Changes in the concentration of melatonin and endogenous proteins regulating carbohydrate and lipid metabolism in rats under conditions of light desynchronosis with pharmacological... by A. V. Sharabanov, E. G. Batotsyrenova, T. Yu. Kretser, E. N. Krasnikova, V. A. Kashuro, I. A. Srago, E. M. Golinets, D. V. Khvostov

“…With constant exposure to PEE in doses 100 mg/kg, it promotes an increase in the concentration of melatonin in the blood serum, approximately equal to the level of the control group.Conclusion. …”
Get full text

Gantry-based pencil beam scanning proton therapy for uveal melanoma: IMPT versus proton arc therapy by Hang Qi, Lei Hu, Sheng Huang, Yen-Po Lee, Francis Yu, Qing Chen, Yunjie Yang, Minglei Kang, Huifang Zhai, Milo Vermeulen, Andy Shim, Peter Park, Xuanfeng Ding, Jun Zhou, David H. Abramson, Jasmine H. Francis, Charles B. Simone, Christopher A. Barker, Haibo Lin

“…Similar target coverage was achieved, with an average GTV D95% equal to 101.1% $$\:\pm\:$$ 1.0% and 101.4% $$\:\pm\:$$ 0.4% for IMPT and proton arc plans, respectively. …”
Get full text

Labor induction at 41+0 gestational weeks or expectant management for the nulliparous woman: The Finnish randomized controlled multicenter trial by Katariina Place, Leena Rahkonen, Aydin Tekay, Kirsi Väyrynen, Maija‐Riitta Orden, Marja Vääräsmäki, Jukka Uotila, Kati Tihtonen, Kirsi Rinne, Kaarin Mäkikallio, Seppo Heinonen, Heidi Kruit

“…Participants were randomized to either early induction (48.8%, n = 186) or expectant management (51.2%, n = 195) with equal randomization ratios of 1:1. This was a superiority trial, and the primary outcomes were rates of cesarean section (CS) and composite of adverse neonatal outcomes. …”
Get full text

Analysis of HMGCS2 Expression and TG Lipidomics in the Perirenal Adipose Tissue of Obese Diabetic Nephropathy Mice by Yuhong Huang, Miao Zeng, Mengxue Yang, Xiaodi Zheng, Lulu Jin, Rui Zhang, Yueyue Wu, Fei Li, Bo Yang, Jun Liu

“…This study was designed to elucidate the contribution of Hmgcs2 in the pathogenesis of obese diabetic kidney disease mice. Methods 12‐week‐old db/db (diabetic) and db/m (control) mice were fed high‐fat or normal diets, respectively. …”
Get full text

How does dispersal shape the genetic patterns of animal populations in European cities? A simulation approach by Savary, Paul, Tannier, Cécile, Foltête, Jean-Christophe, Bourgeois, Marc, Vuidel, Gilles, Khimoun, Aurélie, Moal, Hervé, Garnier, Stéphane

“…Context and objectives: Although urbanization is a major driver of biodiversity erosion, it does not affect all species equally. The neutral genetic structure of populations in a given species is affected by both genetic drift and gene flow processes. …”
Get full text

Retinal progenitor cells (jCell) for retinitis pigmentosa by Jing Yang, Jing Yang, Baruch D. Kuppermann, David Liao, Mitul C. Mehta, Chinhui Hsiang, Chinhui Hsiang, Steven Menges, Steven Menges, David S. Boyer, Henry Klassen, Henry Klassen

“…Each dose group contained equal numbers of subjects from Cohorts 1 and 2.ResultsIntravitreal RPC injection was well tolerated and associated with mostly transient mild to moderate adverse events. …”
Get full text

Comparison of Mallampati test in supine and upright positions with and without phonation in predicting difficult laryngoscopy and intubation in age groups 3-10 years. by P. Awasthi, S. Gautam, A. Malik, V. Singh, M. Kohali, S. Jafa, J. Agarwal

“…Conclusions Evaluation of airway in supine position without phona- tion with Modified Mallampati test is equally good alternative to upright (sitting) position without phonation for predicting difficult airway in bedridden patients and in emergency cases.…”
Get full text

Renoprotective Effects of Hydroxychloroquine and Folinic Acid via ET-1 and NLRP3 Modulation in Reducing Tubular Injury in A Rabbit Model of Methanol-induced Acute Kidney Injury by Prayuda Prayuda, I Gde Raka Widiana, Ketut Suega, Yenny Kandarini, Ni Wayan Winarti, Bambang Purwanto

