Therapeutic Mechanism of Zhuyang Tongbian Decoction in Treating Functional Constipation: Insights from a Pilot Study Utilizing 16S rRNA Sequencing, Metagenomics, and Metabolomics by Zhang X, Yin H, Yang X, Kang J, Sui N

“…Xuan Zhang,1,* Hang Yin,2,* Xu Yang,3,* Jie Kang,1 Nan Sui1,4 1Graduate School, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning Province, People’s Republic of China; 2Scientific Education Section, The Third Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning Province, People’s Republic of China; 3Department of Rehabilitation Medicine, General Hospital of Northern Theater Command, Shenyang, Liaoning Province, People’s Republic of China; 4Department of Anorectal Diseases, The Third Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Nan Sui, The Third Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, No. 35, Eleventh Wei Road, Shenyang, Liaoning, 110003, People’s Republic of China, Email suinan2226@163.comPurpose: To explore the mechanism of Zhuyang Tongbian Decoction (ZTD) in treating functional constipation (FC) by observing its effects on intestinal flora composition, the metabolic function of gut microbiota, fecal short-chain fatty acid (SCFA) levels, and serum concentrations of TLR4, NF-κB, TNF-α, and IL-6 in patients with FC.Patients and Methods: 40 patients with FC were randomly divided into the control group and the treatment group, 20 cases in each group. …”
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The Effect of The Training Program Using (Paper Marbling) Technique on The Ability to Draw and Achievement of Students in The Department of Art Education by Awaz Mirza Faraj, Sabir Bakr Mustafa

“…The study aims to find out the effect of the training program using the technique of drawing on the surface of the water (Paper Marbling) on the ability and skill of drawing and achievement in the subject of self-employment in drawing and comparing the results of the pre-test and post-test and proposing, the technique as a new method in addition to the common methods of introducing new patterns into the subject and lessons of drawing. …”
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Assessing Work–Life Balance in Malta and Italy: A Cross-Cultural Investigation Using Exploratory Structural Equation Modelling (ESEM) by Bottaro R, De Giovanni K, Faraci P

“…Thus, the present cross-cultural study aimed to provide new evidence about the dimensionality, validity, reliability, and cultural invariance of the Work-Life Balance Scale and its practical impact on employee well-being.Participants and Methods: A sample of 362 employees (50% Maltese; 50% Italian), with a mean age of 43.36 (SD = 11.51) completed the WLBS in an online survey from March to April 2023. …”
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Exploring the Therapeutic Mechanism of Jianpi Zhidong Decoction on Tourette Syndrome Based on Proteomics and Network Pharmacology by Zhang N, Zhang H, Guo J, Ma Y, Bai X, Ma N, Ji X, Meng Y, Li H, Sangwanit T, Shi Y, Zhao J, Li X, Lin J, Cui X

“…Ning Zhang,1,* Hongxian Zhang,1,* Jianning Guo,2 Yaluan Ma,3 Xue Bai,1 Ning Ma,1 Xiaoxiao Ji,1 Yanli Meng,1 Huifang Li,1 Tananan Sangwanit,1 Yixin Shi,1 Jing Zhao,1 Xiang Li,1 Jingyuan Lin,1 Xia Cui1 1Pediatric Department, Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing, People’s Republic of China; 2Pediatric Department, China-Japan Friendship Hospital, Beijing, People’s Republic of China; 3Laboratory of Molecular Biology, Institute of Basic Theory of Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xia Cui, Department of Pediatrics, Beijing University of Chinese Medicine Third Affiliated Hospital, No. 51 Xiaoguan Street, Andingmen Wai, Chaoyang District, Beijing, 100029, People’s Republic of China, Email cuixia68@163.comPurpose: To explore the pharmacological effects of Jianpi Zhidong Decoction (JPZDD) on Tourette Syndrome (TS) using proteomics and network pharmacology.Materials and Methods: Chemical components of JPZDD were identified via UPLC-MS/MS. …”
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Treatment of Proximal Humeral Fractures in Older Patients During COVID-19 Pandemic in Germany by Sußiek J, Koeppe J, Fischhuber K, Iking J, Marschall U, Raschke MJ, Katthagen JC, Stolberg-Stolberg J

