Comparison of Efficacy and Safety Outcomes of Different Doses Schedules of Thalidomide for Treating Moderate-to-Severe β-Thalassemia Patients by Yang WJ, Shi LD, Liang Y, Liang LM, Zhang H, Wang L, Zhou Q

“…Wei-Jia Yang,1,* Lian-dong Shi,2,* Ye Liang,3,* Li-ming Liang,4,* Hao Zhang,5 Li Wang,2 Qian Zhou1 1Department of Eugenics and Genetics, Guilin People’s Hospital, Guilin, Guangxi Zhuang Autonomous Region, 541002, People’s Republic of China; 2Department of Ultrasound, Guilin People’s Hospital, Guilin, Guangxi Zhuang Autonomous Region, 541002, People’s Republic of China; 3Department of Cardiology, The People’s Hospital of Guangxi Zhuang Autonomous Region, and Institute of Cardiovascular Diseases, Guangxi Academy of Medical Sciences, Nanning, 530000, People’s Republic of China; 4Department of Genetic Metabolism Center Laboratory, Guilin Women and Children’s Hospital, Guilin, Guangxi Zhuang Autonomous Region, 541001, People’s Republic of China; 5Department of Pharmacy, Guilin People’s Hospital, Guilin, Guangxi Zhuang Autonomous Region, 541002, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wei-Jia Yang, Department of Eugenics and Genetics, Guilin People’s Hospital, No. 12 of Wenming Road, Xiangshan District, Guilin, Guangxi Zhuang Autonomous Region, 541002, People’s Republic of China, Tel +86 18977300052, Fax +86 07732881579, Email weijiayangywj@126.comObjective: In this study, we evaluated the effectiveness and safety of thalidomide by clinically observing 48 individuals with β-thalassemia who have been administered thalidomide in small and medium doses over a period of two years.Methods: Thalidomide’s efficacy was gauged by tracking hemoglobin (Hb) level alterations post its administration. …”
Get full text

Comparative Effectiveness of Bariatric Surgery Versus GLP‐1 Receptor Agonists in Reducing the Risk of New‐Onset of NASH: A Retrospective Multinational Cohort Study From North Ameri... by Abdallah Hussein, Ameer Awashra, Islam Rajab, Mohammad Bdair, Dawoud Hamdan, Ahmad Nouri, Elaf Khatib, Ghiras Khatib, Nyan Latt

“…This study evaluates the comparative effectiveness of BS and GLP‐1 RAs in reducing the incidence of new‐onset NASH and related hepatic complications. Methods This was a large, population‐based, retrospective cohort using data from the TriNetX platform. …”
Get full text

Comparative assessment of echocardiographic parameters, including the left ventricular global function index in patients with myocardial infarction with obstructive (MICAD) and non... by N. I. Maksimov, I. S. Grishin, N. S. Grishina

“…Anterior wall MI was equally common. Patients with MICAD had a larger left atrium diameter and EDV. …”
Get full text

Acupotomy Ameliorates KOA Related Chondrocyte Premature Senescence Through YAP/FOXD1 Pathway by Ma Y, Hu T, Liu N, Guo C, Xing L, Ma W, Cui Y, Chen X

“…KOA, KOA+Apo rabbits were modeled by modified Videman’s method for 6 weeks. After modeling, the KOA+Apo groups were subjected to acupotomy once a week for 3 weeks on the muscles around the left hind knee. …”
Get full text

Bioinformatic Analysis of Apoptosis-Related Genes in Preeclampsia Using Public Transcriptomic and Single-Cell RNA Sequencing Datasets by Liu L, Li X, Yang H, Xu F, Dong X

“…We used transcriptomics and single-cell RNA sequencing (scRNA-seq) to explore apoptosis-related genes (ARGs) and their cellular mechanisms as potential PE biomarkers.Patients and Methods: All the data included in this study were sourced from public databases. …”
Get full text

The Effect of Vitamin E, &Bgr;-Carotene, and Acidophilus Probiotics on The Salivary Gland Flow Rate in Streptozotocin-Induced Diabetes in Rats: An in-vivo Study by Felemban MF, Bin Mubayrik AF, Alotaibi O

