Sex differences in cardiorespiratory control under hypoxia: the roles of oxygen desaturation and hypoxic exposure time by André Luiz Musmanno Branco Oliveira, Gabriel Dias Rodrigues, Gabriel Dias Rodrigues, Bruno Moreira Silva, Philippe de Azeredo Rohan, Pedro Paulo da Silva Soares

“…Accordingly, we hypothesized that sex differences in cardiovascular and ventilatory responses would be more pronounced with equal hypoxia duration (iso-time) but less pronounced at similar oxygen desaturation levels (iso-saturation).MethodsTwenty-two (12 females) healthy individuals were exposed to normoxia (10 min at FiO2 = 0.21) and hypoxia (10 min at FiO2 = 0.115), respectively. …”
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Sleep-Aiding Effect of Casein-Derived Peptide TPTLN and Its Underlying Mechanism by DENG Shijie, LIU Ling, HUANG Ju, FENG Fengqin, ZHAO Minjie, DU Juan

“…Objective: To investigate the sleep-aiding effect of casein-derived peptide TPTLN and explore its possible mechanism of action. Methods: Thirty mice were divided equally into three groups, an experimental, a positive control and a blank control group, which were gavaged with TPTLN at a dose of 5 mg/kg mb, intraperitoneally injected with diazepam at a dose of 1 mg/kg mb, and gavaged with sterilized water at a dose of 5 mg/kg mb, respectively. …”
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Causal Relationships Between Blood Lipid Levels and Chronic Obstructive Pulmonary Disease: A Mendelian Randomization Analysis by Huang P, Zhao Y, Wei H, Wu W, Guo Z, Ma S, Xu M, Wang Q, Jia C, Xiang T, Li H

“…Therefore, this study employed Mendelian randomization (MR) analysis to investigate the potential causal connection between blood lipids and COPD.Materials and Methods: A genome-wide association study (GWAS) on COPD was conducted, encompassing a total of 112,583 European participants from the MRC-IEU. …”
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Impact of Circadian Rhythm and Sleep Architecture Changes on Prognosis in Patients with Acute Hemorrhagic Stroke by Yuan X, Fu Y, Ou Y, Xue J, Yang N, Liu H, Wang T, Wang J, Yan C, Zhang P

“…This study aims to characterize these changes and explore their association with clinical prognosis, offering new insights for diagnosis and treatment.Methods: We enrolled 100 acute hemorrhagic stroke patients who underwent continuous, contactless sleep monitoring via a smart mattress for 3– 5 consecutive days. …”
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Investigating the Analgesic Mechanisms of Acupuncture for Cancer Pain: Insights From Multimodal Bioelectrical Signal Analysis by Huang J, Zhao L, Xie Y, Wang C, Yang X, Huang H, Zhang D

“…This study investigates the neurophysiological mechanisms underlying acupuncture’s analgesic effects using multimodal bioelectrical signal analysis.Patients and Methods: Fifteen cancer pain patients underwent acupuncture while wearing portable, multi-sensor devices to capture bioelectrical signals. …”
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Multicenter Surveillance of Pseudomonas aeruginosa Isolates From Blood: Clinical Distribution Characteristics and Antibiotic Resistance Trends in Hebei Province, China (2016–... by Qiang C, Liu X, Qin P, Wen H, Li Z, Yang J, Niu Y, Wang W, Ouyang Z, Zhao M, Li J, Zhang Y, Zhao J

