A Longitudinal Dynamic Change in LMR Can Be a Biomarker for Recurrence in Fusobacterium Nucleatum-Positive Colorectal Cancer Patients by Chen S, Chang WH, Zhang J, Liu XY, Gao T, Qi XW, Cai DY, Mao Y, Lu TX

“…Shan Chen,1,* Wan-Hua Chang,2,* Jie Zhang,1,* Xiao-Yuan Liu,3,* Ting Gao,1 Xiao-Wei Qi,4 Dong-Yan Cai,1 Yong Mao,1 Ting-Xun Lu1 1Department of Oncology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu Province, People’s Republic of China; 2Department of Gastroenterology, Huaian Hospital of Huaian City, Huai’an, Jiangsu Province, People’s Republic of China; 3Department of Clinical Pharmacy, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu Province, People’s Republic of China; 4Department of Pathology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ting-Xun Lu, Department of Oncology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu Province, People’s Republic of China, Email lutingxun@163.comPurpose: This study assessed lymphocyte-to-monocyte ratio (LMR) changes to predict postoperative recurrence in Fusobacterium nucleatum-positive (Fn-positive) CRC patients.Patients and Methods: Clinical information and paraffin tissue specimens were collected from a retrospective cohort of 332 patients. …”
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On-line Monitoring of H310BO3 Preparation from 10BF3 by ZHOU Wenhui1, HU Shilin1, ZHANG Yanbiao1, ZHOU Xiulin2

“…The most reasonable feeding method for preparing H310BO3 from 10BF3 is that insoluble solid powder SrCO3 and H2O are mixed and stirred to form a suspension, then the suspension is heated to a set temperature and kept constant, and then 10BF3 is added to the suspension. …”

Predictors of diplopia following orbital fractures based on anatomical location, a retrospective cohort study by Honglin Chen, Yiqing Bao, Yuxin Chen, Yiqun Li, Peng Wu, Guohua Fan, Ji Zhang

“…Abstract Purpose This study aimed to identify predictors of diplopia following orbital fractures. Methods We retrospectively analyzed clinical and imaging data from 155 patients who experienced orbital fractures at our center between 2021 and 2023. …”
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Correlation Between Systemic Immune Inflammatory Index and Suicidal Attempt in Patients with First-Episode Untreated Depression and its Risk Factors by Wu Y, Jiang W, Chen M, Jiang Q, Huang H, Guo W, Yuan Y

“…Yigao Wu,1,2,* Wenhao Jiang,1,* Man Chen,2 Qin Jiang,2 Huilan Huang,2 Wenbin Guo,3 Yonggui Yuan1 1Department of Psychiatry and Psychosomatics, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing, People’s Republic of China; 2Department of Medical Psychology, The First Affiliated Hospital of Wannan Medical College, Wuhu, People’s Republic of China; 3Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yonggui Yuan, Department of Psychiatry and Psychosomatics, ZhongDa Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, No. 87 Dingjiaqiao, Gulou District, Nanjing, 210009, People’s Republic of China, Tel +86-025-83285124, Email yygylh2000@sina.comObjective: To examine the relationship between the systemic immune inflammatory index (SII) and suicide attempts (SA) in individuals experiencing their first episode of major depressive disorder (MDD).Methods: A retrospective analysis of 338 MDD patients (2020– 2023) at the First Affiliated Hospital of Wannan Medical College and 76 healthy controls (HC) was conducted. …”
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Correlation Between Tear Film Stability and Myopia in Children by Huang PW, Kuo YK, Chen NN, Li JH, Wu CH, Chen HM, Su KW, Sun CC

