Alteration in ATR protein level does not account for the inherent radiosensitivity of HPV-positive head and neck squamous cell carcinoma by Sibylla Kohl, Florentine S.B. Subtil, Vanessa Climenti, Houmam Anees, Ann C. Parplys, Rita Engenhart-Cabillic, Sebastian Adeberg, Ekkehard Dikomey, Ulrike Theiß

“…Clonogenic survival after photon irradiation was evaluated by colony formation assay and DSBs were visualized by γH2AX/53BP1 co-staining. Results: ATR gene copy number and expression were not altered. …”
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Exome-wide genetic risk score (ExGRS) to predict high myopia across multi-ancestry populations by Jian Yuan, Ruowen Qiu, Yuhan Wang, Zhen Ji Chen, Haojun Sun, Wei Dai, Yinghao Yao, Ran Zhuo, Kai Li, Shilai Xing, Myopia Associated Genetics and Intervention Consortium, Xiaoguang Yu, Liya Qiao, Jia Qu, Jianzhong Su

“…Abstract Background High myopia (HM), characterized by a severe myopic refractive error, stands as a leading cause of visual impairment and blindness globally. HM is a multifactorial ocular disease that presents high genetic heterogeneity. …”
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Closed trans-intersphincteric fistulotomy: a new modified sphincter-sparing technique for high transsphincteric anal fistula by Bo Chen, Yueting Wang, Zubing Mei, Chang Mao, Yicheng Liu, Wenjun Zhao, Yingying Li, Qianqian Ye, Jin Xu, Qingming Wang, Qingming Wang

“…This study evaluated the clinical efficacy of a novel sphincter-sparing technique for treating high transsphincteric anal fistula (HTAF).MethodsThis prospective study included 55 patients with HTAF who underwent closed trans-intersphincteric fistulotomy (CTiF) between July 2021 and April 2022 at our institution. …”
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Outcomes of Multidisciplinary Low-Vision Rehabilitation Using Two Questionnaires and the International Classification of Functioning, Disability, and Health by Suksri Chotikavanich, Akarawit Eiamsamarng, Thanaporn Layangool, Wichuda Krutthong, Siriwan Loket, Rungtip Yingyong, Somthin Dongngam, Waree Nujoi, Jaruwan Jai-ai, Nattapon Sarinak, Ekpipat Eksupapan, Saranya Sagan, Peeraya Chaowalitwong

“… Objective: To evaluate the effectiveness of a low-vision service by using three tools and to identify the specific outcomes obtained from each instrument. Materials and Methods: Patients consecutively visiting the low-vision clinic at Siriraj Hospital, Bangkok, Thailand, were enrolled. …”
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Novel parent survey measures sensory behaviors incorporating sensory modality and stimulus intensity by Connor Yee, Ellie Rather, Sakib Hoque, Joon Lee, Stephanie Marton, Jill Roth, Frederick L. Oswald, Kenneth J. Nobleza, Ankona Banerjee, Holly Harris, Ariel M. Lyons-Warren

“…Responses to high-intensity stimuli were not correlated with responses to low-intensity stimuli for auditory, visual, taste, or tactile hyposensitivity (ρ < .4). …”
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An exploratory assessment of GPT-4o and GPT-4 performance on the Japanese National Dental Examination by Masaki Morishita, Hikaru Fukuda, Shino Yamaguchi, Kosuke Muraoka, Taiji Nakamura, Masanari Hayashi, Izumi Yoshioka, Kentaro Ono, Shuji Awano

“…Further studies are needed to evaluate GPT-4o’s capabilities with visual materials and in diverse question sets to fully ascertain its utility in educational settings.…”
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Dellon Decompression Using WALANT: A Safe and Effective Approach for Patients with Peripheral Artery Disease by Sofija Tusheva, Gordana Georgieva, Blagoja Srbov, Savetka Paljoskovska Jordanova, Katerina Jovanovska, Stefania Azmanova Mladenovska, Muamet Memeti, Darko Aleksovski, Biljana Mileska Krzhaloska, Sofija Pejkova

