Sex-Biased CD3ζ 3ʹ-UTR SNP Increased Incidence Risk in Aplastic Anemia by Guo L, Zhang Y, Liu X, Xiao Y, Luo W, Fang S, Li Y, Lai J, Li Y, Li B

“…In this study, our aim was to analyze whether CD3ζ 3ʹ-UTR SNPs were associated with AA susceptibility and had influence on CD3ζ protein level and provide new research data for exploring the pathogenesis of aplastic anemia.Patients and Methods: We screened the genotypes of SNPs in 101 healthy individuals and 91 AA patients by PCR-RFLP and sequencing. …”
Get full text

Associations of Protein Classes With Cross-Reactivity and Cross-Sensitization in Furry Animal Allergens: A Component-Resolved Diagnostics Study by Lu J, Zhu H, Yang Q, Xu Y, Huang Z, Sun B

“…Jiancai Lu,1,* Huiqing Zhu,2,* Qingqing Yang,1 Yunjian Xu,1 Zhifeng Huang,1 Baoqing Sun1 1Department of Clinical Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510120, People’s Republic of China; 2Department of Clinical Laboratory, Huizhou Central People`s Hospital, Huizhou, Guangdong, 516001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Baoqing Sun; Zhifeng Huang, Department of Clinical Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiang Road, Guangzhou, Guangdong, 510120, People’s Republic of China, Tel +86 020 81568020, Email sunbaoqing@vip.163.com; zfhuang_gzhmu@163.comObjective: This study aimed to investigate the molecular sensitization patterns of cats, dogs, and horses in patients with cat and/or dog sensitization and the IgE cross-reactivity with other furry animals.Methods: In 95 patients diagnosed with allergic diseases and sensitized to cats and/or dogs (confirmed by specific Immunoglobulin E (sIgE) ≥ 0.35 kUA/L to crude cat and/or dog dander extracts), sIgE levels of cat components (Fel d 1/2/4), dog components (Can f 1/2/3/5), horse dander (Equ c 1), as well as allergens from cow, guinea pig, mouse, rat, rabbit, and chicken, were measured. …”
Get full text

A Monocyte-Driven Prognostic Model for Multiple Myeloma: Multi-Omics and Machine Learning Insights by Xie L, Gao M, Tan S, Zhou Y, Liu J, Wang L, Li X

“…Nevertheless, the overall pattern of immune cells and MM pathogenesis within the bone marrow tumor microenvironment (BM-TME) remains underexplored.Methods and Results: Firstly, we performed Mendelian Randomization analysis for 731 immunocyte phenotypes and MM, identifying 21 immune traits significantly associated with increased MM risk (OR> 1, PFDR< 0.05). …”
Get full text

High Prevalence of Diabetic Retinopathy in an Outpatient Podiatry Clinic and Associated Barriers to Ophthalmic Care by Larimer-Picciani AM, Brown RB, Ruan H, Jones CE, DeBlasio RN, Burns PR, Williams AM, Waxman EL

“…This study assesses the prevalence of DR in a podiatric clinic while also investigating participant-reported barriers to routine ophthalmic follow-up.Methods: We conducted a cross-sectional study that included patients age ≥ 18 (n=62) receiving diabetic foot care at an outpatient podiatric clinic in 2021 and 2022. …”
Get full text

The Frequency of CYP2C19*2 Gene Polymorphisms in Burkina Faso Patients Treated with Clopidogrel by Kagambèga YD, Ouattara AK, Ouédraogo TWC, Traoré L, Yaméogo NV, Simpore J

“…This study aimed to assess the frequency of the CYP2C19*2 (rs4244285, 681 G>A1) polymorphism among patients with cardiovascular diseases undergoing clopidogrel therapy.Patients and Methods: This cross-sectional study recruited a total of seventy-three (73) patients from the Cardiology Department of the Centre Hospitalier Universitaire Yalgado Ouédraogo (CHU-YO) between January and June 2023. …”
Get full text

Association between infant feeding practices, COVID-19 related cognitive factors, and postpartum depression during the COVID-19 pandemic: a cross-sectional online study in Thailand by Wichukorn Suriyawongpaisal, Punpawee Kittikul, Eun Young Lee, Li-Yin Chien, Yan-Shing Chang, Kelly Pereira Coca, Doungjai Buntup, Seo Ah Hong

“…., COVID-19-vaccination-related belief and COVID-19-related knowledge and attitude) with infant feeding practices and their associations with PPD during the COVID-19 pandemic in Thai postpartum mothers. Methods A cross-sectional online survey was conducted among 840 postpartum mothers whose infants were less than or equal to 6 months old. …”
Get full text

Evaluation of a content-based image retrieval system for radiologists in high-resolution CT of interstitial lung diseases by Benjamin Böttcher, Marly van Assen, Roberto Fari, Philipp L. von Knebel Doeberitz, Eun Young Kim, Eugene A. Berkowitz, Felix G. Meinel, Carlo N. De Cecco

