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24861
Effect of Telemonitoring on Moderate and Severe Exacerbations in Patients with COPD: Pooled Analysis of Two Randomized Controlled Trials in Denmark
Published 2025-07-01“…Patients were equally randomized to telemonitoring (N=251) in addition to usual care for six months or usual care alone (N=252). …”
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24862
Medical Hemorrhoid Gel Ameliorates Croton Oil-Induced Hemorrhoids by Suppressing the NLRP3 Inflammasome Activation via NF-κB Signaling Pathway
Published 2025-08-01“…This study aims to systematically evaluate the safety, efficacy, and mechanism of action of MHG in treating HD.Methods: The phytochemical composition of MHG was characterized using UPLC-QTOF-MS/MS and GC-MS/MS analyses. …”
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24863
Single-Cell Sequencing Combined with Transcriptome Sequencing to Explore the Molecular Mechanisms Related to Skin Photoaging
Published 2024-12-01“…However, the specific mechanism of skin photoaging is not yet completely elucidated.Methods: Gene expression profiles for photoaging patients were obtained from the Gene Expression Omnibus (GEO) collection. …”
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24864
Multi-Omics Analysis Identifies Immune Regulatory Networks in Sepsis-Associated Liver Injury: Experimental Validation and Clinical Relevance
Published 2025-08-01“…This study aimed to identify key immune-related genes (IRGs) driving T cell-mediated responses in SILI and evaluate their diagnostic potential.Methods: Cecal ligation and puncture (CLP) was performed to establish a murine sepsis model (n=7/group), with sham-operated controls. …”
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24865
A Novel Inflammation-Marker-Based Prognostic Model for Advanced Pulmonary Lymphoepithelioma-Like Carcinoma
Published 2025-02-01“…Xueyuan Chen,1,* Tingting Liu,1,* Silang Mo,1,* Yuwen Yang,1 Xiang Chen,1 Shaodong Hong,1 Ting Zhou,1 Gang Chen,1 Yaxiong Zhang,1 Yuxiang Ma,2 Yuanzheng Ma,1 Li Zhang,1 Yuanyuan Zhao1 1Medical Oncology Department, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 2Department of Clinical Research, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People’s Republic of China*These authors contributed equally to this workCorrespondence: Li Zhang; Yuanyuan Zhao, Sun Yat-sen University Cancer Center, 651 Dong Feng Road East, Guangzhou, 510060, People’s Republic of China, Email zhangli@sysucc.org.cn; zhaoyy@sysucc.org.cnPurpose: This study aimed to investigate the prognostic value of inflammation markers for advanced pulmonary lymphoepithelioma-like carcinoma (PLELC) and develop an effective prognostic model based on inflammation markers to predict the overall survival (OS) of this population.Methods: Cox regression analysis was performed on 18 clinical and inflammation features, and a nomogram was created to predict overall survival (OS). …”
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24866
Left atrial strain in assessing heart failure with preserved ejection fraction in hypertensive patients
Published 2022-09-01“…Further, 172 patients with confirmed or excluded HFpEF were randomly divided into two equal cohorts. In the training cohort, HFpEF was diagnosed in 44 (51,2%) patients, in the validation cohort — in 50 (58,1%). …”
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24867
Longitudinal Changes in Peripheral and Alveolar Monocyte and Inflammatory Biomarkers are Distinct in Hypercapnia Patients Following Pulmonary Sepsis-Induced ARDS
Published 2025-04-01“…Our study was designed to compare initial values and longitudinal changes in cellular composition and inflammatory biomarkers between pneumonia sepsis-induced ARDS patients without hypercapnia and hypercapnia patients.Methods: Between Dec 2022-Apr 2023, we prospectively studied 61 severe pneumonia patients. …”
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24868
Exploring the Mechanisms of Lijin Fang on Treg/Th17 Cell Imbalance in COPD Based on Network Pharmacology
Published 2025-07-01“…This study explores the therapeutic potential of the traditional Chinese medicine(TCM) formula, Lijin Fang (LJF), focusing on its ability to restore Treg/Th17 balance.Methods: We employed bioinformatics and in vitro cell experiments to analyze the active components and targets of LJF. …”
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24869
Development and validation of the health belief model scale for early childhood caries prevention behaviors of parents
Published 2025-07-01“…Specifically, the scale targeted parents with young children. Methods The initial item pool was set up by adapting existing HBM scales to assess parents’ health beliefs regarding their children’s ECC under six HBM domains and then underwent face and content validation. …”
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24870
Research kinetics of the monochloroacetic acid esterification
Published 2020-05-01“…Reaction rate constants were evaluated using a second-order kinetic model following the graphical method, which uses the slope of the best-fit line. …”
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24871
Association Between Systemic Immune-Inflammatory Indices and Severity of Coronary Artery Lesions in Patients With Coronary Artery Disease in Different Glucose Metabolic States
Published 2025-03-01“…However, the relationship between SII and the severity of coronary artery lesions in participants with coronary artery disease (CAD) in different glucose metabolic states has not been fully elucidated.Methods: A total of 2727 patients with CAD were enrolled between January 2018 and April 2022. …”
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24872
Predictive Value of Albumin to Fibrinogen Ratio and CALLY Index for Diagnosis of Ulcerative Colitis and Mucosal Healing After Vedolizumab Treatment
