Co-Delivery of Dacarbazine and miRNA 34a Combinations to Synergistically Improve Malignant Melanoma Treatments by Ding B, Li M, Zhang J, Zhang X, Gao H, Gao J, Shen C, Zhou Y, Li F, Liu A

“…This study developed a promising strategy for tumor-targeted co-delivery of Dacarbazine (DTIC) and miRNA 34a-loaded PHRD micelles (Co-PHRD) for combination treatment of MM.Methods: To construct the dual drug-loaded delivery system Co-PHRD, poly (L-arginine)-poly (L-histidine)-polylactic acid (PLA) was employed as a building block. …”
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Prognostic Value of Peripheral Blood nCD64 Index, mHLA-DR, and CD14+monocyte Percentage in Different Infection Status in COVID-19 Patients by Zhu M, Cheng J, He L, Li C, Shi B, Jin M, Yu J, Huang J

“…Mingli Zhu,1,* Jianghao Cheng,1,2,* Lingyan He,1,* Chaodan Li,1 Bin Shi,1 Meitong Jin,1 Jianhua Yu,3 Jinsong Huang3 1Open Laboratory, Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People’s Republic of China; 2Laboratory Medicine, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, People’s Republic of China; 3Department of Infectious Diseases, Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jianhua Yu, Email yujhmc@126.com Jinsong Huang, Email huangjinsongyz@126.comObjective: To explore the value of the neutrophil CD64 (nCD64) index, monocytic HLA-DR (mHLA-DR), and the percentage of CD14+ monocytes in the prognosis of Coronavirus disease 2019 (COVID-19).Methods: Fifty-seven COVID-19 patients from December 2022 to November 2023 were divided into two groups: non-severe group (mild or moderate cases) and severe group (severe or critical cases). …”
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Association of Systemic Immune-Inflammatory Index with Risk of Foot Ulcer Amputation in Patients with Type 2 Diabetes Mellitus: Insights from a Cross-Sectional Study by Huang Z, Zheng X, Liang H, Zhong SY, Meng J, Yao J

“…This study aimed to explore the relationship between SII and amputation risk in patients with DFU.Methods: In this cross-sectional study, all eligible patients were divided into an amputation group and a non-amputation group based on their amputation status. …”
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Perception of quality and adoption of health-preventive measures in gym-goers after the COVID-19 pandemic peak in Italy by L Falese, E Langiano, M Ferrara, P Diotaiuti, A Rodio, T Di Libero, A Andrade, E De Vito

“…Results The study involved 1321 participants, with a nearly equal gender distribution. Most of the sample was aged between 18 and 25, unmarried, and approximately 45% were students. …”
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Danshensu Ethyl Ester Alleviates LPS-Induced Acute Lung Injury by Targeting the NLRP3 Inflammasome by Ding W, Xu S, Xie S, Dong Y, Jiang Y, Xie N, Wang P, Feng J, Qu G

“…Wensi Ding,1,2,* Sen Xu,1,* Shuyang Xie,1,3,* Yao Dong,4 Yujie Jiang,4 Ning Xie,5 Pingyu Wang,6 Jiankai Feng,2 Guiwu Qu7 1Department of Biochemistry and Molecular Biology, Binzhou Medical University, Yantai, People’s Republic of China; 2Department of Laboratory Medicine, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, People’s Republic of China; 3Shandong Laboratory of Advanced Materials and Green Manufacturing, Yantai, People’s Republic of China; 4Binzhou Medical University, Yantai, People’s Republic of China; 5Yantaishan Hospital, Yantai, People’s Republic of China; 6Department of Epidemiology, Binzhou Medical University, YanTai, People’s Republic of China; 7Department of Traditional Chinese Medicine, School of Pharmacy, Binzhou Medical University, Yantai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jiankai Feng, Department of Laboratory Medicine, Yantai Affiliated Hospital of Binzhou Medical University, No. 717, Jinbu Avenue, Yantai, 264100, People’s Republic of China, Email Fengjiankai@bzmc.edu.cn Guiwu Qu, Department of Traditional Chinese Medicine, School of Pharmacy, Binzhou Medical University, No. 346, Guanhai Road, Yantai, 264003, People’s Republic of China, Email qu_guiwu@bzmc.edu.cnPurpose: To investigate whether Danshensu ethyl ester (DEE) can attenuate acute lung injury (ALI) and explore the detailed mechanism.Methods: The ALI model was induced in mice using LPS. …”
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Significance of serum IgA/C3 ratio in the diagnosis and prognosis of IgA nephropathy by XIE Wei-ji, HONG Gui-tian, XUE Qian, LIN Zhi-jun, XIE Yi, XU Xiao-chang, ZHANG Yi-min

