Real world treatment patterns for recurrent and metastatic head and neck cancer in the post-KEYNOTE 048 era by Daniel Y. Lee, Alexander Pan, Maxim Yaskolko, Michael Chiorazzi, Aarti Bhatia, Barbara Burtness, Jeffrey J. Ishizuka, Jeffrey J. Ishizuka, Jeffrey J. Ishizuka

“…BackgroundWhile KEYNOTE-048 established anti-PD1 with or without chemotherapy as first-line treatment for recurrent and metastatic head and neck squamous cell carcinoma (HNSCC) with combined positive score (CPS) ≥ 1, treatment choice remains ambiguous given additional toxicity of combination treatment.MethodsPatients treated first-line with anti-PD1 monotherapy, anti-PD1+chemotherapy, or cetuximab+chemotherapy in the Flatiron Health database were included. …”
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Causes and MEchanisms foR non-atopic Asthma in Children (CAMERA) study: rationale and protocol by Mary Njoroge, Gabriela Pimentel Pinheiro, Cinthia Vila Nova Santana, Hajar Ali, Stephanie Hobbs, Santiago Mena-Bucheli, Natalia Romero-Sandoval, Steven Robertson, Charlotte E. Rutter, Donna Davoren, Collin Brooks, Jeroen Douwes, Philip J. Cooper, Harriet Mpairwe, Camila A. Figueiredo, Alvaro A. Cruz, Mauricio L. Barreto, Neil Pearce, Lucy Pembrey, the CAMERA study group

“…The focus of this paper is the protocol for sample collection and analysis of clinical data on possible non-atopic mechanisms. Methods In each of the four centres, the CAMERA study will enroll 160 participants aged 10–28 years, equally distributed among atopic asthmatics (AA), non-atopic asthmatics (NAA), atopic non-asthmatics and non-atopic non-asthmatics. …”
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The necessity of thyroid-stimulating hormone suppression therapy for low-risk differentiated thyroid carcinoma following hemithyroidectomy: A systematic review and meta-analysis by Xinyu Wang, Yuqian Ye, Mizaniya Amdulla, Chenglong Ren, Yunhe Liu, Song Ni

“…In both average follow-up period less than 6 years group (P = 0.85) and more than or equal to 6 years group (P = 0.07), postoperative TSH suppression therapy did not affect the recurrence of DTC after hemithyroidectomy. …”
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Transurethral prostate surgery in prostate cancer patients: A population-based comparative analysis of complication and mortality rates by Michele Marchioni, Giulia Primiceri, Alessandro Veccia, Marta Di Nicola, Umberto Carbonara, Fabio Crocerossa, Ugo Falagario, Ambra Rizzoli, Riccardo Autorino, Luigi Schips

“…Moreover, similar rates of perioperative mortality (p=0.255), major acute cardiovascular events (p=0.581), transfusions (p=0.933), and length of stay of more than or equal to 30 days (p=0.174) were found. Additionally, all tests failed to show an interaction between post-operative diagnosis and surgical technique used. …”
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Examining the independent and moderating effects of arterial stiffness and cerebral blood flow on total hippocampal and hippocampal subfield volumes by Michelle Horan, Michelle Horan, Daniel Carey, Daniel Carey, Silvin Knight, Silvin Knight, A. Fagan, James F. M. Meaney, James F. M. Meaney, Rose Anne Kenny, Rose Anne Kenny, Rose Anne Kenny, Céline De Looze, Céline De Looze

“…However, in combination, persistently elevated AS and reduced CBF is associated with smaller HV. These effects were equally exerted across all hippocampal subfields tested. …”
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Prevalence of airway hyperresponsiveness and its seasonal variation in children with asthma by Shu-Jung Huang, Li-Lun Lin, Li-Chen Chen, Liang-Shiou Ou, Tsung-Chieh Yao, Kuo-Chien Tsao, Kuo-Wei Yeh, Jing-Long Huang

“…However, these studies have mostly been conducted in temperate regions.This study evaluated the prevalence of AHR to methacholine and its seasonal variation in asthmatic children in Taiwan, a subtropical country. Methods: A total of 276 children with asthma and their MCCT results were retrospectively reviewed. …”
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Proteomics analysis reveals the mechanism of anemoside B4 in treating clinical mastitis in dairy cows by Zeru Zhang, Yuquan Zhao, Zhetong Su, Ke Dong, Zhicai Zuo, Yixin Huang, Shumin Yu, Suizhong Cao, Liuhong Shen

