Study on the Mechanism of UMI-77 in the Treatment of Sepsis-Induced Acute Lung Injury Based on Transcriptomics and Metabolomics by Zhang J, Xia Z, Dong C, Zhu J, Ni H, Xu Y, Xu Y

“…Although UMI-77 has demonstrated efficacy in mitigating lung injury in sepsis, the molecular mechanisms underlying its action have not yet been fully elucidated.Methods: This study aimed to delineate the mechanism by which UMI-77 counteracts sepsis-induced ALI using comprehensive transcriptomic and metabolomic analyses.Results: UMI-77 significantly ameliorated histopathological changes in the lungs of mice with sepsis-induced ALI Transcriptomic analysis revealed that 124 differentially expressed genes were modulated by UMI-77 and were predominantly implicated in chemokine-mediated signaling pathways, apoptosis regulation, and inflammatory responses. …”
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Exploration of Key Brain Regions Involved in Acupuncture and Moxibustion Analgesia: An Imaging-Based Study by He L, Zhou R, Hou S, Huang D, Zhao X, Wang M, Huang M, Yin T, Yin H, Yu S

“…Advancements in neuroimaging techniques have opened a novel pathway for investigating alterations in brain function resulting from acupuncture and moxibustion analgesia.Purpose: The purpose of this study was to investigate the brain regions activated during acupuncture and moxibustion treatment for pathological pain using neuroimaging, to better understand the underlying analgesic mechanisms.Patients and Methods: An electronic search of PubMed was conducted using the keywords “acupuncture”, “moxibustion”, “analgesia”, and “neuroimaging”. …”
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Synthesis of Zinc Oxide-Doped Carbon Dots for Treatment of Triple-Negative Breast Cancer by Wang M, Lan S, Song M, Zhang R, Zhang W, Sun X, Liu G

“…Mengqi Wang,1,* Shuting Lan,2,* Mingjun Song,3 Rongrong Zhang,2 Wenqi Zhang,2 Xiaomei Sun,2 Gang Liu2 1College of Life Science and Oceanography, Weifang University, Weifang, Shandong, People’s Republic of China; 2Key Laboratory of Medical Cell Biology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, People’s Republic of China; 3College of Chemical Engineering and Environmental Chemistry, Weifang University, Weifang, Shandong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Mengqi Wang; Gang Liu, Email wangmengqi@tju.edu.cn; 20190043@immu.edu.cnIntroduction: The anti-cancer properties of zinc oxide-doped carbon dots (CDs/ZnO) in inhibiting triple-negative breast cancer (TNBC) progression merit more investigation.Methods: With citric acid as the carbon source, urea applied as the nitrogen source, and zinc oxide (ZnO) used as a reactive dopant, CDs/ZnO were synthesized by microwave heating in the current study, followed by the characterization and biocompatibility assessments. …”
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Biliary Microbial Community and Metabolic Potential in Patients with Multiple Common Bile Duct Stones by Xia T, Feng S, Zou Z, Zhou J, Cai X, Ye J, Dai C

“…In this study, we aimed to investigate the characteristics and metabolic potential of biliary microbiota in patients with multiple CBDS.Methods: Eligible patients were prospectively enrolled in this study at First Affiliated Hospital of Soochow University between December 2022 and October 2023. …”
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The role of bioimpedance status in the diagnosis of presarcopenia in elderly and elderly patients with type 2 diabetes mellitus by Ruslan N. Obyedkov, Evgeny I. Dedov, Irina G. Pshennikova

“…The threshold probability p-value at the cut-off point was 0.54. P-values equal to or greater than these values were consistent with predicting the presence of presarcopenia. …”
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The Prognostic Significance of the CALLY Index in Ampullary Carcinoma: An Inflammation-Nutrition Retrospective Analysis by Xi P, Huang G, Huang K, Qin D, Yao Z, Jiang L, Zhu Q, He C

“…This study aims to investigate the relationship between the CALLY index and the prognosis of patients with AC.Methods: We retrospectively analyzed data from 201 patients with AC at Sun Yat-sen University Cancer Center. …”
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Comparison of the Efficacy of Polyvinyl Alcohol Colorless Embolic Microspheres (8Spheres) and Gelatin Embolic Microspheres (Embosphere) in Uterine Artery Embolization for Symptomat... by Gao S, Li F, Song F, Zhang X, Wang Y, Wang J

