Extracellular Vesicles Derived from FGF2-Primed Astrocytes Against Mitochondrial and Synaptic Toxicities in Parkinson’s Disease by Wen X, Cao W, Ding H, Chen A, Sun Z, Wang Y, Xi Y, Wu S

“…The present study was to test this hypothesis.Methods: EVs isolated from FGF2-primed astrocytes (FGF2-EVs) were characterized by transmission electron microscopy and nanoparticle tracking analysis. …”
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A Comparison of Stereotactic Radiation Therapy in Elderly Patients with Central or Peripheral Stage I-II (T1-3 N0 M0) Non-Small Cell Lung Cancer by Ji X, Shi X, Hu J, Jiang W, Zhou B, Zhou H, Yuan X, Li Y, Huang H, Wang J, Ding W, Wang Y, Sun X

“…Xiaoqin Ji,1,* Xuebing Shi,2,* Jun Hu,3 Wanrong Jiang,3 Bin Zhou,3 Houlong Zhou,3 Xi Yuan,3 Yikun Li,3 Hua Huang,3 Jiasheng Wang,3 Wei Ding,3 Yong Wang,4 Xiangdong Sun3 1Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China; 2Department of Radiation Oncology, Nanjing Jiangbei Hospital, Nanjing, People’s Republic of China; 3Department of Radiation Oncology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, People’s Republic of China; 4Department of Outpatient Clinic, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yong Wang; Xiangdong Sun, Email 292917354@qq.com; sunxd_81@126.comPurpose: The objective of this study was to compare the clinical outcomes of stereotactic body radiation therapy (SBRT) in elderly patients aged 65 or older with clinical stage I–II non-small-cell lung cancer (NSCLC), specifically examining the differences between centrally located lung tumors and peripherally located lung tumors.Methods: From April 2009 to January 2020, a total of 136 patients with 136 tumors (65 central, 71 peripheral; NSCLC) at an early stage (T1-3N0M0) were treated with SBRT at a single institution. …”
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Clinical Features of Juvenile Open-angle Glaucoma by A. V. Malyshev, A. S. Apostolova, A. A. Sergienko, A. F. Teshev, G. Yu. Karapetov, M. K. Ashhamahova, B. N. Hatsukova

“…Juvenile open-angle glaucoma (JOAG) is a genetically determined disease of young age, which is diagnosed before the 40, which is based on anomalies in the structure of the drainage system of the eye.Objective: to identify the features of morphometric and biomechanical parameters of the fibrous capsule in patients with JOAG.Materials and methods. 19 eyes of 10 patients with JOAG were examined. …”
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Impact of Fungal Co-Infection on Teicoplanin Plasma Trough Concentration in Critically Ill Adults: A Novel Consideration for Dose Adjustment by Cheng L, Wang L, You X, Xiong L, Dai Q, Wang Q

“…However, the effect of fungal co-infection on the plasma trough concentration (Cmin) of teicoplanin in critically ill patients remains unclear.Materials and Methods: A retrospective cohort study was carried out. …”
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Relative contribution of diet and physical activity to increased adiposity among rural to urban migrants in India: A cross-sectional study. by Sanjay Kinra, Poppy Alice Carson Mallinson, Jenny A Cresswell, Liza J Bowen, Tanica Lyngdoh, Dorairaj Prabhakaran, Kolli Srinath Reddy, Mario Vaz, Anura V Kurpad, George Davey Smith, Yoav Ben-Shlomo, Shah Ebrahim

“…<h4>Conclusions</h4>We found that increased energy intake and reduced energy expenditure contributed equally to greater adiposity among urban migrants in India. …”
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The Aggregate Index of Systemic Inflammation (AISI) is a Novel IgA Nephropathy Prognosis Predictor by Liu H, Tang G, Yu D, Gu P, Zhu X, Wang A, Yuan Y, Jiang X

