Perfluorohexyloctane ophthalmic solution for dry eye disease: pooled analysis of two phase 3 clinical trials by Ahmad M. Fahmy, Jennifer S. Harthan, David G. Evans, Jack V. Greiner, Joseph Tauber, John D. Sheppard, Sonja Krösser, Jason L. Vittitow

“…This study evaluated treatment effects of perfluorohexyloctane ophthalmic drop (formerly NOV03) in the pooled dataset from 2 pivotal clinical trials in patients with DED associated with MGD, both in the overall population and in patient subgroups based on sex, age, and baseline severity of eye dryness.MethodsPooled data from 2 similarly designed, phase 3, randomized controlled trials (GOBI, MOJAVE) were analyzed. …”
Get full text

Impact of religious fasting on ocular dryness: objective and subjective assessment by Amal F. Alomari, Sara Issa, Asma Musleh, Mohammad Abusamak, Mohammad Abusamak, Omar Bdair, Omar Bdair, Saif Aldeen AlRyalat, Saif Aldeen AlRyalat, Alanoud Al-Wakfi, Mohammed Jaber, Ahmad Alloubani, Haitham Sahawneh, Haitham Sahawneh, Muhannd El-Faouri, Ayman Abdul Aziz, Muawyah Al Bdour

Get full text

Efficacy and safety of diacerein in patients with knee osteoarthritis by L. I. Alekseeva, N. G. Kashevarova, E. A. Taskina, E. P. Sharapova, S. G. Anikin, T. A. Korotkova, E. A. Strebkova

“…There was a statistically significant reduction in visual analog scale pain on walking just 1 month after therapy initiation (57.1±9.7 and 44.7±13.9 mm; p<0.0001) and a further significant improvement throughout the 6-month therapy. …”
Get full text

Comparison of the ArtekMed mixed reality teleconsultation system with a standard video call system in critical care: user acceptance and feasibility analysis by Nadine Liebchen, Julia Schrader-Reichling, Frieder Pankratz, Marc Lazarovici, Selina Kim, Jennifer Tempfli, Ulrich Eck, Stephan Prückner

“…Common issues included visual impairment due to insufficient graphical resolution and unfamiliarity with handling the equipment. 80% of the participants expressed willingness to incorporate the system into their ICU work. …”
Get full text

Efficacy of MCU-based and 3D-FEA for Improving Cervical Spondylosis by Meigui KE, Ruixu XU, Ningying HUANG, Hai GUO, Xinghui YAN, Nanxi WU, Sidong DOU

“…Objective:Based on the Muli-Cervical Unit(MCU)and three-dimensional finite element analysis(3D-FEA),this study explored whether the"Tuo tian zhuang"exercise in the Southern Shaolin Yi Jin Jing can improve the efficacy of electroacupuncture in the treatment of cervical spondylosis.Methods:Patients who met the inclusion criteria for cervical spondylosis of cervical type were randomized assigned by age stratification into control group and experimental group. …”
Get full text

Prevalence and risk factors for lameness in dairy cattle on selected farms located in Dessie and Kombolcha, Northeast Ethiopia by Hasen Ahimed Mekonin, Abadi Amare Reda, Abadi Amare Reda, Alula Alemayehu Assen, Alula Alemayehu Assen, Awol Mohammed Assen, Awol Mohammed Assen

“…A cross-sectional study was conducted from May 2022 to February 2023 to estimate the prevalence and identify associated risk factors of lameness in 433 dairy cows across 37 selected farms located in Dessie and Kombolcha, Northeast Ethiopia.MethodsThe selected animals were examined for lameness using a five-point visual locomotion scoring technique during daily outdoor access on a solid walking surface in the designated refreshment areas. …”
Get full text

A study on the effect of platelet-rich plasma (PRP) to promote bone fusion in lateral interbody fusion of the lumbar spine using artificial bone by Hiroshi Noguchi, Toru Funayama, Kosuke Sato, Masao Koda, Hiroshi Takahashi, Kousei Miura, Hiroshi Kumagai, Masashi Yamazaki

“…Objective This study assessed whether PRP enhances intervertebral bone fusion in LLIF surgery using β-tricalcium phosphate artificial bone. Methods The current study was a prospective, randomized, controlled trial. …”
Get full text

Local Infiltration Analgesia with Ropivacaine Improves Postoperative Pain Control in Ankle Fracture Patients: A Retrospective Cohort Study by Bao-Liang Li, Xizhe Liu, Lihua Cui, Wenqian Zhang, Hui Pang, Mingshan Wang, Hai-Qiang Wang

“…The primary outcome indicator was visual analogue scale (VAS) from 8 hours to 48 hours after surgery. …”
Get full text

A telomere-associated molecular landscape reveals immunological, microbial, and therapeutic heterogeneity in colorectal cancer by Yinmeng Zhang, Jiawei Fan, Jiahui Zhao, He Zhu, Yan Xia, Hong Xu

“…Whole-slide histopathological images (WSIs) and immunohistochemical (IHC) staining were utilized to visualize immune features, including tertiary lymphoid structures (TLSs), across subgroups. …”
Get full text

Health-Related Quality of Life with Cervical Cancer and Precancer: A Cross-Sectional Study in Yunnan Province, China by Min Zhao, Meng-Jiao Zhang, Lian-Ju He, Chun-Mei Zuo, Song-Rui Ding, Allison Rabkin Golden, Le Cai

“…This study investigates socioeconomic and clinical variations in HRQoL of women with cervical precancerous lesions and cervical cancer in Yunnan Province, China. Methods: The present study employed a cross-sectional survey design. …”
Get full text

