Association Between Daytime Sleepiness and Quality of Life in Chinese Adolescents: A Moderated Mediation of Cognitive Dysfunction and Depressive Symptoms by Li W, Hu N, Yang X, Zheng W, Tong J, Song J, Song Y, Gao X, Wang Z, Liu W, Wang L, Tan Y, Wang C, Deng H

“…However, the interrelationships among these variables remain unclear, particularly regarding whether cognitive function moderates the association between daytime sleepiness and quality of life.Methods: A large-scale cross-sectional survey was conducted among 52,964 students (grades 7– 12) across five geographically diverse regions of China. …”
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Myocardium-to-cavity ratio derived from simultaneous 99mTc-PYP/201Tl dual-isotope SPECT imaging to differentially diagnose transthyretin cardiac amyloidosis by Shozo Yamashita, Kenichi Nakajima, Teppei Kitano, Hiromu Kato, Tatsuya Yoneyama, Haruki Yamamoto, Kunihiko Yokoyama

“…For M/C ratio calculation, circular regions of interest of equal diameter were set on the myocardium and left ventricular cavity using 201Tl images, then superimposed on 99mTc-PYP images. …”
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Exploring the Therapeutic and Gut Microbiota-Modulating Effects of Qingreliangxuefang on IMQ-Induced Psoriasis by Yu Z, Wang Y, Guo Y, Zhu R, Fang Y, Yao Q, Fu H, Zhou A, Ma L, Shou Q

“…Zhengyao Yu,1– 5,* Yingying Wang,2,3,6,* Yingxue Guo,2,3,6 Ruotong Zhu,1,4 Yimiao Fang,1 Qinghua Yao,7 Huiying Fu,2,3,5,6 Ang Zhou,8 Lili Ma,1 Qiyang Shou2,3,5,6 1The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang, 310006, People’s Republic of China; 2The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, People’s Republic of China; 3Jinhua Academy, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, People’s Republic of China; 4The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, People’s Republic of China; 5Yongkang Hospital of Traditional Chinese Medicine, Jinhua, Zhejiang, 321300, People’s Republic of China; 6School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, People’s Republic of China; 7The Second Affiliated Hospital of Zhejiang Chinese Medical University, Xinhua Hospital of Zhejiang Province, Hangzhou, Zhejiang, 310005, People’s Republic of China; 8Department of Dermatology, Yiwu Central Hospital Medical Community Choujiang Hospital District, Yiwu, Zhejiang, 322000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lili Ma, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang, 310006, People’s Republic of China, Email lilyma163@163.com Qiyang Shou, The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, People’s Republic of China, Email sqy133@126.comPurpose: To investigate the therapeutic and gut microbiota-modulating effects of Qingreliangxuefang (QRLXF) on psoriasis.Materials and Methods: We used network pharmacology, a computational approach, to identify key bioactive compounds and biological targets, and explored the molecular mechanisms of QRLXF. …”
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RESULTS OF TREATMENT OF EDENTULOUS PATIENTS WITH DENTURES MADE OF «FTORAX» by V.M. Dvornyk, H.M. Kuz, O.B. Tumakova, O.S. Shemetov, V.S. Kuz

“…As for the coefficient «K», its value decreased almost twofold compared with the results before prosthetics (2.44±0.14) and equals to 1.25±0.03, which is significantly closer to normal (1,02±0.01). …”
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Biomimetic Aggregation-Induced Emission Luminogens Mediated Effective Phototherapy and Immune Checkpoint Blockade for the Synergistic Treatment of Lung Cancer by Yang L, Wei M, Deng X, He L, Lin Y, Lin X, Zhou D, Li M, Qin A, Zhang L, Ouyang Z

“…However, the disadvantages including hydrophobicity, low specificity, and short circulation lifetime limited their efficacy on cancer therapy.Methods: We developed a biomimetic AIEgens constructed using CD8+ T cells membrane to camouflage the AIEgen C41H37N2O3S2 (named BITT) nanoparticles (termed TB). …”
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The Negative Regulatory Role of Transcriptional Regulator H-NS on the Type VI Secretion System in Acinetobacter baumannii by Zhang Y, Zhou H, Kong J, Hu P, Zhang Y, Cao J, Zhou B

