Effect of Vitamin D Level on Female Vaginitis in Xi’an, China by Guan J, Dong Y, Zhang W, Gui Q, Luo D, Wen H, Dang X, Liang D, Hu S, Zhang Y, Liao G, Zhang L, Lu Z

“…Therefore, this study focused on the therapeutic effects of vitamin D on vaginitis.Methods: The study provided a statistical description of 5978 vaginitis patients who visited Shaanxi Provincial People’s Hospital, presenting data in absolute numbers (%) and mean ± standard deviation (median quartiles were used for non-normally distributed variables). …”
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Artificial Intelligence Enabled Fully Automated CMR Function Quantification for Optimized Risk Stratification in Patients Undergoing Transcatheter Aortic Valve Replacement by Ruben Evertz, Torben Lange, Sören J. Backhaus, Alexander Schulz, Bo Eric Beuthner, Rodi Topci, Karl Toischer, Miriam Puls, Johannes T. Kowallick, Gerd Hasenfuß, Andreas Schuster

“…Fully automated biventricular volumetric assessments enable efficient and equal risk prediction compared to conventional manual approaches. …”
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Exploring the Validity of an Instrument That Measures Final Year Medical Students’ Career Choice Preferences by Guru A, Henning MA, Webster CS, Kool B, Wilkinson TJ, Bagg W

“…This study aimed to explore the validity of an instrument that measures the factors that influence Aotearoa New Zealand (NZ) medical students’ career choices.Methods: The Medical Schools Outcomes Database (MSOD) questionnaire containing 24 question items entitled “Factors Influencing Career Choice” (FICC) section was psychometrically analyzed. …”
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Transarterial Chemoembolization Plus Camrelizumab and Rivoceranib versus Camrelizumab and Rivoceranib Alone for BCLC Stage C Hepatocellular Carcinoma by Zhou WJ, Huang JT, Lu X, Hu D, Hong X, Wang FA, Lv PH, Zhu XL

“…Meanwhile, transarterial chemoembolization (TACE) is an effective method for the local control of the HCC. The study compared the clinical benefit and safety between TACE with camrelizumab-rivoceranib and camrelizumab-rivoceranib alone for Barcelona Clinic Liver Cancer (BCLC)-C HCC patients.Patients and Methods: This multi-center retrospective analysis included continuous BCLC-C HCC patients who received camrelizumab-rivoceranib with TACE and camrelizumab-rivoceranib alone from January 2020 to December 2022. …”
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Clinical Features, Outcomes, and Antifungal Susceptibility Profiles of Invasive Candida Infections in a Tertiary Care Hospital in China by Yao D, Chen J, Zhang G

“…Dongting Yao,1,2,* Jia Chen,3,* Guanyi Zhang3 1Department of Laboratory Medicine, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, People’s Republic of China; 2Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, 200030, People’s Republic of China; 3Department of Laboratory Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200030, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guanyi Zhang, Department of Laboratory Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200030, People’s Republic of China, Tel/Fax +86-021-64385700, Email zhangguanyi1233@163.com Dongting Yao, Department of Laboratory Medicine, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, People’s Republic of China, Tel/Fax +86-021-64070434, Email yaodongting@126.comPurpose: Given the increasing incidence of invasive Candida infection worldwide, particularly among immunocompromised and critically ill patients, we aimed to assess the distribution of Candida species as well as their clinical features and responses to common antifungal agents through a retrospective analysis of patient data in a Chinese traditional medicine hospital.Patients and Methods: In this retrospective single-center study, we analyzed data from 301 patients with invasive Candida infection at our hospital between 2020 and 2022, We report the clinical characteristics, species distribution, and in-vitro susceptibility profiles of Candida isolates to eight antifungal agents. …”
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Procyanidin Improves Erectile Function in Rats by Inhibiting PDE5A Activity by Su Y, Shui J, Qi D, Bai J, Xu X, Huang Y, Li R, Wu Q, Wang H, Cao C, Su Z, Zhang S

“…This study aims to validate the efficacy of procyanidin as a treatment for ED.Methods: The binding affinity of procyanidin for PDE5A was assessed by molecular docking, molecular dynamics (MD) simulations, and microscale thermophoresis (MST) assay. …”
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Identification and Validation of circDOCK1/miR-138-5p/GRB7 Axis for Promoting Breast Cancer Progression by Zhang Y, Yang M, Wang Y, Zhao J, Lee PY, Ma Y, Qu S

