Transanal Irrigation in Patients with Low Anterior Resection Syndrome After Rectal-Sphincter-Preserving Surgery for Oncological and Non-Oncological Disease: A Systematic Review by Andrea Morini, Massimiliano Fabozzi, Magda Zanelli, Francesca Sanguedolce, Andrea Palicelli, Alfredo Annicchiarico, Candida Bonelli, Maurizio Zizzo

“…The aim of the present systematic review was to evaluate the feasibility and effectiveness of TAI in patients with significant LARS symptoms. Methods: We performed a systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and guidelines in addition to the <i>Cochrane Handbook for Systematic Reviews of Interventions</i>. …”
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Resting-State Brain Network Characteristics Related to Mild Cognitive Impairment: A Preliminary fNIRS Proof-of-Concept Study by Guohui Yang, Chenyu Fan, Haozheng Li, Yu Tong, Shuang Lin, Yashuo Feng, Fengzhi Liu, Chunrong Bao, Hongyu Xie, Yi Wu

“…While sRSFC strength did not differentiate between MCI patients and HCs, the dRSFC variability between the dorsal attention network (DAN) and default mode network (DMN), and between the ventral attention network (VAN) and visual network (VIS), emerged as sensitive biomarkers after false discovery rate correction (p < 0.05). …”
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The Impact of Prostate-Specific Antigen and Gleason Scores on Cardiovascular Death in Prostate Cancer Patients after Radiotherapy or Chemotherapy: A Population-Based Study by Huijuan He, Liyu Guo, Peipei Wang, Yuting Yang, Zhenxing Lu, Xiaoping Peng, Tianwang Guan

“…The predicted prostate-specific antigen (PSA) and Gleason score values were visualized using a nomogram, which was subsequently validated through calibration curves and concordance indexes (C-indexes). …”
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Alflutop Russian longitudinal multicenter observational study: use in patients with chronic back pain (message 3) by A. M. Lila, A. E. Karateev, L. I. Alexeeva, E. A. Taskina, An. B. Danilov, S. A. Zhivolupov, I. N. Samartsev, E. R. Barantsevich, A. P. Rachin

“…The use of slow-acting disease-modifying symptomatic drugs, such as bioactive concentrate from small marine fish (BCSMF, Alflutop), is considered a potential element of complex therapy for chronic non-specific back pain (CNBP).Objective: to evaluate the efficacy of the BCSMF in patients with CNBP in real-life clinical practice.Material and methods. An open observational study included 10,047 patients with CNBP (age – 58.3±14.9 years, 58.4% women) with moderate or severe pain – 60 [50; 70] mm on the visual analogue scale (VAS). …”
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Observation of the clinical effectiveness of transanal opening of the intersphincteric space in the treatment of high intersphincteric anal fistula and suprasphincteric anal fistul... by Huang Luqiao, Li Shanshan, Yang Yong, Meng Qingliang, Liang Chunhui, Pan Dong, Sun Shangying, Xie Guangwei, Zhang Zhengguo

“…The clinical effectiveness (total effective rate), surgical indicators (operation time, hospital stay, wound healing time), pain levels [visual analog scale (VAS) pain scores] on the 1st and 7th day after surgery, and anal function (Wexner incontinence score) at 3 months after surgery were compared between the two groups. …”
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PHARMACOEPIDEMIOLOGY OF ORIGINAL DROTAVERINE USE IN DYSMENORRHEA: RESULTS OF AN INTERNATIONAL MULTICENTER STUDY by A. L. Unanyan, V. A. Alimov, S. E. Arakelov, M. S. Afanasyev, D. V. Baburin, D. V. Blinov, T. D. Guriyev, U. V. Zimovina, A. E. Kadyrova, Yu. M. Kossovich, L. S. Polonskaya

“…Pain was evaluated asking patients to rate the worst abdominal pain over the past 12 hours (11-point Numerical Pain Rating Scale, NPRS) and a Visual Analogue Scale (VAS) to evaluate the drotaverine onset of action. …”
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Based on Network Pharmacology Tools to Investigate the Molecular Mechanism of Cordyceps sinensis on the Treatment of Diabetic Nephropathy by Yan Li, Lei Wang, Bojun Xu, Liangbin Zhao, Li Li, Keyang Xu, Anqi Tang, Shasha Zhou, Lu Song, Xiao Zhang, Huakui Zhan

