Comprehensive Analysis of Programmed Cell Death-Related Genes in Diagnosis and Synovitis During Osteoarthritis Development: Based on Bulk and Single-Cell RNA Sequencing Data by Zhou J, Jiao S, Huang J, Dai T, Xu Y, Xia D, Feng Z, Chen J, Li Z, Hu L, Meng Q

“…Diverse programmed cell death (PCD) pathways are closely linked to the pathogenesis of OA, but few studies have explored the relationship between PCD-related genes and synovitis.Methods: The transcriptome expression profiles of OA synovial samples were obtained from the Gene Expression Omnibus (GEO) database. …”
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Risk factors for complicated community-acquired pneumonia in Egyptian children: a hospital-based 6-month study by Abla S. Mostafa, Amr Mahmoud Abdel Khaleq, Yasser Hassan Mohammed, Erini Farid Fawzy

“…Aim To identify and elucidate risk factors that predispose children diagnosed with community-acquired pneumonia (CAP) to develop local pulmonary complications (complicated community-acquired pneumonia) in our Egyptian community. Methods One-hundred pediatric cases with CAP were involved in a case–control study, where cases were classified into 2 groups depending on the absence (41 cases) or the presence (59 cases) of local pulmonary complications. …”
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Ultrasound and Clinicopathological Characteristics of Papillary Thyroid Carcinoma Predict the Coexistence of TERT Promoter and BRAFV600E Mutations by Yu M, Zhang C, Wang Z, Lv S, Sun Y, Zhao W, Li L, Kong Q, Liu K, Wang S

“…This study aimed to develop preoperative and postoperative predictive models for coexisting mutations based on ultrasound and clinicopathological characteristics to stratify prognostic risks and guide clinical decision-making.Methods: Retrospective analysis of the ultrasound and clinicopathological characteristics of 120 patients with a surgical pathology of PTC with TERT promoter and BRAFV600E gene testing results in the Affiliated Hospital of Jining Medical University from December 2020 to December 2023. …”
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Predicting In-Hospital Mortality in Myocardial Infarction: A Nomogram-Based Retrospective Analysis of the MIMIC-IV Database by Peng S, Chen Q, Ke W, Wu Y

“…We aimed to develop and validate a predictive model for in-hospital mortality in myocardial infarction patients.Methods: LASSO regression analysis, univariate analysis, and multivariate logistic analysis were used to construct the nomogram in the training set, followed by model comparison, internal validation, and sensitivity analysis.Results: The analysis comprised 4688 patients in total. …”
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Sleep Quality and Its Predictors Among Pregnant Women in Jordan: A Cross-Sectional Study by Alasmer Z, Nazzal MS, Mohamed Z, Al-Jaber A, Ali R, Alshar F, Ababneh EM, Alshdaifat E, Kanaan SF

“…Furthermore, physical, psychological, and socioeconomic factors may negatively affect sleep in pregnant women.Purpose: The study aims to explore sleep quality and to identify possible physical, psychological, and socioeconomic predictors of poor sleep quality among pregnant women.Patients and Methods: The cross-sectional study was conducted from July 2021 to January 2022. …”
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Systemic Lupus Erythematosus Stimulates Chondrocyte Pyroptosis to Aggravate Arthritis via Suppression of NRF-2/KEAP-1 and NF-κB Pathway by Shen S, Fang X, Zhang H, Lang T, Fu F, Du Y, Xu T, Jin H, Tong P, Wu C, Hu C, Ruan H

“…The study aimed to investigate the impact of SLE exacerbation on arthritis using the MRL/lpr mouse model, which closely mimics human SLE manifestations.Methods: In the present study, we evaluated the impact of SLE onset on knee joint degeneration by comparing arthritic phenotype and complex molecular alterations between 6 female 14-week-old MRL/lpr mice, which manifest SLE, and MRL/MpJ mice, which remain unaffected.Results: Our results demonstrated that MRL/lpr mice exhibited a more severe arthritic phenotype compared to MRL/MpJ mice, characterized by elevated Osteoarthritis Research Society International (OARSI) scores (P < 0.01), disrupted extracellular matrix metabolism, impaired chondrocyte proliferation and increased apoptosis. …”
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Interleukin-1 Receptor-Associated Kinase-3 Aggravates Neuroinflammatory Injury After Intracerebral Hemorrhage via Activation NF-&kappa;B/IL-17A Pathway in Mice by Wang J, Li Y, Tan C, Shao J, Tang W, Kong Q, Sheng W, Ding Z, Li F, Piao J, Lv D, Hu L, Wang Q, Jiang X

