Bioactive natural alkaloid 6−Methoxydihydrosanguinarine exerts anti−tumor effects in hepatocellular carcinoma cells via ferroptosis by Linfen Han, Linfen Han, Chengchang Gao, Xiaorui Jin, Yingping Li, Liangjie Chen, Donglin Li, Qinqin Deng, Xueli Bian, Xueli Bian

“…Natural active compounds have great potential in cancer treatment.MethodsThe impact of 6-ME on the cell viability of HCC cells was assessed using the Cell Counting Kit-8 (CCK‐8) assay and colony formation assay. …”
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Investigating the Effect of Reducing the Signs and Symptoms of Lid Wiper Epitheliopathy in Patients With Dry Eye Disease With Perfluorohexyloctane by Chris Lievens, OD, MS, PhD, FNAP, FAAO, Andrew D. Pucker, OD, PhD, FAAO, Quentin Franklin, BS, Stephen M. Montaquila, OD, FAAO, Brad Giedd, OD, MS, FAAO, Gina Wesley, OD, MS, FAAO, Morgan Bromley, PhD, Zackarias Coker, MS, John Meyers, MS, Marta Vianya-Estopa, PhD

“…Objective: To examine the potential of using perfluorohexyloctane for reducing the signs and symptoms of lid wiper epitheliopathy (LWE). Methods: Data were collected at 4 visits spanning 2 months. …”
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Displacement-related stressors in a Sudanese war-affected community; identifying the impact of war exposure and ongoing stressors on trauma symptom severity: a national multi-cente... by Lina Hemmeda, Alaa S. Ahmed, Gasm Alseed Abdelmonim Gasm Alseed Fadlalmoula, Doaa Rabeie Hassan, Mohammed Haydar Awad, Gotof Salim, Abeer Osman Mukhtar Elabid, Alaa Azhary mohammed Ali, Asmaa O. Algasim, Ethar Hamad, Fatima Afif, Fatima Mustafa, Maha Rhamttallah, Mai Fathi Awadalla Alsedig, Miada Ali Mohammed Taha, Muram Ahmed Sayed Khaleel, Nazik Abdalla Nourin, Roaa Salah Eltaheir Mohieldin, Sara Ali, Shimaa Suliman, Khabab Abbasher Hussien Mohamed Ahmed

“…A structural equation model was generated to visualize the comprehensive relationship between the study variables. …”
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Gallium Resistance in <i>Staphylococcus aureus</i>: Polymorphisms and Morphology Impacting Growth in Metals, Antibiotics and Polyfluorinated Compounds by Akamu Ewunkem, Felicia Simpson, David Holland, Tatyana Bowers, Ariyon Bailey, Ja’nyah Gore, Uchenna Iloghalu, Vera Williams, Sarah Adjei-Fremah, Larisa Kiki, Brittany Justice

“…Additionally, scanning electron microscopy (SEM) observation was utilized to visualize distinct morphological changes on the surface of gallium-resistant populations and compare with the control populations. …”
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Anti-Fibrotic Effect of Tacrolimus on Preventing Adhesion after Achilles Tendon Surgery in a Murine Model by Seyedeh Elnaz Nazari, Elnaz Ghorbani, Abdulridha Mohammed Al-Asady, Sayyed-Hadi Sayyed-Hosseinian, Farzad Rahmani, Ehsan Vahedi, Amir Avan, Mohammad-Mostafa Askarnia-Faal, Hamideh Naimi, Majid Khazaei, Seyed Mahdi Hassanian

“…This study aims to evaluate the repurposed potential of the immunosuppressive approved drug, tacrolimus, in decreasing adhesion band formation post-Achilles tendon surgeries in an animal model.Methods: Rats were randomly assigned to four groups: control, sham with surgical intervention but no adhesion, positive control group with surgical transection and adhesion received no treatment, tacrolimus group was the same as the positive control group except that rats were treated with 2 mg/Kg/day tacrolimus orally for 21 days. …”
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Lung ultrasound outperforms symptom-based screening to detect interstitial lung disease associated with rheumatoid arthritis by Wim Wuyts, Joseph Jacob, Patrick Verschueren, Veerle Taelman, Barbara Neerinckx, Heleen Cypers, Alexandros Kalkanis, Nico De Crem, Marie Vermant, Tinne Goos, Emanuela Elsa Cortesi, Tine Follet, Stefan Gogaert, Nathalie Veyt, Laurens J De Sadeleer

