Cerebral Amyloid Angiopathy-Related Inflammation: Clinical Characteristics and Treatment Experience by Wang X, Li J, Fu Q, Zheng H, Duan S, Gao Y, Luo H, Xu Y

“…Xue Wang,1,* Jiaqi Li,1,* Qichang Fu,2,* Honglin Zheng,1,3 Suying Duan,1 Yuan Gao,1,4 Haiyang Luo,1,3 Yuming Xu1,3,4 1Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, People’s Republic of China; 2Department of Magnetic Resonance, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, People’s Republic of China; 3NHC Key Laboratory of Prevention and Treatment of Cerebrovascular Disease, Zhengzhou, Henan, People’s Republic of China; 4Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Haiyang Luo, Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Jian-She East Road, Zhengzhou, Henan, 450000, People’s Republic of China, Email fccluohy@zzu.edu.cn Yuming Xu, Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Jian-She East Road, Zhengzhou, Henan, 450000, People’s Republic of China, Email xuyuming@zzu.edu.cnObjective: The present study aims to analyze the clinical manifestations, laboratory results, neuroimaging features, treatment interventions, and outcomes in a cohort of patients with cerebral amyloid angiopathy-related inflammation (CAA-ri), providing a deeper understanding of this rare subtype of CAA and enhancing diagnostic precision in clinical practice.Methods: We conducted a systematic retrospective review of clinical records from 13 consecutive patients who met the diagnostic criteria for probable CAA-ri and were evaluated at the First Affiliated Hospital of Zhengzhou University between January 2021 and August 2024.Results: The study cohort comprised 13 patients (7 males, 6 females; mean age 65.2 years, range 42– 81), predominantly presenting with subacute onset (53.8%, n=7). …”
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The Role of Robot-Assisted Technique in Treating Adult Degenerative Scoliosis with Circumferential Minimal Invasive Correction Surgery – A Retrospective Analysis of 51 Co... by Zhang Q, Chen Z, Lin Y, Zhang X, Wu W, Liang Y

“…Robot-assisted technique demonstrates lots of advantages but the data about its application in treating ADS is limited in literatures.Methods: A total of 51 cases diagnosed with ADS were retrospectively analyzed. …”
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Preoperative SII Can Predict Postoperative Recurrence and Serious Complications in Patients with Hepatolithiasis by Mao T, Zhao X, Jiang K, Xie Q, Yang M, Wang H, Zheng P, Lei Z, Gao F

“…This study aims to evaluate the relationship between systemic immune index (SII) in recurrence-free survival (RFS), as well as the incidence of severe postoperative complications in hepatolithiasis patients.Patients and Methods: We retrospectively analyzed 177 patients with hepatolithiasis. …”
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Adjuvant Hepatic Arterial Infusion Chemotherapy Versus Transarterial Chemoembolization for Preventing Early Recurrence After Surgical Resection in Hepatocellular Carcinoma by Xia Y, Wen W, Liao Y, Cai Y, Wan R

“…This study evaluates the comparative efficacy and safety of PA-HAIC versus PA-TACE in preventing early recurrence among HCC patients with postoperative high-risk recurrence factors.Patients and Methods: A retrospective analysis included 170 HCC patients with high-risk recurrence factors following surgical resection (2018– 2023), divided into PA-HAIC (n=23) and PA-TACE (n=147) groups. …”
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Ketamine Infusion as an Adjunct to Opioid Analgesia in Pediatric Patients with High-Risk Neuroblastoma Undergoing Treatment with Dinutuximab: Adverse Effects and Safety in a Non-IC... by Streby KA, Tobias JD, McPhaden E, Downie S, Stanek J, Roth C, Patel PO

“…In addition, the secondary objective is to describe the toxicities of pain management with opioids versus opioid plus ketamine.Methods: A retrospective chart review of 40 hRNBL patients receiving dinutuximab at Nationwide Children’s Hospital, from 2010 to 2022, was conducted. …”
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Examination on the Acceptability, Feasibility and Effectiveness of a Digital Cognitive Training Software in Patients With Stable Schizophrenia in China by Yang L, Tang Y, Zhu J, Xu L, Wang M, Sun W, Shi C