“…We aimed to evaluate its predictive value in IgAN.Patients and Methods: This retrospective single-center study included 1792 biopsy-confirmed IgAN patients from October 2019 to September 2023 with> 12-month follow-up. …”
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Changes in Serum Bilirubin and Total Bile Acids During Biologic Therapy in Patients with Ulcerative Colitis: A Retrospective Study by Ren Z, Zhang Z, Li H, Fu P, Wang R, Wang S, Li Y

“…This study aims to assess their monitoring potential in UC during biologic therapy.Methods: We conducted a retrospective single-center study including 138 UC patients and 150 controls with normal colonoscopy results. …”
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A Nomogram Based on Laboratory Data, Inflammatory Bowel Disease Questionnaire and CT Enterography for Activity Evaluation in Crohn&rsquo;s Disease by Zhang H, Shen Y, Cao B, Zheng X, Zhao D, Hu J, Wu X

“…Han Zhang,1,&ast; Yi Shen,1,&ast; Bo Cao,2 Xiaomin Zheng,1 Dehan Zhao,3 Jing Hu,4 Xingwang Wu1 1Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, People’s Republic of China; 2Department of Radiology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210011, People’s Republic of China; 3Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, Anhui, 230022, People’s Republic of China; 4Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jing Hu, The First Affiliated Hospital of Anhui Medical University, Department of Gastroenterology, Hefei, Anhui, 230022, People’s Republic of China, Tel +86 139-5510-7753, Email hujing810@163.com Xingwang Wu, The First Affiliated Hospital of Anhui Medical University, Department of Radiology, Hefei, Anhui, 230022, People’s Republic of China, Tel +86 153-7533-0696, Email duobi2004@126.comBackground: Accurately assessing the activity of Crohn’s disease (CD) is crucial for determining prognosis and guiding treatment strategies for CD patients.Objective: This study aimed to develop and validate a nomogram for assessing CD activity.Methods: The semi-automatic segmentation method and PyRadiomics software were employed to segment and extract radiomics features from the spectral CT enterography images of lesions in 107 CD patients. …”
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Cancer-Derived Exosomal LINC01615 Induces M2 Polarization of Tumor-Associated Macrophages via RBMX-EZH2 Axis to Promote Colorectal Cancer Progression by Li A, Hong J, Ma X, Huang Y, Jiang Q, Zhang C, Wang Y, Huang Y

“…However, the specific role of cancer derived exosomal lncRNA in the M2 polarization of macrophages remains largely unknown.Methods: Bioinformatic analysis was used to screen out the differentially expressed lncRNAs in colorectal cancer (CRC). …”
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Auxiliary Diagnosis of Pulmonary Nodules&amp;rsquo; Benignancy and Malignancy Based on Machine Learning: A Retrospective Study by Wang W, Yang B, Wu H, Che H, Tong Y, Zhang B, Liu H, Chen Y

“…Ltd, Beijing, People’s Republic of China; 3Department of Pulmonary and Critical Care Medicine, the Seventh Medical Center of Chinese PLA General Hospital, Beijing, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Yuanyuan Chen, Email charry135@163.com Hongwu Liu, Email liuhw1005@163.comBackground: Lung cancer, one of the most lethal malignancies globally, often presents insidiously as pulmonary nodules. …”
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Prediction of Abnormal Functional Performance in Chronic Obstructive Pulmonary Disease Using Respiratory Models: A Pilot Study by Ribeiro CO, Lopes AJ, de Melo PL