“…Songkun Gao,1,* Fengshuang Li,1,* Fang Song,1 Xiaofeng Zhang,2 Yan Wang,1 Jiandong Wang1 1Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, 100026, People’s Republic of China; 2Department of Radiology,Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, 100026, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yan Wang, Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Qihelou Street, Dongcheng District, Beijing, 100006, People’s Republic of China, Email wwyy3196@ccmu.edu.cn Jiandong Wang, Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Qihelou Street, Dongcheng District, Beijing, 100006, People’s Republic of China, Email wangjiandongxy@ccmu.edu.cnObjective: To evaluate the differences in efficacy between polyvinyl alcohol colorless embolic microspheres (8Spheres®) and gelatin embolic microspheres (Embosphere®) in uterine artery embolization for symptomatic uterine fibroids.Methods: We included 259 patients from 12 hospitals who underwent uterine artery embolization for symptomatic uterine fibroids. …”
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A Graphene-Based Lipid Modulation Nanoplatform for Synergetic Lipid Starvation/Chemo/Photothermal Therapy of Oral Squamous Cell Carcinoma by Li R, Li Y, Song Z, Gu Y, Jiao X, Wan C, Liu T, Zhang R, Gao R, Wang X

“…In this study, we developed a graphene-based lipid modulation nanoplatform (NSD) that carries SB-204990, a small molecule inhibitor specific for ATP citrate lyase (ACLY), and doxorubicin (DOX), a chemotherapeutic agent, and the trio enables synergistic treatment of OSCC with lipid starvation, chemotherapy, and photothermal therapy.Methods: We first determined whether ACLY expression was upregulated in OSCC, and then assessed the growth inhibitory effects of SB-204990 on SCC-15 cells and changes in lipid (acetyl coenzyme A, free fatty acids, and cholesterol) levels. …”
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Trends and Dynamics of Respiratory Viruses in Hospitalized Children of Fuzhou: Insights Into the Impact of COVID-19 Pandemic Control Measures by Wu K, Huang H, Chen L, Wu Y

“…Kunhai Wu,1,* Huifang Huang,2,* Lufei Chen,1 Yanan Wu3 1Blood Transfusion Department, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 2Int Care Unit, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 3Department of Clinical Laboratory, Fujian Provincial Hospital, Fuzhou, Fujian, People’s Republic of China*These authors contributed equally to this workCorrespondence: Huifang Huang, Intensive Care Unit, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People’s Republic of China, Tel +8613906913057, Email 190596715@qq.comPurpose: This study aimed to investigate the prevalence of common respiratory viruses among children with acute respiratory infections in Fuzhou from 2017 to 2023, considering the varying Corona Virus Disease 2019 (COVID-19) epidemic control measures in place.Patients and Methods: This study retrospectively analyzed the detection of respiratory viruses in children diagnosed with acute respiratory infections at a tertiary hospital in Fuzhou during the study period. …”
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Thyroid Dysfunction After Intensity-Modulated Radiotherapy and PD⁃1 Inhibitor Treatment for Locally Advanced Nasopharyngeal Carcinoma by Shang K, He Q, Xu X, Luo X, Zhao C, Liu L, Li Z, Li Y, Jin F

“…Kai Shang,1,2,* Qianyong He,1– 3,* Xinyu Xu,2 Xunyan Luo,2 Chaofen Zhao,1,3 Lina Liu,1– 3 Zhuoling Li,1– 3 Yuanyuan Li,1– 3 Feng Jin1,3 1Department of Oncology, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, People’s Republic of China; 2School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, People’s Republic of China; 3Department of Oncology, the Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Feng Jin, Department of Oncology, the Affiliated Hospital of Guizhou Medical University, 28 Guiyi Street, Guiyang, Guizhou, 550004, People’s Republic of China, Tel +851-86512802, Email tjzlk2023@163.comPurpose: Analyze the incidence and risk factors of thyroid dysfunction in patients with advanced nasopharyngeal carcinoma (LA-NPC) after intensity-modulated radiotherapy (IMRT) and PD⁃1 inhibitor treatment and their relationship with treatment efficacy and prognosis.Methods: Eighty-five LA-NPC patients treated with IMRT and PD-1 inhibitors were retrospectively collected from March 1, 2019, to May 30, 2022. …”
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Kisspeptin-10: A Predictor for Fetal Growth Restriction among Preeclamptic Women that Discriminated Early Onset Cases by Manal Madany Abdalqader, Shatha Sami Hussein, Huda Fadhil Jadi, Wassan Nori

“…The current study aimed to examine Kisspeptin’s-10 role in predicting FGR in PE pregnancies and to verify whether it can predict its onset as early or late FGR. Methods: An observational case-control study enrolled 120 eligible cases at matched gestational age (28–40 weeks) and body mass index (BMI); they were divided into 2-groups: (60) healthy controls and (60) PE cases. …”
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Identification and Validation of Feature Genes Related to Mitochondrial Dysfunction and Oxidative Stress in Ulcerative Colitis by Wu Y, Tan Z, Lan Q, Liu Y, Liu C, He H, Zhang J, Dong W

