PENGARUH PERAN KEPEMIMPINAN DAN DISIPLIN KERJATERHADAP KINERJA KARYAWAN PADA PERUSAHAAN DAERAH AIR MINUM (PDAM) KABUPATEN KARAWANG by Cecep Hermana, Uswatun Nurhasanah

“…Teknik analisis yang digunakan yaitu teknik analisis skala likert dan analisis jalur dengan menggunakan alat bantu Method Of Successive Interval (MSI), Microsoft Office dan SPSS versi 16. …”
Get full text

Designing Survey-Based Mobile Interfaces for Rural Patients With Cancer Using Apple’s ResearchKit and CareKit: Usability Study by Alyssa Donawa, Christian Powell, Rong Wang, Ming-Yuan Chih, Reema Patel, Ralph Zinner, Eliah Aronoff-Spencer, Corey E Baker

“… BackgroundDespite the increased accessibility and availability of technology in recent years, equality and access to health-related technology remain limited to some demographics. …”
Get full text

Association of the Monocyte to High-Density Lipoprotein Cholesterol Ratio and Neutrophil to High-Density Lipoprotein Cholesterol Ratio With the Severity of New-Onset Coronary Arter... by Shu H, Han S, Qiu W, Li J, Zhang X, Su H, Wu H, Zhao G, Li Q

“…However, the correlation between MHR, NHR, and the severity of newly diagnosed coronary artery disease (CAD) has not been thoroughly explored.Methods: In this retrospective study, we enrolled 1489 patients who underwent coronary angiography for the first time between January 2022 and December 2023, of which 1143 were diagnosed with CAD. …”
Get full text

Obesity and metabolic syndrome as risk factors for the development of non-alcoholic fatty liver disease as diagnosed by ultrasound by Petrović Gordana, Bjelaković Goran, Benedeto-Stojanov Daniela, Nagorni Aleksandar, Brzački Vesna, Marković-Živković Bojana

“…Metabolic syndrome was determined in 48 (87.27%) patients of the study group. An equal number of patients, 16 of them (29.09%), had 3, 4 and 5 components of MS. …”
Get full text

Evaluation of Estimated Glucose Disposal Rate with Neutrophil-to-Lymphocyte Ratio Integrated for Prognosticating Adverse Cardiovascular and Cerebrovascular Events and Risk Stratifi... by Feng X, Liu Y, Yang J, Zhou Z, Yang S, Zhou Y, Guo Q

“…Xunxun Feng,1,2 Yang Liu,1 Jiaqi Yang,1 Zhiming Zhou,1 Shiwei Yang,1 Yujie Zhou,1,* Qianyun Guo1,* 1Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Beijing Institute of Heart Lung and Blood Vessel Disease, Clinical Center for Coronary Heart Disease, Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Medicine, Division of Cardiology, University of California, Los Angeles, CA, USA*These authors contributed equally to this workCorrespondence: Yujie Zhou; Qianyun Guo, Email azzyj12@163.com; gqydyx3000@163.comObjective: This research aimed to address the critical need for effective prognostic tools in patients with acute coronary syndrome (ACS) and type 2 diabetes mellitus (T2DM) undergoing percutaneous coronary intervention (PCI) by exploring the potential significance of integrating estimated glucose disposal rate (eGDR) and neutrophil-to-lymphocyte ratio (NLR).Methods: Major adverse cardiovascular and cerebrovascular events (MACCE) were the primary endpoint. …”
Get full text

Dysphagia and Body Composition in Cornelia de Lange Syndrome by Aleksandra Mędza, Aleksandra Cieszko, Małgorzata Gliwa, Michał Brzeziński, Jolanta Wierzba, Agnieszka Szlagatys-Sidorkiewicz, Katarzyna Sznurkowska

“…Dysphagia may be a sign or a complication of GERD (gastroesophageal reflux disease), which is the most frequent gastroenterological disorder in CdLS patients; Methods: Fourteen Polish patients with a clinical or genetic diagnosis of CdLS were included in the study. …”
Get full text

Characteristics of the Emotional and Behavioral Reactions of Rats under Chronic Stress Immobilization During Treatment with 5-R-thio-tetrazol [1,5-c] quinazoline Derivatives by О. Y. Tozyuk

“…RESEARCH MATERIALS AND METHODS. Chronic stress immobilization was modeled by keeping rats in small wooden cases for 16 hours / day for 18 days. …”
Get full text

