Virtual reality-guided therapy on a stroke unit: a feasibility study by Jordi Kühne Escolà, Rumeysa Demirdas, Martin Schulze, Woon Hyung Chae, Lennart Steffen Milles, Doreen Pommeranz, Marvin Darkwah Oppong, Christoph Kleinschnitz, Martin Köhrmann, Benedikt Frank

“…The feasibility of VR-guided therapy in the acute phase after stroke has not been assessed. Methods This was a cohort study of consecutive patients with suspected stroke who were admitted to the Essen University Hospital Stroke Unit between March 2022 and May 2022. …”
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Factors associated with decreased anal sphincter tone and the accuracy of forced anal examinations to detect individuals having receptive anal intercourse: an observational study by John A Schneider, Alan G Nyitray, Derek Smith, Michael W Ross, Elizabeth Y Chiao, Timothy J Ridolfi, Bridgett Brzezinski, B R Simon Rosser, Aniruddha Hazra, Jenna Nitkowski, Sandrine Sanos, Ever Mkonyi, Lucy Mgopa

“…Using baseline data from a longitudinal study, we aimed to determine factors associated with sphincter tone and the accuracy of sphincter tonality to detect persons engaging in receptive anal intercourse.Methods Clinicians in Chicago, Houston and Milwaukee, USA conducted digital anal rectal examinations (DARE) to score sphincter resting tone (RT) and squeeze tone (ST). …”
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The real-world evidence to the effects of primary psychological healthcare system in diluting risks of suicide ideation in underrepresented children/adolescents: an observational,... by Wei Li, Xuerong Liu, Qianyu Zhang, Xiaobing Tian, Xianyong An, Jidong Ren, Xiaodi Han, Jingyu Lei, Chang Shen, Yanyan Li, Ji Chen, Lei Xia, Jingxuan Zhang, Yi Wu, Jie Gong, Hai Lan, Yan Wu, Zhengzhi Feng, Zhiyi Chen

“…Subgroup analysis was conducted to examine the equal benefits of the system for underrepresented children/adolescents. …”
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Clinical impact of air pollution on SPECT myocardial perfusion imaging by Océane Bouchot, Stephan Gabet, Loïc Djaileb, Aurélia Robin, Nicolas De Leiris, Julie Roux, Laurent Riou, Gerald Vanzetto, Daniel Fagret, Catherine Ghezzi, Rémy Slama, Gilles Barone-Rochette

“…This study aimed to characterize relations of air pollution exposure to myocardial perfusion imaging (MPI). Methods: Patients referred to SPECT (single-photon emission computed tomography) MPI were prospectively enrolled between 2017 and 2020. …”
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Determining the optimum high-flow nasal cannula flow rate to achieve the desired fraction of inspired oxygen: A bench study by Chao-Lan Huang, Chun-Ching Lu, Cheng Chiang, Heng-Sheng Chao, Ting-Yun Chiang, Wei-Nung Teng, Wen-Kuei Chang, Chien-Kun Ting

“…Therefore, we introduced a new variable, defined as flow ratio, which equaled the HFNC flow divided by inspiratory flow. …”
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Efficacy and safety of electroacupuncture and electroacupuncture combined with warm needling for subjective tinnitus: A multicenter, three-arm randomized controlled trial by Lai Fun Ho, Yuanqi Guo, Liyi Chen, Herbert Fung, Wai Yan Mak, Siu Chuen Cheung, Ping Him Tsang, Min Chen, Kam Leung Chan, Hongwei Zhang, Wai Tsz Chang, Bacon Fung-Leung Ng, Zhi Xiu Lin

“…Ninety eligible participants aged 50–70 years with subjective tinnitus for 0.5–24 months were equally randomized to EA, EAWN, or waitlist groups. …”
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Large-scale analysis highlights obesity as a risk factor for chronic, non-communicable inflammatory diseases by Sadegh Mousavi, Katja Bieber, Henner Zirpel, Artem Vorobyev, Henning Olbrich, Cristian Papara, Cristian Papara, David A. De Luca, David A. De Luca, Diamant Thaci, Enno Schmidt, Gabriele Riemekasten, Peter Lamprecht, Matthias Laudes, Khalaf Kridin, Khalaf Kridin, Khalaf Kridin, Ralf J. Ludwig, Ralf J. Ludwig