“…Liu Yang,1,* Yajing Tang,1,* Jiahui Zhu,2 Lingzi Xu,3 Mingqia Wang,1 Wei Sun,3 Chuan Shi1 1Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, People’s Republic of China; 2The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Beijing Infinite Brain Technologies, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chuan Shi, Peking University Sixth Hospital, 51 huayuan North Road, Beijing, 100089, People’s Republic of China, Email shichuan@bjmu.edu.cn Wei Sun, Beijing Infinite Brain Technologies, 40 Xiaoyun Road, Beijing, 100004, People’s Republic of China, Email sunwei@wjbrain.comObjective: This single-arm study aimed to explore the acceptability and effectiveness of a digital cognitive training software (IBT-004) in patients with stable schizophrenia.Methods: This study conducted an 8-week home-based cognitive training program, IBT-004, for patients with stable schizophrenia. …”
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Improving Large Language Models’ Summarization Accuracy by Adding Highlights to Discharge Notes: Comparative Evaluation by Mahshad Koohi Habibi Dehkordi, Yehoshua Perl, Fadi P Deek, Zhe He, Vipina K Keloth, Hao Liu, Gai Elhanan, Andrew J Einstein

“…H-summaries had higher completeness in 13 notes, and U-summaries had higher or equal completeness in 2 notes, resulting in P=.01, which implied statistical significance. …”
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Moment-curvature response of concrete beams reinforced with steel bars and dual hooked-end fibers: Tests versus predictions by Model Code 2020 and Rilem TC 162-TDF by Amarjeet Kumar, Aleksandr Sokolov, Alinda Dey, Karolis Sakalauskas, Darius Bacinskas, Juozas Valivonis, Gintaris Kaklauskas

“…Further, the beams with varied reinforcement ratio and bar diameter were tested under four-point bending, and the experimental moment-curvature relationships were obtained using both Digital Image Correlation (DIC) and Linear Variable Differential Transformer (LVDT) methods. The study reveals that the DIC-based approach is equally consistent to the LVDT-based method. …”
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Prediction of Clinical Bronchiectasis from Asymptomatic Radiological Bronchiectasis by Fan Y, Li Z, Jiang N, Zhou Y, Song J, Yu F, Zhang J, Wang X

“…Whether the ARB could progress to CB and the risk factors to speed up the process are poorly understood.Methods: This was an observational cohort study. 370 patients with radiological bronchiectasis were included in Wuhan Union Hospital in 2018. 296 ARB patients were followed up in 2022 to verify if they progressed to CB and divided the development and validation of clinical prediction models into a training set (n=207) and a validation set (n=89) by the ratio of 7:3. …”
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Telemedical treatment of diabetic foot ulcer in rural and remote areas: a prospective single centre randomised controlled clinical trial by Usman H Malabu, Venkat N Vangaveti, Julie Goodall, Jacqueline Bulbrook, Erik Biros, Harshal Deshmukh, Kunwarjit S Sangla

“…Therefore, our objective was to conduct a randomized controlled trial comparing the effectiveness of telemedical treatment in rural settings with the standard tertiary healthcare approach for managing diabetic foot ulcers. Methods The study was conducted between 2016 and 2022. …”
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GA-LDV: A Promising Derivative of 18β-Glycyrrhetinic Acid with Enhanced in vitro and in vivo Anti-Cancer Properties by Zheng J, Feng Q, Gao Q, Wang Y, Zhao S, Zhang X, Zhao M

“…Jiaying Zheng,1,* Qiqi Feng,1,* Qi Gao,1 Yaonan Wang,1 Shurui Zhao,1 Xiaoyi Zhang,1 Ming Zhao1,2 1Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University, Beijing, 100069, People’s Republic of China; 2Beijing Laboratory of Biomedical Materials and Key Laboratory of Biomedical Materials of Natural Macromolecules, Department of Biomaterials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100026, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ming Zhao, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University, Beijing, 100069, People’s Republic of China, Tel +861083911535, Fax +861083911533, Email maozhao@126.com Xiaoyi Zhang, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University, No. 10, Youanmenwaixitoutiao, Fengtai District, Beijing, 100069, People’s Republic of China, Tel +861083911530, Fax +861083911533, Email zhangdd@ccmu.edu.cnPurpose: The clinical translation of 18β-Glycyrrhetinic acid (GA) is impeded by its relatively low antitumor potency and poor aqueous solubility, we developed a novel derivative of GA by incorporating the Leu-Asp-Val (LDV) tripeptide to enhance its anti-tumor and anti-metastatic activities both in vitro and in vivo, thereby increasing its potential as a therapeutic agent for cancer treatment.Methods: The water solubility of GA-LDV was evaluated. …”
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Retrospective Analysis of Factors Associated with a Prolonged Nucleic Acid Conversion Time in Patients with COVID-19 at Fangcang Shelter Hospital by Li Y, Wei Y, Wang Y, Chen Q, Hou X

