Treatment with Ceftazidime-Avibactam for Lower Respiratory Tract Infections Caused by the Multidrug-Resistant Gram-Negative Bacteria in the Intensive Care Unit by Pan J, Kong H, Geng Z, Liang M, Yu S, Fang X

“…This study aimed to evaluate the clinical characteristics of patients with LRTIs caused by MDR-GNB who were treated with CAZ-AVI in the ICU, and to investigate the independent risk factors for mortality.Patients and Methods: This single-center retrospective study included patients with LRTIs treated with CAZ-AVI in the respiratory ICU of a tertiary hospital in Anhui Province between December 2022 and November 2024. …”
Get full text

Characterizing Duodenal Immune Microenvironment in Functional Dyspepsia: An AutoML-Driven Diagnostic Framework by Zhang X, Fan X, Hu X, Qian Z, Li J, Wu W, Chen L, Wu S, Ma L, Yang C, Zhang T, Su X, Wei W

“…Recent studies suggest that duodenal immune activation plays a pivotal role in its development.Methods: Mendelian randomization analysis using genome-wide association studies (GWAS) and expression quantitative trait loci (eQTL) data identified genes associated with FD. …”
Get full text

Development and Validation of a Dynamic Online Nomogram for Predicting Inpatient Fall Risk: A Cohort Study by Jiang S, Zhao F, Liang Y, Wang S, Xu Q, Wang R, Wu T, Yang H

“…Su Jiang,1,* Feng Zhao,2,* Yan Liang,2 Sulei Wang,2 Qiuyue Xu,3 Ruilin Wang,4 Tianchen Wu,2 Hui Yang3 1Department of Rehabilitation Medicine, The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou, 225300, People’s Republic of China; 2Department of Neurology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210012, People’s Republic of China; 3School of Nursing, Nanjing University of Chinese Medicine, Nanjing, 210023, People’s Republic of China; 4College of Acupuncture, Moxibustion and Orthopedics, Hubei University of Chinese Medicine, Wuhan, 430000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hui Yang, School of Nursing, Nanjing University of Chinese Medicine, No. 138 of Xianlin Road, Qixia District, Nanjing, 210023, People’s Republic of China, Tel +86 25 85811993, Email yanghuiyhcc@163.com Tianchen Wu, Department of Neurology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, No. 157 Daming Road, Qinhuai District, Nanjing, 210012, People’s Republic of China, Tel +86 25 5227 6666, Email wutianchenwtc@126.comObjective: This study aimed to develop and validate a dynamic online nomogram for predicting inpatient fall risk using data from a Dryad database cohort to strengthen fall prevention strategies and enhance patient safety in hospital settings.Methods: We analyzed data from a cohort study conducted at Fukushima Medical University Hospital, with external validation using an independent dataset from Taizhou People’s Hospital (2019– 2023, n=2000). …”
Get full text

Prediction of Acute Kidney Injury for Critically Ill Cardiogenic Shock Patients with Machine Learning Algorithms by Zhang X, Xiong Y, Liu H, Liu Q, Chen S

“…Xiaofei Zhang,1,* Yonghong Xiong,2,* Huilan Liu,3 Qian Liu,4 Shubin Chen5 1Department of Gerontology, China Aerospace Science & Industry Corporation 731 hospital, Beijing, People’s Republic of China; 2Department of Cardiology, Beijing Feng Tai Hospital, Beijing, People’s Republic of China; 3Department of Nephrology, Zhongnan Hospital of Wuhan University, Wuhan, People’s Republic of China; 4Department of Cardiology, Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, People’s Republic of China; 5Department of Intensive Care Unit, China Aerospace Science & Industry Corporation 731 hospital, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qian Liu, Department of Cardiology, Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science & Technology, No. 100 of Xianggang Road, Jiangan District, Wuhan, 430015, People’s Republic of China, Tel +86027-82433350, Email qian_liu1124@126.com Shubin Chen, Department of Intensive Care Unit, China Aerospace Science & Industry Corporation 731 hospital, No. 3 Zhen Gang Nan Li, Yun Gang Town, Feng Tai District, Beijing, 100074, People’s Republic of China, Tel +86010-68374065, Email 18610074016@163.comBackground: The aim of this study was to use five machine learning approaches and logistic regression to design and validate the acute kidney injury (AKI) prediction model for critically ill individuals with cardiogenic shock (CS).Methods: All patients who diagnosed with CS from the MIMIC-IV database, the eICU database, and Zhongnan hospital of Wuhan university were included in this study. …”
Get full text