“…Cuixin Qiang,1,* Xiaoxuan Liu,1,* Pu Qin,1 Hainan Wen,2 Zhirong Li,1 Jing Yang,1 Yanan Niu,1 Weigang Wang,1 Zirou Ouyang,1 Min Zhao,1 Jiayiren Li,1 Yulian Zhang,1 Jianhong Zhao1 1The Second Hospital of Hebei Medical University, Hebei Provincial Center for Clinical Laboratories, Shijiazhuang, Hebei, People’s Republic of China; 2Department of Laboratory Medicine, Affiliated Hospital of Chengde Medical University, Chengde, Hebei, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jianhong Zhao, The Second Hospital of Hebei Medical University, Hebei Provincial Center for Clinical Laboratories, Shijiazhuang, Hebei, People’s Republic of China, Tel +86 0311 66002711, Email zhaojh_2002@hebmu.edu.cnPurpose: To analyze the clinical distribution and antimicrobial resistance of Pseudomonas aeruginosa (P. aeruginosa) isolated from blood specimens in 75 hospitals in Hebei Province from 2016 to 2021 to aid in the rational selection of antimicrobial drugs.Patients and Methods: WHONET 5.6 and SPSS 24.0 were used to retrospectively analyze clinical distribution characteristics and variations in drug-resistance.Results: Between 2016 and 2021, 2208 P. aeruginosa strains were detected in blood specimens from Hebei Province. …”
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Correlation Between Lipid Accumulation Product and Metabolic Dysfunction-Associated Steatotic Liver Disease in Chinese Adults with Type 2 Diabetes Mellitus by Liu W, Xu L, Yu Y, Qiao L, Zhang L, Chu X, Jing H, Cao L

“…Wei Liu,1,* Lingling Xu,1,* Yuan Yu,2 Liang Qiao,1 Lijuan Zhang,1 Xiaoqiu Chu,1 Haibo Jing,3 Lin Cao1 1Department of Endocrinology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210028, People’s Republic of China; 2Department of Gastroenterology, Jiangning Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu, 211100, People’s Republic of China; 3Department of General Surgery, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210028, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lin Cao, Department of Endocrinology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, NO. 100 Shizi Street, Hongshan Road, Nanjing, Jiangsu, 210028, People’s Republic of China, Tel/Fax +86-25-85608733, Email guodongcl@163.com Xiaoqiu Chu, Department of Endocrinology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, NO. 100 Shizi Street, Hongshan Road, Nanjing, Jiangsu, 210028, People’s Republic of China, Tel/Fax +86-25-85608735, Email chumickey@126.comObjective: To evaluate the value and feasibility of the lipid accumulation product (LAP) in the prediction of metabolic dysfunction-associated steatotic liver disease (MASLD) in Chinese adults with type 2 diabetes mellitus (T2DM).Methods: In this cross-sectional study, we assessed the value of LAP and other novel indices in the prediction of MASLD in Chinese adults with T2DM in a total of 642 patients. …”
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Correlation Between Thyroid Hormone and Controlled Attenuation Parameters: A Cross-Sectional Population-Based Study by Li S, Wu X, Yu J, Jiang J, Qi R, Chen B, Li Z

“…Sumei Li,1,* Xingye Wu,2,* Jingming Yu,2 Jiaqin Jiang,2 Ruibing Qi,2 Bing Chen,3 Zhengming Li2 1Department of Endocrinology and Metabolism, Guangxi Hospital Division of The First Affiliated Hospital, Sun Yat-sen University, Nanning, 530022, People’s Republic of China; 2Department of Endocrinology and Metabolism, Guangxi Academy of Medical Sciences and the People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, People’s Republic of China; 3Department of Endocrinology, Wuming Hospital of Guangxi Medical University, Nanning, 530199, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhengming Li, Email zmli@gxams.org.cnObjective: The aim of the present study was to investigate how thyroid hormone levels are related to controlled attenuation parameters (CAP), which may provide insights for understanding the role of these factors in hepatic steatosis.Methods: A total of 3461 participants who underwent CAP diagnosis between 2018 and 2023 were included. …”
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Adaptation of global primary production model to the Greenland Sea conditions: parameterization and monitoring for 1998-2022 by Aleksandra Cherkasheva, Rustam Manurov, Piotr Kowalczuk, Alexandra N. Loginova, Monika Zabłocka, Astrid Bracher, Astrid Bracher

