Factors Influencing the Development of Metachronous Fractures in Patients with Osteoporotic Vertebral Fractures Treated with Conservative Management or Vertebroplasty by Fernando Ruiz Santiago, Lucía Bueno Caravaca, Francisco Garrido Sanz, Paula María Jiménez Gutiérrez, David Luengo Gómez, Mario Rivera Izquierdo, José Manuel Benítez, Antonio Jesús Láinez Ramos-Bossini

“…<b>Conclusions:</b> The presence of intravertebral cleft, a difference in posterior height loss between X-rays and CT equal to or lower than 2.4%, higher grades of Genant’s numerical classification, and application of CM instead of PV are predictors of MFs. …”
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Utilization and quality of primary and specialized palliative homecare in nursing home residents vs. community dwellers: a claims data analysis by Juliane Poeck, Franziska Meissner, Bianka Ditscheid, Markus Krause, Ulrich Wedding, Cordula Gebel, Ursula Marschall, Gabriele Meyer, Werner Schneider, Antje Freytag

“…For most outcomes, the associations with palliative homecare were equal or smaller in nursing home residents than in community dwellers. …”
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Adjuvanticity of Tannic Acid-Modified Nanoparticles Improves Effectiveness of the Antiviral Response by Janicka M, Chodkowski M, Osinska A, Bylinska K, Obuch-Woszczatyńska O, Patrycy M, Chodaczek G, Ranoszek-Soliwoda K, Tomaszewska E, Celichowski G, Grobelny J, Cymerys J, Krzyżowska M

“…HSV-1 also invades the nervous system where it establishes a lifelong latency-making infection poorly treatable We previously showed that both tannic acid-modified silver and gold nanoparticles (TA-Ag/AuNPs) inhibit HSV-1 infection in vitro.Methods: We used an in vitro and in vivo model of HSV-1 infection to study how metal type, size and tannic acid modification of nanoparticles can influence development of the early innate response and the mounting of specific anti-HSV-1 response upon treatment of the nasal mucosa.Results: We found that tannic acid is necessary for binding with HSV-1, with smaller sizes independent of the NPs composition, whereas for larger NPs, only TA-AgNPs can inhibit HSV-1 infection. …”
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Restoration of limited defects of the cartilage with the use of cell-engineered constructs by S. A. Gerasimov, N. A. Tenilin, D. Ia. Aleynik, S. N. Bugrov, N. Iu. Shirokova, A. A. Zykin

“…The RF in Experiment 1 group equalled to 0.79 ± 0.07, Experiment 2 group revealed RF at the level of 0.88 ± 0.02. …”
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Differentiations in Illness Duration, Thyroid-Stimulating Hormone, Glucose and P300 Latency Between Drug-Na&iuml;ve Unipolar and Bipolar Depression: A Comparative Cross-Sectional S... by Li C, Yang L, Zhang Q, Zhang Y, Li R, Jia F, Wang L, Ma X, Yao K, Tian H, Liu Z, Zhuo C

“…The present study aimed to investigate whether demographic, clinical, and biochemical parameters can help differentiate drug-naïve BD from UD.Methods: Drug-naïve patients with UD and BD were recruited from Shandong Mental Health Center. …”
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Predictive Value of IDEAL-IQ and DWI Imaging Biomarkers for P53 Mutations in Hepatocellular Carcinoma by Wang D, Yin H, Li X, Zhou S, Wang YC

“…Dongdong Wang,1,&amp;ast; Huijia Yin,2,&amp;ast; Xiaoming Li,1 Shuwei Zhou,3 Yuan-Cheng Wang3 1Department of Radiology, Zhengzhou People’s Hospital and The Fifth Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou, People’s Republic of China; 2Department of MR, The First Affiliated Hospital of Xinxiang Medical University, Weihui, People’s Republic of China; 3Department of Radiology, Zhongda Hospital, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging and Interventional Radiology, School of Medicine, Southeast University, Nanjing, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Yuan-Cheng Wang, Department of Radiology, Zhongda Hospital, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging and Interventional Radiology, School of Medicine, Southeast University, Nanjing, 210009, People’s Republic of China, Tel +86 25 83272121, Fax +86 25 83311083, Email yuancheng_wang@seu.edu.cnPurpose: To investigate the application of imaging biomarkers, including R2&amp;ast;, Fat Fraction (FF) and apparent diffusion coefficient (ADC) values, obtained through Iterative Decomposition of water and fat with Echo Asymmetry and Least-squares estimation for Imaging Quantification (IDEAL-IQ) and DWI techniques, in differentiating P53-mutated and non-mutated HCC.Patients and Methods: This retrospective study included patients with pathologically confirmed HCC between January 2019 and July 2024. …”
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A Propensity-Score Matched Analysis to Evaluate Local Treatment Modalities for Esophageal Squamous Cell Carcinoma in Over 80 years on A SEER Database by Li Q, Gao M, Li Y, Tian L, Wang K, Yan X