“…We explored potential targets of H-NS mediated silencing or activation within the regulation of A. baumannii T6SS, along with the specific regulatory mechanisms involved, thereby providing a theoretical foundation for further research on A. baumannii invasive infections stemming from mixed infections and the development of therapeutic target.Methods: Using the plasmids pAT04 and pYMAb2-hyg, we constructed A. baumannii ATCC19606 strains with the hns gene knocked out (ABΔhns) and overexpressed (ABhns+). …”
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Using Human‐Centred Design to Codesign Patient Engagement Tools With a Patient Advisory Council: Successes and Challenges by Madelyn Knaub, Santiago Leon, Surakshya Pokharel, Veronika Kiryanova, Kim Giroux, Prachi Khanna, Anna Rychtera, D'Arcy Duquette, Pamela Mathura, Nancy Verdin, Anshula Ambasta

“…PAC members had participated equally in the conduct of a prior qualitative study to understand patient needs about bloodwork processes in hospitals. …”
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A Clinical Risk Score Based on Albumin and Electrolyte Levels for Predicting Death Risk in Hospitalized Elderly COVID-19 Patients by Wang C, Zheng X, Bi S, Shao M, Xie Z, Wei N, Zhou Q, Feng S

“…Patients were classified into low- and high-risk groups using optimal segmentation thresholds, with survival curves generated by the Kaplan–Meier method. An online risk calculator was developed to facilitate real-time risk assessment in clinical settings.Results: The cohort included 1413 hospitalized COVID-19 patients. …”
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Application of Intravoxel Incoherent Motion in the Prediction of Intra-Tumoral Tertiary Lymphoid Structures in Hepatocellular Carcinoma by Ma L, Liao S, Zhang X, Zhou F, Geng Z, Hu J, Zhang Y, Zhang C, Meng T, Wang S, Xie C

“…., Ltd, Beijing, People’s Republic of China; 4Central Research Institute, United Imaging Healthcare, Shanghai, People’s Republic of China; 5Center of Hepato-Pancreato-Biliary Surgery, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, 510080, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chuanmiao Xie, Department of Radiology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People’s Republic of China, Email xchuanm@sysucc.org.cn Shutong Wang, Center of Hepato-Pancreato-Biliary Surgery, Center of Hepato-Pancreato-Biliary Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, People’s Republic of China, Email wangsht23@mail.sysu.edu.cnObjective: To explore the value of intravoxel incoherent motion (IVIM) sequences in predicting intra-tumoral tertiary lymphoid structures (TLSs).Materials and Methods: This prospective study pre-operatively enrolled hepatocellular carcinoma (HCC) patients who underwent magnetic resonance imaging including IVIM sequences, between January 2019 and April 2021. …”
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Identification and Validation of Epithelial Cell Centre Regulatory Transcription Factors in the Gastric Cancer Microenvironment by Su G, Wang J, Liu S, Fu X, Li Y, Pan G

“…Guomiao Su,1,* Juan Wang,2,* Shiyue Liu,1,* Xiaonan Fu,1 Yanxi Li,1 Guoqing Pan1 1Department of Pathology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yun Nan, People’s Republic of China; 2Clinical Laboratory, Yunnan Province Third People’s Hospital, Kunming, Yun Nan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yanxi Li; Guoqing Pan, Department of Pathology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yun Nan, People’s Republic of China, Email liyanxicuhk@163.com; guoqing_pan@163.comPurpose: To identify the epithelial cell centre regulatory transcription factors in the gastric cancer (GC) microenvironment and provide a new strategy for the diagnosis and treatment of GC.Methods: The GC single-cell dataset was downloaded from the Gene Expression Omnibus (GEO) database. …”
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Mindfulness-based programmes for mental health promotion in adults in nonclinical settings: A systematic review and meta-analysis of randomised controlled trials. by Julieta Galante, Claire Friedrich, Anna F Dawson, Marta Modrego-Alarcón, Pia Gebbing, Irene Delgado-Suárez, Radhika Gupta, Lydia Dean, Tim Dalgleish, Ian R White, Peter B Jones