“…This study aimed to evaluate the effects of the effect of vitamin E, β-carotene, and probiotics blend on the salivary glands of rats with Streptozotocin (STZ)-induced diabetes, addressing gaps in current research.Methods: Eighty rats were induced with diabetes using a single intraperitoneal injection of STZ (60 mg/kg). …”
Get full text

Effect of soft tissue volume on midfacial gingival margin alterations following immediate implant placement in the esthetic zone: a 1-year randomized clinical and volumetric trial by Ahmed Ibrahim Aboul Fettouh, Noha Ayman Ghallab, Khaled Abdel Ghaffar, Azza Ezz Elarab, Nourhan Gamal Abdel-Aziz, Nael Adel Mina, Nesma Mohamed Shemais, Omnia Aboul Dahab

“…Participants were randomly assigned into three equal group; IIP + Bonegraft (Control), IIP + CTG and IIP + CHA. …”
Get full text

Scalable camera traps for measuring the attractiveness of sugar baits for controlling malaria and dengue vectors by Felician C. Meza, Frank C. Tenywa, Simon Ashall, Fredros O. Okumu, Sarah J. Moore, Frederic Tripet

“…Moreover, mosquitoes visited the ASB or sucrose equally, with An. arabiensis visiting the baits more than An. funestus. …”
Get full text

Quick Systemic Lupus Activity Questionnaire (Q-SLAQ): a simplified version of SLAQ for patient-reported disease activity by Susanne Pettersson, Iva Gunnarsson, Andreas Jönsen, Christopher Sjöwall, Dag Leonard, Vera Illescas-Bäckelin, Estelle Trysberg

“…Bivariate correlations between Q-SLAQ and SLAQ were good (ρ=0.82–0.96).Conclusions Q-SLAQ and the original SLAQ performed equally well, demonstrating that the shorter Q-SLAQ can safely be used to monitor patients’ perception of disease impact/activity. …”
Get full text

Candida albicans-Derived β-Glucan as a Novel Modulator of Tumor Microenvironment: Targeting Macrophage Polarization and Inducing Ferroptosis in Lung Cancer by He X, Ran Q, Li X, Xiong A, Zhang L, Jiang M, Bai L, Peng D, Wang J, Sun B, Li G

“…This study investigates the inhibitory effects of β-glucan extracted from Candida albicans on lung cancer progression, focusing on its impact on TAM polarization and the induction of ferroptosis, a form of regulated cell death.Methods: Utilizing both in vivo animal models and in vitro cellular assays, we assessed the impact of β-glucan on tumor growth, cellular proliferation, and migration. …”
Get full text

USC-Derived Small Extracellular Vesicles-Functionalized Scaffolds Promote Scarless Vaginal Defect Repair via Delivery of Decorin and DUSP3 Proteins by Xu Y, Li J, Qiu Y, Wu F, Xue Z, Liu B, Fan H, Zhou Y, Wu Q

“…Designing functional scaffolds that incorporate sEVs is a promising approach for scarless vaginal defect repair.Methods: sEVs-loaded scaffolds were developed through electrostatic interactions between negatively charged sEVs secreted by urine-derived stem cells (USC-sEVs) and positively charged human acellular amniotic membranes. …”
Get full text

Vulnerability in research ethics: A systematic review of policy guidelines and documents. by Asia Grigis, Giorgia Beretta, Pascal Borry, Virginia Sanchini

“…<h4>Background</h4>The history of research involving human subjects has demonstrated the importance of offering everyone an equal opportunity to participate in research, while safeguarding those who require special attention. …”
Get full text

Robot-assisted donor nephrectomy in horseshoe kidney: Possible with indocyanine green and firefly by Swapnil Singh Kushwaha, Amit Aggarwal, Karandeep Guleria, Samit Chaturvedi, Anant Kumar

“…The renal scan indicated equal function of both moieties. The right moiety was supplied by a main renal artery and branches of a common lower polar artery. …”
Get full text

Methodology for determining effect of starting modes of internal combustion engine on change in engine performance characteristics by N. A. Zagorodnii, Yu. A. Zayats, A. S. Semykina