“…Expression of NLRP3 was lowest in combination group (58.94±1.05%), followed by folinic acid and hydroxychloroquine group, which showed equal values (60.57±1.38%), compared to control group (72.15±1.02%). …”
Get full text

Randomized Clinical Trial of Surgical vs. Percutaneous vs. Hybrid Revascularization in Multivessel Coronary Artery Disease: Residual Myocardial Ischemia and Clinical Outcomes at On... by Vladimir Ganyukov, Nikita Kochergin, Aleksandr Shilov, Roman Tarasov, Jan Skupien, Wojciech Szot, Aleksandr Kokov, Vadim Popov, Kirill Kozyrin, Olga Barbarash, Leonid Barbarash, Piotr Musialek

“…We evaluated, in a randomized clinical trial, residual myocardial ischemia (RI) and clinical outcomes of MV-CAD revascularization using coronary artery bypass grafting (CABG), hybrid coronary revascularization (HCR), or MV-PCI. Methods. Consecutive MV-CAD patients (n = 155) were randomized (1 : 1 : 1) to conventional CABG (LIMA-LAD plus venous grafts) or HCR (MIDCAB LIMA-LAD followed by PCI for remaining vessels) or MV-PCI (everolimus-eluting CoCr stents) under Heart Team agreement on equal technical and clinical feasibility of each strategy. …”
Get full text

Measurement invariance of HIV-related stigma scales among men who have sex with men (MSM) and non-MSM populations: implications for comparative studies in China by Tianyue Mi, Xueying Yang, Guanghua Lan, Shan Qiao, Zhiyong Shen, Yuejiao Zhou, Xiaoming Li

“…This study examines the measurement invariance of internalized, anticipated, and enacted HIV-related stigma scales between MSM and non-MSM populations in China.MethodsData were derived from two studies: a prospective cohort study with 193 MSM and 579 non-MSM, and a cross-sectional survey of 402 MSM. …”
Get full text

Impact of male peer‐led outreach on uptake of HIV testing among male partners of pregnant women in Uganda: a randomized trial by Faith Naddunga, Michelle A. Bulterys, Agnes Nakyanzi, Deborah Donnell, Juliet Kyomugisha, Juliet E. Birungi, Paul Ssendiwala, Rogers Nsubuga, Timothy R. Muwonge, Joshua Musinguzi, Sue Peacock, Connie L. Celum, Andrew Mujugira, Monisha Sharma

“…We evaluated the impact of male peer outreach to increase HIV testing among partners of pregnant women in Uganda. Methods We conducted a randomized trial in Kampala, Uganda, enrolling an equal number of pregnant women with and without HIV from public ANC clinics who were randomized 1:1 to intervention or standard‐of‐care (SOC) with delayed intervention after 1 month. …”
Get full text

A high‐resolution model of the grapevine leaf morphospace predicts synthetic leaves by Daniel H. Chitwood, Efrain Torres‐Lomas, Ebi S. Hadi, Wolfgang L. G. Peterson, Mirjam F. Fischer, Sydney E. Rogers, Chuan He, Michael G. F. Acierno, Shintaro Azumaya, Seth Wayne Benjamin, Devendra Prasad Chalise, Ellice E. Chess, Alex J. Engelsma, Qiuyi Fu, Jirapa Jaikham, Bridget M. Knight, Nikita S. Kodjak, Adazsofia Lengyel, Brenda L. Muñoz, Justin T. Patterson, Sundara I. Rincon, Francis L. Schumann, Yujie Shi, Charlie C. Smith, Mallory K. St. Clair, Carly S. Sweeney, Patrick Whitaker, James Wu, Luis Diaz‐Garcia

“…Societal Impact Statement Grapevine leaves are emblematic of the strong visual associations people make with plants. Leaf shape is immediately recognizable at a glance, and therefore, this is used to distinguish grape varieties. …”
Get full text

Comorbidity health pathways in heart failure patients: A sequences-of-regressions analysis using cross-sectional data from 10,575 patients in the Swedish Heart Failure Registry. by Claire A Lawson, Ivonne Solis-Trapala, Ulf Dahlstrom, Mamas Mamas, Tiny Jaarsma, Umesh T Kadam, Anna Stromberg