“…Objective To study the significance of serum IgA/C3 ratio in the diagnosis of IgA nephropathy(IgAN) and differential diagnosis of other non-IgAN glomerular diseases, and the changes of IgA/C3 ratio in patients with IgAN before and after treatment. Methods The results of serum IgA, C3 and related laboratory tests from patients treated preliminarily in the Second Affiliated Hospital of Shantou University and the Sixth Affiliated Hospital of Sun Yat-sen University from January. 2013 to December.2017, whose were diagnosed with IgAN or primary non-IgAN or secondary glomerular diseases, were collected. …”
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Effects of Dexmedetomidine on Minimum Alveolar Concentration of Sevoflurane for Blunting Sympathetic Response to Pneumoperitoneum: A Randomized Trial by Yuan Y, Zheng G, Guan J, Zhou C, Gao W, Li J, Dai D, Yao Y

“…We determined sevoflurane MACBAR using Dixon’s up-and-down method, defined as the concentration preventing ≥ 20% increase in heart rate or mean arterial pressure following pneumoperitoneum. …”
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The Impact of Social, Cultural, and Identity-Related Factors on Delayed Childbearing: A Multi-Center Study by Lei Y, Wang X, Zhou Y, Li Y, Wang L, Jia X, Ma Q, Lin C, Liao J, Li X, Liu T

“…This study aimed to explore the impact of these factors on the timing of childbirth among women of reproductive age.Methods: A cross-sectional study was conducted with 1,128 women attending their first prenatal visit at six hospitals between January and December 2023. …”
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Prevalence and Clinically Related Factors of Hypertriglyceridemia in Patients with Bipolar Disorder in Anhui Province, China by Li J, Lei W, Wang Y, Wu Q

“…This study aims to explore the prevalence and clinical factors of comorbid hypertriglyceridemia in patients with bipolar disorder (BD) in Anhui, China.Patients and Methods: A total of 1072 patients with bipolar disorder were recruited from a large specialized hospital in Anhui, China. …”
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Effects of Different Gonadotropin-Releasing Hormone Agonists on IVF/ICSI-ET Outcomes in Long Protocol: A Retrospective Study by Xu M, Li H, Zhao Y, Li H, Zhao C, Zhang X, Ni R, Liang J, Xu J

“…In this study, we aimed to compare the clinical outcomes of IVF/ICSI-ET using different GnRH-a formulations in long protocol during follicle phase.Methods: This is a retrospective study. A total of 154 infertile women undergoing IVF/ICSI-ET in long protocol during follicle phase from September 2019 to December 2023 were assigned to three groups according to different GnRH-a formulations (A: triptorelin acetate; B: leuprorelin; C: goserelin acetate). …”
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Unraveling the Role of Oxygen Pulse Variability in Endurance Exercise Training in Individuals with COPD: A Novel Approach to Response of Oxygen Pulse and Quality of Life in Pulmona... by Huang SY, Hsieh PC, Huang KL, Yang MC, Jao LY, Tzeng IS, Lan CC, Wu YK

“…Cardiopulmonary exercise testing (CPET) measures oxygen pulse (O2P), an indicator of stroke volume, yet the impact of baseline O2P on PR effectiveness remains unclear.Methods: This retrospective study included 97 participants with COPD who had received PR, of whom 48 were classified as Group 1 (normal O2P) and 49 as Group 2 (low O2P). …”
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Combined Oxaliplatin with 5-Fluorouracil for Effective Chemotherapy Against Gastric Cancer in Animal Model by Ren J, Song M, Ding D, Lan T, Li Y, Liang R, Huang S, Jiang G, You J, Yang J, Chen C, Luan W, Abdullaev B, Huang H, Zhao Y, Wei B

“…These limitations underscore the need for innovative approaches to improve chemotherapy sensitivity and treatment efficacy.Methods: We developed a glucose-responsive, RGD peptide-functionalized biporous silica nanocarrier (R-BSN). …”
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Comparative immunohistochemical characteristics of expression of estrogen receptors-alpha, progesterone receptors, p16, p53, Ki-67 and caspase 3 in invasive endometrial adenocarcin... by V. A. Tumanskiy, A. V. Chepets

“…To characterize the expression of the estrogen receptors-alpha, progesterone receptors, p53, p16, ki-67 and caspase 3 in the invasive endometrioid endometrial adenocarcinoma compared with the normal proliferative endometrium. Materials and methods. The uteruses of 56 women with the verified diagnosis of endometrial cancer (stage pT1-4MxNx) and biopsies of 30 women with normal proliferetive endometrium were analyzed. …”
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Optimizing Timing and Preparation for Allogeneic Hematopoietic Stem Cell Transplantation in Higher-Risk Myelodysplastic Syndromes by Geng L, Chen E, Ji Y, Liu H, Sun Z