“…Caroline Oliveira Ribeiro,1,&amp;ast; Agnaldo José Lopes,2,&amp;ast; Pedro Lopes de Melo1,3,&amp;ast; 1Biomedical Instrumentation Laboratory - Institute of Biology and Faculty of Engineering, State University of Rio de Janeiro, Rio de Janeiro, Brazil; 2Pulmonary Function Laboratory, State University of Rio de Janeiro, Rio de Janeiro, Brazil; 3BioVasc Research Laboratory - Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil&amp;ast;These authors contributed equally to this workCorrespondence: Pedro Lopes de Melo, Email plopes@uerj.brIntroduction: The contribution of respiratory models to understanding and predicting functional capacity abnormalities in chronic obstructive pulmonary disease (COPD) has not yet been investigated.Purpose: The aims of this study were: (1) To investigate the associations between the extended Resistance-Inertance-Compliance (eRIC) and the fractional-order (FrOr) models with changes in Glittre-ADL and handgrip tests and; (2) To evaluate the accuracy of these models in predicting abnormal functional capacity in COPD.Patients and Methods: The study was carried out in a group of 40 adults with COPD and a control group of 40 healthy individuals, both evaluated by respiratory oscillometry, spirometry, Glittre-ADL test and handgrip test. eRIC and fractional order models were also used to quantify biomechanical changes and obtain physiological information. …”
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Prevalence of Urinary Incontinence, Risk Factors and Its Impact: Multivariate Analysis from Indonesian Nationwide Survey by Rochani Sumardi, Chaidir A Mochtar, Junizaf Junizaf, Budi I Santoso, Siti Setiati, Siti A Nuhonni, Partini P Trihono, Harrina E Rahardjo, Firtantyo A Syahputra

“… Aim: to describe the profile of urinary infection (UI) and to analyze its risk factors and impacts. Methods: subjects were enrolled consecutively from pediatric, urology, obstetrics & gynecology, and geriatric outpatient clinics at six teaching hospitals in various regions of Indonesia. …”
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Exploring Mechanisms of Lang Qing Ata in Non-Alcoholic Steatohepatitis Based on Metabolomics, Network Pharmacological Analysis, and Experimental Validation by Li S, Zhu H, Zhai Q, Hou Y, Yang Y, Lan H, Jiang M, Xuan J

“…However, the therapeutic effects and potential mechanisms of Lang Qing Ata (LQAtta) against NASH remain elusive.Materials and Methods: The components of LQAtta were identified using Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry (UHPLC-MS/MS). …”
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Impact of Radiation Therapy Techniques on Hippocampal Doses and Psychological Status in Patients With Nasopharyngeal Carcinoma by Gai X, Huang S, Zeng J, Chen J, Liu F, Li S, Lv W, Guo F, Cai C, Hong J, Su L

“…Xiujuan Gai,1– 3,&ast; Shiqi Huang,1,2,&ast; Jiang Zeng,1,2,4 Jun Chen,1,2,4 Feng Liu,1,2,4 Shan Li,1,2,4 Wenlong Lv,1,2,4 Feibao Guo,1,2,4 Chuanshu Cai,1,2,4 Jinsheng Hong,1,2,4 Li Su1,2,4 1Department of Radiotherapy, Cancer Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, People’s Republic of China; 2Department of Radiotherapy, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical Universisty, Fuzhou, Fujian, 350212, People’s Republic of China; 3Department of Oncology, Laiyang Central Hospital of Yantai, Yantai, 265200, People’s Republic of China; 4Key Laboratory of Radiation Biology of Fujian Higher Education Institutions, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Li Su; Jinsheng Hong, Department of Radiotherapy, Cancer Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, People’s Republic of China, Email lily2230@126.com; 13799375732@163.comPurpose: To investigate the impact of Intensity-Modulated Radiation Therapy (IMRT) and Volumetric Modulated Arc Therapy (VMAT) on hippocampal radiation dosage and psychological status in patients newly diagnosed with nasopharyngeal carcinoma (NPC).Patients and Methods: A retrospective analysis was conducted on 269 NPC patients who received initial treatment between January 2013 and April 2022. …”
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Phytosomes Loaded with Mastoparan-M Represent a Novel Strategy for Breast Cancer Treatment by Zhao H, Bao S, Chen S, Yang Q, Lou K, Gai Y, Lin J, Liu C, Liu H, Zhang C, Yang R