“…Patient-rated health measures included the EuroQol-5 dimension (EQ-5D) questionnaire and the EuroQol visual analogue scale (EQ-VAS). EQ-VAS score ranges from 0 (worst health) to 100 (best health). …”
Get full text

Vibration Energy Color Doppler Imaging (VECDI) in Evaluating the Effect of Screw Fixation on Sacroiliac Joint Stiffness: A Prospective Pilot Study by Caleb Gottlich, Thomas Githens, Alex Drusch, Neil Jain, Cyrus Caroom, Phillip S. Sizer

“…One investigator performed SIJ measurements on healthy subjects to establish reliability and then evaluated post SIJ fixation stiffness in experimental subjects at four-weeks (T1) and eight-weeks (T2). Visual analog scales were used to collect subjective pain scores at each time point. …”
Get full text

A prospective randomized controlled trial comparing biphasic cartilage repair implant with microfracture in small chondral lesions of knee: findings at five-year-follow-up by Yao-Yi Kuo, Si-Qi Chiu, Wen-Pei Chang, Chih-Yu Chen, Chih-Hwa Chen, Chen-Kun Liaw, Cheng-Aun Tan, Pei-Wei Weng

“…This study aimed to compare the clinical and radiological outcomes of Biphasic Cartilage Repair Implant (BiCRI) and microfracture treatments for knee cartilage defects. Methods This randomized controlled clinical trial enrolled patients with symptomatic knee chondral lesions smaller than 3 cm2. …”
Get full text

Impact of cessation of caffeine citrate therapy on intermittent hypoxemia patterns among preterm infants born before 34 weeks by Peter Kipkurui Mashep, Roseline Ochieng, Jesse Coleman, Mary Waiyego, Amy Sarah Ginsburg, Dorothy Chomba, Morris Ogero Ondieki, Grace Irimu, William M. Macharia, J. Mark Ansermino

“…Change in slope compared visually in two time periods interrupted at 34 weeks and objective statistical analysis done using the Student-T-test, CI 95% with p-value <0.05 considered significant.Results49 patients medical records available for secondary analysis. …”
Get full text

Microcirculation Disorders in Patients with Severe COVID-19 by E. E. Ladozhskaya-Gapeenko, K. N. Khrapov, Yu. S. Polushin, I. V. Shlyk, N. N. Petrishchev, I. V. Vartanova

“…The presence of avascular zones,  the number of capillaries in the visualized field with circulating aggregates in the lumen, and the shape of capillaries were taken into account.  …”
Get full text

Association of self-efficacy, risk attitudes, and time preferences with health-related quality of life and functioning after total hip or knee replacement – Results of the MobilE-T... by Sebastian Fuchs, Lars Schwettmann, Benedict Katzenberger, Alexander Paulus, Boris Michael Holzapfel, Johanna Theresia Biebl, Martin Weigl

“…As indicators for the surgical outcome, HRQoL was assessed by the EuroQol Five-Dimensional Five-Level Questionnaire (EQ-5D-5L), including the visual analogue scale (EQ-VAS), and functioning was assessed by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) using the global score, function score, and pain score. …”
Get full text

Effects of the subanesthetic dose of esketamine on postoperative sleep quality in patients undergoing modified radical mastectomy: a randomized, double-blind controlled trial by Ying Chen, Junchen He, Rong Huang, Zhuoqi Pan, Min Zhong, Wenxuan Zhang

“…The purpose of this study was to observe the effects of intraoperative subanesthetic dose of esketamine on the sleep of patients undergoing modified radical mastectomy.MethodsThis randomized, double-blind, controlled trial enrolled 145 female patients, who were randomly assigned to either the esketamine group (Group E, n = 72) or the control group (Group C, n = 73). …”
Get full text

Mapping the Epidemiologic Features of Endotracheal Tube ObstructionTake-Home Points by Vimal Bhardwaj, MD, FNB(Critical Care), EDIC, Abhishek Samprathi, MD, DrNB, EDIC, Manu M.K. Varma, MD, DM, Kingshuk Saha, MSc, Ross Prager, MD, John Basmaji, MD, Nicolas Orozco, MD, Srirang Ramamoorthy, MSc, Jose Chacko, MD, EDIC, Arjun Alva, MD

“…Tubes were inspected visually and were cut at the point of maximum blockage, and cross-sectional images captured with a 12-megapixel camera were analyzed for ETB percentage using the SketchAndCalc algorithm. …”
Get full text