“…Abstract Background This retrospective study aims to evaluate the impact of a content-based image retrieval (CBIR) application on diagnostic accuracy and confidence in interstitial lung disease (ILD) assessment using high-resolution computed tomography CT (HRCT). Methods Twenty-eight patients with verified pattern-based ILD diagnoses were split into two equal datasets (1 and 2). …”
Get full text

Association of Serum Ferritin Levels With Obstructive Sleep Apnea in Overweight/Obese US Populations: A Population-Based Study From the NHANES by Zhang Y, Zhou P, Xu C, Su H, Li R, Sun L, Yang Y

“…Yang Zhang,1,* Pinglang Zhou,2,* Chuan Xu,3,* Hua Su,1 Rendong Li,1 Longhua Sun,2 Yihan Yang1 1Jiangxi Provincial Key Laboratory of Respiratory Diseases, Jiangxi Institute of Respiratory Diseases, The Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, People’s Republic of China; 2The Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, People’s Republic of China; 3Department of Thoracic Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yihan Yang, Jiangxi Provincial Key Laboratory of Respiratory Diseases, Jiangxi Institute of Respiratory Diseases, The Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, People’s Republic of China, Email yangyihan@email.ncu.edu.cn Longhua Sun, The Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, People’s Republic of China, Email ndyfy05715@ncu.edu.cnObjective: To investigate the relationship between serum ferritin levels and OSA in overweight/obese individuals and assess the association between ferritin levels and all-cause mortality in overweight/obese female OSA patients.Methods: Cross-sectional (n = 4,809) and prospective (n = 832) data from overweight/obese adults from the 2005– 2008, and 2015-March 2020 NHANES cycles were analyzed. …”
Get full text

Microbiological Characteristics, Risk Factors, and Short-Term Mortality of Carbapenem-Resistant Enterobacteriaceae Bloodstream Infections in Pediatric Patients in China: A 10-Year... by Liang Y, Zhao C, Lu Y, Liao K, Kong Y, Hong M, Li L, Chen Y

“…The purpose of this study was to summarize etiological characteristics and identify risk factors relevant to CRE bloodstream infection (BSI) and short-term mortality among pediatric patients in China.Methods: In this study, we included 370 inpatients ≤ 17 years old with BSI caused by Enterobacteriaceae in China from January 2013 to December 2022. …”
Get full text

Construction and Brain Validation of circRNAs-miRNAs-mRNAs Regulatory Axis in Early-Onset Schizophrenia by Zhang X, Li Z, Li R, Wang X, Liu H, Du X, Gao Y, Liu S, Xu Y

“…This study aimed to investigate the regulatory patterns and brain validation of circular RNAs-microRNAs-messenger RNAs in early-onset schizophrenia.Methods: Differentially expressed circular RNAs and microRNAs were identified in blood samples from 32 patients with early-onset schizophrenia and 29 healthy controls. …”
Get full text

Zuogui Pill Promotes Neurovascular Regeneration and Corticospinal Tract Remodeling After Ischemic Stroke by Wu D, Yan X, Mei S, Hua H, Fei X, Xu X, Liu Y, Wu M, Zhu J, Li W

“…Zuogui pill (ZGP) has good efficacy in treating cerebral ischemia, but the mechanism remains unclear.Purpose: To investigate the effects of ZGP on angiogenesis, neurogenesis, corticospinal tract (CST) remodeling, and further evaluate its mechanisms of action in mice with ischemic stroke.Methods: Network pharmacology was used to analyze the active components, related targets, and mechanisms of ZGP’s action in promoting neurovascular regeneration after ischemic stroke. …”
Get full text

IN VITRO INVESTIGATION OF THE TRANSPLANTATION PROSPECTS OF MULTICELLULAR SPHEROID MICROAGGREGATES OF DONOR RETINAL PIGMENT EPITHELIUM by S. A. Borzenok, I. A. Popov, I. N. Saburina, P. M. Arbukhanova

“…To study in experiment the criteria for transplantability of multicellular spheroid microaggregates of retinal pigment epithelium (RPE), prepared by the method of 3D cell culture. Materials and Methods. 11 donor eyes (6 of adrenaline index «A», 5 of index «B») were used as a source of RPE cell cultures (group «A» – 6 cultures, group «B» – 5 cultures), of which over 2000 RPE spheroids were obtained by the method of three-dimensional cell culture. 1760 spheroids of them were selected for transplantability investigation (960 – group «A», 800 – group «B»). …”
Get full text

Epidemiology and classification of scapular fractures: a detailed survey on a large sample of patients by Matteo Cantore, MD, Davide Manni, MD, Vittorio Candela, MD, Jacopo Preziosi Standoli, PT, Alessandro Are, MD, Stefano Gumina, PhD, MD

“…Conclusions: Scapular fractures occur equally in both genders, although with different age distribution. …”
Get full text