“…As part of solving the urgent problem of forecasting technical impacts and residual life depending on operating time, a method for determining the effect of the starting mode on a change in the structural parameter determining reliability is presented. …”
Get full text

Comparative Analysis of Surgical Outcomes Between Robotic-Assisted Pyelolithotomy and Mini-Percutaneous Nephrolithotomy for Renal Stones Larger Than 2 cm in Older Adults: A One-Yea... by Tu HA, Weng SC, Lin YH, Chen CL, Chen YT, Juang HH, Hou CP

“…We hypothesized that robotic-assisted pyelolithotomy (RAPL) is a safe and effective approach for managing large renal stones (&gt; 2 cm) in older adults.Patients and Methods: We retrospectively analyzed 605 patients aged 50– 80 years who underwent either RAPL (n=31) or mini-PCNL (n=574) for renal stones &gt; 2 cm at Chang Gung Memorial Hospital, Taiwan, between December 2016 and November 2023. …”
Get full text

Clinical Utility of the Trajectory of Serum Bilirubin and International Normalized Ratio Values in Hepatitis B Virus-Related Acute-on-Chronic Liver Failure by Song YQ, Fu XY, Yan SY, Qi RB, Zhou YJ, Liang JW, Zhang JQ, Ye LP, Mao XL, Li SW

“…This study aims to investigate the clinical application of dynamic trajectories of TB and INR in HBV-ACLF patients.Methods: Retrospective data from 194 patients at Taizhou Hospital, China (Jan 2012 - June 2023), meeting COSSH-ACLF criteria, were analyzed. …”
Get full text

Cognitive status and health-related quality of life for medical students by V. V. Kuznetsov, K. V. Kosilov, E. Yu. Kostina, E. V. Karashchuk, E. K. Fedorishcheva, O. A. Barabash

“…The composite indicator of the quality of life associated with health was equal to 60 points for 1–3 year students, 67 points for 4–6 year students, (p≤0.05). …”
Get full text

ACE Loss Drives Renal Cell Carcinoma Growth and Invasion by Modulating AKT-FOXO1 by Yin L, Mao L, Yin R, Lv C, Shi X, Yue C, Chen Y, Lu C, Wu Z, Xu K, Cao W

“…However, the function of RAAS has not been verified in Clear-cell renal cell carcinoma (ccRCC).Methods: ACE expression in ccRCC tissues was determined using RT-PCR, Western blot, and immunohistochemistry staining. …”
Get full text

IL7-IL7R Interaction Mediates Fibroblast-Driven Macrophage-to-Osteoclast Differentiation in Periodontitis by Huang P, Gao L, Guan J, Li Y, Jia Y, Zeng Z, Chen Y, Wang L, Li W, Wang Y, Yang B

“…Pengjie Huang,1,&amp;ast; Li Gao,1,&amp;ast; Jiezhong Guan,1 Yijiao Li,1 Yibing Jia,1 Zixiang Zeng,1 Yurun Chen,1 Linge Wang,2 Weichang Li,1 Yan Wang,1 Bo Yang1 1Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, People’s Republic of China; 2South China Advanced Institute for Soft Matter Science and Technology, School of Molecular Science and Engineering, Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices, South China University of Technology, Guangzhou, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Yan Wang, Email wangyan9@mail.sysu.edu.cn Bo Yang, Email yangb86@mail.sysu.edu.cnAim: To identify osteoclastogenic macrophage subsets and their regulatory mechanisms in periodontitis.Methods: We integrated single-cell RNA sequencing datasets from human and murine periodontitis to construct a comprehensive macrophage and monocyte atlas. …”
Get full text

Identification and Validation of Key Genes Related to Lipophagy in Osteoporosis by Hu YX, Zuo ML, Wu Y, Yang Y, Shi XB, Zhang Q, Wu J, Xie RQ, Bi Y, Lin B, Mo C

“…This study aimed to determine the key genes linked to lipophagy in osteoporosis (OP) and provided a reference for the treatment of OP.Methods: The study analyzed OP-related datasets (GSE56815, GSE62402) and lipophagy-related genes (LRGs). …”
Get full text