“…Further studies are needed to understand drivers of this bias and enhance equality in old patient treatment.Keywords: elderly patients, esophageal squamous cancer, surgery, radiotherapy…”
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Identification of a Missense Mutation in the FLNC Gene from a Chinese Family with Restrictive Cardiomyopathy by Dong J, Zhang W, Chen Q, Zha L

“…By using WES, we attempted to identify the genetic cause of an RCM family and clarify the clinical diagnosis of the patient and then provide a personalized treatment plan.Materials and Methods: Blood samples were obtained from the proband and his healthy parents. …”
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The Value of Integrating Hormone Receptors into Immunohistochemistry-Based Simplified Molecular Classification in Endometrial Cancer by Zhao S, Yan Y, Wang T, Zhang J, Zheng X, Li X, Zhao J, Yang E, Zhao X, Tian L, Xue F, Tian W, Wang Y

“…Shuangshuang Zhao,1,2,&ast; Ye Yan,1,2,&ast; Tianqi Wang,1,2,&ast; Jingying Zhang,1,2 Xingyu Zheng,1,2 Xianxian Li,1,2 Jianzhen Zhao,1,2 Eryan Yang,1,2 Xue Zhao,1,2 Lina Tian,1,2 Fengxia Xue,1,2 Wenyan Tian,1,2 Yingmei Wang1,2 1Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin, 300052, People’s Republic of China; 2Tianjin Key Laboratory of Female Reproductive Health and Eugenics, Tianjin Medical University General Hospital, Tianjin, 300052, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yingmei Wang, Tianjin Medical University General Hospital, No. 154 Anshan Street, Heping District, Tianjin, 300052, People’s Republic of China, Tel +86-22-60362255, Email wangyingmei@tmu.edu.cn Wenyan Tian, Tianjin Medical University General Hospital, No. 154 Anshan Street, Heping District, Tianjin, 300052, People’s Republic of China, Tel +86-22-60362255, Email tianwenyan1108@163.comPurpose: To explore the clinical utility of immunohistochemistry (IHC)-based molecular classification and evaluate the distribution patterns and clinical implications of hormone receptor (HR) expression across different molecular classifications in endometrial cancer (EC).Patients and Methods: This study retrospectively conducted simplified molecular classification based on IHC analysis of mismatch repair (MMR) and p53 protein from 322 EC patients admitted to the Obstetrics and Gynecology Department of Tianjin Medical University General Hospital from March 2017 to April 2024. 121 patients underwent WHO molecular classification by gene sequencing and IHC analysis. …”
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Personality Traits and Social Support: Their Role in Postpartum Depression by Richa S, Parveen S, Abullais SS, Mahmood SE, Alsamghan A, Alshaikh AA

“…Given the cross-sectional design and sampling method, results should be interpreted cautiously. …”
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Effects of Stretching and Resistance Training on Psychophysical Awareness: A Pilot Study by Giovanni Esposito, Rosario Ceruso, Pietro Luigi Invernizzi, Vincenzo Manzi, Gaetano Raiola

“…The study involved 24 male amateur track-and-field athletes (mean age 23 ± 2.5 years), randomized into two equal groups. Over 12 weeks, both groups trained three times per week. …”
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Gender and age effects on the incidence and severity of chemotherapy-induced neuropathic pain: a propensity score matching analysis by Andreas A. Argyriou, Roser Velasco, Foteini Kalofonou, Pantelis Litsardopoulos, Montse Alemany, Dimitrios Rikos, Haralabos P. Kalofonos, Jordi Bruna

“…Abstract Objective To determine whether the clinical phenotype of chemotherapy-induced neuropathic pain (CINP) varies based on the gender and age of patients. Methods Retrospective, file-based analysis of cancer patients who received any conventional standard of care chemotherapy and were referred to assess the extent of painful chemotherapy-induced peripheral neurotoxicity (CIPN). …”
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Associations Between Psychosocial Influence, Positive Thinking, and Vaccine Attitudes in Patients with Schizophrenia During the COVID-19 Pandemic by Li DJ, Wang WC, Chou FHC, Hsu ST, Hsieh KY, Lin GG, Wu PJ, Liu CL, Wu HC, Huang JJ