Nanomedicine-Based Ophthalmic Drug Delivery Systems for the Treatment of Ocular Diseases by Lin X, Zhou Y, Lv K, Wu W, Chen C

“…Conventional drug delivery methods—topical, local injection, and systemic administration—face challenges such as low bioavailability (< 5%), rapid clearance, and physiological barriers like the cornea and blood-retinal barrier (BRB). …”
Get full text

MANAGEMENT OF MAGNESIUM DEFICIENCY IN PREGNANT WOMEN: PHARMACOEPIDEMIOLOGIC STUDY by D. V. Blinov, U. V. Zimovina, E. M. Dzhobava

“…Objectives: to evaluate Mg deficiency incidence and management in a pregnant population monitored in Russian polyclinics. Materials and Methods: pregnant women (at any trimester) aged over 18 years were included. …”
Get full text

Mechanism of Action and Efficacy of Wu-Hua-Yan-Xiao in the Treatment of Pediatric Acute Pharyngitis Based on Network Pharmacology and Experimental Validation by Zhang X, Zhang Z, Xu Y, Luo J, Shen Z, Liang H, Zeng Y, Liu W, Zheng C, Li J

“…Xinyun Zhang,1,* Zengyu Zhang,2,* Yingzi Xu,1 Jiawei Luo,1 Zihao Shen,3 Hao Liang,1,4 Yidi Zeng,1,4 Wanghua Liu,1,4 Caixing Zheng,1 Jinxia Li1,4 1Hunan University of Chinese Medicine, Changsha, 410208, People’s Republic of China; 2Research Center for Clinical Medicine, Jinshan Hospital Affiliated to Fudan University, Shanghai, 20000, People’s Republic of China; 3Xiangxing College, Hunan University of Chinese Medicine, Changsha, 410208, People’s Republic of China; 4Provincial Key Laboratory of TCM Diagnostics, Hunan University of Chinese Medicine, Changsha, 410208, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jinxia Li; Caixing Zheng, Hunan University of Chinese Medicine, Changsha, 410208, People’s Republic of China, Email 531249042@qq.com; 947726363@qq.comEthnopharmacological Relevance: Wu-Hua-Yan-Xiao (WHYX) is an innovative volatile oil formulation derived from the traditional Yinqiao-Mabo decoction, developed for the treatment of pediatric acute pharyngitis.Materials and Methods: Network pharmacology was utilized to identify active components and potential therapeutic targets of WHYX in acute pharyngitis. …”
Get full text

Geriatric Nutritional Risk Index (GNRI) and Prognostic Nutritional Index (PNI) Before Treatment as the Predictive Indicators for Bone Metastasis in Prostate Cancer Patients by Chen L, Rao H, Chen N, Li R, Chen D, Jiang H

“…The purpose of this study was to investigate the relationship of nutritional status indices (geriatric nutritional risk index (GNRI), neutrophil to albumin ratio (NAR), prognostic nutritional index (PNI)), and comprehensive inflammatory indices (pan-immune inflammation value (PIV), systemic immune inflammation index (SII), and system inflammation response index (SIRI)) and bone metastasis of prostate cancer.Methods: A retrospective analysis was performed on 888 prostate cancer patients treated in Meizhou People’s Hospital from November 2017 to December 2022. …”
Get full text

Gut Microbiome Composition Changes During Insomnia Treatment with Lemborexant by Miyata S, Iwamoto K, Ito M, Okada I, Matsuyama N, Fujimoto A, Kogo Y, Nishiwaki H, Ueyama J, Ohno K, Ozaki N

“…Here, we investigated the relationship between the gut microbiota and hypnotic use in insomnia.Participants and Methods: We enrolled 29 adults with insomnia and performed sleep electroencephalography and stool analyses at baseline and after 4 and 12 weeks of open-label lemborexant treatment. …”
Get full text

Stomatobaculum longum-Derived Extracellular Vesicles Enhance Oral Squamous Cell Carcinoma Malignancy Through BRCA1/EXO1/TP53BP1 Modulation by Yan L, Wu F, Jiao J, Maimaiti A, Li Y, Shao L, Liang Q, Xiong X, Qin Z

“…This study investigates the role of the oral microbiome, particularly Stomatobaculum longum (S. longum), in OSCC progression and explores the underlying molecular mechanisms involving bacterial extracellular vesicles (EVs).Methods: 16S rRNA sequencing was conducted on tumor and adjacent non-tumor tissues from OSCC patients to identify microbial composition. …”
Get full text

Refractory Gout and Metabolic Syndrome in a Chinese Cohort: A Propensity Score Matching and Nonlinear Relationship Analysis by Li J, Zhang J, Lu H, Li S, Zhang L, Tan N, Shang S, Li R, Ka Y, Wang S, Liu W

“…This study aimed to explore this association and reveal its potential nonlinear patterns in a Chinese cohort.Methods: This retrospective study included clinical data from 4111 gout patients from a single center in Tianjin, China between 2014 and 20234. …”
Get full text