“…This study aims to explore novel circular RNAs and their mechanisms of biological function in breast cancer.Methods: Six HER2-positive breast cancer tissues and paired normal tissues were obtained for the whole transcriptome RNA sequencing. …”
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Etiological Factors and Development of a Predictive Model for Urinary Tract Infections in Cervical Cancer Patients Undergoing Intensity-Modulated Radiotherapy by Yao Y, Tao L, Ma L, Fan Y, Zheng D, Wang J, Chen W

“…Furthermore, to explore the risk factors and predictive factors associated with urinary tract infections, and to establish a personalized risk prediction model.Methods: A retrospective study analyzed 160 cervical cancer patients undergoing intensity-modulated radiotherapy at the People’s Hospital of Ningxia Hui Autonomous Region from 2020 to 2023. …”
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Association Between Serum Uric Acid to High-Density Lipoprotein Cholesterol Ratio and Pneumonia After Endovascular Treatment of Vertebrobasilar Artery Occlusion by Lan W, Yuan K, Xiao L, Qiu F, Sun W, Xu L, Cao H, Zhu W, Du M, Liu X

“…We aimed to explore the association of UHR with pneumonia after endovascular thrombectomy (EVT) in patients with vertebrobasilar artery occlusion (VBAO).Methods: We retrospectively enrolled participants diagnosed with acute VBAO treated with EVT within 24 hours of estimated occlusion time from the multicenter PERSIST study. …”
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Identifying cross-tissue molecular targets of lung function by multi-omics integration analysis from DNA methylation and gene expression of diverse human tissues by Shisheng Peng, Jinlong Fang, Weiliang Mo, Guodong Hu, Senquan Wu

“…Results Eight genes from blood tissue were prioritized as FEV1 causal genes using multi-omics SMR analysis and COLOC colocalization analysis: EML3, UBXN2A, ROM1, ZBTB38, RASGRP3, FAIM, PABPC4, and SNIP1. Equally, five genes (CD46, EML3, UBXN2A, ZBTB38, and LMCD1) were prioritized as FVC causal genes and one gene (LMCD1) was prioritized as FEV1/FVC causal genes. …”
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Efficacy and Safety of Transcatheter Arterial Chemoembolization Combined with Lenvatinib Plus Anti-PD-1 Inhibitors for Hepatocellular Carcinoma Patients with Extrahepatic Metastase... by Liu DY, Li YN, Wu JY, Zeng ZX, Fu YK, Li H, Ou XY, Zhang ZB, Wang SJ, Wu JY, Yan ML

“…In this study, we aimed to determine the efficacy and safety of triple therapy in HCC patients with EM.Patients and Methods: This study retrospectively reviewed HCC patients with EM who received triple therapy and analyzed their survival rate using the Kaplan–Meier method. …”
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Ciprofol Ameliorates Myocardial Ischemia/Reperfusion Injury by Inhibiting Ferroptosis Through Upregulating HIF-1α by Ding J, Wang BY, Yang YF, Kuai LY, Wan JJ, Zhang M, Xia HY, Wang Y, Zheng Z, Meng XW, Peng K, Ji FH

“…Herein, we assessed the effects of ciprofol on ferroptosis during myocardial I/R injury.Methods: Experimental models of myocardial I/R injury in mice (ischemia for 30 min and reperfusion for 24 h) and hypoxia/reoxygenation (H/R) injury in H9c2 cardiomyocytes (hypoxia for 6 h followed by 6 h of reoxygenation) were established. …”
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Mendelian Randomization Analysis Identifies Causal Effects of Multi-Site Chronic Pain on Obstructive Sleep Apnea by Wang Z, Chen L, Kang R, Li Z, Fan J, Peng Y, He Y, Zhao X