“…Other preventative interventions may be equally effective. Implementation of MBPs in nonclinical settings should be partnered with thorough research to confirm findings and learn which settings are most likely to benefit.…”
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Comparison of the Impact of tNGS with mNGS on Antimicrobial Management in Patients with LRTIs: A Multicenter Retrospective Cohort Study by Li D, Li Q, Huang Z, Wu W, Fan X, Liu J, Li R, Zhang Q, Su X

“…However, the impact of tNGS and mNGS on antimicrobial stewardship in patients with LRTIs remains unclear.Methods: Patients diagnosed with LRTIs who underwent tNGS or mNGS between June 2021 and January 2024 were included. …”
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Platelet Membrane-Coated Poly (Lactic-Co-Glycolic Acid) Nanoparticles as a Targeting Drug Delivery System for Multidrug-Resistant Breast Cancer by Song B, Na YG, Kim BJ, Jin M, Song YH, Kim DE, Hwang S, Baek JS, Lee HK, Cho CW

“…To overcome these challenges, we developed a triple-functionalized nanocarrier system incorporating poly(lactide-co-glycolide) (PLGA)-based nanoparticles (PNs), D-α-tocopheryl polyethylene glycol succinate (TPGS) for P-gp inhibition, and platelet membrane (PM) coating for targeted tumor delivery.Methods: The PM-coated TPGS-modified PNs with PTX (PTPNs) was characterized by particle size analysis, transmission electron microscopy (TEM), and protein assay to confirm PM coating. …”
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Integrating CEUS Imaging Features and LI-RADS Classification for Postoperative Early Recurrence Prediction in Solitary Hepatocellular Carcinoma: A Machine Learning-Based Prognostic... by Liang L, Pang J, Zhang B, Que Q, Gao R, Wu Y, Peng J, Zhang W, Bai X, Wen R, He Y, Yang H

“…Li Liang,1,2,* Jinshu Pang,1,* Bulin Zhang,2 Qiao Que,1 Ruizhi Gao,1 Yuquan Wu,1 Jinbo Peng,1 Wei Zhang,2 Xiumei Bai,1 Rong Wen,1 Yun He,1 Hong Yang1 1Department of Medical Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China; 2Department of Medical Ultrasound, Liuzhou People’s Hospital, Liuzhou, Guangxi Zhuang Autonomous Region, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hong Yang, Department of Medical Ultrasound, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China, Tel +8607715356706, Email yanghong@gxmu.edu.cn Yun He, Department of Medical Ultrasound, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China, Tel +8607715356706, Email heyun@gxmu.edu.cnPurpose: To develop and validate a machine learning (ML) model for predicting early postoperative recurrence in hepatocellular carcinoma (HCC) patients by integrating contrast-enhanced ultrasound (CEUS) features with Liver Imaging Reporting and Data System (LI-RADS) classification.Materials and Methods: A retrospective analysis was conducted on data from 279 patients who underwent surgical resection for HCC. …”
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APPLICABILITY OF SIMILARITY CONDITIONS TO ANALOGUE MODELLING OF TECTONIC STRUCTURES by Mikhail A. Goncharov

“…Belousov as a «realist» as he supported «the liberal point of view» [Methods of modelling…, 1988, p. 21–22], whereas M.V. …”
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The Correlation Between the Expression Levels of Serum miR-19b and SOCS-1 mRNA and Clinical Symptoms in Patients with Allergic Rhinitis by Kang Z, Di L, Liu Y, Qu W, Zeng Y, Lu X, Wang L

“…Zhaopeng Kang,1,* Lingling Di,2,* Yi Liu,3 Wei Qu,3 Yi Zeng,3 Xue Lu,3 Lixin Wang3 1Department of Andrology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, People’s Republic of China; 2Department of Otolaryngology Head and Neck Surgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, 756099, People’s Republic of China; 3Department of Otolaryngology Head and Neck Surgery, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lixin Wang, Department of Otolaryngology Head and Neck Surgery, Renmin Hospital, Hubei University of Medicine, No. 39 Chaoyang Middle Road, Shiyan, Hubei, 442000, People’s Republic of China, Tel +86-719-8666352, Email 1043275363@qq.comObjective: To investigate the correlation between the expression levels of microRNA-19b (miR-19b) and suppressor of cytokine signaling 1 messenger RNA (SOCS-1 mRNA) in the serum of patients with allergic rhinitis (AR) and clinical symptoms.Methods: This prospective study included a total of 86 patients with allergic rhinitis who were admitted to the People’s Hospital Affiliated to Hubei University of Medicine from January 2022 to January 2023. …”
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The First Case of Antimicrobial-Resistant Salmonella Stanley ST29 Diagnosed Secondary to Acute Cholecystitis by Wang W, Liu S, Zhang M, Chen Y, Liang Y, You S, Lv P, Xu X, Zhang F