Combination of Three Treatment Modes of 1064 nm Nd: YAG Laser in the Treatment of Melasma: A Retrospective Observational Study by Qiu H, Zhu Y, Wu B, Zhou S, Zhou X, Pan F

“…To investigate a more effective laser-based approach, this retrospective study evaluates the clinical outcomes of combining Low-fluence QS 1064 nm Nd: YAG laser, Fractional-mode QS 1064 nm Nd: YAG laser, and Long-pulsed 1064 nm Nd: YAG laser in the treatment of melasma.Methods: This retrospective observational study enrolled 43 patients with clinically diagnosed melasma, all of whom underwent treatment with a 1064 nm Nd: YAG laser using a combination of three modes: low-fluence QS, fractional-mode QS, and long-pulsed settings. …”
Get full text

Prediction of Ki-67 Expression in HIV-Associated Lung Adenocarcinoma Patients Using Multiple Machine Learning Models Based on CT Imaging Radiomics by Song C, Chen J, Zhao C, Song S, Yang T, Huang A, Liu R, Pan Y, Xu C, Chen C, Zhu Q

“…Therefore, developing a non-invasive and accurate method for Ki-67 prediction holds significant clinical importance. …”
Get full text

Vertebral Osteoporosis in Systemic Lupus Erythematosus: A Possible Involvement of Inflammation-Related Osteoblast Ferroptosis by Lao Z, Chen X, Chen X, Zhang H, Zhang Z, Bian Y, Zhou C, Tian K, Jin H, Fu F, Wu C, Gan K, Ruan H

“…This study utilized the MRL/lpr mouse model, which effectively replicates human SLE manifestations, to investigate the impact of SLE on vertebral bone homeostasis.Methods: Female MRL/lpr mice were employed to investigate SLE-induced bone loss. …”
Get full text

Copper-Based Metal-Organic Framework Nanoplatform for miRNA Delivery: Synergistic Antitumor Therapy by Tu M, Deng X, Lai B, Liu J, Tao Y, Xu S, Li X, Niu X, Li Z, Huang J, Li J, Mao S, Ouyang X, Cao J

“…However, antioxidant mechanisms in tumor cells greatly reduce CDT efficacy.Methods: We propose using MOF-199 nanoparticles (NPs) with tumor microenvironment responsiveness as a carrier for miR-4521 to construct miR-4521@MOF-199 for cancer treatment. …”
Get full text

Safety Profile of Intravenous Ferulic Acid Nanoparticles: Acute Toxicity and Neurological Effects in Sprague-Dawley Rats by Huang H, Xuan Y, Ma ZC

“…This study aimed to develop and evaluate FA-loaded lipid nanoparticles (FA-LNPs) as a safe and efficient drug delivery system.Methods: FA-LNPs were prepared via an optimized active loading method. …”
Get full text

Analgesic Efficacy of Thoracoscopic Direct-View Versus Ultrasound-Guided Thoracic Paravertebral Block in Multi-Port Video-Assisted Thoracoscopic Lung Surgery: A Randomized Controll... by Tong Y, Wu J, Wu X, Mo Y, Wang F

“…Yao Tong,1,* Jimin Wu,2,* Xuhui Wu,3 Yunchang Mo,1 Faxing Wang2,4 1Department of Anesthesiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China; 2Department of Anesthesiology, Lishui People’s Hospital, Lishui Hospital of Wenzhou Medical University, Lishui, People’s Republic of China; 3Department of Thoracic Surgery, Lishui People’s Hospital, Lishui Hospital of Wenzhou Medical University, Lishui, People’s Republic of China; 4Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Medical University, Wenzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Faxing Wang, Department of Anesthesiology, Lishui People’s Hospital, Lishui Hospital of Wenzhou Medical University, No. 15, Dazhong Street, Lishui, Zhejiang Province, 323000, People’s Republic of China, Email wfx2023@wmu.edu.cn Yunchang Mo, Department of Anesthesiology, the First Affiliated Hospital of Wenzhou Medical University, Shangcai Village, Nanbaixiang Street, Ouhai District, Wenzhou, Zhejiang, 325000, People’s Republic of China, Email myc1104@wmu.edu.cnPurpose: This study compares the analgesic effects of the Thoracoscopic Direct-view Thoracic Paravertebral Nerve Block (DTPVB) with those of the Ultrasound-guided Thoracic Paravertebral Nerve Block (UTPVB), providing a clinical reference.Patients and Methods: Sixty-eight patients undergoing three-port video-assisted thoracic surgery (VATS) with general anesthesia were randomly assigned to either the DTPVB group (Group D, n = 34) or the UTPVB group (Group U, n = 34). …”
Get full text