“…Although previous studies have shown that IRAK3 is involved in immune responses, the potential effects of IRAK3 on ICH remain unclear.Methods: Collagenase IV–induced ICH mouse model. Western blotting was used to determine the expression of IRAK3 at different time points following ICH. …”
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The Application of Multifunctional Endoscope Transport Carts in Bedside Endoscopy in Intensive Care Unit Patients by Zhang M, Du J, Zhang Q, Qiao F, Ye L, Hu B, Tao S

“…Miao Zhang,1,2,&amp;ast; Jiang Du,1,2,&amp;ast; Qiongying Zhang,1,2 Fu Qiao,3 Liansong Ye,1,4 Bing Hu,1,4 Siyuan Tao3 1Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 2West China School of Nursing, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 3Department of Infection Control, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 4Digestive Endoscopy Medical Engineering Research Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Qiongying Zhang, Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Wuhou District, Chengdu, Sichuan, 610041, People’s Republic of China, Email hxnjzqy@163.com Fu Qiao, Department of Infection Control, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Wuhou District, Chengdu, Sichuan, 610041, People’s Republic of China, Email qiaofu2005@scu.edu.cnBackground: This study aimed to investigate whether the application of multifunctional endoscope transport carts, in bedside endoscopy in intensive care unit (ICU) patients, can improve the cleaning quality of the endoscopes.Methods: A total of 175 endoscopes, used for bedside endoscopy in ICU patients in a hospital in China during November 2023 to January 2024, were randomly classified into the control group (n=88) and the experimental group (n=87). …”
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A Health Literate Healthcare Organization Index System for China: Based on CiteSpace and Qualitative Analysis by Zhao S, Chen Y, Xia X, Zhou J, Wang X, Sun Q, Chang J, Ge J, Hu L, Lu R

“…Shenyu Zhao,1,&amp;ast; Yang Chen,2,&amp;ast; Xiyang Xia,2 Jing Zhou,2 Xiaoyu Wang,2 Qing Sun,1 Jiaqian Chang,2 Jiaying Ge,2 Lingmin Hu,2 Renjie Lu1,3 1Changzhou Third People’s Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, People’s Republic of China; 2Department of Reproduction, Changzhou Maternity and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, People’s Republic of China; 3Changzhou Institute for Advanced Study of Public Health, Nanjing Medical University, Changzhou, Jiangsu, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Renjie Lu, Changzhou Third People’s Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, 213000, People’s Republic of China, Email renjie_lu@126.com Lingmin Hu, Department of Reproduction, Changzhou Maternity and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, 213000, People’s Republic of China, Email hulingmin1986@126.comObjective: This study aims to analyze the current status and development trends of health literate healthcare organization (HLHO) worldwide, and preliminarily construct an index system suitable for HLHO in China.Methods: This study first utilized CiteSpace for bibliometric analysis to explore global research hotspots and trends in HLHO. …”
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Impact of the COVID-19 pandemic on hospital-based heart failure care in New South Wales, Australia: a linked data cohort study by Daniel McIntyre, Desi Quintans, Samia Kazi, Haeri Min, Wen-Qiang He, Simone Marschner, Rohan Khera, Natasha Nassar, Clara K. Chow

“…A rapid shift from patient-facing to remotely delivered care enabled compliance with restrictions and was associated with increased time to heart failure-related adverse events, but access was not afforded equally across the socio-demographic spectrum.…”
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Clinical efficacy of 177Lu-DOTATATE peptide receptor radionuclide therapy in thyroglobulin-elevated negative iodine scintigraphy: A “not-so-promising” result compared to GEP-NETs... by Sandip Basu, Rahul Parghane, Chinna Naik

“…According to the qualitative uptake of the tracer in somatostatin receptor (SSTR)-based imaging (with either 99mTc-HYNIC-TOC/68Ga-DOTATATE), the lesions were divided into the following four categories: Grade 0: no uptake, Grade I: uptake less than the liver but more than background, Grade II: uptake equal to the liver, and Grade III: uptake more than the liver. …”
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Understanding Mental Health Service Perceptions in Chinese Americans with Type 2 Diabetes and Co-Occurring Mental Health Challenges Living in New York City: A Qualitative Study by Liu J, Cao J, Shi Y, Jiang Y, Ruan J, Wu B, Tsai W, Hu L