“…Our modelled regional annual primary production estimates are equal to 346 TgC/year for the Nordic Seas region and 342 TgC/year for the Greenland Sea sector of the Arctic defined as 45°W-15°E, 66°33′N-90°N. …”
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Proteomic Profiling and Clinical Insights: The Role of MMP9 in Differentiating Psoriasis Vulgaris from Generalized Pustular Psoriasis by Gong T, Chen J, Xiao Z, Luo R, Tong Z, Ke H, Liu Z, Xiao C, Xiang N, Ji C

“…The IL-36 pathway has been identified as a key element in GPP pathogenesis.Objective: To explore protein expression between PV and GPP, providing insights into potential mechanisms.Methods: We performed proteomic analysis of tissue specimens from patients with PV and GPP to identify differentially expressed proteins. …”
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Effect of Position-Based Dosing Strategy for Metaraminol on Neonatal Acid–Base Status During Elective Caesarean Delivery: A Noninferiority Randomised Controlled Trial by Liu T, Jiang H, Xu C, Li L, Zhang H, Feng Y

“…We hypothesize that using a higher starting dose of metaraminol in the supine position will result in a non-inferior umbilical arterial pH, compared to the 15° left tilt position.Methods: Healthy women undergoing elective caesarean delivery were randomized to the supine position (n = 62) or 15° left tilt position (n = 62) after spinal anaesthesia (0.5% bupivacaine 9 mg). …”
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Successful Treatment of Freckles Using a 730-nm Picosecond Laser: A Prospective Study by Huang Y, Liu X, Zhang M, Lin T

“…This study aims to evaluate the efficacy and safety of a novel 730‐nm Ti: Sapphire picosecond laser in the treatment of freckles in Chinese patients.Methods: A total of 12 patients with freckles were enrolled. …”
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Campus closures and students’ mental health in Lebanon and Sharjah: A comparative cross-sectional study by Michael Clinton, Jacqueline Maria Dias, Myrna A. Doumit, Mohamad Alameddine, Murielle Mardi, Karen Bou- Karroum

“…Parametric test results were interpreted for non-equal sample sizes. Results: All the non-nursing students in Lebanon and 87.1 % of the nursing students in Sharjah screened positive for anxiety. …”
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Machine Learning Prognostic Model for Post-Radical Resection Hepatocellular Carcinoma in Hepatitis B Patients by Zhu D, Tulahong A, Abuduhelili A, Liu C, Aierken A, Lin Y, Jiang T, Lin R, Shao Y, Aji T

“…This study sought to develop and validate a machine learning-based prognostic model to predict survival outcomes in patients with HBV-related HCC following radical resection, with the potential to inform personalized treatment strategies.Patients and Methods: This study retrospectively analyzed clinical data from 146 patients at Xinjiang Medical University and 75 patients from The Cancer Genome Atlas (TCGA) database. …”
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Clinical and microbial study of reinforced 3D-printed maxillary denture base resin: a randomized trial by Eman Mohamed Ahmed Teama, Hoda Mohamed Amin Rashad, Eman Abd El-salam Mohamed Shakal, Eman Elsayed Hegazy

“…Purpose To evaluate the effects of adding nano ZrO2 and nano TiO2 on microbial colonization and patient satisfaction with 3D-printed maxillary complete dentures. Materials and methods Twenty-four patients who needed complete dentures were randomly distributed into three equal groups. …”
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A Strategy to Design Non-Symmetric Compound by Modifying the End-Group Functional Atoms for Photothermal and Photodynamic Therapy of Tumor by Xie X, Zeng J, Xu MY, Han XH, Fan B, Li X, Wei DD, Han XJ, Huang S