“…Zuxing Wang,1,* Lili Chen,1,* Ruishi Kang,2,* Zhuowei Li,2 Jiangang Fan,2 Yi Peng,3,* Yunqi He,4,5 Xiaolong Zhao2 1Sichuan Provincial Center for Mental Health, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Key Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences, Chengdu, 610072, People’s Republic of China; 2Department of Otolaryngology Head and Neck Surgery, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, People’s Republic of China; 3Department of Otorhinolaryngology Head and Neck Surgery, Second People’s Hospital of Chengdu, Chengdu, 610000, People’s Republic of China; 4Sichuan Provincial Key Laboratory for Human Disease Gene Study, Center for Medical Genetics and Department of Laboratory Medicine, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, People’s Republic of China; 5Research Unit for Blindness Prevention, Chinese Academy of Medical Sciences (2019RU026), Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu, Sichuan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaolong Zhao, Email sczhaoxiaolong@163.com Yunqi He, Email yunqihe223@163.comBackground: Observational studies have suggested an association between obstructive sleep apnea (OSA) and chronic pain disorders, but causal evidence have not been confirmed.Methods: Here we performed Mendelian randomization (MR) study to explore the potential causal association and mediating roles of modifiable factors between multi-site chronic pain (MCP) and OSA. …”
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Serum Lipid Biomarkers for the Diagnosis and Monitoring of Neuromyelitis Optica Spectrum Disorder: Towards Improved Clinical Management by Li R, Wang J, Wang J, Xie W, Song P, Zhang J, Xu Y, Tian D, Wu L, Wang C

“…This study aimed to identify serum lipid biomarkers for the diagnosis and monitoring of NMOSD and to assess their potential to improve clinical decision-making.Methods: We conducted a comprehensive serum proteomic analysis in a discovery cohort of NMOSD patients and controls to identify lipid-related proteins associated with NMOSD. …”
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Identification of Anoikis-Related Genes in Chronic Kidney Disease Based on Bioinformatics Analysis Combined with Experimental Validation by Liu H, Mei M, Zhong H, Lin S, Luo J, Huang S, Zhou J

“…We aimed to establish the Anoikis-related gene signature in CKD by bioinformatics analysis.Methods: We retrieved 3 datasets from the Gene Expression Omnibus (GEO) database to obtain differentially expressed genes (DEGs), followed by Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, Gene Set Enrichment Analysis (GSEA) and Gene Set Variation Analysis (GSVA) of them, which were intersected with Anoikis-related genes (ARGs) to derive Anoikis-related differentially expressed genes (ARDEGs). …”
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Irisin Mitigates Doxorubicin-Induced Cardiotoxicity by Reducing Oxidative Stress and Inflammation via Modulation of the PERK-eIF2α-ATF4 Pathway by Zhang Z, Yu X, Li J, Shen X, Fu W, Liu Y, Dong X, Wang Z

“…This study investigates the potential cardioprotective function of irisin in reducing the cardiac injury induced by DOX.Methods: In vitro, H9c2 cells were pretreated with irisin (20 nM) for 24 hours before exposure to DOX (1 μM). …”
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University Students’ Knowledge, Attitudes, and Practices Regarding Cervical Spine Health by Liu Y, Wang H, Liu H, Li L

“…This study investigated their knowledge, attitudes, and practices (KAP) concerning cervical spine health.Methods: From May 25 to June 16, 2023, a cross-sectional survey was conducted among students at various Chinese universities. …”
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Retrospective Analysis of Gut Microbiota and Metabolomic Profiles in Pregnant Women: Association with Cesarean Section Risk by Yuan J, Wang Y, Liu L

“…This study aimed to investigate gestation-specific alterations in gut microbiota and serum metabolomes and evaluate their association with CS risk.Methods: We conducted a retrospective analysis of 80 healthy pregnant women with singleton pregnancies who delivered at our hospital between January 2022 and December 2023. …”
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Comparison of the effect of Tabata training on soft and hard surfaces on left ventricular structure and function and some physical fitness factors in elite beach soccer players by Hamed Mohamadi Bazneshin, Arsalan Damirchi, Hamid Arazi

“…Thus, the aim of the present study was to compare the effect of six weeks of Tabata training on indoor hardcourt vs. sand on some physical fitness factors and the structure and function of the left ventricle in elite beach soccer players.Materials and Methods: Sixteen players from one of the Iran Premier Beach Soccer League teams were randomly divided into two equal groups including the sand group and the indoor group. …”
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Predictive Value of Advanced Lung Cancer Inflammation Index and Development of a Nomogram for Prognosis in Patients with Cervical Cancer Treated with Radiotherapy by Yu Q, Sun Y, Zhang S, Xu X, Pi G, Jin X

“…Overall survival (OS) and progression-free survival (PFS) were evaluated using the Kaplan–Meier method and Cox proportional hazards models. A nomogram was developed using prognostic factors based on multivariate analyses.Results: A total of 178 patients with cervical cancer were included. …”
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