“…This study aimed to provide an in-depth exploration of mental health care perceptions in this population.Patients and Methods: Two focus group discussions involving 12 participants were conducted in Mandarin. …”
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The Association Between Medication Adherence and Health-Related Quality of Life in Patients with COPD: A Cross-Sectional Study by Saja MF, Younis AS, Alzahrani LA, Alkhlassi IN, Aldakhil LS, Albayyat RM, Alnasser NA, Alokla KS, Alghamdi LA, Rashed AN, Azer SA

“…This study aimed to measure medication adherence and its impact on HRQoL in patients with COPD.Patients and Methods: This cross-sectional observational study included patients with COPD from two health centers in Riyadh, Saudi Arabia. …”
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Supported Telemonitoring and Glycemic Control in People with Type 2 Diabetes: The Telescot Diabetes Pragmatic Multicenter Randomized Controlled Trial. by Sarah H Wild, Janet Hanley, Stephanie C Lewis, John A McKnight, Lucy B McCloughan, Paul L Padfield, Richard A Parker, Mary Paterson, Hilary Pinnock, Aziz Sheikh, Brian McKinstry

“…There were few adverse events and these were equally distributed between the intervention and control groups. …”
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Qing&amp;rsquo;e Pills Ameliorates Osteoporosis by Regulating Gut Microbiota and Th17/Treg Balance in Ovariectomized Rats by Hao F, Guo M, Zhao Y, Zhu X, Hu X, Zhu W, Mei C, Zhou N, Qin K, Zhu H, Li W

“…However, the mechanism of its immune action remains unclear.Methods: QEP components were identified via HPLC. …”
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Klasifikasi Kelas Kata (Part-Of-Speech Tagging) untuk Bahasa Madura Menggunakan Algoritme Viterbi by Ilham Firmansyah, Putra Pandu Adikara, Sigit Adinugroho

“…Part-Of-Speech Tagging is a method to assign a predefined set of tags (word classes) into a word or a phrase. …”
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Abnormal CSF-Specific OCBs in Neuronal Surface Antibody-Associated Autoimmune Encephalitis Differentiating from Viral Encephalitis by Qiao S, Zhang C, Li H, Zhou T, Wang A, Zhang S

“…Additionally, the study aimed to assess the impact of cerebrospinal fluid (CSF) oligoclonal bands (OCBs) on the severity and prognosis of NSAE.Patients and Methods: This retrospective analysis included patients with NSAE, encompassing NMDAR-E, LGI1-E, and GABABR-E, alongside individuals with VE. …”
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Effects of Electroacupuncture and Mecobalamin for Utidelon-Induced Peripheral Neuropathy in Breast Cancer Patients: A Randomized Controlled Clinical Trial by Lu C, Shen Q, Deng D, Zhang Y, Wang P, Shao X, Deng Y, Bao W, Chen W, Li G

“…This study aims to evaluate the clinical effects of electroacupuncture (EA) and Mecobalamin (MeCbl) in treating Utidelone-induced peripheral neuropathy (UIPN), providing preliminary evidence to optimize clinical management strategies.Methods: A total of 60 eligible breast cancer patients with UIPN were randomly assigned in a 1:1 ratio to either the EA group or the MeCbl group. …”
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Analysis and 15-Year Projections of the Global Burden of Tension-Type Headache by Sex from 1990 to 2021: A Systematic Review of GBD 2021 Data by Xu H, Qin X, Zhao G, Feng Z, You S

“…However, comprehensive analyses and predictive studies on the global TTH burden stratified by gender are currently lacking.Aim: This study utilized data from the Global Burden of Disease (GBD) Study to analyze the global burden of tension - type headache by sex from 1990 to 2021 and conducted a 15 - year projection (up to 2036).Methods: We conducted a systematic review of GBD 2021 data, employing Joinpoint regression analysis and decomposition analysis to assess TTH incidence, prevalence, YLDs, and DALYs. …”
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Multifunctional Indomethacin Conjugates for the Development of Nanosystems Targeting Cancer Treatment by Thiruchenthooran V, Świtalska M, Maciejewska G, Palko-Łabuz A, Bonilla-Vidal L, Wietrzyk J, Souto EB, Sánchez-López E, Gliszczyńska A

“…Therefore, this study aimed to develop a nanosystem with reduced toxicity and risk of side effects for the delivery of IND for cancer treatment.Methods: IND was encapsulated in nanostructured lipid carriers (NLC) in the form of a phospholipid conjugate, where a covalent bond exists between the drug and phosphatidylcholine skeleton. …”
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