“…Outcomes assessed included operative time, Visual Analogue Scale (VAS) pain scores, posterior tibial artery blood flow (via Doppler ultrasonography), and complications. …”
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Utilization of near infrared spectroscopy coupled with chemometrics for non-destructive detection of mold in sweet tamarind by Muhammad Zeeshan Ali, Pimjai Seehanam, Parichat Theanjumpol, Katthareeya Sonthiya, Kawinthida Suksai, Phonkrit Maniwara

“…Four data preprocessing methods (standard normal variate; SNV, multiplicative scatter correction; (MSC), and first and second derivatives) were used to correct the spectral baseline and remove noises. …”
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Minimal dose CT for left ventricular ejection fraction and combination with chest-abdomen-pelvis CT by Martin Weber Kusk, Søren Hess, Oke Gerke, Lone Deibjerg Kristensen, Christina Stolzenburg Oxlund, Tina Elisabeth Ormstrup, Janus Mølgaard Christiansen, Shane J. Foley

“…Furthermore we assessed its potential for combining it with Chest-Abdomen-Pelvis CT (CAP-CT) for a one-stop examination. Materials &amp; methods: Eighty-two patients underwent helical low-dose CT. …”
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Assessing ResNeXt and RegNet Models for Diabetic Retinopathy Classification: A Comprehensive Comparative Study by Samara Acosta-Jiménez, Valeria Maeda-Gutiérrez, Carlos E. Galván-Tejada, Miguel M. Mendoza-Mendoza, Luis C. Reveles-Gómez, José M. Celaya-Padilla, Jorge I. Galván-Tejada, Antonio García-Domínguez

“…To enhance transparency, SHapley Additive exPlanations were employed to visualize the pixel-level contributions for each model’s predictions. …”
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Integrative Multi-Omics Analysis Reveals Critical Molecular Networks Linking Intestinal-System Diseases to Colorectal Cancer Progression by Shiliang Ji, Haoran Hu, Ruifang Zhu, Dongkai Guo, Yujing Liu, Yang Yang, Tian Li, Chen Zou, Yiguo Jiang, Guilai Liu

“…We employed a comprehensive bioinformatics approach to elucidate shared genetic signatures and pathways between CRC and ISDs. <b>Methods</b>: We systematically analyzed 12 microarray and RNA-seq datasets encompassing 989 samples across seven ISDs and CRC. …”
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CRISPR/Cas13a-assisted rapid and portable HBV DNA detection for low-level viremia patients by Yuan Tian, Zihao Fan, Ling Xu, Yaling Cao, Sisi Chen, Zhenzhen Pan, Yao Gao, Hao Li, Sujun Zheng, Yingmin Ma, Zhongping Duan, Xiangying Zhang, Feng Ren

“…This study provides a visual and faster alternative to current PCR-based diagnosis for HBV infection.…”
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Towards Context-Rich Automated Biodiversity Assessments: Deriving AI-Powered Insights from Camera Trap Data by Paul Fergus, Carl Chalmers, Naomi Matthews, Stuart Nixon, André Burger, Oliver Hartley, Chris Sutherland, Xavier Lambin, Steven Longmore, Serge Wich

“…Camera traps offer enormous new opportunities in ecological studies, but current automated image analysis methods often lack the contextual richness needed to support impactful conservation outcomes. …”
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Effects of non-contact electric fields on the kidneys and livers of tumour-bearing rats [version 6; peer review: 1 approved, 2 approved with reservations, 1 not approved] by Luthfi Nurhidayat, Ahmad Ghitha Fadhlurrahman, Firman Alamsyah, Warsito Purwo Taruno, Nisrina Firdausi, Subekti Evi Dwi Nugraheni, Rarastoeti Pratiwi

“…Histopathological cross-sections of the kidneys and livers were made using the paraffin method and Hematoxylin-Eosin staining. Histological scoring used the post-examination masking method with 100 visual fields per group. …”
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CMV Retinitis in the Context of SARS-CoV-2 Infection: A Case Study and Comprehensive Review of Viral Interactions by Emil Robert Stoicescu, Laura Andreea Ghenciu, Roxana Iacob, Adina Iuliana Ardelean, Ecaterina Dăescu, Ovidiu Alin Hațegan, Diana Manolescu, Emanuela Tudorache, Casiana Boru, Mirabela Dima