“…Xin Xie,1,2,* Jie Zeng,1,2,* Miao-Yan Xu,1,2 Xin-Hao Han,1 Bing Fan,3 Xianglong Li,4 Duo-Duo Wei,1,2 Xiao-Jian Han,1,5 Shaorong Huang1 1Institute of Geriatrics, Jiangxi Provincial People’s Hospital, the First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, 330006, People’s Republic of China; 2School of Pharmacy, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, People’s Republic of China; 3Department of Radiology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, 330006, People’s Republic of China; 4Jiangxi Key Laboratory of Organic Chemistry, Institute of Organic Chemistry, Jiangxi Science & Technology Normal University, Nanchang, 330013, People’s Republic of China; 5The Second Department of Neurology, Jiangxi Provincial People’s Hospital, the First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, 330006, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiao-Jian Han; Shaorong Huang, Email hanxiaojian@hotmail.com; huangshaorong@ncmc.edu.cnBackground: The exploration of non-symmetric compound for combined photothermal therapy (PTT) and photodynamic therapy (PDT) in tumor treatment remains largely unexplored.Methods: Through a molecular design strategy, a series of compound (Y-4Cl, Y-2Br, and Y-2Cl-Br) with fused - ring benzothiazole - pyrrole - thiophene - indenone constructure were synthesized to explore its phototherapy properties, to investigate their phototherapeutic properties, respectively. …”
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Temporal and Seasonal Trends in Pediatric Eye Trauma in California by Bishay MN, Xu A, Nesemann JM, Keenan JD, Oatts JT

“…Proctor Foundation, University of California, San Francisco, CA, USA; 4Division of Ophthalmology, Children’s Hospital of Philadelphia, Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA*These authors contributed equally to this workCorrespondence: Julius T Oatts, Division of Ophthalmology; Children’s Hospital of Philadelphia, Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, 3500 Civic Center Blvd, Philadelphia, PA, 19104, USA, Tel +1-215-590-2791, Email oattsj2@chop.eduPurpose: This study aims to evaluate temporal and seasonal trends in pediatric eye trauma based on emergency department (ED) visits in California.Design: Retrospective, population-based cohort study.Methods: Children who presented with ocular trauma to EDs in California between 2016 and 2021 were identified using the California Department of Health Care Access and Information datasets and classified by International Classification of Diseases (ICD) diagnosis codes. …”
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Comparative evaluation of aqueous solution and oil emulsion formulations of 0.05% cyclosporine eye drops in dry eye disease – A randomized clinical trial by Ayesha A Salam, Seema Sen, Neiwete Lomi, Noopur Gupta, Murugesan Vanathi, Radhika Tandon

“…Conclusion: Both aqueous solution and oil emulsion 0.05% cyclosporine formulations appear to be equally effective in the management of dry eye disease with a comparatively better response with oil emulsion formulations.…”
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Antidepressant use in the Canary Islands (Spain): a retrospective study of provincial, island and municipal trends and associated factors by Alexis Oliva, Vanessa Moreno, Mariana Sapino, Sandra Dévora, Susana Abdala-Kuri

“…To this end, several factors were analyzed, such as living in a rural or urban area, the population over 65 years of age, the population density or the socioeconomic status.MethodsData were extracted from the community pharmacy wholesaler at the population level. …”
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Evaluation of Applying Standardized Patients in Certification Assessment of Clinical Practice Ability Standardized Training for Psychiatric Resident Physicians by Yao F, Chen JS, Chen LH, Ye BY, Yang CJ, Li XZ

“…Fei Yao,1,2,* Jian-Song Chen,1,2,* Li-Hong Chen,1,2 Bi-Yu Ye,1,2 Chan-Juan Yang,1,2 Xuan-Zi Li1,2 1Department of Education, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 510370, People’s Republic of China; 2School of Mental Health, Guangzhou Medical University, Guangzhou, Guangdong, 510370, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xuan-Zi Li; Chan-Juan Yang, Department of Education, The Affiliated Brain Hospital, School of Mental Health, Guangzhou Medical University, No. 36 mingxin Road, Guangzhou, Guangdong, 510370, People’s Republic of China, Tel +86 20 81268042, Email lixuanzi@gzhmu.edu.cn; yangw2020@gzhmu.edu.cnObjective: The aim of this study was to explore the application of standardized patient (SP) in the certification assessment of clinical practice ability standardized training for psychiatric resident physicians.Methods: Candidates and examiners who participated in the graduation examination of clinical practice ability standardized training for psychiatric resident physicians in Guangdong Province from 2020 to 2023 were selected as the research participants. …”
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