“…Yet, several knowledge gaps remain: For several CIDs, inconsistent results have been reported, relating to their obesity-imposed risk, data on most rare CIDs remain unavailable, sex differences and racial disparities remain mostly unaddressed.MethodsA large-scale cohort study compared the risk of developing 46 CIDs in individuals with overweight/obesity (n=3,101,824) to an equal number of non-overweight/obese individuals. …”
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An interpretable machine learning model based on computed tomography radiomics for predicting programmed death ligand 1 expression status in gastric cancer by Lihuan Dai, Jinxue Yin, Xin Xin, Chun Yao, Yongfang Tang, Xiaohong Xia, Yuanlin Chen, Shuying Lai, Guoliang Lu, Jie Huang, Purong Zhang, Jiansheng Li, Xiangguang Chen, Xi Zhong

“…The SHAP waterfall plots were used to visualize the decision-making process for a single individual. …”
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Massive rotator cuff tears: geometric classification, complete repair, and prognosis by Liwei Ying, MA, Qingguo Zhang, MA, Li Ying, PhD, Linlin Sha, MA, Dawei Han, MA, Yu Hui, BA, Quan Gan, BA, Huixia Fan, BA, Junbo Liang, PhD, Xiaobo Zhou, PhD

“…Background: This study aims to summarize tear patterns of massive rotator cuff tears (MRCTs) and outline our surgical techniques for complete repair. Methods: From January 2018 to May 2023, 394 shoulders in 389 individuals with consecutive MRCT received arthroscopic MRCT repair. …”
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Real-time intestinal perfusion assessment for anastomotic site selection using laser speckle contrast imaging: Verification in a porcine model by Danique J.I. Heuvelings, Mahdi Al-Taher, Joost Calon, Manish Chand, Laurents P.S. Stassen, Tim Lubbers, Kevin P. Wevers, Luigi Boni, Nicole D. Bouvy, Wido Heeman

“…Therefore, we explored the efficacy and feasibility of a new laser speckle contrast imaging system to assess real-time intestinal perfusion. Methods: Three gradually perfused porcine small bowel loops were created, and five senior surgeons were asked to assess the perfusion differences based on laser speckle contrast images using PerfusiX-Imaging®. …”
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Rapid Therapeutic Drug Monitoring of Voriconazole Based on High-Performance Liquid Chromatography: A Single-Center Pilot Study in Outpatients by Satoru Morikawa, Yusuke Yagi, Moemi Okazaki, Narika Yanagisawa, Tomoaki Ishida, Kohei Jobu, Takumi Maruyama, Takahiro Kato, Miyuki Matsushita, Yu Arakawa, Yuka Yamagishi, Yukihiro Hamada

“…Safety was monitored for renal, hepatic, and visual toxicities. <b>Results</b>: HPLC-UV significantly reduced reporting times (0.433 h vs. 74.3 h, <i>p</i> < 0.001), and Deming’s regression analyses showed a strong correlation with LC-MS/MS results (Pearson’s r = 0.988). …”
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Efficacy and Safety of a Dexamethasone Implant in Patients with Diabetic Macular Edema at Tertiary Centers in Korea by Byung Gil Moon, Joo Yong Lee, Hyeong Gon Yu, Ji Hun Song, Young-Hoon Park, Hyun Woong Kim, Yong-Sok Ji, Woohyok Chang, Joo Eun Lee, Jaeryung Oh, Inyoung Chung

“…A total of 186 eyes from 165 patients were included. Best-corrected visual acuity (BCVA), central retinal thickness (CRT), complications, and number of retreatments were collected. …”
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Association between psychosocial factors at work and health outcomes after retirement: a protocol for a systematic review and meta-analysis by Hisashi Eguchi, Akizumi Tsutsumi, Akiomi Inoue, Yuka Kobayashi, Norito Kawakami, Kotaro Imamura, Asuka Sakuraya, Natsu Sasaki, Yumi Asai, Hideaki Arima, Emiko Ando, Reiko Inoue, Mai Iwanaga, Yasumasa Otsuka, Kanami Tsuno, Ayako Hino, Kazuhiro Watanabe, Akihito Shimazu

“…For the assessment of meta-bias, publication bias will be assessed by using Egger’s test, as well as visually on a funnel plot. Heterogeneity will be assessed using the χ² test with Cochran’s Q statistic and I2.Ethics and dissemination Results and findings will be submitted and published in a scientific peer-reviewed journal and will be disseminated broadly to researchers and policy-makers interested in the translatability of scientific evidence into good practices.PROSPERO registration number CRD42018099043.…”
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Identification of Causal Genes and Potential Drug Targets for Restless Legs Syndrome: A Comprehensive Mendelian Randomization Study by Ruiyi Qian, Xue Zhao, Dongbin Lyu, Qingqing Xu, Kai Yuan, Xin Luo, Wanying Wang, Yang Wang, Yutong Liu, Yu Cheng, Yingting Tan, Fan Mou, Chengmei Yuan, Shunying Yu

