Establishing the Median and 95% Effective Doses of Oliceridine for Immediate Post-Surgical Analgesia Following Laparoscopic Cholecystectomy: A Double-Blind, Sequential Dose-Finding... by Cao X, Xiao H, Yan H, Wei Y, Wen Q, Zhang Z, Xu G, Xu B, Chen J, Li X

“…Using Dixon and Massey’s up-and-down sequential allocation method, the median effective dose (ED50) and the dose required for 95% effective dose (ED95) were determined, alongside an evaluation of the agent’s safety profile.Methods: In this prospective trial, 82 participants scheduled for LC were enrolled and randomly assigned to receive either oliceridine or saline (control). …”
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Comparative effects of Zumba and Yoga on stress, body satisfaction, and self-esteem in working women: a randomized control trial by Noortje Anita Kumaat, Afif Rusdiawan, Procopio B. Dafun JR., Heri Wahyudi, Popy Elisano Arfanda, Fransisca Januarumi Marhaendra Wijaya, Himawan Wismanadi, Ary Artanty

“…Conclusions. Yoga and Zumba are equally effective, culturally adaptable interventions for improving psychological well-being and reducing stress among working women. …”
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Experiences, Challenges, and Needs of People Living with HIV in Hunan Province, China: A Qualitative Study by Shi C, Li X, Dai Y, Chen M, Mao L, Zhou X, Lei Y, Yuan W

“…Colaizzi’s seven-step analysis method and NVivo 14 was used to analyze the transcripts.Results: The participants, aged 23 to 83 years, had been living with HIV for durations ranging from one month to 19 years. …”
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Incomplete Thermal Ablation-Induced FOXP4-Mediated Promotion of Malignant Progression in Liver Cancer via NDST2 by Wan W, Pan Y, Pang J, Bai X, Li L, Kang T, Chen J, Wen R, Wen D, Yang H, He Y

“…We investigated the mechanism by which Forkhead box P4 (FOXP4) promotes the malignant transformation of residual HCC cells through N-deacetylase and N-sulfotransferase 2 (NDST2) after incomplete thermal ablation.Methods: The clinical significance of FOXP4 and NDST2 in HCC was evaluated using big data analysis. …”
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A Systematic Literature Review of the Humanistic, Economic, Sociodemographic, and Environmental Burden Associated with Severe COPD by Vlachaki I, Donhauser S, Wise RA, Chen Y, Madoni A, Scaffidi Argentina U, Mir JN, Quint JK

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PRECIS-2 used as an implementation science tool for global environmental health: A cross-sectional evaluation of the Ecolectivos study protocol to reduce burning of household plast... by Lisa M Thompson, Annalyse Ferguson, Hina Raheel, Amy E Lovvorn, Mayari Hengstermann-Artiga, Maria Renee Lopez, Melinda Higgins, Eri Saikawa, Margaret A Handley

“…Four were evaluated to be equally pragmatic as explanatory-recruitment, organization, flexibility-adherence, and primary outcome. …”
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Correlation Between Intrinsic Capacity and Muscle Strength and Quality in Older Patients with Cardiovascular Disease: A Cross-Sectional Study by Yu X, Wu D, Li F, Qiao W, Chen X

“…This study aims to explore the relationship between the decline of IC, muscle strength, and muscle quality in older patients with CVD, providing a new method and basis for early recognition of IC decline in the older adults.Methods: This cross-sectional study included 475 older individuals from communities in Zhejiang. …”
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Changing Trends in the Mental Health Status of Healthcare Workers at COVID-19 Wards Three Years After the COVID-19 Pandemic Outbreak in Saudi Arabia by Alharbi SH, Almoajel AM, Tharkar S, Alharbi AH, Almutairi K, Alzaidi HA, Kattan BF