“…Yang Li,1,* Yang Wei,2,* Yu Wang,1 Qiuxia Chen,1,3 Xianhua Hou1,3 1Department of Neurology, The First Affiliated Hospital of Army Medical University, Chongqing, People’s Republic of China; 2Department of Vascular Surgery, The First Affiliated Hospital of Army Medical University, Chongqing, People’s Republic of China; 3Department of Neurology of Jiangbei Campus, The First Affiliated Hospital of Army Medical University, Chongqing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xianhua Hou, Department of Neurology, The First Affiliated Hospital of Army Medical University, No. 30 Gaotanyan Main St, Shapingba District, Chongqing, 400038, People’s Republic of China, Email houxianhua@tmmu.edu.cn Qiuxia Chen, Department of Neurology of Jiangbei Campus, The First Affiliated Hospital of Army Medical University, No. 29 Jianxin East Road St, Jiangbei District, Chongqing, 400020, People’s Republic of China, Email chenqiuxia@tmmu.edu.cnObjective: The aim of this study was to explore the related factors for prolonged nucleic acid conversion time (NCT) in patients with SARS-CoV-2 Omicron variant, so as to help to prevent and control the epidemic.Methods: This study retrospectively included 307 patients diagnosed with mild to moderate COVID-19 who were hospitalized in Shanghai International Exhibition Fangcang Shelter Hospital. …”
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The Duration of Prophylactic Antibiotic Use for Esophageal Cancer Patients with Postoperative Infection and Nutritional Status by Ning D, Zhou L, Shi G, Fu M

“…Dong Ning,1,* Lin Zhou,2,* Guidong Shi,1 Maoyong Fu1 1Department of Thoracic Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, People’s Republic of China; 2Department of Ultrasound, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Dong Ning, Department of Thoracic Surgery, Affiliated Hospital of North Sichuan Medical College, No. 1, Maoyuan South Road, Shunqing District, Nanchong, Sichuan, 63000, People’s Republic of China, Email dongningcb@21cn.comObjective: To verify the hypothesis that “the prophylaxis use time of antibiotics after esophageal cancer (EC) surgery ≤ 24 hours is associated with a lower postoperative infection rate and improvement of nutritional indicators”, a retrospective cohort analysis was conducted to compare the infection incidence and differences in serum nutritional indicators among patients with different medication durations (< 24 hours, 24– 48 hours, > 48 hours), and to identify independent risk factors for postoperative infection.Methods: A retrospective analysis was conducted on the data of 566 patients who underwent EC surgery in Affiliated Hospital of North Sichuan Medical College from January 2020 to October 2022. …”
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3D-Printed PCL-Based Scaffolds with High Nanosized Synthetic Smectic Clay Content: Fabrication, Mechanical Properties, and Biological Evaluation for Bone Tissue Engineering by Furtado ASA, Cunha MHS, Sousa LMR, Brito GC, Verde TFCL, Filgueiras LA, Sobral-Silva LA, Santana MV, Sousa GF, Santos FEP, Mendes AN, Figueredo-Silva J, Maia Filho ALM, Marciano FR, Vasconcellos LMR, Lobo AO

“…The main challenge lies in achieving a uniform distribution of nanoceramics across low to high concentrations within the polymer matrix while preserving mechanical properties and biological performance essential for successful osseointegration.Methods: This study utilized 3D printing to fabricate PCL scaffolds enriched with nanosized synthetic smectic clay (LAP) to evaluate its effects on structural, chemical, thermal, mechanical, and degradative properties, with a focus on in vitro biological performance and non-toxicity. …”
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EPIDEMIOLOGY AND SURVIVAL OF PATIENTS WITH MALIGNANT TUMORS OF CONNECTIVE AND SOFT TISSUE by V. M. Merabishvili, O. F. Chepik, E. N. Merabishvili

“…According to official data a one-year lethality of patients with tumors of connective and soft tissue in 2013 was 20.1 %, and for all malignant tumors – 25.3 %, however the index accuracy for all malignant tumors was equal to 0.72, and for malignant tumors of connective and soft tissue – 0.88. …”
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Cecal coccidiosis in Japanese quails (Coturnix Japonica): Eimeria tsunodai identification and comparative prophylactic phytochemotherapy with immune stimulant impact by Reham M. ElBakrey, Amal A.M. Eid, Ahmed A. ElKholy, Mohamed R. Mousa, Mohamed A. El-Morsy, Walaa S. Abdelaziz