“…Liangquan Geng,1,* Erling Chen,2,* Yanping Ji,3,* Huilan Liu,1 Zimin Sun1,2,4 1Department of Hematology, The First Affiliated Hospital of University of Science and Technology of China, Hefei, People’s Republic of China; 2Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, People’s Republic of China; 3Department of Hematology, Affiliated Hospital of Jiangsu University, Zhenjiang, People’s Republic of China; 4Blood and Cell Therapy Institute, Division of Life Sciences and Medicine, Anhui Provincial Key Laboratory of Blood Research and Applications, University of Science and Technology of China, Hefei, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zimin Sun, Department of Hematology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, No. 17 Lujiang Road, Luyang District, Hefei, Anhui, 230001, People’s Republic of China, Email zmsun@ustc.edu.cnIntroduction: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only curative treatment for higher-risk myelodysplastic syndromes (MDS), but optimal timing and donor selection remain controversial.Methods: We conducted a retrospective analysis of 70 higher-risk MDS patients classified by the revised International Prognostic Scoring System (IPSS-R) undergoing allo-HSCT. …”
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PENGARUH PERAN KEPEMIMPINAN DAN DISIPLIN KERJATERHADAP KINERJA KARYAWAN PADA PERUSAHAAN DAERAH AIR MINUM (PDAM) KABUPATEN KARAWANG by Cecep Hermana, Uswatun Nurhasanah

“…Teknik analisis yang digunakan yaitu teknik analisis skala likert dan analisis jalur dengan menggunakan alat bantu Method Of Successive Interval (MSI), Microsoft Office dan SPSS versi 16. …”
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Nomogram Incorporating Inflammatory Index, Pathology, and Molecular Classification for Predicting Recurrence in Patients with Stage I-III Endometrial Cancer: A Multi-Institutional... by Xiao Y, Zheng Y, Tu Y, Tian C, Yu J, Lin H, Wen T, Jiang P, Wang Y

“…A nomogram was developed based on clinicopathological parameters, HALP score, and immunohistochemical markers to predict recurrence-free survival (RFS) in patients with stage I–III endometrial cancer.Methods: This retrospective study included 1,083 patients who underwent hysterectomy at the First Affiliated Hospital of Chongqing Medical University from January 2013 to January 2021. …”
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The Role of EZH2 in Initiating Epigenetic Regulation of CRSwNP by Zeng R, Wang Y, Song X, Wang J

“…Particularly on EZH2, a key epigenetic regulator and histone methyltransferase, to explore its potential for CRSwNP immunotherapy.Patients and Methods: A total of 86 individuals were included between July 2021 and July 2023, including 43 patients with CRSwNP who underwent nasal polyp surgery and 43 patients with a deviated septum. …”
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Epidemiology of neonatal disorders attributable to low birthweight-global burden of disease research, 1990–2021 by Qi Zhang, Lan Luo, Lai-lai Yan, Lai-lai Yan, Jing Guo, Hui-jun Wu, Zi-wei Zhang, Yu-hua Zhu, Rui Qiao, Rui Qiao

“…BackgroundTo evaluate global, regional, and national trends in the burden of neonatal diseases attributable to LBW, as well as associated health inequalities, from 1990 to 2021.MethodsUsing data from the Global Burden of Disease Study (GBD2021), we analyzed deaths and DALYs due to LBW-attributable neonatal diseases. …”
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Lifestyle and Job-Related Factors Associated with Sleep Quality: Gender-Specific Insights from Taiwanese Hospital Physicians by Hou WH, Hsu TC, Chen FL, Wu JC

“…In this cross-sectional study, we explored gender-specific differences in factors associated with sleep quality in physicians.Participants and Methods: Self-report questionnaires were distributed to 401 hospital physicians in Taiwan. …”
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Diagnostic Utility of Pentraxin 3 Expression in Septic Cardiomyopathy: Findings from a Prospective Observational Study by Cui N, Lv XW, Shao TH, Yu ZB, Chen Z, Sun T, Li TM, Zhang JW, Hu ZJ

“…Na Cui,1,2,* Xiao-Wei Lv,2,* Teng-Hao Shao,2 Zhan-Biao Yu,2 Zhi Chen,2 Tao Sun,2 Tie-Min Li,2 Jin-Wen Zhang,2 Zhen-Jie Hu1 1Department of Critical Care Medicine, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, 050010, People’s Republic of China; 2Department of Critical Care Medicine, Affiliated Hospital of Hebei University, Baoding, 071000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhen-Jie Hu, Department of Critical Care Medicine, The Fourth Affiliated Hospital of Hebei Medical University, No. 12, Jiankang Road, Shijiazhuang, 050010, People’s Republic of China, Tel +86 13933856908, Email 46400533@hebmu.edu.cnObjective: The aim of this study is to investigate the expression levels of Pentraxin 3, PTX3 in patients with septic cardiomyopathy, SCM and evaluate its diagnostic potential for predicting SCM.Methods: A prospective observational study was conducted involving 122 patients diagnosed with septic shock between February 2023 and August 2024. …”
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