“…Sami Hamoud Alharbi,1,* Alia Mohammed Almoajel,1,* Shabana Tharkar,1 Abdullah Hamoud Alharbi,2 Khalid Almutairi,1 Hanan Abdullah Alzaidi,1 Basmah Faisal Kattan1 1Department of Community Health Science, College of Applied Medical Science, King Saud University, Riyadh, Saudi Arabia; 2Ministry of Health, Riyadh, Saudi Arabia*These authors contributed equally to this workCorrespondence: Khalid Almutairi, Department of Community Health Science, College of Applied Medical Sciences, King Saud University, Riyadh, 12372, Saudi Arabia, Email kalmutairim@ksu.edu.saBackground: The current study aimed to investigate the severity of anxiety and depression symptoms among the healthcare workers of COVID-19 wards three years after the pandemic outbreak in Saudi Arabia.Methods: An online cross-sectional survey was conducted during the fourth quarter of 2022 and early 2023 at the COVID-19 wards of public primary healthcare hospitals of the AlQassim region of Saudi Arabia. …”
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Altered Immune Cell Profiles in the Follicular Fluid of Patients with Poor Ovarian Response According to the POSEIDON Criteria by Zhou L, Zhao S, Luo J, Rao M, Yang S, Wang H, Tang L

“…Multivariable logistic regression assessed the relationship between immune cell counts and POR, Pearson correlation determined associations with the number of retrieved oocytes, and receiver operating characteristic (ROC) curves evaluated the predictive power of immune cell counts for POR.Results: Immune cells accounted for 52.57% (± 23.90%) of the total cell population in the follicular microenvironment, which was approximately equal to that of granulosa cells, with M&phis;s being the most abundant, followed sequentially by T cells, DCs, and neutrophils. …”
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Combination Fractional Carbon Dioxide Laser Treatment and Bone Marrow Mesenchymal Stem Cell Therapy Enhances the Treatment of Skin Photoaging in a Murine Model System by Li L, He Z, Yu C, Zhang C, Yu Y, Li Y, Xu X

“…Li Li,1– 3,* Zeyu He,3– 5,* Chengqian Yu,3– 5 Chao Zhang,3– 5 Yanqiu Yu,6 Yuanhong Li,3– 5 Xuegang Xu3– 5 1ShanXi Medical University, Taiyuan, People’s Republic of China; 2Department of Dermatology, The First Hospital of ShanXi Medical University, Taiyuan, 030001, People’s Republic of China; 3Department of Dermatology, The First Hospital of China Medical University, Shenyang, 030001, People’s Republic of China; 4Key Laboratory of Immunodermatology (China Medical University), Ministry of Education, Shenyang, 110001, People’s Republic of China; 5NHC Key Laboratory of Immunodermatology (China Medical University), Shenyang, 110001, People’s Republic of China; 6Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang, 110122, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xuegang Xu, Department of Dermatology, The First Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping District, Shenyang, Liaoning Province, 110001, People’s Republic of China, Email xuxuegang2749290@163.com Li Li, Department of Dermatology, The First Hospital of ShanXi Medical University, No. 85 South Jiefang Road, Yingze District, Taiyuan, Shanxi Province, 030001, People’s Republic of China, Email lilizaimu0807@163.comBackground: Fractional carbon dioxide lasers and bone marrow mesenchymal stem cells (BMSCs) are commonly employed in the treatment of skin photoaging.Objective: This study was developed to explore the effects of combination carbon dioxide laser treatment and BMSC injection on skin photoaging and the underlying molecular mechanisms.Methods & Materials: In total, 24 mice with experimentally photoaged skin were separated into control, carbon dioxide fractional laser treatment, combination therapy, and BMSC injection groups. …”
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Similarity Criterion Based on the Analytical Solution of Heat Conduction Equation in Frozen Soil by BO Yin, WANG Cong, FENG Yan-fang, ZHANG Bin, ZHANG Ying, GUO Xiao-gang, YAO Jin-song, WEI Lai, CHEN Rong, XU Chen