Dynamics of uric acid concentration against the background of early dapagliflozin use in patients with acute decompensation of heart failure by Laura H. Sarieva, Anastasiya E. Poskakalova, Svetlana N. Nasonova, Igor V. Zhirov, Sergey N. Tereshchenko

“…In patients with ADHF and reduced LVEF, a uric acid level equal to or greater than 667.9 μmol/L during hospitalisation predicted a high risk of death during the 6-month follow-up period. …”
Get full text

Efficacy and Safety of Low-Dose Lenvatinib and Toripalimab in Patients With Recurrent Platinum-Resistant Ovarian Cancer: Study Protocol of a Multicenter, Open-Label, Single-Arm, Ph... by Su H, Shang X, Liu H, Wang Y, Yu Y, Xu Y, Jiang K, Feng F

“…This study is designed to further validate the efficacy and safety of the combination therapy of low-dose lenvatinib and PD-1 inhibitor toripalimab in patients with recurrent PROC.Study Design and Methods: The study is designed as a multicenter, open-label, single-arm, prospective phase II study. …”
Get full text

MAP17 is a Novel NASH Progression Biomarker Associated with Macrophage Infiltration, Immunotherapy Response, and Oxidative Stress by Huang Z, Chen J, Liu S, Xiang X, Long Y, Tan P, Fu W

“…However, the role of membrane-associated protein 17 (MAP17) in NASH remains unclear, which prompted this study to explore its relationship with immune infiltration and its regulatory mechanisms.Methods: We employed weighted correlation network analysis (WGCNA) to construct a gene co-expression network aimed at identifying key genes associated with NASH progression. …”
Get full text

Treatment With Schistosoma Japonicum Peptide SJMHE1 and SJMHE1-Loaded Hydrogel for the Mitigation of Psoriasis by Liu X, Wang S, Jiang Y, Luo X, Yang Y, Huo L, Ye J, Zhou Y, Yang Z, Du F, Dong L, Mao C, Wang X

“…This study evaluates the effects of the peptide SJMHE1 from Schistosoma japonicum (S. japonicum) on the inflammatory response in imiquimod (IMQ)-induced psoriasis mice and LPS-stimulated keratinocytes, as well as the efficacy of SJMHE1-loaded hydrogel on psoriasis in mice.Methods: SJMHE1 was administered to mice with IMQ-induced psoriasis via topical administration or subcutaneous injection, and effects were evaluated by detecting the skin inflammation of mice. …”
Get full text

The Median Effective Dose of Ciprofol Combined with Sufentanil for Inhibiting Responses to Gastroscope Insertion in Obese Patients: A Prospective, Single-Center Study by Xue Z, Liu X, Qian W, Yang N, Pan Y, Zhou Y, Jiang W, Li F, Qian B

“…All patients received 0.1 μg/kg of sufentanil, and the ciprofol dose was determined by the modified Dixon sequential method with an initial dose of 0.4 mg/kg and a dose gradient of 0.01 mg/kg. …”
Get full text

A systematic review of evidence on the intersection of gender, sociocultural determinants of health, and antimicrobial resistance in a changing climate by Ms Ambika Lall, Dr. Vrinda Nampoothiri, Dr. Abdul Baasit Isaacs, Dr. Hope Mackline, Dr. Anastasia Koch, Dr. Deepshikha Batheja, Dr. Esmita Charani

“…Conclusion: For a renewed and strengthened gender equality and health equity focus, evidence is critically needed on the intersection of AMR, gender, and climate.…”
Get full text

More Physical Exercise is Beneficial to Glycemic Control in Late Pregnancy Among Women with Gestational Diabetes Mellitus: Findings Based on Trajectory Model in a Prospective Cohor... by Zhang X, Ding Y, Duan Z, Cai R, Gao X, Zhang R, Wang R

“…This study aimed to explore this association using a group-based trajectory model (GBTM) among women with GDM.Patients and Methods: We constructed two types of models (A and B) by applying GBTM analysis based on a series of abnormal plasma glucose (PG) prevalence values calculated at each prenatal checkup in the GDM cohort. …”
Get full text