“…A selected E. tsunodai was used to evaluate the comparative anticoccidial efficacy of a commercial herbal product containing oregano and garlic essential oils (EOs) as a prophylactic supplement via drinking water taking into consideration that it had never been applied in quails' coccidiosis before. Methods: A total of 300 Japanese quails were equally assigned to four groups. …”
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A Simplified Immune-Dysregulation Index (IL-6/LY) as a Robust Predictor of 28-Day In-Hospital Mortality and MODS in Patients with Sepsis by Liu M, You T, Li S, Hao Y, Wang Z, Huang F, Wang J

“…Meili Liu,1,2,* Tao You,3,* Shifeng Li,1,* Yan Hao,1,* Zhiyang Wang,1 Fang Huang,1 Jun Wang1 1Department of Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China; 2Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China; 3Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jun Wang; Fang Huang, Department of Critical Care Medicine, The First Affiliated Hospital of Soochow University, No. 188 Shizi Street, Suzhou, 215006, People’s Republic of China, Email dr_wangjun@suda.edu.cn; blue-virus@163.comObjective: To evaluate the prognosis significance of a newly simplified immune-dysregulation index, interleukin-6-to-lymphocyte ratio (IL-6/LY), in individuals diagnosed with sepsis.Methods: This was a retrospective cohort study enrolling consecutive patients diagnosed with sepsis who qualified the inclusion criteria and were admitted to the intensive care unit of the First Affiliated Hospital of Soochow University between March 2017 and January 2023. …”
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Eepidemiological Interregional Multicenter Study of Healthcare-Associated Infections in the Intensive Care Units. First Results by R. V. Polibin, E. B. Brusina, O. V. Kovalishena, E. V. Glushkova, A. A. Gridina, B. I. Aslanov, N. I. Briko

“…The intensive development of medical technologies is accompanied by equally rapid changes in the epidemic process of healthcare-associated infections (HAIs). …”
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Integration of Diaphragmatic Ultrasonography and Intra-Abdominal Pressure Measurement for Optimizing Weaning from Mechanical Ventilation by Su D, Li R, Chen Z, Cui N, Yu Z, Ding X, Wu J

“…Dan Su,1,* Ruixin Li,1,* Zhi Chen,2 Na Cui,1 Zhanbiao Yu,1 Xiaoxu Ding,1 Jiaqian Wu1 1Intensive Care Unit, The Affiliated Hospital of Hebei University, Baoding, Hebei Province, 071000, People’s Republic of China; 2Department of Hepatobiliary Surgery, The Affiliated Hospital of Hebei University, Baoding, Hebei Province, 071000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhi Chen, Department Hepatobiliary Surgery, The Affiliated Hospital of Hebei University, No. 212 of Yuhua Road, Lianchi District, Baoding, Hebei Province, 071000, People’s Republic of China, Tel +86 13832296881, Fax +86 0312-5983782, Email chenzhi6295@126.com Na Cui, Intensive Care Unit, The Affiliated Hospital of Hebei University, No. 212 of Yuhua Road, Lianchi District, Baoding, Hebei Province, 071000, People’s Republic of China, Tel +86 13503382865, Fax +86 0312 5983752, Email nacuilika@126.comObjective: The objective of this study was to evaluate the effectiveness of diaphragmatic ultrasonography in conjunction with intra-abdominal pressure (IAP) measurement for assessing diaphragm function and determining the optimal timing for weaning from mechanical ventilation (MV).Methods: A cohort of 100 patients undergoing MV at the intensive care department of the Affiliated Hospital of Hebei University between January 2023 and July 2023 was enrolled. …”
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Application Effectiveness of a Pre-Analytical Quality Management Pathway Based on the Structure–Process–Outcome Model by Cui L, Li W, Li Y, Feng X, Wang Y, Gao P

“…Liping Cui,1,* Wanling Li,1,2,* Yueqin Li,3 Xiaofang Feng,3 Yue Wang,4 Pei Gao4 1Department of Nursing, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, People’s Republic of China; 2Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China; 3Department of General Medical, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, People’s Republic of China; 4Nursing College, Shanxi Medical University, Taiyuan, 030032, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yueqin Li, Department of General Medical, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, No. 99 Longcheng Street, Xiaodian District, Taiyuan, Shanxi, 030032, People’s Republic of China, Tel +86 0351-8368114, Email li_yueqin@163.comObjective: This single-center, before-and-after study applied the structure–process–outcome (SPO) model to pre-analytical quality control to investigate its effect on laboratory testing quality, nursing practices, patient satisfaction, and clinician trust in test results.Methods: A before-and-after design was conducted in a provincial Class A tertiary hospital. …”
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