Statistical learning to identify and characterise neurodevelopmental outcomes at 2 years in babies born preterm: model development and validation using population-level data from E... by Sadia Haider, Athanasios Tsanas, G. David Batty, Rebecca M. Reynolds, Heather C. Whalley, Simon R. Cox, Riccardo E. Marioni, Cheryl Battersby, James P. Boardman

“…This study applies statistical learning to a national database to identify transdomain clusters and their maternal and neonatal predictors. Methods: Latent class analysis (LCA) was used to derive transdomain clusters from parent-reported visual, auditory, neuromotor, and communication impairments in preterm-born children at two years corrected age using the UK National Neonatal Research Database data (N = 27,261). …”
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Blood-brain barrier disruption mediates the association between cerebral small vessel disease and clinical outcome after stroke: a secondary analysis of the Lesion Evolution in Str... by Derrick N. Okine, Derrick N. Okine, Kyle C. Kern, Kyle C. Kern, Kyle C. Kern, Marie Luby, Lawrence L. Latour, Rebecca F. Gottesman

“…WMH were visually graded on baseline FLAIR for presence and severity (minor or moderate-severe). …”
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Layered structural engineering of Bi2O3/PP and WO3/PP composites for γ-ray shielding in high energy range: anisotropic attenuation mechanisms via Monte Carlo simulation and experim... by Xiangjie Duan, Jie Zhao, Shuaida Song, Na Zhou, Jizhuang Fan, Bo Tian, Yunchen Du

“…Herein, FLUKA Monte Carlo simulations capable of visualizing γ-photon transport behaviors are investigated in Bi2O3/PP and WO3/PP multi-layer composites with various layered configurations. …”
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Associations of long-term joint exposure to multiple ambient air pollutants with the incidence of age-related eye diseases by Yingan Li, Yuzhou Zhang, Ka Wai Kam, Poemen Chan, Dong Liu, Ebenezer Zaabaar, Xiu Juan Zhang, Mary Ho, Mandy PH Ng, Patrick Ip, Alvin Young, Chi Pui Pang, Clement C. Tham, Mei Po Kwan, Li Jia Chen, Jason C. Yam

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Comparison between Spectral-domain and Swept-source OCT Angiography Scans for the Measurement of Hyperreflective Foci in Age-related Macular Degeneration by Gissel Herrera, MD, Yuxuan Cheng, PhD, Yamini Attiku, MD, Farhan E. Hiya, MD, Mengxi Shen, MD, PhD, Jeremy Liu, MD, Jie Lu, PhD, Alessandro Berni, MD, Omer Trivizki, MD, Jianqing Li, MD, Robert C. O’Brien, PhD, Giovanni Gregori, PhD, Ruikang K. Wang, PhD, Philip J. Rosenfeld, MD, PhD

“…Participants: Forty eyes from 35 patients with iAMD. Methods: Patients underwent SD-OCTA and SS-OCTA imaging at the same visit using a 6 × 6 mm OCTA scan pattern. …”
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Evaluation of the risk factors for rhegmatogenous retinal detachment associated with choroidal detachment from the viewpoint of treatment patterns: a retrospective study by Kai Gao, Zi-Ye Chen, Zhuang-Ling Lin, Ya-Ping Liu, Bao-Yi Liu, Yuan Ma, Zi-Tong Chen, Rebiya●Tuxun, Lan Jiang, Zhuo-Jun Xu, Chin-Ling Tsai, Kun-Bei Lai, Tao Li

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A matched pilot cohort study of intravenous omadacycline in the treatment of severe pneumonia associated with carbapenem-resistant Acinetobacter baumannii by Dayu Chen, Yechao Chen, Yechao Chen, Na Hu, Qiaoling Gu, Qiaoling Gu, Jingjing Kan, Jingjing Kan, Jinchun Liu, Haixia Zhang

“…The clinical success rate at day 14 or at the EOT was 65% (13/20) in the omadacycline group compared to 55% (11/20) in the tigecycline group. Both groups had an equal mortality rate, with 8 patients dying within 28 days. …”
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Cognitive Impairment in CMV Seropositive and CMV Seronegative Deceased Donor Kidney Transplant Recipients by Maheen Z. Abidi, MD, Xiaomeng Chen, MSPH, Yi Liu, ScM, Nadia M. Chu, PhD, Aarti Mathur, MD, PhD, Adriana Weinberg, MD, Bruce Kaplan, MD, Silas Norman, MD, Jingyao Hong, MHS, Dorry L. Segev, MD, PhD, Kristine M. Erlandson, MD, Mara A. McAdams-DeMarco, PhD