“…Was a SARS-CoV-2 infection associated with a worse outcome?Methods: Retrospective claims data of the BARMER health insurance were analysed. …”
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Effects of immersive virtual therapy on psychological and physical wellbeing in women with breast cancer at different stages of disease and treatment conditions: an experimental co... by Oliver Czech, Rafal Matkowski, Rafal Matkowski, Jakub Skórniak, Iwona Malicka

“…Virtual Reality (VR) has shown promise as a supportive, non-pharmacological intervention by reducing anxiety, depression, pain and aiding physical rehabilitation in cancer care.ObjectiveThis study evaluated the impact of immersive VR therapy in improving the psychological and physical wellbeing of women with BC at different stages of treatment and compared outcomes across treatment groups.MethodsFifty-six women were recruited at the Lower Silesian Oncology, Pulmonology and Hematology Center in Wroclaw, Poland, and divided into four equal groups (n = 14) based on their treatment stage: recently diagnosed before treatment (diagnosis group), in the perioperative period (surgery group), undergoing radiotherapy (radiotherapy group), and post-treatment (healed group). …”
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Sodium Propionate Alleviates Atopic Dermatitis by Inhibiting Ferroptosis via Activation of LTBP2/FABP4 Signaling Pathway by Xie A, Li W, Ye D, Yin Y, Wang R, Wang M, Yu R

“…This study aims to explore whether SP alleviates AD by modulating ferroptosis-related pathways through bioinformatic and in vitro analyses.Methods: We analyzed the GEO AD cohort (GSE107361). …”
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FGF-2 enriched nanofiber scaffold for advancing achilles tendon healing: a comparative experimental investigation by Necmettin Turgut, Funda Cengiz Çallıoğlu, Aytül Bayraktar, Mehtap Savran, Halil Aşcı, Kanat Gülle, Meriç Ünal

“…This study aims to investigate the efficacy of FGF-2 in promoting tendon healing in a rat model of Achilles tendon rupture, providing insights into its potential as a therapeutic option.Materials and methodsForty-eight rat hind legs with complete Achilles tendon ruptures were divided into four equal groups: the Sham (S) group (tendon repair only), the Polymer (P) group (tendon repair with scaffold wrapping), the Produced FGF-2 (PF) group (scaffold coated with lab-produced FGF-2), and the Commercial FGF-2 (CF) group (scaffold coated with commercially sourced FGF-2). …”
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Effects of specific symbiotic supplements on anthropometric measurements, glycaemic control, and lipid profiles among individuals with type 2 diabetes mellitus in two teaching hosp... by Sarah Hayder Ali Zalzala, Ban Abdul-Ridha Salman Al-Hashimi, Zahraa Hayder Ali Zalzala, Khalid Saeed Fahad

“…This study aimed to investigate the effects of symbiotics on the anthropometric measures, glycaemic control, and lipid profiles of patients with T2DM. Methods A double-blind, placebo-controlled, parallel clinical trial was conducted at two diabetes outpatient clinics. …”
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Apoptotic Vesicles Attenuate Acute Lung Injury via CD73-Mediated Inhibition of Platelet Activation and NETosis by Tan L, Zhang C, Kou X, Zhao L, Wu D, Li J, Yu C, Xu T, Gao L, Mao X, Zhao C

“…In this study, our aim was to investigate the therapeutic effects and underlying mechanisms of apoVs in ALI.Methods: ALI was induced in mice through intratracheal instillation of lipopolysaccharide (LPS). …”
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Cholera in conflict: outbreak analysis and response lessons from Gadaref state, Sudan (2023–2024) by Ahmad Izzoddeen, Hafsa Abualgasim, Mazza Abasher, Hala Elnoor, Mustafa Magbol, Safaa Fadlelmoula, Ali Abolgassim, Alaa Hamed Dafaalla, Khalid Elgamry, Anwar Banaga, Babiker Magboul, Muntasir M. Osman, Elfadil Mahmoud

“…The mean age was 16.8 (SD, 15.8) with an equal gender distribution. The case fatality ratio was 2.4% and the overall attack (AR) rate was 7.38 cases per 10,000 population, with the highest in Medeinat Gadaref locality (21.07/10,000). …”
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Effect of a Narrative-Based Online Course Aimed at Reducing Stigma Toward Transgender Children and Adolescents: Longitudinal Observational Study by Merlin Greuel, Van Kinh Nguyen, Doron Amsalem, Maya Adam, Till Bärnighausen