“…This study was based on Label free relative quantitative proteomics technology to reveal the internal mechanism of AB4 treatment of CM; (2) Methods: Twelve healthy Chinese Holstein cows (group C) and twelve Chinese Holstein cows (group T) with CM were selected. …”
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Evaluating the Reliability of Anatomic Landmarks in Safe Lumbar Puncture Using Magnetic Resonance Imaging: Does Sex Matter? by Maryam Rahmani, Seyed Mehran Vaziri Bozorg, Ahmad Reza Ghasemi Esfe, Afsaneh Morteza, Omid Khalilzadeh, Elham Pedarzadeh, Madjid Shakiba

“…Each vertebra was divided into 3 equal segments (upper, middle, and lower), and intervertebral disc space was also assumed as one segment. …”
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Clinical and epidemiological characteristics of imported intestinal infections in children by E. Yu. Pylaeva, N. N. Zverevа, А. А. Erovichenkov, S. K. Pylaeva, E. A. Artamonova, N. Yu. Pshenichnaya, A. M. Demkina, O. N. Solodovnikova, Yu. N. Khlypovka, A. Yu. Dyagileva, A. Kh. Nurpeysova, A. U. Berestovskaia, O. V. Shamsheva, D. N. Protsenko

“…In the case of traveling abroad, the prevailing purpose was tourism, with equal proportions staying in a hotel or private sector. …”
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Acute safety, cardiovascular, perceptual and neuromuscular responses to autoregulated and non-autoregulated blood flow restriction training during elbow rehabilitation in people wi... by Daniel C. Ogrezeanu, Andrea Tur-Boned, Nicholas Rolnick, Nicholas Rolnick, Juan J. Carrasco, Juan J. Carrasco, Carlos Cruz-Montecinos, Carlos Cruz-Montecinos, Joaquín Calatayud, Santiago Bonanad, Sofía Pérez-Alenda

“…No adverse events were observed.ConclusionsBFR at 50%LOP during arm exercise with either AUTO or NAUTO appears to be equally safe in PWH, but AUTO showed trends for improved cardiovascular and neuromuscular responses. …”
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Humanising processes after harm part 2: compounded harm experienced by patients and their families after safety incidents by Lauren Ramsey, Joanne Hughes, Debra Hazeldine, Sarah Seddon, Mary Gould, Jo Wailling, Jenni Murray, Siobhan McHugh, Ruth Simms-Ellis, Ruth Simms-Ellis, Daisy Halligan, Katherine Ludwin, Jane K. O’Hara

“…However, the latter, termed ‘compounded harm’ is rarely acknowledged.AimsWe aimed to explore the ways compounded harm is experienced by patients and their families as a result of organisational responses to safety incidents and propose how this may be reduced in practice.MethodsWe used framework analysis to qualitatively explore data derived from interviews with 42 people with lived or professional experience of safety incident responses. …”
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Development and the need for implementation of a health-related quality of life measurement strategy for patients with soft tissue sarcoma undergoing preoperative radiotherapy by Geraldien Florine Foppele, Lisette M. Wiltink, Marta Fiocco, Jules Lansu, Astrid N. Scholten, Winan J. van Houdt, Yvonne Schrage, Winette T.A. van der Graaf, Rick L.M. Haas, Olga Husson

“…Patients and methods: To address this gap, a sarcoma-specific tool was developed complementing the most used cancer-generic EORTC QLQ-C30 questionnaire, with additional items tailored to the specific challenges of radiotherapy and surgery in sarcoma patients. …”
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Evaluation of GFAP/UCH-L1 biomarkers for computed tomography exclusion in mild traumatic brain injury (mTBI) by Jacopo M. Legramante, Marilena Minieri, Marzia Belli, Alfredo Giovannelli, Alessia Agnoli, Daniela Bajo, Lorenza Bellincampi, Anna Maria De Angelis, Alessandro Terrinoni, Massimo Pieri, Eleonora Nicolai, Vito N. Di Lecce, Carla Paganelli, Gianluigi Ferrazza, Susanna Longo, Marco Ciotti, Sergio Bernardini

“…Combined biomarkers had a sensitivity equal to 1.00 (95% CI 0.64-1.00) and a negative predictive value (NPV) of 1.00 (0.99-1.00) in mTBI diagnosis with a negative CT. …”
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Real-World Validity of Tissue-Agnostic Circulating Tumor DNA Response Monitoring in Lung Cancers Treated With Chemotherapy, Immunotherapy, or Targeted Agents by Anne C. Chiang, MD, PhD, Russell W. Madison, MS, Zoe June Assaf, PhD, Alexander Fine, PhD, Yi Cao, PhD, Ole Gjoerup, PhD, Yanmei Huang, PhD, Dexter X. Jin, PhD, Jason Hughes, PhD, Vladan Antic, MD, PhD, Amanda Young, PhD, David Fabrizio, MS, David Shames, PhD, Sophia Maund, PhD, Alexia Exarchos, MPH, Shailendra Lakhanpal, MD, Richard Zuniga, MD, Lincoln W. Pasquina, PhD, Katja Schulze, PhD