“…This study is aimed at revealing the therapeutic mechanisms of Cordyceps in DN by undertaking a network pharmacology analysis. Materials and Methods. In this study, active ingredients and associated target proteins of Cordyceps sinensis were obtained via Traditional Chinese Medicine Systems Pharmacology Database (TCMSP) and Swiss Target Prediction platform, then reconfirmed by using PubChem databases. …”
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Correlations between symptoms, nasal endoscopy and computed tomography findings in patients with chronic rhinosinusitis without nasal polyps by Savović Slobodan, Dragnić Nataša, Kljajić Vladimir, Jovančević Ljiljana, Buljčik-Čupić Maja, Lemajić-Komazec Slobodanka

“…The aim of this paper was to determine if there is a correlation between the symptoms, nasal endoscopy and CT in patients with CRSsNP. Methods. The study included 110 patients with CRSsNP. …”
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NUCLEAR MEDICINE IMAGING IN THE DETECTION OF LOCALLY ADVANCED LARYNGEAL AND HYPOPHARYNGEAL CANCER by A. A. Medvedeva, V. I. Chernov, R. V. Zeltchan, I. G. Sinilkin, I. G. Frolova, S. V. Chizevskaya, E. L. Choynzonov, O. V. Cheremisina, A. V. Goldberg

“…The 99mTc-MIBI uptake in metastatic lymph nodes was visualized in 2 (17 %) of the 12 patients. 28 SLNs were detected by SPECT and 31 SLNs were identifed using the intraoperative gamma probe. …”
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Effect of Laser Photobiomodulation on Postoperative Pain After Single-Visit Endodontic Treatment in Children: A Randomized Control Trial by Yashaswini S. Angolkar, Sadanand Kulkarni, Chandrashekar M. Yavagal, Puja C. Yavagal, Umesh Bhosle, Viplavi Chavan Patil, Sultan Abdulrahman Almalki, Inderjit Murugendrappa Gowdar, Khalid Gufran

“…Pain scores were measured using a 10-point Visual Analog Scale (VAS) at 4, 12, 24, and 48 h post-treatment. …”
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Oral donor site evaluation in the early and late postoperative periods for augmentation and replacement urethroplasty by M. M. Iritsyan, A. A. Klimenko, A. A. Mantsov, I.-N. K. Suyundikov, A. P. But, R. A. Rakhmatov, M. V. Prismakova, E. M. Alekberov, S. V. Kotov

“…The intensity of pain syndrome in the graft sampling area was assessed by patients on a visual analog scale (VAS). The donor area was sutured only in the case of tongue and lip mucosa sampling.Results. …”
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Language function improvement and cortical activity alteration using scalp acupuncture coupled with speech-language training in post-stroke aphasia: A randomised controlled study by Bingbing Lin, Jinglei Ni, Xiao Xiong, Lanlan Zhang, Jian Song, Mengxue Wang, Linsong Chai, Yunshi Huang, Jia Huang

“…Among non-global aphasia patients, acupuncture improved comprehension and naming tasks, with lower OxyHb in the right visual association cortex and angular gyrus (P < 0.05). …”
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Generating synthetic brain PET images of synaptic density based on MR T1 images using deep learning by Xinyuan Zheng, Patrick Worhunsky, Qiong Liu, Xueqi Guo, Xiongchao Chen, Heng Sun, Jiazhen Zhang, Takuya Toyonaga, Adam P. Mecca, Ryan S. O’Dell, Christopher H. van Dyck, Gustavo A. Angarita, Kelly Cosgrove, Deepak D’Souza, David Matuskey, Irina Esterlis, Richard E. Carson, Rajiv Radhakrishnan, Chi Liu

“…We therefore aim to generate synthetic [11C]UCB-J PET images based on MRI in this study. Methods We implemented a convolution-based 3D encoder-decoder to predict [11C]UCB-J SV2A PET images. …”
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Health-related quality of life with bemarituzumab plus mFOLFOX6 in patients with FGFR2b-overexpressing, advanced gastric or gastroesophageal junction cancer by Z.A. Wainberg, P.C. Enzinger, S. Qin, K. Yamaguchi, J. Wang, X. Zhou, A. Gnanasakthy, K. Taylor, A. Yusuf, I. Majer, A. Jamotte, Y.-K. Kang

“…Least-squares mean changes from baseline on key EORTC QLQ-C30 scales (global health status/QoL, physical functioning, fatigue, nausea and vomiting, and appetite loss) and the EQ-5D-5L visual analog scale were similar over time between treatment arms. …”
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Functional Recovery After Hip Arthroplasty with a Minimal Invasive or Classical Approach Eight Years After Intervention by Mirela Vuckovic, Lana Ruzic, Karlo Tudor, Tomislav Prpic, Zdravko Jotanovic, Silvije Segulja, Andrica Lekic, Ksenija Bazdaric