“…We assessed the role of symptoms and lung ultrasound (LUS) as potential screening tools.Methods 116 adult patients with RA presenting to the rheumatology outpatient clinic underwent high-resolution CT (HRCT) scans, pulmonary function tests, LUS (72 zones) and completed a Visual Analogue Scale (VAS) for cough and modified Medical Research Council dyspnoea scale (mMRC). …”
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Preliminary results of the EPIDIA4Kids study on brain function in children: multidimensional ADHD-related symptomatology screening using multimodality biometry by Yanice Guigou, Alexandre Hennequin, Théo Marchand, Théo Marchand, Mouna Chebli, Lucie Isoline Pisella, Pascal Staccini, Pascal Staccini, Vanessa Douet Vannucci, Vanessa Douet Vannucci

“…Currently, early diagnosis is constrained by clinical complexity and limited resources of professionals to conduct evaluations. Scalable methods for ADHD screening are thus needed. Recently, digital epidemiology and biometry, such as the visual, emotional, or digit pathway, have examined brain dysfunction in ADHD individuals. …”
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Histological Grade, Tumor Breadth, and Hypertension Predict Early Recurrence in Pediatric Sarcoma: A LASSO-Regularized Micro-Cohort Study by Alexander Fiedler, Mehran Dadras, Marius Drysch, Sonja Verena Schmidt, Flemming Puscz, Felix Reinkemeier, Marcus Lehnhardt, Christoph Wallner

“…Dimensionality reduction (PCA) and SHAP-value analyses were used to visualize patient clustering and interpret variable contributions. …”
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Comprehensive 1-year multilevel study of sports injuries in para athletes: impact of season timing, years of sports experience, impairment and sports type by Evert Verhagen, Erik Witvrouw, Evi Wezenbeek, Fernanda Madaleno, Juliana Ocarino, Renan Resende, Marco Túlio de Mello, Andressa Silva, Larissa Pinheiro, Mauro Heleno Chagas, Dawit Gonçalves

“…Moreover, para athletes with visual impairments were less likely to experience gradual-onset injuries (OR=0.55) and had less time loss (RR=0.12) than those with physical impairments. …”
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Psychometric properties of the pain anxiety symptom scale among postoperative patients in Amol, Iran by Hamid Sharif-Nia, Hamid Sharif-Nia, Erika Sivarajan Froelicher, Erika Sivarajan Froelicher, João Marôco, Esmaeil Hoseinzadeh, Sima Hejazi, Sima Hejazi, Reza Fatehi, Poorya Nowrozi, Bita Mohammadi

“…Therefore, this study was conducted to determine the validity and reliability of the Persian version of the Pain Anxiety Symptom Scale among a group of Iranian patients in Amol.MethodsThis methodological study was conducted in 2023 with a sample of 400 postoperative patients from Amol, Iran, selected through convenience sampling. …”
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Acupuncture for chronic nonspecific low back pain in middle-aged and older patients: A randomized controlled trial by Fei XU, Kai-qiong JIAO, Lin-peng WANG, Fan ZHANG

“…Objective: To observe the specific effects of acupuncture in middle-aged and older patients with chronic nonspecific low back pain (CNSLBP). Methods: Sixty-six patients with CNSLBP were randomized into the acupuncture or sham acupuncture groups (n = 33). …”
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Implementation and Pilot Data on Diabetic Retinopathy in a Teleophthalmology Program at a Multispecialty Primary Care Clinic by Joanne B. Tayapad, MD, Alfonso U. Bengzon, MD, Sherman O. Valero, MD, Milagros H. Arroyo, MD, Ricardo Tobias M. Papa, MD, Egidio Jose S. Fortuna, MD, Jocelyn G. Erni, BS, Myra Alisa J. Reyes, RN, Jerry D. Cavallerano, OD PhD, Lloyd Paul Aiello, MD PhD, Paolo S. Silva, MD

“…Teleophthalmology for DR in this setting allows early detection of potentially sight threatening disease and may prevent visual loss and complications.…”
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Habitat radiomics assists radiologists in accurately diagnosing lymph node metastasis of adenocarcinoma of the esophagogastric junction by Pingfan Jia, Yueying Li, Haonan Li, Yuan Li, Huijuan Qin, Anyu Xie, Yuru Li, Luyao Wang, Luqin Ke, Huijie Feng, Hongwei Yu, Juan Li, Ning Yuan, Xing Guo