“…We tested whether CMV was associated with post-KT cognitive impairment. Methods. In a 2-center prospective cohort study of 574 KTRs (mean age: 54.7 y), we obtained CMV donor/recipient (D/R) serostatus and measured pre- and post-KT cognitive function using the Modified Mini-Mental State Examination. …”
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Unsupervised machine learning clustering approach for hospitalized COVID-19 pneumonia patients by Nuttinan Nalinthasnai, Ratchainant Thammasudjarit, Tanapat Tassaneyasin, Dararat Eksombatchai, Somnuek Sungkanuparph, Viboon Boonsarngsuk, Yuda Sutherasan, Detajin Junhasavasdikul, Pongdhep Theerawit, Tananchai Petnak

“…Variables were normalized before clustering to ensure equal contribution to the analysis. The optimal number of clusters was determined using the elbow method and Silhouette scores. …”
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Screening and mechanistic study of natural compounds that enhance T cell anti-tumor effects post-heat treatment by Zhaoyi Wang, Zhongqi Diao, Yiyan Zhang, Jiangying Liu, Yeshan Li, Zijin Sun, Huimin Zhen, Haojia Wang, Siyun Yang, Tieshan Wang, Lei Ni

“…Optimizing the cytotoxic effects of immune cells under in vitro culture conditions represents a current hot research topic in this domain.MethodsIn the current experiment, we conducted in vitro heat treatment on Jurkat-derived T cells at 39°C. …”
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Immunomodulatory Effects of <i>Cucurbita pepo</i> L. Extract in Chronic Stress-Induced Dysregulation of Lymphoid Organs in Rats by Safa H. Qahl, Hailah M. Almohaimeed, Sami A. Algaidi, Ashwaq H. Batawi, Zuhair M. Mohammedsaleh, Tarek Hamdy Abd-Elhamid, Nawal H. Almohammadi, Nasra N. Ayuob, Amany Refaat Mahmoud

“…(<i>CP</i>) on chronic unpredictable mild stress (CUMS)-induced changes in lymphoid organs through evaluating its effect on the histological structure of spleen, thymus gland, and lymph nodes compared to the antidepressant fluoxetine (FLU). <b>Materials and Methods</b>: Fifty male albino rats equally distributed into five groups that included control, control + <i>CP</i>, CUMS-exposed, FLU-treated, and <i>CP</i>-treated groups were used in this study. …”
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Comparative Efficacy and Safety of Cryoballoon vs Laser Balloon Ablation for Pulmonary Vein Isolation in Patients With Paroxysmal Atrial Fibrillation by Mahmoud Ali, Dorota Magdon, Abdulghani Mounir, Lynn Erickson, James Adefisoye, Jim Kanani, Andy Kieu, Abdullah Malik, Ali Ali, Nour Ghosoun, Jodi Zilinski, Arshad Jahangir, M. Eyman Mortada, Imran Niazi, Atul Bhatia

“…Conclusions: In patients with paroxysmal AF undergoing PVI, CBA and LBA were equally efficacious at one year and demonstrated acceptably low complication rates. …”
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Examining patient safety protocols amidst the rise of digital health and telemedicine: nurses’ perspectives by Ateya Megahed Ibrahim, Ibrahim Naif Alenezi, Asmaa Kamal Hassan Mahfouz, Ishraga A. Mohamed, Marwa A. Shahin, Elsayeda Hamdy Nasr Abdelhalim, Laila Zeidan Ghazy Mohammed, Takwa Rashwan Mohamed Abd-Elhady, Rehab Saad Salama, Aziza Mohamed Kamel, Rania Abdel Khalik Gouda, Noura Elgharib Mohamed Moustafa Eldiasty

“…Results The sample was predominantly composed of nurses aged 18–35 (40.65%) and 36–55 (44.72%), with a near-equal gender distribution (48.78% male, 51.22% female). …”
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Inhibitory activity of dry ethanol extracts of <i>Artemisia</i> spp. on SARS‐CoV‐2 replication <i>in vitro</i> by Е. I. Каzachinskaia, V. D. Romanova, A. V. Ivanоva, А. А. Chepurnov, Z. A. Murtazalieva, Yu. V. Коnonova, D. N. Shaulo, V. V. Romanyuk, А. М. Shestopalov