“…Furthermore, we investigated the underlying anti-tumor mechanisms of Mast-M.Methods: The synthesis of Phy-Mast-M involved a co-solvent technique, followed by solvent evaporation. …”
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Age, Sex, and Symptom-Dependent Variations in Total IgE and Eosinophils in Atopic Patients: A Five-Year Retrospective Study by Zhao L, Wu Y, Zhu H, Lin Y, Su H, Hu J, Zhang M, Bao W

“…Age, sex and allergic symptoms may influence these biomarkers and the relationship among t-IgE, eosinophils, and atopic diseases remained unknown.Methods: A five-year retrospective study enrolled 7654 patients with allergic symptoms underwent allergen testing. …”
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Construction of a Prediction Model for Sleep Quality in Embryo Repeated Implantation Failure Patients Undergoing Assisted Reproductive Technology Based on Machine Learning: A Singl... by Zhao Y, Xu C, Qin N, Bai L, Wang X, Wang K

“…Yanjun Zhao,1,&amp;ast; Chenying Xu,1,&amp;ast; Ningxin Qin,2,&amp;ast; Lina Bai,1 Xuelu Wang,1 Ke Wang2 1Operating Room, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, People’s Republic of China; 2Reproductive Medicine Center, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Xuelu Wang, Email wangxuelu@51mch.com Ke Wang, Email wangkeyfy@126.comObjective: Constructing a predictive model for sleep quality in embryo Repeated Implantation Failure(RIF) patients using multiple machine learning algorithms, verifying its performance, and selecting the optimal model.Methods: Retrospective collection of clinical data from RIF patients who underwent assisted reproductive technology at the Reproductive Medicine Center of Tongji University Affiliated Obstetrics and Gynecology Hospital from January 2022 to June 2022, divided into a training set and a validation set in an 8:2 ratio. …”
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Anatomical Location of the Segmental Spinal Arteries in the Cervical Intervertebral Foramina: 3D-Micro CT Findings Relevant to Transforaminal Epidural Injection by Jun B, Yang HM, Shin DA, Jung HH, Cho TH, Kim SH

“…This study analyzed the precise anatomical location of the segmental spinal artery (SSA) within the cervical IVF using 3D micro-CT imaging to provide guidance for safer TFESI procedures.Participants and Methods: Fourteen embalmed cadavers were used in this study: three for serial sectional dissection, two for histological examination, and nine for micro-CT analysis. …”
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Comparison of Effects of Glucagon-Like Peptide-1 Receptor Agonists Compared to Long-Acting Insulin, Added to Oral Anti-Diabetic Agents on Self-Management Behaviors, Anxiety, and Sl... by Song X, Yang X, Liu Q, Bian X, Gao L, Tao J

“…Xiaoqing Song,1– 3,&ast; Xueke Yang,1– 4,&ast; Qinghua Liu,1– 4 Xuna Bian,1– 4 Lianlian Gao,1– 4 Jing Tao1– 4 1Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, People’s Republic of China; 2Hubei Clinical Medical Research Center for Endocrinology and Metabolic Diseases, Wuhan, Hubei Province, People’s Republic of China; 3Branch of National Clinical Research Center for Metabolic Disease, Wuhan, Hubei Province, People’s Republic of China; 4Department of Nursing, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Lianlian Gao; Jing Tao, Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Road, Wuhan, Hubei, 430030, People’s Republic of China, Email gll821991@163.com; tjskc@126.comAim: This study aimed to investigate the impact of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on individuals with type 2 diabetes (T2DM) by comparing self-management behaviors, anxiety, and sleep quality in T2DM patients.Methods: This is a single-center prospective study. …”
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EFFECT OF PERFLUORANE ON THE REGULATION OF SKIN BLOOD FLOW IN ACUTE BLOOD LOSS: EXPERIMENTAL STUDY by I. A. Ryzhkov, Yu. V. Zarzhetsky, I. S. Novoderzhkina

“…The LDF (ЛАКК-02 device, LAZMA, Russia) method was used to record blood flow in the microvessels of the internal surface of the right ear. …”
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