“…<b>Background:</b> The aim of this study was to investigate differences in functional recovery eight years after total hip arthroplasty in patients who underwent hip joint surgery using two different approaches: the classic lateral approach and the anterolateral minimally invasive surgical approach. <b>Methods:</b> Eight years after the hip replacement, 68 subjects, 32 in the classic and 36 in the minimally invasive group, underwent follow-up measurements involving the Harris Hip Score (HHS), range of motion, strength of the abductor muscles, 50-m walk time, body mass index (BMI), physical activity questionnaire, and visual analogue scale (VAS) pain during general activities. …”
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Bipolar disorders and creativity: the roles of ambition, effort-based decision-making, and exploration by Samson Tse, Sheri L. Johnson, Chong Ho Yu, Winnie Yuen, Iris Lo, Luke Clark, Luke Clark, Erin E. Michalak, Erin E. Michalak, Manon Ironside, Kiana Modavi

“…The current work is the first to examine ambition, exploration versus exploitation ratio, and insensitivity to effort/rewards among individuals with and without BD in an Asian cultural context.MethodsWriters and visual artists from Hong Kong who were diagnosed with BD completed a questionnaire to assess lifetime creative accomplishments, a self-rated measure of ambition, and two laboratory-based tasks: the observe-or-bet task to detect exploration versus exploitation tendencies, and an effort discounting task to measure sensitivity to effort required and reward level.ResultsThe sample included 44 participants diagnosed with BD and 69 control participants, with 87 (77%) being female and an average age of 35.1 years (range: 18 to 65). …”
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Exploring the interaction effects of subclinical hypothyroidism and major depressive disorder on brain networks by Shuai Zhao, Jindan Wu, Xiaomei Liu, Yishan Du, Xiaoqin Wang, Yi Xia, Hao Sun, Haowen Zou, Xumiao Wang, Zhilu Chen, Rui Yan, Hao Tang, Qing Lu, Zhijian Yao

“…This study aimed was to investigate the neurological mechanisms underlying this co-occurrence using a data-driven approach to analyze brain activity patterns. Methods Twenty-nine patients diagnosed with MDD without any comorbid conditions (nSHypo-MDD) were included in the study, along with 29 MDD patients who also had SHypo (SHypo-MDD), 26 patients with SHypo only, and 29 healthy individuals as controls (HCs). …”
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Long-Term Outcomes of Modified Expansive Open-Door Laminoplasty Combined with Short-Level Anterior Cervical Fusion in Multilevel Cervical Spondylotic Myelopathy by Szu-Wei Chen, Kuang-Ting Yeh, Cheng-Huan Peng, Chia-Ming Chang, Hao-Wen Chen, Tzai-Chiu Yu, Ing-Ho Chen, Jen-Hung Wang, Wan-Ting Yang, Wen-Tien Wu

“…Key outcome measures included the Pavlov ratio, C2–C7 angle, Japanese Orthopedic Association (JOA) score, and Visual Analog Scale (VAS) for neck pain. Patients were monitored for adjacent segment degeneration (ASD) and other postoperative changes over the long-term follow-up. …”
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The cellular and extracellular proteomic signature of human dopaminergic neurons carrying the LRRK2 G2019S mutation by Felix Knab, Giambattista Guaitoli, Mohamed Ali Jarboui, Felix von Zweydorf, Fatma Busra Isik, Franziska Klose, Anto Praveen Rajkumar, Thomas Gasser, Thomas Gasser, Christian Johannes Gloeckner

“…With LRRK2 inhibitors entering clinical trials, there is an unmet need for biomarkers that reflect LRRK2-specific pathology and target engagement.MethodsIn this study, we used induced pluripotent stem cells derived from a patient with Parkinson’s disease carrying the LRRK2 G2019S mutation and an isogenic gene-corrected control to generate human dopaminergic neurons. …”
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The effects of the physical procedures in patients with diabetic neuropathy by Grbović Vesna, Stefanović Srđan, Đukić Svetlana, Nurković Jasmin, Zdravković-Petrović Nataša, Parezanović-Ilić Katarina, Divjak Ana, Jurišić-Škevin Aleksandra

“…To asses their pain before and after every of 3 cycles, we used visual analog scale (VAS). We also evaluated quality of life before the 1st and after the 3rd cycle with the European Quality of Life Questionnaire (EQ-5D-3L). …”
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