A CDKN2B-Associated Immune Prognostic Model for Predicting Immune Cell Infiltration and Prognosis in Esophageal Carcinoma by Peng X, Han J, Huang J, Zhou L, Chen X, Zhou W

“…This study explored the association between CDKN2B deletion, immunophenotype, and the prognosis of EC.Methods: We investigated CDKN2B status and RNA expression, identified differentially expressed immune-associated genes between wild-type CDKN2B (CDKN2BWT) and deleted CDKN2B (CDKN2Bdeletion) in Cancer Genome Atlas (TCGA) EC samples. …”
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The impact of COVID-19 infection on multiple sclerosis disease course across 12 countries: a propensity-score-matched cohort study by David Levitz, Yi Chao Foong, Paul Sanfilippo, Tim Spelman, Louise Rath, Angie Roldan, Anoushka Lal, Mastura Monif, Vilija Jokubaitis, Serkan Ozakbas, Raed Alroughani, Cavit Boz, Murat Terzi, Tomas Kalincik, Yolanda Blanco, Matteo Foschi, Andrea Surcinelli, Katherine Buzzard, Olga Skibina, Guy Laureys, Liesbeth Van Hijfte, Cristina Ramo-Tello, Aysun Soysal, Jose Luis Sanchez-Menoyo, Mario Habek, Elisabetta Cartechini, Juan Ignacio Rojas, Rana Karabudak, Barbara Willekens, Talal Al-Harbi, Yara Fragoso, Tamara Castillo-Triviño, Danny Decoo, Maria Cecilia Aragon de Vecino, Eli Skromne, Carmen-Adella Sirbu, Chao Zhu, Daniel Merlo, Melissa Gresle, Helmut Butzkueven, Anneke Van Der Walt

“…The mean follow-up period was 1.7 years. Methods: Data were retrieved from the MSBase Registry. …”
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Rethinking Language by Gastor Mapunda, Tracey Costley, Hannah Gibson, Nancy Kula, Colin Reilly

“…We view these pedagogies as an essential factor in teacher training which is linked to wider notions of access and equality, but which is currently being overlooked.   …”
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Impact of Antimicrobial Stewardship and Infection Prevention and Control Programmes on Antibiotic Usage and A. baumannii resistance: A 2016–2023 Multicentre Prospective Study by Liu L, Liu B, Li L, Li Y, Zhou X, Li Q

“…Lei Liu,1,2,* Bin Liu,1,2,* Liang Li,1,2 Yu Li,3 Xiangdong Zhou,1,2 Qi Li1,2 1Department of Respiratory Medicine, The First Affiliated Hospital, Hainan Medical University, Haikou, Hainan, People’s Republic of China; 2Hainan Province Clinical Medical Center of Respiratory Disease, Haikou, Hainan, People’s Republic of China; 3Department of Respiratory Medicine, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qi Li, Email lqlq198210@sina.comObjective: This study assesses the efficacy of antimicrobial stewardship (AMS) and infection prevention and control programmes (IPCP) in guiding the use of antibiotics and the control of A. baumannii (AB) resistance at multiple medical centres.Methods: We evaluated the effectiveness of the policy on antibiotic consumption and AB resistance by determining the relationship between the defined daily doses (DDD) for antibiotics – or alcohol-based hand gel (ABHG) consumption – and the incidence of carbapenem-resistant AB (CR-AB), multidrug-resistant AB (MDR-AB) and extensively drug-resistant AB (XDR-AB) at two medical centers from 2016– 2023.Results: In total, 4057 AB isolates were collected; 64.95% of the AB isolates were CR, 59.48% were MDR and 1.41% were XDR. …”
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Midpalatal suture osteotomy combined with microimplant-assisted rapid palatal expansion for adult maxillary transverse deficiency treatment: a study protocol of a randomised contro... by Lei Zhang, Yifeng Qian, Wenyi Zhang, Miri Chung, Yanfei Zhu, Lingyong Jiang

“…Therefore, we proposed a novel minimally invasive method for maxillary expansion, which is midpalatal suture osteotomy combined with microimplant-assisted rapid palatal expansion (MSO-MARPE). …”
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Digital outdoor exercise program for obese patients with type 2 diabetes mellitus: a non-inferiority randomized controlled trial by Jian Cui, Qiang Liu, Lihua Huang, Haoyan Yu