“…Finally, the prediction process of the optimal model was visualized using SHAP plots. Results The HR model demonstrated superior performance, achieving the highest AUC values of 0.876, 0.869, and 0.795 in the training, validation, and test cohorts, respectively. …”
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‘Water is life’: developing community participation for clean water in rural South Africa by Kathleen Kahn, Rhian Twine, Jennifer Hove, Lucia D'Ambruoso, Denny Mabetha, Maria van der Merwe, Peter Byass, Sonto Khosa, Sophie Witter

“…Thematic analysis of narrative and visual data was performed.Results Repeated and prolonged periods when piped water is unavailable were reported, as was unreliable infrastructure, inadequate service delivery, empty reservoirs and poor supply exacerbated by droughts. …”
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Repeated Cranial and Large‐Vessel Positron Emission Tomography/Computed Tomography Scans and the Association With Structural Aortic Disease in Giant Cell Arteritis: A Five‐Year Obs... by Anthony M. Sammel, Ivan Ho Shon, Daniel A. Moses, Stacey Fredericks, Gita Mathur, Claudia M. Hillenbrand, Edward Hsiao, Geoffrey Schembri, Rodger Laurent, Eva A. Wegner

“…Scans were reported for overall metabolic disease activity and a visual FDG avidity grade at each vascular territory. …”
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Standardized low-resolution brain electromagnetic tomography does not improve EEG Alzheimer's disease assessment by Wolfgang Frühwirt, Martin Mairhofer, Andreas Hahn, Heinrich Garn, Markus Waser, Reinhold Schmidt, Thomas Benke, Peter Dal-Bianco, Gerhard Ransmayr, Dieter Grossegger, Stephen Roberts, Georg Dorffner

“…Therefore, they should not be generalized to other neurological or psychiatric disorders or to other 3D source localization methods without further validation. Finally, these findings do not diminish the value of 3D source localization for visual EEG inspection.…”
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Neuroadaptive changes in brain structural–functional coupling among pilots by Xi Chen, Qingbin Meng, Qingsong Song, Peiran Xu, Shicong Zhang, Donglin Huang, Qi Chu, Jiamin Fan, Cheng Luo, Xiuyi Li

“…However, prior research has predominantly focused on identifying structural and functional differences in the brain, while the relationship between structure and function remains insufficiently elucidated.MethodsThis study collected T1-weighted structural magnetic resonance imaging (MRI), resting-state functional MRI (rs-fMRI), and diffusion tensor imaging (DTI) data from 47 pilots and 38 matched controls. …”
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Effects of gut microbiota on cognitive impairment in Parkinson’s disease: a comprehensive Mendelian randomization and case–control study by Yukun Feng, Yukun Feng, Qi Chang, Hao Zhou, Wei Zhang, Wei Zhang, Ling Xie, Xueyang Deng, Xueyang Deng, Tao Chen, Tao Chen, Weiguo Liu

“…In our analysis, inverse-variance weighting (IVW) was used as the primary method. Clinical validation was performed using metagenomic sequencing and bioinformatic analysis. …”
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Evaluation of blood flow in arteritic anterior ischemic optic neuropathy using laser speckle flowgraphy: A case series by Chiaki Yamaguchi, Naoki Kiyota, Noriko Himori, Takahiro Oshima, Takayuki Takeshita, Kazuko Omodaka, Satoru Tsuda, Toru Nakazawa

“…Results: At the initial visit, all affected eyes had no light perception in best-corrected visual acuity (BCVA) testing, and three cases had a severe increase in circumpapillary retinal nerve fiber layer thickness (cpRNFLT; 191.00 ± 42.03 μm). …”
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Long-term Quality of Life After Intensive Care Unit Admission (a Single-Center Observational Study) by C. Leggieri, L. Dezza, B. Oltolini, R. Lembo, B. Noto, S. M. Villa, A. Belletti, G. Lombardi, A. Battaini, E. Pedrini, C. F. Zuccato, A. Zangrillo

“…All EQ-5D-5L parameters improved significantly in the IT group, while only Visual Analog Scale Health Perception improved in the IM group.Conclusion. …”
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