Patient-reported outcomes and radiographic progression in patients with rheumatoid arthritis in sustained remission versus low disease activity by Annette H M van der Helm-van Mil, Pascal H P de Jong, Marijn Vis, Selinde V J Snoeck Henkemans, Agnes E M Looijen

“…Objective To compare clinical and patient-reported outcomes (PROs) over 5 years between patients with rheumatoid arthritis (RA) in sustained remission (sREM), sustained low disease activity (sLDA) or active disease (AD) in the first year after diagnosis.Methods All patients with RA from the treatment in the Rotterdam Early Arthritis CoHort trial, a multicentre, stratified, single-blinded trial with a treat-to-target approach, aiming for LDA (Disease Activity Score (DAS) ≤2.4), were studied. …”
Get full text

Gender-related differences in clinical presentation, electrocardiography signs, laboratory markers and outcome in patients with acute pulmonary embolism by Obradović Slobodan, Džudović Boris, Rusović Siniša, Subota Vesna, Obradović Dragana

“…All the patients confirmed PE by visualized thrombus on the multidetector computed tomography with pulmonary angiography (MDCTPA), ECG and echocardiographic examination at admission. …”
Get full text

Direct anterior approach versus posterior approach in total hip arthroplasty after ONFH with failed vascularized iliac crest bone grafting for hip preservation: a retrospective com... by Kun Chu, Yuchuan Wang, Bo Liu, Zihang Li, Zhaolong Wang, Junheng Zhang, Yongqiang Fan, Binquan Zhang, Huijie Li

“…Abstract Background Hip preservation surgery with vascularized iliac bone flap transplantation is currently an important method for treating patients with early-stage femoral head necrosis and collapse. …”
Get full text

Open surgery and minimally invasive repair of acute Achilles tendon rupture: stratified outcomes based on immobilization duration in a prospective cohort study by Yuan Cao, Xiuzhi Li, Zengzhen Cui, Yang Lv, Gao Si

“…Data regarding the operative times, incision lengths, the visual analog scale (VAS) score, the Achilles tendon Total Rupture Score (ATRS), and the American Orthopaedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot Scale score, and the relative Achilles tendon resting angle (ATRA) were also collected. …”
Get full text

Endovascular management of carotid-cavernous fistulas: a 16-year retrospective analysis of multimodal treatment strategies and long-term clinical outcomes by Chingiz Nurimanov, Iroda Mammadinova, Karashash Menlibayeva, Yeldar Kydyrmoldin, Ramazan Duisengali, Diana Kerimbayeva, Serik Akshulakov, Yerbol Makhambetov

“…Over the years, endovascular techniques have become the preferred method for treating CCFs, offering high success rates with fewer complications. …”
Get full text

Barriers and Facilitators to the Preadoption of a Computer-Aided Diagnosis Tool for Cervical Cancer: Qualitative Study on Health Care Providers’ Perspectives in Western Cameroon by Magali Jonnalagedda-Cattin, Alida Manoëla Moukam Datchoua, Virginie Flore Yakam, Bruno Kenfack, Patrick Petignat, Jean-Philippe Thiran, Klaus Schönenberger, Nicole C Schmidt

“… BackgroundComputer-aided detection and diagnosis (CAD) systems can enhance the objectivity of visual inspection with acetic acid (VIA), which is widely used in low- and middle-income countries (LMICs) for cervical cancer detection. …”
Get full text

Clinical Value of Continuous Fascia Iliaca Compartment Block in Perioperative Management of Elderly Patients with Intertrochanteric Fracture: A Propensity Score-Matched Retrospecti... by Xu G, Deng Y, Gao H, Wang B, Wang G, Ma J

“…This study investigated the efficacy of continuous fascia iliaca compartment block (CFICB) in perioperative management.Methods: A retrospective analysis was conducted on elderly patients (≥ 65 years) with intertrochanteric fractures treated between January 2020 and December 2023. …”
Get full text

Antimicrobial peptides for treatment of patients with herpes virus-associated chronic prostatitis by E. V. Kulchavenya, S. Yu. Shevchenko, A. A. Baranchukova

“…To determine the efficacy of cytokines-antimicrobial peptides complex in therapy of patients with herpes virus-associated chronic prostatitis.Materials & methods. The pilot, open, prospective, non-comparative study included 23 patients who were followed up for CP for a mean of 9.7 ± 4.2 years. …”
Get full text

Efficacy of minimally invasive vascular interventions assessed with mobile multispectral near-infrared spectroscopy by Alisha Roberta Oropallo, MD, Amit Rao, MD, Jo Ann Eisinger, PA, Larry Leonardi, PhD

“…Conclusions: The study demonstrates that NIRS imaging effectively tracks treatment-related changes, providing a noninvasive and reliable method for the real-time assessment of StO2. By visualizing changes in microcirculation, this technology offers clinicians valuable insights, enabling earlier detection of treatment success or failure and facilitating timely interventions. …”
Get full text

Proteomic and metabolomic analysis of serum in women infected with COVID-19 during late pregnancy by Yi Zheng, Jinyu Ning, Jiang Zhu, Honglin Zhu, Zhihua She, Pei Cai

“…IntroductionTo investigate the alterations of serum proteins and metabolomics in women infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at the end of pregnancy and their potential effects on fetal development.MethodsThe corona virus disease 2019 (COVID-19) group (n=31) included women in the third trimester diagnosed with SARS-CoV-2 infection and who delivered, while the control group (n=30) comprised uninfected women in the same gestational period. …”
Get full text