“…Adherence and cost-effectiveness were also assessed.MethodsWe conducted a randomized controlled noninferiority trial at a single tertiary center. …”
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Factors associated with malaria in pregnancy among antenatal care mothers at Gulu Regional Referral Hospital in northern Uganda by Solomon Oguta, Brian Serumaga, Lameck Odongo, Donald Otika, Jackline Ayikoru, Raymond Otim, Jimmyy Opee, Baifa Arwinyo, Francis Pebolo Pebalo, Vincentina Achora, Sande Ojara, Benard Abola, Silvia Awor

“…This study aimed to assess the factors associated with malaria in pregnancy among antenatal care mothers at Gulu Regional Referral Hospital. Methods This was a cross-sectional study at Gulu Regional Referral Hospital antenatal clinic from July to August 2023. …”
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Seroprevalence and Clinical Insights of Ocular Herpesvirus Infections: A Cross-Sectional Study Evaluating ELISA as a Diagnostic Tool by Chen S, Peng Q, Wang H, Xie J, Cao H, Xu X

“…This study aimed to investigate the seroprevalence of HSV and VZV infections in patients with suspected ocular infections and to evaluate associated risk factors.Methods: We conducted a cross-sectional study using enzyme-linked immunosorbent assay (ELISA) to detect antibodies against HSV and VZV in patients with ocular symptoms. …”
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Gait Characteristics and Neuroanatomical Alterations in Obstructive Sleep Apnea–Hypopnea Syndrome by Jiang J, Mo Y, Abuduwaili Z, Mao C, Fang S, Ke Z, Hu Z, Huang L, Xu S, Yang D, Xiong R, Xie P, Zhu X, Xu Y

“…Recently, it has been found to contribute to gait disorders, but there is limited information regarding how various indicators of OSAHS affect gait patterns.Methods: A total of 136 subjects recruited from Nanjing Drum Tower Hospital were categorized based on apnea hypopnea index (AHI) and oxygen saturation (SpO2), respectively. …”
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Open donor nephrectomy via singular pararectal extraperitoneal mini-incision: single-center experience with 425 consecutive cases by Philipp Tessmer, Oliver Beetz, Anna Meyer, Clara A. Weigle, Simon Stoerzer, Gunilla Einecke, Wilfried Gwinner, Florian W. R. Vondran, Felix Oldhafer, Moritz Schmelzle, Nicolas Richter

“…Conclusions Unlike the endoscopic technique, SPEM is equally suitable for right- and left-sided nephrectomy. …”
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Supplement Use Among Athletes: Insights from Gyms in Sarajevo by Denis Čaušević, Cristina Ioana Alexe, Nedim Čović, Elena Adelina Panaet, Ensar Abazović, Raul Marian Todor, Babina Rani, Gabriel Lupu, Dan Iulian Alexe

“…Magnesium was the most commonly used supplement, equally favored across genders and age groups. Creatine, fish oil capsules, and multivitamins were also frequently consumed (<i>p</i> < 0.05). …”
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Innovative Cardiac Rehabilitation: Effects of Adaptive Postural Balance Exercise on Coronary Artery Disease and Type 2 Diabetes by Qin D, Liu G, Zhang J, Lin S, Liu X, Zhao J, Zhang Q, Ma M, Wang S

“…Specifically, we compared the efficacy of APBCRE with aerobic exercise (AE) alone and irregular exercise (IE).Patients and Methods: This randomized controlled trial included 348 patients with CAD, comprising 261 patients with T2DM and 87 non-diabetic CAD patients as a control group. …”
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Predictive Factors and Nomogram for Spontaneous Bacterial Peritonitis in Decompensated Cirrhosis Among the Elderly by Yan F, Peng X, Yang X, Yuan L, Zheng X, Yang Y

“…We aimed to develop a predictive tool for the occurrence of SBP in elderly individuals with decompensated cirrhosis (DC).Methods: Elderly patients diagnosed with DC were enrolled from Chengdu Fifth People’s Hospital in China, spanning from January 1, 2015, to September 31, 2023. …”
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The Effect of Minimal-Dose S-Ketamine Administration Post-Surgery on Opioids Consumption and Functional Rehabilitation Exercises in Patients Undergoing Minimally Invasive Radical R... by Xie J, Shen F, Wang X, Yao J, Zhou L, Huang L, Sun J