Painting the Portrait of Fibro-osseous Lesions: An In-vitro Study on Staining Duel of Modified Gallego versus Hematoxylin and Eosin (H&E) Staining by Akash Shegaonkar, Shilpa Patel, Jigna Pathak, Niharika Swain, Rashmi Hosalkar, Rutuj Waghmare

“…Conclusion: The MGS is a better histochemical stain than the routine H&E stain, with increased differentiation and clarity in identifying bone and cemental tissues; hence, it can be considered a reliable method to differentiate pathological tissues.…”
Get full text

Differential Causal Associations of Chronic Gastritis and Ulcerative Colitis with Melanoma Risk: A Mendelian Randomization Study Using Large-Sample GWAS Data by Jin R, Lu J, Cheng S, Shi S

“…In contrast, a positive causal association was found for ulcerative colitis, with the IVW method showing a significant increase in melanoma risk (p = 0.014, OR = 1.130, 95% CI = 1.025– 1.246). …”
Get full text

Adjuvant Lenvatinib for High-Risk CNLC IIb/IIIa Hepatocellular Carcinoma After Curative Hepatectomy: A Prospective Exploratory Study by Sun HC, Huang ZY, Wen T, Liu L, Zhu XD, Zhang E, Li C, Zhang X, Wang J, Fan J, Zhou J

“…This study aimed to evaluate the efficacy and safety of lenvatinib as adjuvant therapy for HCC.Methods: In this open-label, single-arm, prospective, multicenter Phase II clinical study, a total of 51 hCC patients with China Liver Cancer (CNLC) stage IIb/IIIa (ie tumor number ≥ 4 or vascular invasion, equivalent to BCLC B/C) who underwent R0 resection 4– 6 weeks after curative surgery were enrolled. …”
Get full text

ESTIMATION OF EFFICACY OF THE THREATMENT PREVENTIVE COMPLEX IN PATIENTS WITH GENERALIZED PERIODONTITIS, WORKING IN CONDITIONS OF GREENHOUSES UNDER THE INFLUENCE OF PESTICIDES ON SE... by T. D. Zabolotnyj, N. N. Bandrivska, V. T. Dyryk

“…The material and research methods. A complex treatment of inflammatory diseases of periodontal tissues was conducted for 120 workers of greenhouses with generalized periodontitis (71 patient of the main group and 49 persons of the control group). …”
Get full text

Comparing the impact of foot and hand reflexology on anxiety and physiological indices in colonoscopy candidates: A randomized clinical trial by Mohamad Golitaleb, Ali Safdari, Fatemeh Rafiei, Ameneh Yaghoobzadeh, Najmeh Mohamadi, Razieh Mokhtari

“…A total of 105 patients were randomly assigned to three equal-sized groups (n = 35) using block randomization: foot reflexology, hand reflexology, and a control group. …”
Get full text

Mechanisms of Zanthoxyli Pericarpium-Zingiberis Rhizoma in the Treatment of Gastric Cancer Based on Network Pharmacology and Experimental Validation by Gu Q, Duan S, Tibenda JJ, Gou B, Huang S, Chen G, Ning N, Du Y, Liu W, Nan Y, Yuan L