“…In this study, we investigated factors influencing vaccine attitudes in patients with schizophrenia and explored the interactions among these factors.Methods: Cross-sectional, self-report surveys were conducted among Taiwanese patients with schizophrenia to collect data on vaccine attitudes and associated variables. …”
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Role of Peripheral Blood Regulatory T Cells and IL-2 in the Collateral Circulation of Acute Ischemic Stroke by Zhang S, Rao C, Wen M, Zhang X, Zha Z, Gu T, Zhu L, Yu C

“…The objective of this investigation was to explore the link between peripheral regulatory T cells (Tregs), interleukin-2 (IL-2), and the status of collateral circulation.Methods: Between September 2023 and May 2024, the study incorporated 117 AIS patients from the neurology department, with 60 identified as having good collateral status (GCS) and 57 with poor collateral status (PCS). …”
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The Inhibitory Effect of the Active Ingredients in the Bushen Huoxue Formula on the IL-17A Signaling Pathway and Its Alleviating Effect on Osteoarthritis by Wang X, Zhang Y, Chang X, Wen X, Tian F, Yu H, Li Y

“…In this study, we employed network pharmacology alongside in vitro and in vivo experiments to elucidate the molecular mechanism by which BSHXF treats OA.Methods: Based on the TCMSP database, active components of BSHXF were screened, and OA-related targets were retrieved from GeneCard and DisGeNET to construct a “component-target-pathway” network using Cytoscape. …”
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Machine Learning Radiomics for Predicting Response to MR-Guided Radiotherapy in Unresectable Hepatocellular Carcinoma: A Multicenter Cohort Study by Su K, Liu X, Zeng YC, Xu J, Li H, Wang H, Du S, Wang H, Yue J, Yin Y, Li Z

“…Machine learning-based radiomics was utilized to predict responses in these patients.Methods: This retrospective study included 118 hCC patients who received MR-guided hypofractionated radiotherapy. …”
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Anemarrhena asphodeloides Bunge-Fritillaria Cirrhosae Bulbus Herb Pair Alleviates Ovalbumin-Induced Asthma by Regulating Arachidonic Acid Pathway by Tian X, Cui Q, Wei J, Zhang Q, Zhang H, Yang M, Xing Y, Niu Y, Li W, Wang N, Jin Y, Du Y

“…This study aimed to investigate how ZC affects asthma and its mechanism.Methods: Asthma model rats were sensitized by ovalbumin. …”
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Barriers and facilitators to maternal healthcare in East Africa: a systematic review and qualitative synthesis of perspectives from women, their families, healthcare providers, and... by Manaye Yihune Teshale, Agegnehu Bante, Abebe Gedefaw Belete, Rik Crutzen, Mark Spigt, Sarah E. Stutterheim

“…Results Of the 3181 records identified, 81 studies (63 qualitative and 18 mixed method) met the inclusion criteria, representing 4816 individuals from six East African countries. …”
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Optimizing Radiation Dose and Image Quality in Stroke CT Protocols: Proposed Diagnostic Reference Levels for Multiphase CT Angiography and Perfusion Imaging by Robert Forbrig, Christoph G. Trumm, Paul Reidler, Wolfgang G. Kunz, Konstantinos Dimitriadis, Lars Kellert, Johannes Rückel, Thomas Liebig, Robert Stahl

“…The Kruskal-Wallis test was used initially to test for overall equality of median values in each data group. Single post-test comparisons were performed with Dunn’s test, with an overall statistical significance level of 0.05. …”
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The Effects of Novel Thymoquinone-Loaded Nanovesicles as a Promising Avenue to Modulate Autism Associated Dysregulation by Restoring Oxidative Stress in Autism in Mice by Eissa N, Alwattar JK, Jayaprakash P, Chkier D, Ahmed AO, Ahmed A, Rizwan R, Mujeeb S, Rahal M, Sadek B

“…Moreover, a novel TQ-loaded nanovesicle drug delivery system was optimized and utilized to enhance the bioavailability of TQ in the central nervous system.Methods: Through a battery of standard behavioral tests, primary parameters such as social behavior, locomotor activity, and anxiety levels were assessed following systemic administration with TQ (10mg/kg, i.p). …”
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