“…Given their close association, it is crucial to clarify the molecular characteristics and biological functions of MD and OS-related genes in UC.Methods: Gene expression profiles, mitochondrial-related genes, and OS-related genes were obtained from the corresponding databases. …”
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Inequalities in early childhood care and development in low/middle-income countries: 2010–2018 by Kai Liu, Günther Fink, Bernadette Daelmans, Zhihui Li, Linda Richter, Chunling Lu, Jorge Cuartas, Dana McCoy

“…Improving and applying population-level measurements on ECD in more countries over time are important for ensuring equal opportunities for young children globally.…”
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Utilization of drug checking services in Austria: a cross-sectional online survey by Alexandra Karden, Tobias Fragner, Cornelia Feichtinger, Julian Strizek, Daragh T. McDermott, Igor Grabovac

“…In addition, reasons for not using these services are explored. Methods A secondary data analysis of the Austrian data from the European Web Survey on Drugs (EWSD), a targeted survey conducted between March and May 2021 was performed. …”
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Adaptation to Sodium Hypochlorite and Potassium Permanganate May Lead to Their Ineffectiveness Against <i>Candida albicans</i> by Tomasz M. Karpiński, Marzena Korbecka-Paczkowska, Marcin Ożarowski, Donald Włodkowic, Marzena Liliana Wyganowska, Agnieszka Seremak-Mrozikiewicz, Judyta Cielecka-Piontek

“…The MIC values for NaOCl and KMnO₄ were close to or equal to the clinical concentrations used in commercial products. …”
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The Effectiveness of Multisensory-Based Perceptual-Motor Exercises on Quality of Life and Daily Living Activities in Older Adults with Mild Cognitive Impairment: A Clinical Trial by Maryam Binesh, Jamil Eslami, Shima Shahrokhi, Hossein Mirzabeigi, Ensieh Naimi, Mina Sadat Mirshoja

“…Purposive and convenience sampling was used to select 30 older adults, who were then randomly and equally assigned to control and intervention groups. …”
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miR-424-5p Promotes Proliferation, Migration and Invasion of Colorectal Cancer Cells via the Targeting TXNIP/Hippo Axi by Zhang F, Zhu KL, Chen R, Su F

“…The study was designed to clarify the function of miR-424-5p and thioredoxin interacting protein (TXNIP) in the progression of CRC.Methods: The expression pattern of TXNIP and miR-424-5p was detected by immunohistochemistry, qRT-PCR and/or Western blotting. …”
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AXIOLOGEMES IN DEFENSE VS PROSECUTION ENGLISH COURT DISCOURSE by Margaryta O. Zaitseva

“…Mention should be made of the following methods that were used here to achieve the aim: linguistic observation and analysis, as well as cognitive method, critical discourse analysis method, pragmatic analysis method. …”
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Cluster-randomized trial of the implementation of the Responses to Illness Severity Quantification (RISQ) system in children with acute malnutrition 6 to 59 months of age in Ngouri... by Nancy M. Dale, Youssouf Djidita Hagre, Susan Shepherd, George Tomlinson, Stanley Zlotkin, Masra Ngaradoum, Mahmat Bechir, Marius Madjissem, Charles Tehoua, Christopher Parshuram

“…The objective of the CRIMSON study is to estimate the effect of implementation of the RISQ System on mortality and processes of care in a nutritional program. Methods A cluster randomized trial will compare the RISQ System to usual care. …”
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Prevalence of EGFR Mutations in Vietnamese Patients with Resected Early Stage Non-Small Cell Lung Cancer: EARLY-EGFR Study by Dao TV, Dinh VL, Doan TV, Phuong TL

“…Tu Van Dao,1,2,&ast; Van Luong Dinh,3,4,&ast; Thanh Vinh Doan,5 Tri Le Phuong6 1Cancer Research and Clinical Trials Center, Department of Optimal Therapy, Vietnam National Cancer Hospital, Hanoi, Vietnam; 2Oncology Department, Hanoi Medical University, Hanoi, Vietnam; 3Lung Transplant Center, National Lung Hospital, Hanoi, Vietnam; 4TB and Lung Diseases Department, Hanoi Medical University, Hanoi, Vietnam; 5Oncology Department, Pham Ngoc Thach Hospital, Ho Chi Minh City, Vietnam; 6Medical Affairs, AstraZeneca Vietnam, Ho Chi Minh City, Vietnam&ast;These authors contributed equally to this workCorrespondence: Tu Van Dao, Cancer Research and Clinical Trials Center, Department of Optimal Therapy, Vietnam National Cancer Hospital, Hanoi, Vietnam, Email daovantu@hmu.edu.vnIntroduction: Comprehensive profiling of mutations in the EGFR gene is vital for selecting patients eligible for EGFR targeted therapies.Methods: We investigated the prevalence of EGFR mutations and treatment patterns in patients with early stage non-small cell lung cancer (NSCLC) in Vietnam as a part of EARLY-EGFR (Clinical Trial Identifier: NCT04742192), a global, real-world study. …”
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