“…ObjectiveThis study aims to evaluate the impact of an animated online course, rooted in authentic, personal narratives, on course participants’ stigma toward transgender youth. MethodsThe online course was offered free of charge on Coursera and contained 19 teaching videos (3-7 minutes each), intermittent practice quizzes, and discussion prompts. …”
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Hsa_circ_0078767 Enhances Osteosarcoma Chemoresistance to Doxorubicin Through the Regulation of the miR-188-3p/GPX4 Axis by Tang Y, He Y, Wu L

“…This analysis sought to examine hsa_circ_0078767 as a mediator of doxorubicin (DOX) resistance in OS.Methods: Levels of hsa_circ_0078767, miR-188-3p, and glutathione peroxidase 4 (GPX4) in OS clinical tissue samples and cell lines were evaluated by quantitative polymerase chain reaction (qPCR) and Western blotting. …”
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Evaluation of the Shear Bond Strength of Orthodontic Adhesive Incorporated with Titanium Dioxide Nanoparticle: An In-vitro Study by M Ashfaq Ahmed, S Sumalatha, N Narendran, G Dinesh Nandakumar, A Agasthiya

“…Study included 60 samples of extracted human maxillary first premolar teeth. The samples were equally divided into two groups. In group 1, brackets were bonded with conventional composite, and in group 2, brackets were bonded with TiO2 nanocomposite. …”
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A Mortality Risk Prediction Model for Septic Shock in Patients Aged ≥50: Role of Norepinephrine Index and Procalcitonin by Li XL, Mi T, Liu C, Feng M

“…This study aimed to develop and validate a predictive model using norepinephrine index (NEI)—a novel biomarker defined as the norepinephrine dose administered within the first 24 hours of ICU admission divided by BMI and 24 hours—and procalcitonin (PCT) to improve risk stratification and clinical decision-making.Methods: A retrospective cohort of 94 patients aged ≥ 50 years with septic shock was analyzed. …”
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Pregnancy in adolescence and adverse neonatal outcomes in Ecuadorian mestizo newborns by Fabricio González-Andrade, Xavier Saeteros-Cordero

“…Background: To establish the association between pregnancy in early and middle adolescence and adverse neonatal outcomes in Ecuadorian mestizo newborns. Methods: Study design: epidemiological, observational/descriptive, and cross-sectional. …”
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Hyaluronic Acid is Associated with Severity and Prognosis in Patients with Community-Acquired Pneumonia by Lin Y, Li Y, Cui X, Zhu N, Li X

“…This study investigated the association of HA with severity and prognosis in hospitalized patients with community-acquired pneumonia (CAP).Patients and Methods: We analyzed the differences of HA levels in different groups. …”
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Effects of Specific RAMP Protocol Phase on Change of Direction Speed of Police Students by Filip Kukić, Nemanja Zlojutro, Darko Paspalj, Senka Bajić, Saša Kovačević, Lazar Vulin, Nenad Rađević, Nenad Koropanovski

“…., tactical athletes). <b>Methods:</b> A longitudinal design with two experimental and one control group was employed. …”
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Characteristics of the microbiota in patients with various clinical phenotypes of occupational COPD and chronic bronchitis by Fedotov V.D., Zhestkov A.V., Lyamin A.V., Lavrenyuk N.А., Dobrotina I.S., Falaleeva E.A.

“…Antimicrobial susceptibility was determined by disk diffusion method. Results. The common characteristics of the microbiota in COPD patients with both phenotypes were: the predominance of the Firmicutes type, equal bacterial load (p = 0.48), the absence of protective commensals and microorganisms typical for COPD patients (Moraxella catarrhalis). …”
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Micro-Electro Nanofibrous Dressings Based on PVDF-AgNPs as Wound Healing Materials to Promote Healing in Active Areas by Liu T, Xie F, Geng L, He R, Sun M, Ni T, Xu P, Xing C, Peng Y, Chen K, Fang Y

“…By designing a micro-electro-Nanofiber dressing composed of piezoelectric polyvinylidene fluoride (PVDF) integrated with antimicrobial silver nanoparticles (AgNPs), this research aims to address the dual challenges of promoting effective wound healing and maintaining joint mobility.Methods: Herein, we developed a novel micro-electro-Nanofiber dressing using electrospinning technology, incorporating polyvinylidene fluoride (PVDF) with silver nanoparticles (AgNPs). …”
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