“…Molecular docking was used to visualize the binding structure and fine affinity for <i>MAN1A2</i> and the drugs predicted by DSigDB. …”
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External application of Traditional Chinese medicine in the treatment of acute gouty arthritis (中药外敷治疗急性痛风性关节炎临床效果及护理) by LI Juan (李娟), ZHENG Xiaoya (郑小雅), ZHANG Haiying (张海英), DU Danying (杜丹颖), HAN Shuhua (韩淑花), LI Yan (李雁)

“…Objective To observe the clinical effect of external application of Traditional Chinese Medicine(TCM) in the treatment of acute gouty arthritis. Methods Totally 61 patients with acute gouty arthritis who met the inclusion criteria were included as research subjects. …”
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CHI study: protocol for an observational cohort study on ageing and mental health in community-dwelling older adults by Lei Feng, Lieng Hsi Ling, Qiushi Feng, Rachael Zhi Yi Lee, Junhong Yu, Iris Rawtaer, Patrick Finbarr Allen, Zhiming Bao, Jeong Kyu Lee, Chin Tat Lim, Leng Leng Thang, Thet Naing, D Y Wang, Kai Zhen Yap, EH Kua, Rathi Mahendran

“…The Community Health and Intergenerational study aims to holistically examine ageing in place by investigating the resilience and vulnerability factors of the ageing process in the biological, psychological and social domains within the environment.Methods and analysis Using a cohort multiple randomised controlled trial design, comprehensive health profiles of community-dwelling older adults will be collected. …”
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Distinctive clinical features of early and late-onset Ménière’s disease by Jianwei Lin, Heng Xiao, Heng Xiao, Heng Xiao, Chenxin Lin, Gengliang Huang, Xiaojing Guo, Huimin Cai, Huimin Cai, Huimin Cai, Shengnan Ye, Shengnan Ye, Shengnan Ye

“…PurposeTo compare the clinical characteristics of patients with early and late-onset Ménière’s disease (MD) and to investigate the impact of psychological factors between the two groups.MethodsThe patients were divided into two groups based on their age of onset: early-onset (&lt;45 years old) and late-onset (&gt;55 years old). …”
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Combining patient-reported outcome measures to screen for active disease in rheumatoid arthritis and psoriatic arthritis by Annette H M van der Helm-van Mil, Pascal H P de Jong, Paco M J Welsing, Ilja Tchetverikov, Jolanda J Luime, Marijn Vis, Marc R Kok, Paul Baudoin, Lindy-Anne Korswagen, Selinde V J Snoeck Henkemans, Agnes E M Looijen, Gonul Hazal Koc

“…Objectives To investigate whether a combination of general health (Visual Analogue Scale (VAS)), Health Assessment Questionnaire-Disability Index (HAQ-DI), pain (VAS/Numerical Rating Scale (NRS)), quality of life (EQ-5D), fatigue (VAS/NRS) and presenteeism (0%–100% productivity loss) could aid as a screening tool to detect active disease in patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA).Methods RA patients from the tREACH trial and TARA trial (n=683) and PsA patients from the DEPAR cohort (n=525) were included. …”
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Increased Risk of Central Serous Chorioretinopathy among Patients with Nonorganic Sleep Disturbance by Peng-Tai Tien, Chien-Yu Lai, Chun-Ju Lin, Wen-Lu Chen, Po-Kang Lin, Chih-Hsin Muo, Yi-Yu Tsai, Lei Wan, Wen-Chao Ho, Hui-Ju Lin

“…Patients with central serous chorioretinopathy (CSC) typically present with acute visual impairment and metamorphopsia. The disease previously has been associated with psychological stress. …”
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Systemizing and Transforming Preterm Oral Feeding Through Innovative Algorithms by Rena Rosenthal, Jean Chow, Erin Sundseth Ross, Rudaina Banihani, Natalie Antonacci, Karli Gavendo, Elizabeth Asztalos

“…These resources included detailed instructions, visual aids, and step-by-step guides to help staff understand and apply the algorithms effectively. …”
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