“…In vitro analysis of the inhibitory activity of dry ethanol extracts of some Artemisia spp. growing in the Novosibirsk region for SARS‐CoV‐2 replication.Materials and Methods. The laboratory strain SARS‐CoV‐2/human/RUS/Nsk‐FRCFTM‐1/2020 was passed on Vero cell culture. …”
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S index: a predictor comparable to ultrasound shear wave elastography in assessing liver fibrosis in patients with chronic hepatitis B by Sujuan Guo, Lu Gan, Feng Du, Qiang Feng, Jiahua Li, Qinyun Wan, Qiannan Meng, Yaoren Zhang, Yonghao Ji, Jianxue Liu

“…Conclusion The S index is equally effective as the USWE in diagnosing liver fibrosis among patients with chronic hepatitis B, and it is superior to both the Z index and Fibrometer.…”
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Effect of Hypertensive Disorders of Pregnancy (HDP) on maternal and perinatal birth outcomes in Eastern Ethiopia: a prospective cohort study by Ebisa Zerihun, Firaol Girma, Nimona Amena, Wubet Tazeb Wondie, Belete Feyera Olkaba, Lemma Mideksa Egu, Solomon Seyife Alemu, Gemechu Gelan Bekele, Belay Tafa Regassa, Meseret Robi Tura, Fekadu Abera Kebede

“…Objectives The aim of this study was to examine the effect of hypertensive disorders of pregnancy on maternal and perinatal birth outcomes in Eastern Ethiopia. Methods We employed a prospective cohort study design involving 374 pregnant women, equally divided into hypertensive ((n = 187) and normotensive (n = 187). …”
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Longer Drug Retention of Interleukin-12/23 or Interleukin-17 Inhibitors Compared With TNF Inhibitors in Female Patients With TNF Inhibitor-Experienced Psoriatic Arthritis by Godehard A. Scholz, MD, PhD, Eleftherios Papagiannoulis, MSc, Christoph Blapp, MSc, Raphael Micheroli, MD, Adrian Ciurea, MD, Michael J. Nissen, MD, Nikhil Yawalkar, MD, Diana Dan, MD, Jennifer Amsler, MD, Almut Scherer, PhD, Burkhard Möller, MD

“…Furthermore, differences in static skin scores between the groups at baseline were equalized at follow-up. However, improvements in the disease activity in PsA were similar in both groups, and ACR20 (33% [29%] vs 14% [13%]; P=.03) and ACR50 response rates (24% [21%] vs 7% [6%]; P=.02) were even higher for TNFi in unadjusted and (LUNDEX-adjusted) analyses. …”
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Distinct sex differences in ethanol consumption and operant self-administration in C57BL/6J mice with uniform regulation by glutamate AMPAR activity by Sara Faccidomo, Sara Faccidomo, Vallari R. Eastman, Taruni S. Santanam, Katarina S. Swaim, Seth M. Taylor, Clyde W. Hodge, Clyde W. Hodge

“…The lack of sex differences in the relative effects of GYKI 52466 suggests that AMPAR activity is equally required for EtOH reinforcement in both sexes.…”
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Predicting infection with COVID-19 disease using logistic regression model in Karak City, Jordan [version 3; peer review: 2 approved] by Lina AlTamimi, Liana Dalaeen, Anas Khaleel, Wael Abu Dayyih, Abdallah Ahmed Elbakkoush, Mohammad Niazi, Baker Albadareen, Zainab Zakaraya, Alhareth Ahmad

“…Among the participants 295 (76.4%) were aged less than or equal 45 years old, and 91 (23.6%) were aged over 45 years old. …”
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The risk associated with ultra-processed food intake on depressive symptoms and mental health in older adults: a target trial emulation by Belayneh Mengist, Mojtaba Lotfaliany, Julie A. Pasco, Bruno Agustini, Michael Berk, Malcolm Forbes, Melissa M. Lane, Suzanne G. Orchard, Joanne Ryan, Alice J. Owen, Robyn L. Woods, John J. McNeil, Mohammadreza Mohebbi

“…Therefore, this study investigated the effect of UPF on depressive symptoms and mental health in community-dwelling older adults. Methods A pragmatic target trial was designed and emulated using the ASPirin in Reducing Events in the Elderly longitudinal data. …”
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