“…Pei-Wei Huang,1,2,* Yu-Kai Kuo,2,* Nan-Ni Chen,3 Ju-Hsien Li,2 Cheng‐Hsiu Wu,2 Ho-Min Chen,2 Kuan-Wen Su,4,5 Chi-Chin Sun2,6 1Department of Ophthalmology, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, Yilan, Taiwan; 2Department of Ophthalmology, Keelung Chang Gung Memorial Hospital, Keelung City, Taiwan; 3Department of Ophthalmology, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan; 4Department of Paediatrics, Keelung Chang Gung Memorial Hospital, Keelung City, Taiwan; 5Department of Paediatrics, College of Medicine, Chang Gung University, Taoyuan, Taiwan; 6Department of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan*These authors contributed equally to this workCorrespondence: Chi-Chin Sun, Department of Ophthalmology, Chang Gung Memorial Hospital, 222 Mai Chin Road, An Leh District, Keelung, Taiwan, Email chichinsun@gmail.comPurpose: To investigate the correlation between dry eye and myopia in Taiwanese school children.Methods: This retrospective cohort study enrolled children aged 5– 14-years-old between January 2021 and April 2022. …”
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Association of MTMR3 rs12537 at miR-181a Binding Site with Ischemic Stroke in Southern Chinese Han Population by Chen L, Wei S, Zhang Y, Li Y, Li Z, Huang P, Xiao C, Zhang Y

“…This research examined the potential association between the SNP rs12537 in the miRNA-181a binding location within the 3′ untranslated region (3′-UTR) of MTMR3 and the incidence and prognosis of IS.Methods: An improved multitemperature ligase detection reaction assay was used to perform genotyping analysis in two independent case-control datasets consisting of 1128 subjects with IS and 1140 healthy controls with matched ages.Results: The distribution frequencies of the T allele (p = 5.2× 10− 4) of SNP rs12537 in MTMR3 were elevated significantly in IS patients as compared to healthy controls. …”
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Cholinesterase Inhibitor Reveals Synergistic Potential for Neural Stem Cell-Based Therapy in the 5xFAD Mouse Model of Alzheimer’s Disease by Wu CC, Lee YK, Tsai JK, Su YT, Ho YC, Chu TH, Chen KT, Chang CL, Chen JS

“…This study aimed to determine if combining ChEI treatment with stem cell therapy could improve therapeutic outcomes.Methods: Neural stem cells (NSCs) were injected into the hippocampus of the 5xFAD AD mice using a stereotactic technique. …”
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Establishing a Prediction Model for Weight Loss Outcomes After LSG in Chinese Obese Patients with BMI ≥ 32.5 Kg/m2 Using Body Composition Data by Wang L, Sun Y, Sang Q, Wang Z, Yu C, Li Z, Shang M, Zhang N, Du D

“…However, suboptimal results are observed in certain patients.Objective: Drawing from body composition data at our center, clinically accessible predictive factors for weight loss outcomes were identified, leading to the development and validation of a preoperative predictive model for weight loss following LSG.Methods and Materials: A retrospective analysis was conducted on the general clinical baseline and body composition data of obese patients (body mass index [BMI] ≥ 32.5 kg/m2) who underwent LSG between December 2016 and December 2022. …”
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Increment of Skeletal Muscle Mass Predicts Survival Benefit for Hepatocellular Carcinoma Treated with Transarterial Chemoembolization Combining Molecular Targeted Agents and Immune... by Chen W, Yan HT, Zhang JX, Shen X, Liu J, Liu S, Shi HB, Ding Y, Zu QQ

“…Wen Chen,1,* Hai-Tao Yan,1,* Jin-Xing Zhang,1 Xiao Shen,1 Jin Liu,2 Sheng Liu,1 Hai-Bin Shi,1 Ye Ding,3 Qing-Quan Zu1 1Department of Interventional Radiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, People’s Republic of China; 2Department of Clinical Medicine Research Institution, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, People’s Republic of China; 3Department of Maternal, Child and Adolescent Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ye Ding, Department of Maternal, Child and Adolescent Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, People’s Republic of China, Tel +86-025-8686-8459, Email dingye@njmu.edu.cn Qing-Quan Zu, Department of Interventional Radiology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Road, Nanjing, 210029, People’s Republic of China, Tel +86-13913807470, Email zuqingquan@njmu.edu.cnPurpose: To assess the relationship between clinical prognosis and changes of skeletal muscle mass for unresectable hepatocellular carcinoma (uHCC) patients who received transarterial chemoembolization (TACE) with molecular-targeted agents and immune checkpoint inhibitors (TACE-MTAs-ICIs).Methods: From June 2019 to June 2023, a total of 92 uHCC patients who received TACE-MTAs-ICIs therapy were included. …”
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Au@Pt@HP1-HP2@Fe3O4 Nanoenzymatic Complexes Based on CHA Signal Amplification Strategy for Ultrasensitive SERS Detection of ctDNA in Liver Cancer by Wang X, Sheng J, Yang H, Shen K, Yao J, Qian Y, Chen G