“…[Methods] First, analytical solutions to one-dimensional heat conduction differential equations, under both constant and nonlinear thermal parameters, were obtained using the method of separation of variables with different boundary conditions. …”
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Comparison of Biometric Measurements and IOL Power Calculation Between a Swept-Source OCT and an Optical Low-Coherence Reflectometry Biometer by Romero D, Monera CE, Cooke D, Alio JL, Tarazona C, Martínez-Toldos JJ

“…Estimated intraocular lens (IOL) power for emmetropia was significantly higher using Anterion by 0.146 ± 0.398D (P < 0.001), necessitating an A-constant adjustment of approximately 0.16 to equal mean IOL power in both devices.Conclusion: a good correlation was found between both biometers. …”
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Protective Effect of Rosmarinic Acid on Endotoxin-Induced Neuronal Damage Through Modulating GRP78/PERK/MANF Pathway by Li Q, Zheng JW, Wang ZY, Liao SP, Zhu L, Wang X, Wan LH

“…This study was conducted to explore the protective effects and mechanism of rosmarinic acid (RA) against ERS in endotoxin-induced cognitive dysfunction in mice and neuronal injury in cells.Methods: The efficacy of RA was evaluated using an endotoxin-induced cognitive dysfunction mice model and an in vitro neuronal injury model. …”
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Association Between Weight-Adjusted Waist Index and Cognitive Function in Older Adults Without Diabetes: A Cross-Sectional Study by Wang Q, Yin Y, Liu W, Li L, Wang Z, Tian Y, Fan J

“…Qing Wang,1,* Yishan Yin,2,* Wei Liu,3,* Lingyu Li,1 Zhen Wang,1 Yue Tian,1 Jing Fan1 1Department of Laboratory Medicine, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, Shandong, 253000, People’s Republic of China; 2Department of Orthopedics, The Armed Police Forces Hospital of Shandong, Jinan, Shandong, 250000, People’s Republic of China; 3Department of Emergency Critical Care Medicine, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, Shandong, 253000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jing Fan, Department of Laboratory Medicine, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, Shandong, 253000, People’s Republic of China, Email sddzfanjing@163.comBackground: This study investigates the correlation between the weight-adjusted waist index (WWI) and cognitive performance in the senior American population, focusing on those without diabetes from 2011 to 2014.Methods: We analyzed data from the 2011– 2012 and 2013– 2014 National Health and Nutrition Examination Surveys (NHANES), focusing on non-diabetic participants aged 60 and older who completed cognitive tests: Establish a Registry for Alzheimer’s disease (CERAD), the Animal Fluency test (AFT), and Digit Symbol Substitution test (DSST). …”
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Interprofessional collaboration on oral health for frail home-dwelling older people: a focus group study on needs and barriers experienced by general practitioners and community ph... by Natalie Hoste, Ellen Baele, Aster De Vleeschauwer, Fien Mertens, Louise Poppe, Barbara Janssens, Peter Pype

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Association Between Percent Body Fat Reduction and Changes of the Metabolic Score for Insulin Resistance in Overweight/Obese People with Metabolic Dysfunction-Associated Steatotic... by Han Y, Liu J, Li W, Zhang F, Mao Y

“…Yan Han,1,2,* Jinhan Liu,2,3,* Wenjian Li,4 Fan Zhang,1,2 Yonghua Mao1,5 1Department of Endocrinology, Changzhou Third People’s Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, People’s Republic of China; 2Department of Clinical Nutrition, Changzhou Third People’s Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, People’s Republic of China; 3Department of Liver Diseases, Changzhou Third People’s Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, People’s Republic of China; 4Department of Urology, Changzhou Third People’s Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, People’s Republic of China; 5Department of Nursing, Changzhou Third People’s Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fan Zhang; Yonghua Mao, Department of Endocrinology, Changzhou Third People’s Hospital, Changzhou Medical Center, Nanjing Medical University, 300 Lanling North Road, Changzhou, Jiangsu, 213001, People’s Republic of China, Tel +86-0519-82008311, Email yifan52518@163.com; symyh2103@163.comPurpose: This study investigated the relationship between the difference in percent body fat (∆PBF) decrease and the change in the metabolic score for insulin resistance (METS-IR) in Chinese overweight/obese people with combined metabolic dysfunction-associated steatotic liver disease (MASLD) after weight loss.Patients and Methods: A total of 357 overweight/obese MASLD patients were included using a retrospective study method. …”
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Vaccination against the SARS-CoV-2 in individuals with comorbidities by S A Berns, M G Chashсhin, A Yu Gorshkov, O V Zhdanova, L N Ryzhakova, O A Litinskaya, O M Drapkina

