyoshi PhD, Kota Kihara PhD, Hidemichi Watari MD

“…Patients were randomized with a 1:1 equal allocation ratio to the rikkunshito group or placebo groups and given oral administration on days 1 to 5 with standard antiemetics (granisetron, aprepitant, and dexamethasone). …”
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The Prognostic Value of Platelet Kinetics Assessment in Pediatric Chronic Idiopathic Thrombocytopenic Purpura by Nebojsa Igrutinovic, Jelena Pantovic, Bojana Markovic, Marija Medovic, Milica Cekerevac, Vladimir Markovic, Strahinja Odalovic, Sanja Knezevic, Ana Vujic, Isidora Mihajlovic, Nevena Stojadinovic, Dragan Knezevic, Nina Urakovic, Ivana Andrejevic, Gordana J. Ristic, Vladimir Slavkovic, Kristina Andric, Rasa Medovic

“…The remaining 10%, which represented the most severe cases, required all available therapies, had equally mixed and liver sequestration, and splenectomy showed no effect. …”
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Bahir Dar Child Development Cross-Sectional Study, Ethiopia: study protocol by Alemayehu Worku, Yemane Berhane, Lian V Folger, Anne CC Lee, Krysten North, Nebiyou Fasil, Kalkidan Yibeltal, Fred Van Dyk, Firehiwot Workneh, Theresa I Chin, Sarah K G Jensen, Unmesha Roy Paladhi, Betelhem Haimanot Abate, Atsede Teklehaimanot, Tizita Lemma Melka, Moriah E Thomason, Terrie Inder, Patricia Ellen Grant

“…A battery of paper and tablet-based assessments of neurocognitive outcomes including visual and verbal reasoning, executive functions and school readiness will be completed for children aged 48–60 months. …”
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Retinal biomarkers for the risk of Alzheimer’s disease and frontotemporal dementia by Ruihan Wang, Jiajie Cai, Yuzhu Gao, Yingying Tang, Hui Gao, Linyuan Qin, Hanlin Cai, Feng Yang, Yimeng Ren, Caimei Luo, Shiyu Feng, Hongbo Yin, Ming Zhang, Chunyan Luo, Qiyong Gong, Xiong Xiao, Qin Chen

“…Our aim was to identify retinal biomarkers for the risk of AD and FTD in populations without dementia and explore underlying brain structural mechanisms.MethodsWe included a total of 3,0573 UK Biobank participants without dementia, ocular disorders, and diabetes who underwent baseline retinal optical coherence tomography (OCT) imaging. …”
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Identification of genetic mechanisms of non-isolated auditory neuropathy with various phenotypes in Chinese families by Yang Cao, Xiaolong Zhang, Lan Lan, Danyang Li, Jin Li, Linyi Xie, Fen Xiong, Lan Yu, Xiaonan Wu, Hongyang Wang, Qiuju Wang

“…Functional enrichment analysis revealed that genes associated with non-isolated AN predominantly involve mitochondrial processes, affecting the central and peripheral nervous, musculoskeletal, and visual systems. Conclusion This study identifies novel mutations in FDXR and TWNK that contribute to non-isolated AN through mitochondrial dysfunction. …”
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Large-Scale Cortical Network Analysis and Classification of MI-BCI Tasks Based on Bayesian Nonnegative Matrix Factorization by Shiqi Yu, Bin Mao, Yuanhang Zhou, Yunhong Liu, Chanlin Yi, Fali Li, Dezhong Yao, Peng Xu, X. San Liang, Tao Zhang

“…Here, we combined EEG source reconstruction and Bayesian nonnegative matrix factorization (NMF) methods to construct large-scale cortical networks of left-hand and right-hand MI tasks. …”
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Do neonatal intensive care unit (NICU) health workers know about retinopathy of prematurity (ROP)? A qualitative study at a Regional Referral Hospital in Uganda by Henry Muwonge, Innocent Ayesiga, Primrose Magala, Tom Didimus Ediamu, Hana El Diwany, Ian LY Yeung, Alex Wasomoka, Phillip Musoke, Elias Musiime, Abraham Tumwesigye, Pius Atwau, Noreen Atwijukire, Iddi Ndyabawe, Anne Mpaire Musika, Himanshu I Patel, Aeesha NJ Malik, Ibrahim Bwaga, Sheba Gitta Nakacubo

“…Introduction Retinopathy of prematurity (ROP) is a significant cause of blindness and visual impairment in preterm infants globally, particularly in low-income and middle-income countries. …”
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