Published 2025-01-01“…The aim of this study was to evaluate the clinical significance of AFR and CALLY index in UC.Methods: The study included 109 UC patients and 126 healthy controls. …”
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24873
Associations Between Psychological Stress and the Risk of First Onset of Major Depression Disorder: Results from a Longitudinal Study in 6,985 Chinese First-Year Students
Published 2024-10-01“…This study aimed to estimate the effect of psychological stress on the risk of first onset MDD in a sample of Chinese freshmen.Methods: Using a longitudinal design, 8079 Chinese first-year students were recruited at baseline, and 6985 were followed up one year later. …”
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24874
Functional Liver Imaging Score to Predict Clinically Significant PHLF for Hepatocellular Carcinoma After Resection
Published 2025-07-01“…Xihua Zheng,* Yumin Zhang,* Huiying Huang, Ningbin Luo Departments of Radiology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ningbin Luo, Departments of Radiology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China, Fax +860734-5312000, Email luoningbin2012@hotmail.comPurpose: To develop a model based on Functional Liver Imaging Score (FLIS) to estimate the risk of clinically significant post-hepatectomy liver failure (PHLF) for hepatocellular carcinoma (HCC) after resection.Patients and Methods: This retrospective study analyzed 885 patients with HCC who undergoing liver resection at our medical center between January 2017 and December 2021. …”
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24875
Association of Metabolic Score for Visceral Fat (METS-VF) with Gout Risk in Patients with Hypertension and Hyperuricemia: A Multicenter Study Based on the Chinese Population
Published 2025-03-01“…Visceral adipose tissue (VAT) plays a crucial role in cardiometabolic diseases, and the metabolic score for visceral fat (METS-VF) is a non-invasive tool for estimating VAT and predicting cardiometabolic risk.Methods: We conducted a multicenter cross-sectional study involving 8877 patients with hypertension and hyperuricemia from three Chinese medical centers between March 2021 and September 2024. …”
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24876
Associations Between Postoperative Symptom Clusters and Functional Status in Lung Cancer Patients: A Cross-Sectional Study
Published 2025-06-01“…Yali Liu,1,* Siya Lin,2,* Meirong Bai,1 Huochun Yi3 1Department of Thoracic Surgery, Zhongshan Hospital Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, 361004, People’s Republic of China; 2School of Nursing, Fujian Medical University, Fuzhou, Fujian, 350122, People’s Republic of China; 3Center of Clinical Laboratory, Zhongshan Hospital Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, 361004, People’s Republic of China*These authors contributed equally to this workCorrespondence: Meirong Bai, Department of Thoracic Surgery, Zhongshan Hospital Xiamen University, School of Medicine, Xiamen University, 201 hubin South Road, Siming District, Xiamen, Fujian, 361004, People’s Republic of China, Email 157576198@qq.com Huochun Yi, Center of Clinical Laboratory, Zhongshan Hospital Xiamen University, School of Medicine, Xiamen University, 201 hubin South Road, Siming District, Xiamen, Fujian, 361004, People’s Republic of China, Email yhc1818@163.comBackground: Symptom clusters in cancer symptom management research, providing a scientific basis for developing effective strategies for symptom assessment and intervention aimed at improving patient quality of life and survival.Objective: To analyze symptom clusters in postoperative lung cancer patients, examine its influenced factor, and explore the relationship between postoperative symptom clusters and functional status in lung cancer patients.Methods: Between August 2023 and February 2024, 441 lung cancer patients who underwent surgical treatment in the Department of Thoracic Surgery at a tertiary hospital in Xiamen were selected. …”
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24877
Construire des ressources relationnelles pour franchir des frontières multiples : Trajectoires de jeunes Tunisiens
Published 2023-07-01“…This information was then analysed using methods relating to the analysis of social relations, in particular the so-called “name generator” protocol. …”
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24878
Bioinformatics and Network Pharmacology Identify the Therapeutic Role of Guominkang in Allergic Asthma by Inhibiting PI3K/Akt Signaling
Published 2025-02-01“…The aim of this study was to explored the mechanism of action through which GMK combats AA.Methods: Potential target genes for the compounds were identified from the database and subjected to functional enrichment analysis. …”
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24879
Treatment of Psoriasis with II-17 Inhibitors: Comparison of Long-Term Effectiveness and Drug Survival of Secukinumab vs Ixekizumab in Real-World Practice
Published 2025-03-01“…The study aimed to compare the characteristics of patients treated with secukinumab or ixekizumab and in addition to analyze associated factors and independent predictors of drug survival in a real-world setting.Methods: This study was designed as a single-center retrospective study. …”
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24880
A Nomogram Based on Tumor Response to Induction Chemotherapy and Plasma Epstein–Barr Virus DNA Level after Induction Chemotherapy to Explore Individualized Treatment of...
Published 2025-03-01“…A nomogram was subsequently constructed to explore the individualized optimal cumulative cisplatin dose (CCD) in concurrent chemoradiotherapy (CCRT).Methods: A total of 581 LA-NPC patients were included, randomly divided into training and validation cohorts in a 7:3 ratio. …”
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