“…<b>Conclusions:</b> Our case suggests that SARS-CoV-2 may trigger reactivation of CMV infection, leading to bilateral involvement in patients with low CD4 lymphocyte counts, which can result in severe visual impairment. The review discusses the molecular and cellular interactions between CMV and SARS-CoV-2, as well as risk factors, pathophysiology, and diagnostic methods for CMV retinitis, providing recommendations based on the literature findings.…”
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Co-design and content validation of psychosis care assessment material for medical, pharmacy, nursing, and occupational therapy curricula by Jenny Chen, Jack Charles Collins, Justin Newton Scanlan, Andrea McCloughen, Rosa Howard, Claire Ashton-James, Claire L. O’Reilly, Rebekah J. Moles, Tina X. Ung, Carl R. Schneider, Bandana Saini, Jennifer Ong, Paul Beckett, Karen Watson, Margaret McGrath, Timothy F. Chen, Sarira El-Den

“…This study aimed to co-design and content validate psychosis care assessment material for medical, pharmacy, nursing, and occupational therapy curricula. Methods A nominal group technique (NGT) meeting was conducted to generate and rank ideas among people with lived/living experience of mental illness. …”
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Prevalence of use, perceptions of harm and addictiveness, and dependence of electronic cigarettes among adults in Kuwait: A cross-sectional study by Munairah Alshaibani<sup>*<sup/>, Mays Alajmi<sup>*<sup/>, Noura Alabduljalil, Hajar Alajmi, Yousef Alsalem, Danah Aloqab, Hamad Alawadhi, Sara Sayed Ali, Yaqoub Sharhan, Ahmed Alzeeny, Ali H. Ziyab

“…Relative to cigarette smoking, 40.6% of participants reported that e-cigarettes are less harmful, and 41.8% indicated that e-cigarettes are equally addictive. Among current e-cigarette users (n=892), 84.8% were ascertained to have developed either low, medium, or high dependence. …”
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Three-dimensional analysis of the proximal radial shaft and its intramedullary canal: a cadaver imaging study by Johannes M. Sieberer, MS, Michael Cobo, BS, Albert L. Rancu, BS, Julia LaMonica, MD, Kelsey Brennan, Lynn E. Copes, PhD, Steven M. Tommasini, PhD, Daniel H. Wiznia, MD, Lisa L. Lattanza, MD

“…We hypothesize that IC morphology differs significantly between age, sex, and height groups. Methods: One hundred fifty-one three-dimensional models of the PR and the corresponding ICs were created from CT scans of adult females and males with average height, divided into 3 equally sized age groups (25-30, 40-45, and 60-65 years), and adult females and males of short and tall built. …”
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Quantifying the impacts of diverse vegetation-covered patterns on hillslope soil erosion: a case experiment of alfalfa-covered hillslopes by Chong Yao, Qingwei Zhang, Kebing Chen, Shige Zhang, Ming Zhu, Zhijia Gu, Wei Yan, Faqi Wu

“…However, knowledge about the influence of herbage spatial distribution pattern on hillslope erosion is still limited.MethodsIn the current study, runoff plots (length × width × depth, 2 × 1 × 0.5 m) with slope gradient of 8.75%–36.40% and a side-spray rainfall simulator with rainfall intensity of 90 mm h-1 were adopted to rainfall simulation. …”
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The effect of follow-up reexamination on the long-term prognosis of patients with acute coronary syndrome undergoing coronary angiography by Chao Wang, Lina Cui, Xianqin Ma, Meng Sun, Yulin Wang, Fuhong Dong, Chen Zhao, Xueqin Tian, Yini Wang, Haihong Zhang, Tianhui Cao, Xinyu Hou, Jian Wu, Sining Hu, Jiannan Dai, Duolao Wang, Haibo Jia, Bo Yu

“…Among patients who underwent reexamination, the risk of cardiac death was 50% lower (aHR, 0.50; 95% CI, 0.35–0.70) and 63% lower (aHR, 0.37; 95% CI, 0.20–0.67) in the high-frequency (more than or equal to 2 times within one year) and long-term (continued reexamination after the first year of follow-up) reexamination groups, respectively. …”
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