“…The assay’s performance was validated using gold standard qRT-PCR.Results: Under optimized conditions, the method achieved a detection limit for PIK3CA E542K as low as 4.12 aM. …”
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Feasibility and Safety of Anlotinib Plus Docetaxel versus Docetaxel Monotherapy in Patients with Previously Immunotherapy-Treated NSCLC: A Retrospective Exploratory Study by Li DW, Li YD, Jin H

“…Da-Wei Li,1,* Ying-Dong Li,2,* Hong Jin3 1Department of Prescription Teaching and Research, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150006, People’s Republic of China; 2Department of Intensive Care Rehabilitation, The Fourth Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150070, People’s Republic of China; 3Department of Acupuncture, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hong Jin, Department of Acupuncture, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, No. 26, He Ping Street, Xiang Fang District, Harbin, Heilongjiang, 150040, People’s Republic of China, Tel +86 13836129681, Email 9937200@qq.comObjective: This study aims to evaluate the efficacy and safety of anlotinib plus docetaxel in patients with advanced non-small cell lung cancer (NSCLC) who have previously treated with immunotherapy.Methods: This retrospective analysis was conducted on 86 previously immunotherapy-treated patients with advanced NSCLC from December 2018 to October 2024 in clinical practice. …”
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Time-Course Renal and Pulmonary Injury Analysis and Bioinformatics Screening of Core Pathogenic Genes and Immune Cell Infiltration Patterns in a Sepsis by Apizi A, Li J, Kamilijiang P, Yang CB, Wang ZK, Chai RF, Yu ZX

“…Anwaier Apizi,* Jian Li,* Paiheriding Kamilijiang, Chun-Bo Yang, Zheng-Kai Wang, Rui-Feng Chai, Zhao-Xia Yu Department of Intensive Care Unit, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhao-Xia Yu, Department of Intensive Care Unit, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, People’s Republic of China, Tel +86 13899858397, Email zhaoxia_yu01@126.com Rui-Feng Chai, Department of Intensive Care Unit, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, People’s Republic of China, Tel +86 13999819217, Email chairuifeng_chai@126.comObjective: This study aimed to evaluate the extent of organ damage associated with sepsis and to identify key genes implicated in its pathogenesis.Methods: Eighteen rats were randomized into experimental and control groups. …”
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Diabetes mellitus as an economic problem in Russian Federation by Ivan Ivanovich Dedov, Vitaliy Vladimirovich Omelyanovskiy, Marina Vladimirovna Shestakova, Maria Vladimirovna Avksentieva, Viktoria Igorevna Ignatieva

“…For DMT2, the proportion spent on inpatient care (43%) was almost equal to medication costs (46%). Mean expenditures per patient with DM complications were higher; in the case of DMT2, the presence of complications increased the costs by 3 times. …”
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Therapeutic Innovations in Nanomedicine: Exploring the Potential of Magnetotactic Bacteria and Bacterial Magnetosomes by Yadav VK, Pramanik S, Alghamdi S, Atwah B, Qusty NF, Babalghith AO, Solanki VS, Agarwal N, Gupta N, Niazi P, Patel A, Choudhary N, Zairov R

“…Further authors have reviewed the various functionalization methods of the magnetosomes for cancer treatment. …”
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Trends and Hospitalization Outcomes of Tetanus Cases: A Multicenter Retrospective Study in Suzhou, 2013–2023 by Yu J, Zheng B, Liu N, Zhu Y, Hui F, Zhang J, Luan L