“…The use of Russian vaccines (Gam-COVID-Vac and CoviVac) is equally effective in each of the studied groups. There were no significant differences between them in COVID-19 incidence after vaccination/revaccination. …”
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An Integrated Machine Learning Framework for Developing and Validating a Diagnostic Model of Hub Genes Related to Lipid Metabolism in Chronic Rhinosinusitis by Xiong P, Liu L, Pi J, Wang J, Lu T, Ke X, Jiang Y, Shen Y, Yang Y

“…Panhui Xiong,1,* Lei Liu,1,2,* Jingting Pi,3,* Ji Wang,1 Tao Lu,1 Xia Ke,1 Yu Jiang,1 Yang Shen,1 Yucheng Yang1 1Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People’s Republic of China; 2Department of Otolaryngology Head and Neck Surgery, Mianyang Central Hospital, Mianyang, 621000, People’s Republic of China; 3Department of Otolaryngology Head and Neck Surgery, Yongchuan Hospital Affiliated of Chongqing Medical University, Chongqing, 402160, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yucheng Yang, Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People’s Republic of China, Email yychxh@163.com Yang Shen, Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People’s Republic of China, Email sy_smile@sina.cnPurpose: The study aimed to identify key genes related to lipid metabolism in chronic sinusitis and understand their biological implications, considering the growing interest in the association between chronic sinusitis - a complex inflammatory condition - and lipid metabolism due to lipids’ role in inflammation and immunity.Methods: Gene expression data from bulk - RNA sequence was analyzed and intersected with lipid metabolism genes and WGCNA module genes from the MSigDB database. …”
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Impact of Initial Heart Rate, Diastolic Pressure, and Pulse Pressure on Prognostic Outcomes in Heart Failure Patients with Mildly Reduced Ejection Fraction by Hu H, Liu Z, Zeng J, Jiang M

“…This study aims to elucidate their effects on HFmrEF patient outcomes.Methods: We retrospectively analyzed 1,653 hFmrEF patients treated at Xiangtan Central Hospital (2015– 2020). …”
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Promotion of Random Flap Neovascularisation in Rats with Diabetes Using Botulinum Toxin Type A Through the HIF-1α/VEGF Pathway by Yan HJ, Lin FM, Li JJ, Qin H, Wang YH, You CH

“…Hong-Jie Yan,1,* Fang-Ming Lin,2,* Jing-Jing Li,1 Hao Qin,1 Yi-He Wang,1 Chuan-Hua You1 1Department of Plastic and Cosmetic Surgery, The First Affiliated Hospital of Hainan Medical University, Haikou, 570102, People’s Republic of China; 2Department of Vascular Surgery, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, Haikou, 570100, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chuan-Hua You, Department of Plastic and Cosmetic Surgery, The First Affiliated Hospital of Hainan Medical University, No. 31 of Longhua Street, Longhua District, Haikou, 570102, People’s Republic of China, Tel +8615120793168, Fax +86-1083161294, Email youchuanhua3063@163.comObjective: This study aimed to investigate the effects of botulinum toxin type A (BoTA) on the neovascularisation of diabetic flaps through the factor-1alpha (HIF-1α)/vascular endothelial growth factor (VEGF) pathway.Methods: A total of 60 male Wistar rats (250– 300 g) were randomly divided into 4 groups. …”
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