“…Jue Xie,1 Fangming Shen,1 Xingming Wang,2 Juan Yao,1 Lingzhen Zhou,3 Luxin Huang,1 Jie Sun1 1Department of Anesthesiology, Surgery and Pain Management &amp; Key Laboratory of Clinical Science and Research, Zhongda Hospital Southeast University, Southeast University School of Medicine, Nanjing, Jiangsu, People’s Republic of China; 2Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, People’s Republic of China; 3Department of Thoracic Surgery, Zhongda Hospital Southeast University, Southeast University School of Medicine, Nanjing, Jiangsu, People’s Republic of ChinaCorrespondence: Jie Sun, Email dgsunjie@hotmail.comStudy Objective: To examine the impact of minimal-dose S-ketamine on postoperative analgesia in patients undergoing minimally invasive radical resection for esophageal cancer, with a focus on reducing opioid consumption, enhancing analgesic quality, and facilitating postoperative recovery.Methods: A total of 216 patients undergoing minimally invasive radical resection of esophageal cancer under general anesthesia were randomly assigned into two groups (S-ketamine and control group), receiving intravenous S-ketamine (0.015 mg/kg/h) or an equal volume of saline for 48 h postoperatively. …”
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The Predictive Value of Soluble Fms-Like Tyrosine Kinase-1 for Prognosis in COVID-19 Patients by Lai C, Wang Y, Shi F, Geng N, Liu Z, Pan W, Shi H, Ma Y, Liu B

“…This study aimed to investigate the prognostic value of soluble fms-like tyrosine kinase-1 (sFlt-1) in COVID-19 patients.Methods: A prospective cohort study was conducted involving 154 COVID-19 patients, with comprehensive clinical data and laboratory parameters analyzed to evaluate the effectiveness of sFlt-1 in determining disease severity and prognosis.Results: The results revealed that sFlt-1 levels correlated significantly with disease severity, showing higher levels in severe/critical cases compared to mild cases (P< 0.05). …”
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Assessing Sedation Depth with PSI in Elderly ERCP Patients: A Prospective Cohort Study by Huang L, Liu LL, Lu YD, Zhuang MY, Dou W, Liu H, Ji FH, Peng K

“…We aimed to assess the correlation between PSI and Modified Observer’s Assessment of Alertness/Sedation (MOAA/S) scores in elderly patients undergoing ERCP.Methods: This prospective cohort study included 57 elderly patients scheduled for ERCP procedures. …”
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Exploring the Potential Regulatory Mechanisms of Mitophagy in Ischemic Cardiomyopathy by Li Z, Kong J, Xi S, Jin Z, Yang F, Zhu Z, Liu L

“…However, it is still uncertain how mitophagy related genes (MRGs) may affect the diagnosis of ICM.Patients and Methods: Data were obtained from public databases. …”
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Bromocriptine for Idiopathic Intracranial Hypertension: A Retrospective Multicenter Cohort Study by Morsy MM, Azzam AY, Mirdad MT, Abadi AM, Alqahtani SAM, Abukhadijah HJ, Elamin O, Morsy MD, Altschul DJ

“…This study aims to evaluate the safety and efficacy of bromocriptine in IIH management through a retrospective cohort analysis.Methods: A retrospective analysis was conducted, focusing on patients with IIH. …”
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Hyodeoxycholic Acid Ameliorates Metabolic Syndrome Through Pathways of Primary Bile Acid Synthesis and Fatty Acid Degradation: Insights From a Rat Model by Chen M, Huang K, Luo W, Zhang F, Gan H, Yang Z

“…Hyodeoxycholic acid (HDCA) has shown potential effects in non-alcoholic fatty liver disease (NAFLD), yet its role in MS is unexplored.Aim: This study aims to assess whether HDCA is a characteristic BA of MS and to investigate its intervention effects and potential mechanisms.Methods: We employed 16S rDNA sequencing and UHPLC-MS/MS to investigate the dynamics of the gut microbiota and BA profiles in rats and conducted a correlation study between indices, identifying HDCA as the potential characteristic BA. …”
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Effect of aloe vera and coconut in the management of xerostomia in patients with Sjogren’s syndrome: a crossover randomized clinical trial by Alaa Mahmoud, Basma Elsaadany, Mervat Eissa, Wesam Abd Elmoneim, Sherifa Tarek, Mai Zakaria

“…Aim: This study aimed to evaluate the efficacy of carboxymethyl cellulose (CMC)-based natural mixture of aloe vera gel and coconut oil as a salivary substitute in comparison to the conventional CMC for the management of xerostomia in a sample of patients with Sjogren’s syndrome (SS). Methods: This crossover randomized clinical trial included 24 patients diagnosed with SS. …”
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