“…Jiangtao Yu,1,* Benfeng Zheng,2,* Na Liu,2,3 Yiheng Zhu,4 Fen Hui,5 Jin Zhang,5 Lin Luan1,2 1Department of Epidemiology, School of Public Health, National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, 210000, People’s Republic of China; 2Department of Immunization Program, Suzhou Center for Disease Control and Prevention, Suzhou, 215000, People’s Republic of China; 3Center for Immunization Planning, Chinese Center for Disease Control and Prevention, Beijing, 100050, People’s Republic of China; 4Suzhou Municipal Health Commission, Suzhou, 215000, People’s Republic of China; 5The Fifth People’s Hospital of Suzhou, Suzhou, 215000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lin Luan, Email szluanlin@163.comObjective: To investigate the epidemiology, and hospitalization of tetanus in Suzhou, Jiangsu Province, China, focusing on the severity of the disease, treatment, outcomes and hospitalization costs, and to explore the risk factors for severe tetanus.Methods: This retrospective, multicenter observational study analyzed tetanus patients admitted to various medical institutions between 2013 and 2023. …”
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Clinicopathological Features and Prognostic Factors of Renal Cell Carcinoma in Young Patients Under 45 Years: A Single-Center Retrospective Study by Gao Y, Yan H, Zhang T, Lu G, Ma L

“…Yu Gao,1,* Haisheng Yan,2,* Tao Zhang,2 Guanjun Lu,1 Lianghong Ma1,3 1Urology Department of General Hospital of Ningxia Medical University, Yinchuan, 750004, People’s Republic of China; 2The First Clinical Medical College, Ningxia Medical University, Yinchuan, 750004, People’s Republic of China; 3Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, 750004, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lianghong Ma, Email mmm1770@163.comObjective: To explore the clinicopathological characteristics, diagnostic approaches, and therapeutic strategies for renal cell carcinoma (RCC) in young patients under 45 years of age, aiming to provide insights for early detection and improved prognosis.Methods: We retrospectively analyzed the clinical data of 150 RCC patients aged 18 to 45 years treated at the General Hospital of Ningxia Medical University from 2011 to 2023. …”
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Seroprevalence of SARS-CoV-2 antibodies in people with an acute loss in their sense of smell and/or taste in a community-based population in London, UK: An observational cohort stu... by Janine Makaronidis, Jessica Mok, Nyaladzi Balogun, Cormac G Magee, Rumana Z Omar, Alisia Carnemolla, Rachel L Batterham

“…New loss of smell was more prevalent in participants with SARS-CoV-2 antibodies, compared with those without antibodies (93.4% versus 78.7%, p < 0.001), whereas taste loss was equally prevalent (90.2% versus 89.0%, p = 0.738). …”
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Association and Predictive Ability between Inflammatory Burden Index and Fever Following Endobronchial Forceps Biopsy in Lung Cancer Patients by Zhang M, Yang C, Guo Y

“…Then, the most influential factors were selected through the application of Boruta algorithm and LASSO regression method and nomogram model was developed using multivariate logistic regression. …”
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Restricted kinematic total knee arthroplasty provided better functional outcomes and higher satisfaction rates for Asians of genu varum with apex distal joint line over unrestricte... by Jia Yi Loh, Ming Han Lincoln Liow, Glen Purnomo, Merrill Lee, Jerry Yongqiang Chen, Hee-Nee Pang, Keng Jin Darren Tay, Seng-Jin Yeo

“…Unrestricted calipered KA-TKA targeted equal bone cuts while restricted KA-TKA utilized intraoperative navigation to restrict tibia varus to 4°. …”
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Risk Factors Affecting Quality of Life in Chronic Limb Threatening Ischemia Patients by Wu R, Yu Y, Guo J, Gao X, Tong Z, Guo J, Cui S, Zhang C, Guo L

“…Understanding these relationships could provide insights into optimizing patient management and improving their overall QoL.Patients and Methods: This study was conducted at our center from January 2021 to January 2024. …”
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