“…As the core combination of the traditional prescription “Dajianzhong Tang”, the medicinal pair of Zanthoxyli Pericarpium and Zingiberis Rhizoma (ZP-ZR) has shown unique advantages in tumor treatment.Purpose: To explore the mechanism of action of ZP-ZR in the treatment of GC using network pharmacology, bioinformatics analysis and in vitro experimental validation, and to provide a theoretical basis for subsequent experimental studies.Patients and Methods: Subsequently, the effects of ZP-ZR on the proliferative ability of gastric cancer HGC-27 and AGS cell lines were verified by CCK-8, apoptosis, cycle and colony formation assays. …”
Get full text

Getting Up in the Morning and Chronotype in Relation to Polycystic Ovarian Syndrome: A Mendelian Randomization and Cross-Sectional Study by Dilimulati D, Lu J, Li J, Cai M, Zhang Y, Shao X, Chen H, Wan Q, He F, Yue C, Zhang M, Qu S

“…Diliqingna Dilimulati,1,* Jiayi Lu,2,* Jinghua Li,2,* Meili Cai,1 Yuqin Zhang,1 Xiaowen Shao,3 Haibing Chen,1 Qian Wan,4 Fang He,4 Chaoyan Yue,5 Manna Zhang,1,6 Shen Qu1 1Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, 200072, People’s Republic of China; 2Department of Clinical Laboratory, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, 200072, People’s Republic of China; 3Department of Obstetrics and Gynecology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, 200072, People’s Republic of China; 4Department of Endocrinology and Metabolism, The First People’s Hospital of Chenzhou, Chenzhou, Hunan, 423000, People’s Republic of China; 5Department of Laboratory Medicine, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, 200011, People’s Republic of China; 6Department of General Practice, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, 200072, People’s Republic of China*These authors contributed equally to this workCorrespondence: Manna Zhang, Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, No. 301, Middle Yanchang Road, Jingan District, Shanghai, 200072, People’s Republic of China, Tel +86 13774448495, Email mannazhang@126.com Chaoyan Yue, Department of Laboratory Medicine, Obstetrics and Gynecology Hospital of Fudan University, No. 419, Fangxie Road, Huangpu District, Shanghai, 200011, People’s Republic of China, Tel +86 02133189900, Email 20111250007@fudan.edu.cnBackground: Although a connection between circadian rhythm and polycystic ovarian syndrome (PCOS) has been shown in previous studies, the exact cause of this association is not well understood.Purpose: This study aimed to use Mendelian randomization (MR) method to analyze the potential association between getting up in the morning and chronotype with PCOS, and a cross-sectional study was conducted to further validate these results.Methods: Using summary information from large-scale genome-wide association studies (GWASs) in people of European ancestry, we conducted univariable MR (UVMR) and multivariable MR (MVMR) analyses to examine the causal effect of genetically determined getting up in the morning and chronotype on PCOS. …”
Get full text

Follow-Up in Primary Care After Ischemic Stroke – Insights From the Nor-COAST Study by Sande IS, Helgheim KL, Saltvedt I, Røsstad TG, Spigset O, Ellekjær H, Gynnild MN

“…Olavs Hospital, Trondheim, Norway*These authors contributed equally to this workCorrespondence: Mari Nordbø Gynnild, Clinic of Cardiology, St. …”
Get full text

A Network Pharmacology-Based Investigation into the Mechanism of Quercetin Combined with Rosuvastatin in Delaying Diabetic Nephropathy via Inhibiting NRK-52E Cell Ferroptosis by Gan M, Lin Z, Ma J, Li N, Wu B

“…This study aimed to investigate the potential synergistic effects of quercetin (QCT) and rosuvastatin (RSV) on inhibiting RTEC ferroptosis and ameliorating DN progression, providing a novel combinatorial therapeutic strategy.Methods: Public database data were analyzed using network pharmacology to identify QCT-DN-related and RSV-DN-related targets, followed by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses. …”
Get full text