“…We evaluated the validity of tissue-agnostic ctDNA quantification across four treatment modalities in NSCLC and SCLC. Methods: Data from consenting patients were collected from electronic health records as part of the Prospective Clinico-Genomic study (NCT04180176). ctDNA tumor fraction (TF) was retrospectively calculated for plasma collected six to 15 weeks after therapy initiation. …”
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Association of Sociodemographic Factors With Overtriage, Undertriage, and Value of Care After Major Surgery by Tyler J. Loftus, MD, Matthew M. Ruppert, MS, Benjamin Shickel, PhD, Tezcan Ozrazgat-Baslanti, PhD, Jeremy A. Balch, MD, Kenneth L. Abbott, MD, Die Hu, MS, Adnan Javed, MD, Firas Madbak, MD, Faheem Guirgis, MD, David Skarupa, MD, Philip A. Efron, MD, Patrick J. Tighe, MD, William R. Hogan, MD, Parisa Rashidi, PhD, Gilbert R. Upchurch, Jr, MD, Azra Bihorac, MD

“…In a fair system, overtriage of low-acuity patients to intensive care units (ICUs) and undertriage of high-acuity patients to general wards would affect all sociodemographic subgroups equally. Methods:. This multicenter, longitudinal cohort study of hospital admissions immediately after major surgery compared hospital mortality and value of care (risk-adjusted mortality/total costs) across 4 cohorts: overtriage (N = 660), risk-matched overtriage controls admitted to general wards (N = 3077), undertriage (N = 2335), and risk-matched undertriage controls admitted to ICUs (N = 4774). …”
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Clinical and Genetic Features of Autosomal Recessive Bestrophinopathy: A Case Series from a Vietnamese Cohort by Trang Thi Thu Nguyen, Van Khanh Tran, Ngoc Lan Nguyen, Nguyen Van Huy, Thinh Huy Tran, Le Thi Phuong, Phan Long Nguyen, Thuy Thu Nguyen, Tran Thi Quynh Trang, Do Thanh Huong, Ngo Thi Thu Huong, Trong Van Pham, Quoc Tung Mai

“…The patients underwent a visual acuity assessment, retinal multimodal imaging, and molecular testing through <i>BEST1</i> gene sequencing. …”
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Accuracy of IOL power calculation in pediatric aphakia secondary implantation by Ying-Shi Zou, Jia-Xin Jin, Yun-Qian Li, Ling Jin, Jing-Min Xu, Wei-Ning Zhu, Hui Chen, Qiu-Xia Yin, Yi-Zhi Liu, Zhen-Zhen Liu

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Retinal Oxygen Kinetics and Hemodynamics in Choroidal Melanoma After Iodine‐125 Plaque Radiotherapy Using a Novel Structural‐Functional Imaging Analysis System by Haihan Zhang, Jingyuan Zhu, Yueming Liu, Shiyi Yin, Jinyuan Wang, Yao Yao, Haowen Li, Ximeng Feng, Chuanqing Zhou, Qiushi Ren, Wenbin Wei

“…Future research should focus on rapidly screening radiation microvascular complications and exploring more timely and effective interventions to protect visual function in CM patients.…”
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Complication rates after shoulder arthroplasty in patients aged 45 years and younger by Blake Hajek, BS, Jeff Klott, MD, Erick Marigi, MD, Brian Wahlig, MD, John Sperling, MD, Jeff Murphy, MS, Tyler J. Brolin, MD, Thomas W. Throckmorton, MD

“…Secondary outcomes included American Shoulder and Elbow Surgeons scores, visual analog scale pain scores, and range of motion (ROM). …”
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Impact of prior arthroscopic rotator cuff repair on postoperative outcomes of reverse shoulder arthroplasty: a comparative analysis of muscle strength recovery and clinical results by Yoshihiro Hirakawa, MD, PhD, Tomoya Manaka, MD, PhD, Katsumasa Nakazawa, MD, PhD, Yoichi Ito, MD, PhD, So Taniguchi, MD, Ayako Ogura, PT, Hidetomi Terai, MD, PhD

“…The key metrics assessed were range of motion, American Shoulder and Elbow Surgeons (ASES) score, Constant score (CS), visual analog scale score for pain, and muscle strength. …”
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