“…Wenqing Wang,1,2,* Shufen Liu,3,* Minlan Zhang,3 Yan Chen,4 Yanru Liang,1,2 Shuqi You,1,2 Peijun Lv,4 Xuebin Xu,5 Fenghua Zhang3 1Department of Microbiology, Shanghai Pudong New Area Center for Disease Control and Prevention (Shanghai Pudong New Area Health Supervision Institute), Shanghai, People’s Republic of China; 2Fudan University Pudong Institute of Preventive Medicine, Shanghai, People’s Republic of China; 3Department of Laboratory Medicine, Zhoupu Hospital Affiliated to Shanghai University of Medicine and Health, Shanghai, People’s Republic of China; 4Department of Microbiology, Panzhihua City Center for Disease Control and Prevention, Panzhihua, People’s Republic of China; 5Division of Pathogen Testing and Analysis, Shanghai Center for Disease Control and Prevention, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fenghua Zhang, Email zpyyzfh@163.comObjective: To analyze the phenotypic and genomic characteristics of a non-typhoidal Salmonella bile isolate from a patient with chronic diarrhoea secondary to acute cholecystitis.Methods: The patient presented with chronic diarrhoea lasting for two weeks, which was secondary to acute cholecystitis. …”
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Digital Inclusion Pathways and Influencing Factors Among Older Adults in Outpatient Settings: A Grounded Theory Study by Chen Y, Yin Q, Zhou T, Gu S, Xie L, Xiao M, Wang L, Zhao Q

“…This study aims to investigate the experiences, attitudes, and perceptions of older adults in outpatient regarding smart healthcare service in order to develop an explanatory digital inclusion pathway and construct a comprehensive path model for older adults.Patients and Methods: We conducted semi-structured interviews with 27 older adults in outpatients in Chongqing, China to understand their experiences, attitudes, and perceptions of attending smart healthcare services through theoretical sampling. …”
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Long Non-Coding RNA EPB41L4A-AS1 Serves as a Diagnostic Marker for Chronic Periodontitis and Regulates Periodontal Ligament Injury and Osteogenic Differentiation by Targeting miR-2... by Li R, Huang Z, Chen M

“…Rui Li,1,* Zhibin Huang,2,* Mengmeng Chen3 1Department of Stomatology, Affiliated Hospital of Nantong University, Nantong, People’s Republic of China; 2Medical Room, Nantong College of Science and Technology, Nantong, People’s Republic of China; 3Department of Stomatology, The Fourth Hospital of Harbin, Harbin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Mengmeng Chen, Department of Stomatology, The Fourth Hospital of Harbin, No. 119, Jingyu Street, Daowai District, Harbin City, Heilongjiang Province, 150026, People’s Republic of China, Tel +86 0451-88029850, Email chenmengm74@163.comBackground: Several long non-coding RNAs (lncRNAs) are dysregulated in chronic periodontitis (CP).Purpose: The study aimed to elucidate the molecular mechanisms and clinical significance of lncRNA EPB41L4A antisense RNA 1 (EPB41L4A-AS1) in CP.Patients and Methods: This study enrolled 101 patients with CP and 90 subjects with healthy periodontal tissues. …”
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Pattern of changes in morpho-densitometric parameters of magnocellular neurons of the hypothalamic paraventricular nucleus under restraint stress of different duration by K. B. Romanova, O. V. Hancheva, Yu. M. Kolesnyk

“…In the nuclei of cells after 6 and 15 weeks of restriction, the content was decreased approximately equally by 37 % and 35 %, respectively, and long-term restriction (21 weeks) contributed to a 41 % decrease. …”
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