A Randomized, Sham-Controlled Trial on the Efficacy and Safety of Electroacupuncture for Lumbar Disc Herniation with Radiculopathy: Rationale and Study Protocol by Yang Y, Liu L, Yuan L, Liu X, Ding H, Zhou X, Cao Q

“…This trial aims to evaluate the efficacy and safety of electroacupuncture in patients with LDHR.Methods: This randomized, single-blind, sham-controlled trial will enroll 170 participants diagnosed with LDHR and who present Numerical Rating Scale (NRS) scores ≥ 4 for both lower back and leg pain. …”
Get full text

Association of <i>SEPT9</i> Gene Methylation with the Clinicopathologic Features and <i>Fusobacterium nucleatum</i> Infection in Colorectal Cancer Patients by Siew-Wai Pang, Subasri Armon, Jack-Bee Chook, Kaik-Boo Peh, Suat-Cheng Peh, Sin-Yeang Teow

“…For FN detection, a TaqMan probe-based method targeting the 16S rRNA gene was used. The differences in <i>mSEPT9</i> levels and FN expression between cancer and non-cancer tissues were evaluated. …”
Get full text

Inhibition of microRNA-139-5p Improves Fibroblasts Viability and Enhances Wound Repair in Diabetic Rats Through AP-1 (c-Fos/c-Jun) by Mo J, Zhang J, Meng X, Wang F, Tang W, Liu Y, Fu L, Liang F, Mo Z

“…MicroRNA-139-5p participates in various biological processes, including cancer and vascular endothelial injury, while its role in diabetic wound healing has not been reported.Methods: Sprague-Dawley (SD) rats were intraperitoneally injected with streptozotocin and a 1.0 cm full-layer dorsal skin wound was made to establish a diabetic wound model. …”
Get full text

Investigating Falls Risk Awareness in Hospitals Using the Self‐Awareness of Falls Risk Measure (SAFRM): Empirical Research Quantitative by Elissa Dabkowski, Simon J. Cooper, Jhodie Duncan, Karen Missen

“…Impact: Registered nurses, health professionals, inpatients. Reporting Method: STROBE checklist for cross‐sectional studies. …”
Get full text

Increased CD163+ Macrophage Activation and High Expression of CD163 Promote Granulosa Cell Apoptosis in Polycystic Ovary Syndrome by Ye J, Wang S, Wang Z, Jiang Y, Jia J, Yang Y, Huo L, Liu X, Zhou Y, Yang Z, Mao J, Ma Y, Wang X

“…However, the precise mechanisms by which inflammation influences granulosa cell function remain poorly understood.Methods: Differentially expressed genes (DEGs) were identified from the GSE34526 dataset, with the inflammatory marker CD163 selected for further investigation due to its upregulation in ovarian granulosa cells in PCOS. …”
Get full text

Incidence of malignant brain and other central nervous system tumors (С70–C72) in Siberia and the Russian Far East by L. D. Zhuikova, E. L. Choynzonov, O. A. Ananina, L. V. Pikalova, I. N. Odintsova, G. A. Kononova

“…In females, brain and other central nervous system malignances were the 16th most common cancers, with the equal incidence of 1.3 % in 2010 and 2020. Overall, the incidence rate of malignant brain and other central nervous system tumors in Siberian and the Russian Far Eastern regions increased from 5.1 to 5.6 per 100 000 with rate of increase of 9.8 %, including the territories of the Republic of Kamchatka (238.5 %), Amur (147.8 %), Khakassia (89.1 %), Irkutsk (65,1 %), Krasnoyarsk (37.8 %), and Primorsky (33.3 %) regions. …”
Get full text

Jacmel, entre rêve et réalité by Jean Davoigneau, Isabelle Duhau

“…The local commercial bourgeoisie rebuilt their houses and warehouses using imported construction methods and materials. The Bord de Mer neighbourhood, the seaside neighbourhood, acquired a new appearance with structures in brick, in moulded cast iron, in riveted steel and in wrought iron. …”
Get full text